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  1. Article ; Online: Artificial sweeteners and cardiovascular risk.

    Gomez-Delgado, Francisco / Torres-Peña, Jose David / Gutierrez-Lara, Gema / Romero-Cabrera, Juan Luis / Perez-Martinez, Pablo

    Current opinion in cardiology

    2023  Volume 38, Issue 4, Page(s) 344–351

    Abstract: Purpose of review: Globalization and the increase in consumption of ultra-processed foods have led to a need for greater knowledge on the health impacts of certain nutrients such as artificial sweeteners. This review aims to analyse the role of ... ...

    Abstract Purpose of review: Globalization and the increase in consumption of ultra-processed foods have led to a need for greater knowledge on the health impacts of certain nutrients such as artificial sweeteners. This review aims to analyse the role of artificial sweeteners (nutritive and nonnutritive) and their impact on cardiometabolic and cardiovascular disease (CVD) risk.
    Recent findings: The detrimental effects of a high-calorie, high-sugar diet have been well established. In light of this, health authorities recommend limiting sugar consumption. This has led the food industry to develop different artificial sweeteners with specific properties, such as flavour and stability (nutritive artificial sweeteners: NAS), and others aimed at limiting sugar in the diet (nonnutritive artificial sweeteners: nNAS). Likewise, recent evidence explores the influence of artificial sweeteners (NAS and nNAS) on CVD risk through risk factors such as obesity and type 2 diabetes mellitus, among others.
    Summary: This review aims to provide an updated overview of the impact of NAS and nNAS on cardiovascular health and provide recommendations regarding their consumption.
    MeSH term(s) Humans ; Sweetening Agents/adverse effects ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Diabetes Mellitus, Type 2/etiology ; Risk Factors ; Heart Disease Risk Factors ; Sugars
    Chemical Substances Sweetening Agents ; Sugars
    Language English
    Publishing date 2023-04-12
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 645186-x
    ISSN 1531-7080 ; 0268-4705
    ISSN (online) 1531-7080
    ISSN 0268-4705
    DOI 10.1097/HCO.0000000000001048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2556: Show issues Location:
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  2. Article ; Online: Adherence to a Mediterranean lifestyle improves metabolic status in coronary heart disease patients: A prospective analysis from the CORDIOPREV study.

    Romero-Cabrera, Juan Luis / García-Ríos, Antonio / Sotos-Prieto, Mercedes / Quintana-Navarro, Gracia / Alcalá-Díaz, Juan Francisco / Martín-Piedra, Laura / Torres-Peña, José David / Luque, Raúl M / Yubero-Serrano, Elena María / Delgado-Lista, Javier / Katsiki, Niki / Kales, Stefanos N / López-Miranda, José / Pérez-Martínez, Pablo

    Journal of internal medicine

    2023  Volume 293, Issue 5, Page(s) 574–588

    Abstract: Background and objectives: A Mediterranean lifestyle may prevent and mitigate cardiometabolic disorders. We explored whether adherence to a Mediterranean lifestyle was prospectively associated with the risk of metabolic syndrome (MetS) among coronary ... ...

    Abstract Background and objectives: A Mediterranean lifestyle may prevent and mitigate cardiometabolic disorders. We explored whether adherence to a Mediterranean lifestyle was prospectively associated with the risk of metabolic syndrome (MetS) among coronary heart disease (CHD) patients.
    Methods: The Coronary Diet Intervention with Olive Oil and Cardiovascular Prevention (CORDIOPREV) study was an interventional diet study to compare a Mediterranean diet with a low-fat diet, in 1002 CHD patients. The Mediterranean lifestyle (MEDLIFE) index was used to assess adherence to a MEDLIFE at baseline, and after 5 years, in 851 participants from the CORDIOPREV study. Subjects were classified as having high (>13 points), moderate (12-13 points), and low (<12 points) adherence to the MEDLIFE. Multivariable logistic regression models were used to determine the association between MEDLIFE adherence and the risk of MetS development or reversal.
    Results: During the 5-year follow-up, CORDIOPREV participants with high adherence to MEDLIFE had a lower risk of MetS development (odds ratio [OR] 0.37, 95% confidence interval [CI] 0.19-0.75, p < 0.01) and a higher likelihood of reversing preexisting MetS (OR 2.08 CI 95% 1.11-3.91, p = 0.02) compared with participants in the low MEDLIFE adherence group. Each additional one-point increment in the MEDLIFE index was associated with a 24% lower risk of MetS development (OR 0.76, 95% CI 0.64-0.90, p < 0.01) and a 21% higher likelihood of reversing preexisting MetS (OR 1.21 CI 95% 1.04-1.41, p = 0.01).
    Conclusions: Our results showed that greater adherence to a MEDLIFE reduced the risk of subsequent MetS development and increased the likelihood of reversing preexisting MetS among patients with CHD at baseline.
    MeSH term(s) Humans ; Coronary Disease/epidemiology ; Coronary Disease/prevention & control ; Life Style ; Metabolic Syndrome/complications ; Metabolic Syndrome/prevention & control ; Diet, Fat-Restricted ; Diet, Mediterranean
    Language English
    Publishing date 2023-01-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 96274-0
    ISSN 1365-2796 ; 0954-6820
    ISSN (online) 1365-2796
    ISSN 0954-6820
    DOI 10.1111/joim.13602
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  3. Article ; Online: Gut Microbiota: A New Marker of Cardiovascular Disease.

