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  1. Article ; Online: α-Synuclein seed amplification technology for Parkinson's disease and related synucleinopathies.

    Soto, Claudio

    Trends in biotechnology

    2024  

    Abstract: Synucleinopathies are a group of neurodegenerative diseases (NDs) associated with cerebral accumulation of α-synuclein (αSyn) misfolded aggregates. At this time, there is no effective treatment to stop or slow down disease progression, which in part is ... ...

    Abstract Synucleinopathies are a group of neurodegenerative diseases (NDs) associated with cerebral accumulation of α-synuclein (αSyn) misfolded aggregates. At this time, there is no effective treatment to stop or slow down disease progression, which in part is due to the lack of an early and objective biochemical diagnosis. In the past 5 years, the seed amplification technology has emerged for highly sensitive identification of these diseases, even at the preclinical stage of the illness. Much research has been done in multiple laboratories to validate the efficacy and reproducibility of this assay. This article provides a comprehensive review of this technology, including its conceptual basis and its multiple applications for disease diagnosis, as well for understanding of the disease biology and therapeutic development.
    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 47474-5
    ISSN 1879-3096 ; 0167-7799
    ISSN (online) 1879-3096
    ISSN 0167-7799
    DOI 10.1016/j.tibtech.2024.01.007
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  2. Article: Editorial: Prion-Like transmission of pathogenic proteins in neurodegenerative diseases: structural and molecular bases.

    Banerjee, Victor / Wang, Fei / Sarnataro, Daniela / Soto, Claudio

    Frontiers in molecular biosciences

    2023  Volume 10, Page(s) 1294465

    Language English
    Publishing date 2023-09-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2814330-9
    ISSN 2296-889X
    ISSN 2296-889X
    DOI 10.3389/fmolb.2023.1294465
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  3. Article ; Online: Correction: Prion Protein Misfolding Affects Calcium Homeostasis and Sensitizes Cells to Endoplasmic Reticulum Stress.

    Torres, Mauricio / Castillo, Karen / Armisén, Ricardo / Stutzin, Andrés / Soto, Claudio / Hetz, Claudio

    PloS one

    2022  Volume 17, Issue 1, Page(s) e0262628

    Abstract: This corrects the article DOI: 10.1371/journal.pone.0015658.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pone.0015658.].
    Language English
    Publishing date 2022-01-11
    Publishing country United States
    Document type Published Erratum
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0262628
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  4. Article ; Online: α-synuclein seed amplification in Parkinson's disease - Authors' reply.

    Siderowf, Andrew / Concha-Marambio, Luis / Marek, Kenneth / Soto, Claudio

    The Lancet. Neurology

    2023  Volume 22, Issue 11, Page(s) 985–986

    MeSH term(s) Humans ; alpha-Synuclein/genetics ; Parkinson Disease/genetics
    Chemical Substances alpha-Synuclein
    Language English
    Publishing date 2023-10-27
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2081241-3
    ISSN 1474-4465 ; 1474-4422
    ISSN (online) 1474-4465
    ISSN 1474-4422
    DOI 10.1016/S1474-4422(23)00371-X
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  5. Article ; Online: Correction

    Mauricio Torres / Karen Castillo / Ricardo Armisén / Andrés Stutzin / Claudio Soto / Claudio Hetz

    PLoS ONE, Vol 17, Iss

    Prion Protein Misfolding Affects Calcium Homeostasis and Sensitizes Cells to Endoplasmic Reticulum Stress

    2022  Volume 1

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
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  6. Article ; Online: Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.

    Hetz, Claudio / Russelakis-Carneiro, Milene / Maundrell, Kinsey / Castilla, Joaquin / Soto, Claudio

    The EMBO journal

    2021  Volume 40, Issue 18, Page(s) e109151

    Language English
    Publishing date 2021-09-14
    Publishing country England
    Document type Published Erratum
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.2021109151
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  7. Article ; Online: PMCA for ultrasensitive detection of prions and to study disease biology.

    Wang, Fei / Pritzkow, Sandra / Soto, Claudio

    Cell and tissue research

    2022  Volume 392, Issue 1, Page(s) 307–321

    Abstract: The emergence of a novel class of infectious agent composed exclusively of a misfolded protein (termed prions) has been a challenge in modern biomedicine. Despite similarities on the behavior of prions with respect to conventional pathogens, the many ... ...

    Abstract The emergence of a novel class of infectious agent composed exclusively of a misfolded protein (termed prions) has been a challenge in modern biomedicine. Despite similarities on the behavior of prions with respect to conventional pathogens, the many uncertainties regarding the biology and virulence of prions make them a worrisome paradigm. Since prions do not contain nucleic acids and rely on a very different way of replication and spreading, it was necessary to invent a novel technology to study them. In this article, we provide an overview of such a technology, termed protein misfolding cyclic amplification (PMCA), and summarize its many applications to detect prions and understand prion biology.
    MeSH term(s) Humans ; Prions/metabolism ; Prion Diseases/diagnosis ; Prion Diseases/metabolism ; Protein Folding ; Biology
    Chemical Substances Prions
    Language English
    Publishing date 2022-12-26
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 125067-x
    ISSN 1432-0878 ; 0302-766X
    ISSN (online) 1432-0878
    ISSN 0302-766X
    DOI 10.1007/s00441-022-03727-5
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  8. Article: Another in need enhances prosociality and modulates frontal theta oscillations in young adults.

