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Article ; Online: Strain-dependent role of copper in prion disease through binding to histidine residues in the N-terminal domain of prion protein.

Hara, Hideyuki / Miyata, Hironori / Chida, Junji / Sakaguchi, Suehiro

2023 Volume 167, Issue 3, Page(s) 394–409

Abstract: The cellular prion protein, ... ...

Abstract	The cellular prion protein, PrP
Language	English
Publishing date	2023-09-30
Publishing country	England
Document type	Journal Article
ZDB-ID	80158-6
ISSN	1471-4159 ; 0022-3042 ; 1474-1644
ISSN (online)	1471-4159
ISSN	0022-3042 ; 1474-1644
DOI	10.1111/jnc.15971
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Article ; Online: Prion Protein is a Novel Modulator of Influenza: Potential Implications for Anti-Influenza Therapeutics.

Sakaguchi, Suehiro / Chida, Junji

Current issues in molecular biology

2019 Volume 37, Page(s) 21–32

Abstract: Worldwide spread of influenza A virus (IAV) strains, which are resistant to currently available anti- influenza agents such as viral neuraminidase inhibitors, has encouraged identification of new target molecules for anti-influenza agents. Reactive ... ...

Abstract	Worldwide spread of influenza A virus (IAV) strains, which are resistant to currently available anti- influenza agents such as viral neuraminidase inhibitors, has encouraged identification of new target molecules for anti-influenza agents. Reactive oxygen species (ROS) causing oxidative stress play a pivotal role in the pathogenesis of lung injuries induced by infection with IAVs, therefore suggesting that anti-oxidative therapeutics targeting cellular molecules could be beneficial against IAV infection without inducing drug-resistant IAV strains. We recently found that the normal cellular prion protein, PrP
MeSH term(s)	Animals ; Antioxidants/pharmacology ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Host-Pathogen Interactions ; Humans ; Influenza A virus/drug effects ; Influenza A virus/physiology ; Influenza, Human/drug therapy ; Influenza, Human/genetics ; Influenza, Human/metabolism ; Influenza, Human/virology ; Oxidation-Reduction/drug effects ; Prion Proteins/pharmacology ; Protective Agents/pharmacology ; Reactive Oxygen Species/metabolism ; Virus Replication/drug effects
Chemical Substances	Antioxidants ; Antiviral Agents ; Prion Proteins ; Protective Agents ; Reactive Oxygen Species
Language	English
Publishing date	2019-12-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.21775/cimb.037.021
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Article ; Online: Roles of Prion Protein in Virus Infections.

Sakaguchi, Suehiro / Chida, Junji

DNA and cell biology

2018 Volume 37, Issue 10, Page(s) 808–811

Abstract: The normal cellular prion protein, designated ... ...

Abstract	The normal cellular prion protein, designated PrP
MeSH term(s)	Animals ; Copper/immunology ; Copper/metabolism ; Enzyme Activation ; Epithelial Cells/enzymology ; Epithelial Cells/immunology ; Epithelial Cells/virology ; Gene Expression Regulation/immunology ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/immunology ; Influenza A virus/pathogenicity ; Influenza A virus/physiology ; Lung/enzymology ; Lung/immunology ; Lung/virology ; Mice ; Orthomyxoviridae Infections/enzymology ; Orthomyxoviridae Infections/genetics ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/virology ; Oxidative Stress ; PrPC Proteins/genetics ; PrPC Proteins/immunology ; Protective Factors ; Reactive Oxygen Species/immunology ; Reactive Oxygen Species/metabolism ; Superoxide Dismutase-1/genetics ; Superoxide Dismutase-1/immunology
Chemical Substances	Heat-Shock Proteins ; PrPC Proteins ; Reactive Oxygen Species ; Stip1 protein, mouse ; Copper (789U1901C5) ; Sod1 protein, mouse (EC 1.15.1.1) ; Superoxide Dismutase-1 (EC 1.15.1.1)
Language	English
Publishing date	2018-09-14
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1024454-2
ISSN	1557-7430 ; 0198-0238 ; 1044-5498
ISSN (online)	1557-7430
ISSN	0198-0238 ; 1044-5498
DOI	10.1089/dna.2018.4402
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Article ; Online: Central residues in prion protein PrP

Pasiana, Agriani Dini / Miyata, Hironori / Chida, Junji / Hara, Hideyuki / Imamura, Morikazu / Atarashi, Ryuichiro / Sakaguchi, Suehiro

The Journal of biological chemistry

2022 Volume 298, Issue 9, Page(s) 102381

Abstract: Conformational conversion of the cellular prion protein, ... ...