    Garcia-Rios, Antonio / Torres-Peña, Jose David / Perez-Jimenez, Francisco / Perez-Martinez, Pablo

    Current pharmaceutical design

    2017  Volume 23, Issue 22, Page(s) 3233–3238

    Abstract: Cardiovascular disease (CVD) continues to be the major cause of death in the developed countries. Moreover, the cardiovascular risk factors leading towards the development of CVD, mainly type 2 diabetes and obesity, are on the rise. The current ... ...

    Abstract Cardiovascular disease (CVD) continues to be the major cause of death in the developed countries. Moreover, the cardiovascular risk factors leading towards the development of CVD, mainly type 2 diabetes and obesity, are on the rise. The current preventive and therapeutic management, centred on the control of traditional risk factors, is clearly not enough to stop this pandemic. Therefore, the search for new biomarkers in CVD is a priority in most clinical research programs. Currently, interest in gut microbiota has peaked due to its association with cardiovascular and non-cardiovascular diseases. The present review considers the current situation regarding the influence of gut microbiota on CVD and particularly, its influence on the main traditional risk factors that lead to CVD, such as lipids, diabetes, hypertension and obesity.
    Language English
    Publishing date 2017
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/1381612823666170317144853
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  4. Article ; Online: Chronodisruption and diet associated with increased cardiometabolic risk in coronary heart disease patients: the CORDIOPREV study.

    Romero-Cabrera, Juan Luis / Garaulet, Marta / Jimenez-Torres, Jose / Alcala-Diaz, Juan F / Quintana Navarro, Gracia M / Martin-Piedra, Laura / Torres-Peña, Jose David / Rodriguez-Cantalejo, Fernando / Rangel-Zuñiga, Oriol Alberto / Yubero-Serrano, Elena Maria / Luque, Raul M / Ordovas, Jose M / Lopez-Miranda, Jose / Pérez-Martínez, Pablo / García-Rios, Antonio

    Translational research : the journal of laboratory and clinical medicine

    2021  Volume 242, Page(s) 79–92

    Abstract: Individuals with evening chronotypes are prone to suffer chronodisruption and display worse lifestyle habits than morning-types, exhibiting higher cardiovascular diseases (CVD). However, it is unknown whether CVD patients, who are evening chronotypes, ... ...

    Abstract Individuals with evening chronotypes are prone to suffer chronodisruption and display worse lifestyle habits than morning-types, exhibiting higher cardiovascular diseases (CVD). However, it is unknown whether CVD patients, who are evening chronotypes, have higher cardiometabolic risk than morning-types. This study explored whether individual chronotypes were associated with cardiometabolic risk in patients from the CORDIOPREV study (n = 857). We also investigated whether potential associations were moderated by long-term consumption of two healthy diets (Mediterranean and Low-fat diets). This population was classified into chronotypes using the Morningness-Eveningness Questionnaire. Seven-day daily rhythms in wrist temperature (T), rest-activity (A) and position (P) were recorded in a subset of patients (n = 168), and an integrative variable TAP was determined. Metabolic Syndrome (MetS) was determined at baseline, and metabolic and inflammation markers were measured at baseline and yearly during the 4 years of follow-up. Differences in several lifestyle factors were analyzed according to chronotype. At all times, evening-types had higher triglycerides, C-reactive protein and homocysteine and lower high density lipoprotein cholesterol than morning-types (P < 0.05). Evening-types had a higher prevalence of MetS (OR 1.58 IC 95% [1.10 - 2.28], P = 0.01). Moreover, they were more sedentary, displayed less and delayed physical activity and ate and slept later. In addition, evening-types had lower amplitude, greater fragmentation, lower robustness and less stable circadian pattern at TAP (P < 0.01), all related to a less healthy circadian pattern. In conclusion, evening-types with CVD had higher cardiometabolic risk and less robust circadian-related rhythms than morning-types, regardless of the nutritional intervention.
    MeSH term(s) Cardiovascular Diseases/etiology ; Circadian Rhythm ; Coronary Disease ; Diet ; Humans ; Metabolic Syndrome/complications ; Sleep ; Surveys and Questionnaires
    Language English
    Publishing date 2021-11-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2246684-8
    ISSN 1878-1810 ; 1532-6543 ; 1931-5244
    ISSN (online) 1878-1810 ; 1532-6543
    ISSN 1931-5244
    DOI 10.1016/j.trsl.2021.11.001
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  5. Article ; Online: The Fluid Aspect of the Mediterranean Diet in the Prevention and Management of Cardiovascular Disease and Diabetes: The Role of Polyphenol Content in Moderate Consumption of Wine and Olive Oil.