    Lavín, Claudio / Soto-Icaza, Patricia / López, Vladimir / Billeke, Pablo

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1160209

    Abstract: Introduction: Decision-making is a process that can be strongly affected by social factors. Evidence has shown how people deviate from traditional rational-choice predictions under different levels of social interactions. The emergence of prosocial ... ...

    Abstract Introduction: Decision-making is a process that can be strongly affected by social factors. Evidence has shown how people deviate from traditional rational-choice predictions under different levels of social interactions. The emergence of prosocial decision-making, defined as any action that is addressed to benefit another individual even at the expense of personal benefits, has been reported as an example of such social influence. Furthermore, brain evidence has shown the involvement of structures such as the prefrontal cortex, anterior insula, and midcingulate cortex during decision settings in which a decision maker interacts with others under physical pain or distress or while being observed by others.
    Methods: Using a slightly modified version of the dictator game and EEG recordings, we tested the hypothesis that the inclusion of another person into the decision setting increases prosocial decisions in young adults and that this increase is higher when the other person is associated with others in need. At the brain level, we hypothesized that the increase in prosocial decisions correlates with frontal theta activity.
    Results and discussion: The results showed that including another person in the decision, setting increased prosocial behavior only when this presence was associated with someone in need. This effect was associated with an increase in frontocentral theta-oscillatory activity. These results suggest that the presence of someone in need enhances empathy concerns and norm compliance, raising the participants' prosocial decision-making.
    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1160209
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  9. Article: Role of boron and its interaction with other elements in plants.

    Vera-Maldonado, Peter / Aquea, Felipe / Reyes-Díaz, Marjorie / Cárcamo-Fincheira, Paz / Soto-Cerda, Braulio / Nunes-Nesi, Adriano / Inostroza-Blancheteau, Claudio

    Frontiers in plant science

    2024  Volume 15, Page(s) 1332459

    Abstract: Boron (B) is an essential microelement for plants, and its deficiency can lead to impaired development and function. Around 50% of arable land in the world is acidic, and low pH in the soil solution decreases availability of several essential mineral ... ...

    Abstract Boron (B) is an essential microelement for plants, and its deficiency can lead to impaired development and function. Around 50% of arable land in the world is acidic, and low pH in the soil solution decreases availability of several essential mineral elements, including B, magnesium (Mg), calcium (Ca), and potassium (K). Plants take up soil B in the form of boric acid (H
    Language English
    Publishing date 2024-02-12
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2024.1332459
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  10. Article ; Online: Secretory and transcriptomic responses of mantle cells to low pH in the Pacific oyster (Crassostrea gigas)

    Nicolás Zúñiga-Soto / Ingrid Pinto-Borguero / Claudio Quevedo / Felipe Aguilera

    Frontiers in Marine Science, Vol

    2023  Volume 10

    Abstract: Since the Industrial Revolution, the concentration of atmospheric carbon dioxide (CO2) due to anthropogenic activities has increased at unprecedented rates. One-third of the atmospheric anthropogenic CO2 emissions are dissolved in the oceans affecting ... ...

    Abstract Since the Industrial Revolution, the concentration of atmospheric carbon dioxide (CO2) due to anthropogenic activities has increased at unprecedented rates. One-third of the atmospheric anthropogenic CO2 emissions are dissolved in the oceans affecting the chemical equilibrium of seawater, which in turn leads to a decrease in pH and carbonate ion (CO32-) concentration, a phenomenon known as ocean acidification (OA). This chemical disequilibrium can be detrimental to marine organisms (e.g., mollusks) that fabricate mineralized structures based on calcium carbonate (CaCO3). Most studies on the effect of reduced pH in seawater have been conducted on the early developmental stages of shell-building invertebrates, given less attention to how adult individuals face OA stress. Here, we evaluate histological, secretory, and transcriptional changes in the mantle of adult oysters (Crassostrea gigas) exposure to ambient (8.0 ± 0.2) and reduced (7.6 ± 0.2) pH during 20 days. Most histological observations did not show differences in terms of mantle cell morphology. However, Alcian Blue/PAS staining revealed significant differences in the number of Alcian Blue positive cells in the mantle edge, suggesting a decrease in the secretory activity in this morphogenetic zone. Transcriptomic analysis revealed 172 differentially expressed genes (DEGs) between mantle tissues from adult oysters kept in normal and reduced pH conditions. Almost 18% of the DEGs encode secreted proteins that are likely to be contributing to shell fabrication and patterning. 17 of 31 DEGs encoding secreted proteins correspond to oyster-specific genes, highlighting the fact that molluscan shell formation is underpinned by a rapidly evolving secretome. The GO analysis of DEGs encoding secreted proteins showed that they are involved in the cellular response to stimulus, response to stress, protein binding, and ion binding, suggesting these biological processes and molecular functions are altered by OA. This study demonstrates that histology and gene expression ...
    Keywords Crassostrea gigas ; ocean acidification ; adult oyster ; secretory cells ; transcriptome ; mantle secretome ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
    Subject code 612
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
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