Abstract	Conformational conversion of the cellular prion protein, PrP
MeSH term(s)	Animals ; Mice ; Prion Diseases/genetics ; Prion Proteins/chemistry ; Prion Proteins/genetics ; Prions/pathogenicity ; Proline ; Protein Isoforms/genetics ; Translocation, Genetic
Chemical Substances	Prion Proteins ; Prions ; Protein Isoforms ; Proline (9DLQ4CIU6V)
Language	English
Publishing date	2022-08-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2022.102381
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Article ; Online: Real-world perioperative outcomes of segmentectomy versus lobectomy for early-stage lung cancer: a propensity score-matched analysis.

Ichinose, Junji / Yamamoto, Hiroyuki / Aokage, Keiju / Kondo, Haruhiko / Sato, Yukio / Suzuki, Kenji / Chida, Masayuki

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

2021 Volume 63, Issue 1

Abstract: Objectives: This study aimed to compare the real-world outcomes of segmentectomy and lobectomy for lung cancer after adjusting for background factors and the extent of lymphadenectomy.: Methods: This retrospective cohort study used a nationwide ... ...

Abstract	Objectives: This study aimed to compare the real-world outcomes of segmentectomy and lobectomy for lung cancer after adjusting for background factors and the extent of lymphadenectomy. Methods: This retrospective cohort study used a nationwide database in Japan. The data of patients with clinical stage 0/IA lung cancer who underwent segmentectomy or lobectomy between 2017 and 2019 were retrieved. Short-term postoperative outcomes were compared between the segmentectomy and lobectomy groups using propensity score-matched analysis. Results: In the total cohort of 59 663 patients, 11 975 and 47 688 patients were in the segmentectomy and lobectomy groups, respectively. After propensity score matching, 8426 matched patients from each group were retrieved. All confounders including age, sex, comorbidities, smoking history, respiratory function, tumour size, clinical stage, affected lobe and extent of lymphadenectomy were appropriately adjusted. The overall complication rate and the cardiopulmonary complication rate were lower in the segmentectomy group than in the lobectomy group (8.5% vs 11.2%, P < 0.001 and 7.5% vs 10.3%, P < 0.001, respectively). The incidence of prolonged air leak was also lower after segmentectomy than after lobectomy (3.6% vs 5.3%). Surgical mortality, operative time and blood loss volume were comparable between the 2 groups. Conclusions: The postoperative complication rate was lower with segmentectomy than with lobectomy for early-stage lung cancer.
MeSH term(s)	Humans ; Pneumonectomy/adverse effects ; Retrospective Studies ; Propensity Score ; Treatment Outcome ; Lung Neoplasms ; Neoplasm Staging
Language	English
Publishing date	2021-08-16
Publishing country	Germany
Document type	Journal Article
ZDB-ID	639293-3
ISSN	1873-734X ; 1010-7940 ; 1567-4258
ISSN (online)	1873-734X
ISSN	1010-7940 ; 1567-4258
DOI	10.1093/ejcts/ezac529
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Article ; Online: Neurotropic influenza A virus infection causes prion protein misfolding into infectious prions in neuroblastoma cells.

Hara, Hideyuki / Chida, Junji / Uchiyama, Keiji / Pasiana, Agriani Dini / Takahashi, Etsuhisa / Kido, Hiroshi / Sakaguchi, Suehiro

Scientific reports

2021 Volume 11, Issue 1, Page(s) 10109

Abstract: Misfolding of the cellular prion protein, ... ...