    Ditano-Vázquez, Paola / Torres-Peña, José David / Galeano-Valle, Francisco / Pérez-Caballero, Ana Isabel / Demelo-Rodríguez, Pablo / Lopez-Miranda, José / Katsiki, Niki / Delgado-Lista, Javier / Alvarez-Sala-Walther, Luis A

    Nutrients

    2019  Volume 11, Issue 11

    Abstract: A growing interest has emerged in the beneficial effects of plant-based diets for the prevention of cardiovascular disease, diabetes and obesity. The Mediterranean diet, one of the most widely evaluated dietary patterns in scientific literature, includes ...

    Abstract A growing interest has emerged in the beneficial effects of plant-based diets for the prevention of cardiovascular disease, diabetes and obesity. The Mediterranean diet, one of the most widely evaluated dietary patterns in scientific literature, includes in its nutrients two fluid foods: olive oil, as the main source of fats, and a low-to-moderate consumption of wine, mainly red, particularly during meals. Current mechanisms underlying the beneficial effects of the Mediterranean diet include a reduction in inflammatory and oxidative stress markers, improvement in lipid profile, insulin sensitivity and endothelial function, as well as antithrombotic properties. Most of these effects are attributable to bioactive ingredients including polyphenols, mono- and poly-unsaturated fatty acids. Polyphenols are a heterogeneous group of phytochemicals containing phenol rings. The principal classes of red wine polyphenols include flavonols (quercetin and myricetin), flavanols (catechin and epicatechin), anthocyanin and stilbenes (resveratrol). Olive oil has at least 30 phenolic compounds. Among them, the main are simple phenols (tyrosol and hydroxytyrosol), secoroids and lignans. The present narrative review focuses on phenols, part of red wine and virgin olive oil, discussing the evidence of their effects on lipids, blood pressure, atheromatous plaque and glucose metabolism.
    MeSH term(s) Animals ; Blood Glucose/metabolism ; Blood Pressure ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/physiopathology ; Cardiovascular Diseases/prevention & control ; Diet, Healthy ; Diet, Mediterranean ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/physiopathology ; Health Status ; Humans ; Lipids/blood ; Olive Oil ; Polyphenols/administration & dosage ; Protective Factors ; Risk Assessment ; Risk Factors ; Risk Reduction Behavior ; Wine
    Chemical Substances Blood Glucose ; Lipids ; Olive Oil ; Polyphenols
    Language English
    Publishing date 2019-11-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu11112833
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  6. Article ; Online: Prior Treatment with Statins is Associated with Improved Outcomes of Patients with COVID-19: Data from the SEMI-COVID-19 Registry.

    Torres-Peña, José David / Pérez-Belmonte, Luis M / Fuentes-Jiménez, Francisco / López Carmona, Mª Dolores / Pérez-Martinez, Pablo / López-Miranda, José / Carrasco Sánchez, Francisco Javier / Vargas Núñez, Juan Antonio / Del Corral Beamonte, Esther / Magallanes Gamboa, Jeffrey Oskar / González García, Andrés / González Moraleja, Julio / Cortés Troncoso, Andrés / Taboada Martínez, María Luisa / Del Fidalgo Montero, María Del Pilar / Seguí Ripol, José Miguel / Gil Sánchez, Ricardo / Alegre González, Diana / Boixeda, Ramon /
    Cortés Rodríguez, Begoña / Ena, Javier / García García, Gema María / Ventura Esteve, Ana / Ramos Rincón, José Manuel / Gómez-Huelgas, Ricardo

    Drugs

    2021  Volume 81, Issue 6, Page(s) 685–695

    Abstract: Background: The impact of statins on COVID-19 outcomes is important given the high prevalence of their use among individuals at risk for severe COVID-19. Our aim is to assess whether patients receiving chronic statin treatment who are hospitalized with ... ...