Abstract	Misfolding of the cellular prion protein, PrP
MeSH term(s)	Cell Line, Tumor ; Humans ; Influenza A virus/physiology ; Influenza, Human/genetics ; Influenza, Human/metabolism ; Influenza, Human/virology ; Neuroblastoma/genetics ; Neuroblastoma/metabolism ; Neuroblastoma/virology ; Prion Proteins/chemistry ; Prion Proteins/metabolism ; Protein Conformation ; Protein Folding
Chemical Substances	Prion Proteins
Language	English
Publishing date	2021-05-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-89586-6
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Article ; Online: Ethanolamine Is a New Anti-Prion Compound.

Uchiyama, Keiji / Hara, Hideyuki / Chida, Junji / Pasiana, Agriani Dini / Imamura, Morikazu / Mori, Tsuyoshi / Takatsuki, Hanae / Atarashi, Ryuichiro / Sakaguchi, Suehiro

International journal of molecular sciences

2021 Volume 22, Issue 21

Abstract: Prion diseases are a group of fatal neurodegenerative disorders caused by accumulation of proteinaceous infectious particles, or prions, which mainly consist of the abnormally folded, amyloidogenic prion protein, designated ... ...

Abstract	Prion diseases are a group of fatal neurodegenerative disorders caused by accumulation of proteinaceous infectious particles, or prions, which mainly consist of the abnormally folded, amyloidogenic prion protein, designated PrP
MeSH term(s)	Animals ; Brain/metabolism ; Cell Line, Tumor ; Ethanolamine/pharmacology ; Mice ; Mice, Inbred ICR ; PrPSc Proteins/antagonists & inhibitors ; PrPSc Proteins/genetics ; PrPSc Proteins/metabolism ; Prion Diseases/drug therapy ; Prion Diseases/genetics ; Prion Diseases/metabolism
Chemical Substances	PrPSc Proteins ; Ethanolamine (5KV86114PT)
Language	English
Publishing date	2021-10-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms222111742
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Article: Electrochemical enzyme-based blood ATP and lactate sensor for a rapid and straightforward evaluation of illness severity

Nishiyama, Keine / Mizukami, Ryohei / Kuki, Shizuka / Ishida, Akihiko / Chida, Junji / Kido, Hiroshi / Maeki, Masatoshi / Tani, Hirofumi / Tokeshi, Manabu

Biosensors & bioelectronics. 2022 Feb. 15, v. 198

2022

Abstract: This study aimed to develop an electrochemical system for measuring blood ATP and lactate levels in a single format. The ratio of lactate to ATP levels was previously reported to provide an alternative illness severity score. Although severity evaluation ...

Abstract	This study aimed to develop an electrochemical system for measuring blood ATP and lactate levels in a single format. The ratio of lactate to ATP levels was previously reported to provide an alternative illness severity score. Although severity evaluation is crucial to treat patients with acute disease admitted to intensive care units, no sensors are currently available to simply and rapidly measure ATP and lactate levels using the same detection method. Therefore, we constructed an integrated sensing system for ATP and lactate using enzymatic reactions and two sets of electrodes integrated into a chip connected to a single potentiostat operated by a microcontroller. The enzymatic system involves adenylate kinase, pyruvate kinase, and pyruvate oxidase for ATP, and lactate oxidase for lactate, both of which produce hydrogen peroxide. Multiplex enzyme-based reactions were designed to minimize the corresponding operations significantly without enzyme immobilization onto the electrodes. The system was robust in the presence of potentially interfering blood components, such as ascorbate, pyruvate, ADP, urate, and potassium ions. The ATP and lactate levels in the blood were successfully measured using the new sensor with good recoveries. The analytical results of blood samples obtained using our sensor were in good agreement with those using conventional methods. Integrating electrode-based analysis and a microcontroller-based system saved further operations, enabling the straightforward measurement of ATP and lactate levels within 5 min. The proposed sensor may serve as a useful tool in the management of serious infectious diseases.
Keywords	acute course ; adenylate kinase ; biosensors ; blood ; electrochemistry ; hydrogen peroxide ; immobilized enzymes ; lactate 2-monooxygenase ; lactic acid ; potassium ; pyruvate kinase ; pyruvate oxidase ; pyruvic acid
Language	English
Dates of publication	2022-0215
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2021.113832
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Article ; Online: Extraction and quantification of adenosine triphosphate in mammalian tissues and cells.

Chida, Junji / Kido, Hiroshi

Methods in molecular biology (Clifton, N.J.)

2014 Volume 1098, Page(s) 21–32

Abstract: Adenosine 5'-triphosphate (ATP) is the "energy currency" of organisms and plays central roles in bioenergetics, whereby its level is used to evaluate cell viability, proliferation, death, and energy transmission. In this chapter, we describe an improved ... ...

Abstract	Adenosine 5'-triphosphate (ATP) is the "energy currency" of organisms and plays central roles in bioenergetics, whereby its level is used to evaluate cell viability, proliferation, death, and energy transmission. In this chapter, we describe an improved and efficient method for extraction of ATP from tissues and cells using phenol-based reagents. The chaotropic extraction reagents reported so far co-precipitate ATP with insoluble proteins during extraction and with salts during neutralization. In comparison, the phenol-based reagents extract ATP well without the risks of co-precipitation. The extracted ATP can be quantified by the luciferase assay or high-performance liquid chromatography.
MeSH term(s)	Adenosine Triphosphate/analysis ; Adenosine Triphosphate/blood ; Adenosine Triphosphate/isolation & purification ; Animals ; Chemical Fractionation/methods ; Chromatography, High Pressure Liquid ; Ethylene Glycol/chemistry ; Indicators and Reagents/chemistry ; Luciferases, Firefly/metabolism ; Luminescent Measurements ; Mice ; Phenols/chemistry ; Trichloroacetic Acid/chemistry
Chemical Substances	Indicators and Reagents ; Phenols ; Trichloroacetic Acid (5V2JDO056X) ; Adenosine Triphosphate (8L70Q75FXE) ; Luciferases, Firefly (EC 1.13.12.7) ; Ethylene Glycol (FC72KVT52F)
Language	English
Publishing date	2014
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-62703-718-1_2
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Article ; Online: Electrochemical enzyme-based blood ATP and lactate sensor for a rapid and straightforward evaluation of illness severity.

Nishiyama, Keine / Mizukami, Ryohei / Kuki, Shizuka / Ishida, Akihiko / Chida, Junji / Kido, Hiroshi / Maeki, Masatoshi / Tani, Hirofumi / Tokeshi, Manabu

Biosensors & bioelectronics

2021 Volume 198, Page(s) 113832

Abstract	This study aimed to develop an electrochemical system for measuring blood ATP and lactate levels in a single format. The ratio of lactate to ATP levels was previously reported to provide an alternative illness severity score. Although severity evaluation is crucial to treat patients with acute disease admitted to intensive care units, no sensors are currently available to simply and rapidly measure ATP and lactate levels using the same detection method. Therefore, we constructed an integrated sensing system for ATP and lactate using enzymatic reactions and two sets of electrodes integrated into a chip connected to a single potentiostat operated by a microcontroller. The enzymatic system involves adenylate kinase, pyruvate kinase, and pyruvate oxidase for ATP, and lactate oxidase for lactate, both of which produce hydrogen peroxide. Multiplex enzyme-based reactions were designed to minimize the corresponding operations significantly without enzyme immobilization onto the electrodes. The system was robust in the presence of potentially interfering blood components, such as ascorbate, pyruvate, ADP, urate, and potassium ions. The ATP and lactate levels in the blood were successfully measured using the new sensor with good recoveries. The analytical results of blood samples obtained using our sensor were in good agreement with those using conventional methods. Integrating electrode-based analysis and a microcontroller-based system saved further operations, enabling the straightforward measurement of ATP and lactate levels within 5 min. The proposed sensor may serve as a useful tool in the management of serious infectious diseases.
MeSH term(s)	Adenosine Triphosphate ; Biosensing Techniques ; Electrodes ; Humans ; Lactic Acid ; Patient Acuity
Chemical Substances	Lactic Acid (33X04XA5AT) ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2021-11-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1011023-9
ISSN	1873-4235 ; 0956-5663
ISSN (online)	1873-4235
ISSN	0956-5663
DOI	10.1016/j.bios.2021.113832
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