    Abstract Background: The impact of statins on COVID-19 outcomes is important given the high prevalence of their use among individuals at risk for severe COVID-19. Our aim is to assess whether patients receiving chronic statin treatment who are hospitalized with COVID-19 have reduced in-hospital mortality if statin therapy is maintained during hospitalization.
    Methods: This work is a cross-sectional, observational, retrospective multicenter study that analyzed 2921 patients who required hospital admission at 150 Spanish centers included in the nationwide SEMI-COVID-19 Network. We compared the clinical characteristics and COVID-19 disease outcomes between patients receiving chronic statin therapy who maintained this therapy during hospitalization versus those who did not. Propensity score matching was used to match each statin user whose therapy was maintained during hospitalization to a statin user whose therapy was withdrawn during hospitalization.
    Results: After propensity score matching, continuation of statin therapy was associated with lower all-cause mortality (OR 0.67, 0.54-0.83, p < 0.001); lower incidence of acute kidney injury (AKI) (OR 0.76,0.6-0.97, p = 0.025), acute respiratory distress syndrome (ARDS) (OR 0.78, 0.69- 0.89, p < 0.001), and sepsis (4.82% vs 9.85%, p = 0.008); and less need for invasive mechanical ventilation (IMV) (5.35% vs 8.57, p < 0.001) compared to patients whose statin therapy was withdrawn during hospitalization.
    Conclusions: Patients previously treated with statins who are hospitalized for COVID-19 and maintain statin therapy during hospitalization have a lower mortality rate than those in whom therapy is withdrawn. In addition, statin therapy was associated with a decreased probability that patients with COVID-19 will develop AKI, ARDS, or sepsis and decreases the need for IMV.
    MeSH term(s) Aged ; Aged, 80 and over ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/mortality ; Cross-Sectional Studies ; Female ; Hospital Mortality/trends ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage ; Male ; Middle Aged ; Propensity Score ; Retrospective Studies ; Risk Assessment ; SARS-CoV-2 ; Spain/epidemiology
    Chemical Substances Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Language English
    Publishing date 2021-03-29
    Publishing country New Zealand
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 120316-2
    ISSN 1179-1950 ; 0012-6667
    ISSN (online) 1179-1950
    ISSN 0012-6667
    DOI 10.1007/s40265-021-01498-x
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    Zs.A 762: Show issues Location:
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  7. Article: Ethnicity and Clinical Outcomes in Patients Hospitalized for COVID-19 in Spain: Results from the Multicenter SEMI-COVID-19 Registry.

    Ramos-Rincon, Jose-Manuel / Cobos-Palacios, Lidia / López-Sampalo, Almudena / Ricci, Michele / Rubio-Rivas, Manuel / Martos-Pérez, Francisco / Lalueza-Blanco, Antonio / Moragón-Ledesma, Sergio / Fonseca-Aizpuru, Eva-María / García-García, Gema-María / Beato-Perez, Jose-Luis / Josa-Laorden, Claudia / Arnalich-Fernández, Francisco / Molinos-Castro, Sonia / Torres-Peña, José-David / Artero, Arturo / Vargas-Núñez, Juan-Antonio / Mendez-Bailon, Manuel / Loureiro-Amigo, Jose /
    Hernández-Garrido, María-Soledad / Peris-García, Jorge / López-Reboiro, Manuel-Lorenzo / Barón-Franco, Bosco / Casas-Rojo, Jose-Manuel / Gómez-Huelgas, Ricardo / On Behalf Of The Semi-Covid-Network

    Journal of clinical medicine

    2022  Volume 11, Issue 7

    Abstract: 1) Background: This work aims to analyze clinical outcomes according to ethnic groups in patients hospitalized for COVID-19 in Spain. (2) Methods: This nationwide, retrospective, multicenter, observational study analyzed hospitalized patients with ... ...

    Abstract (1) Background: This work aims to analyze clinical outcomes according to ethnic groups in patients hospitalized for COVID-19 in Spain. (2) Methods: This nationwide, retrospective, multicenter, observational study analyzed hospitalized patients with confirmed COVID-19 in 150 Spanish hospitals (SEMI-COVID-19 Registry) from 1 March 2020 to 31 December 2021. Clinical outcomes were assessed according to ethnicity (Latin Americans, Sub-Saharan Africans, Asians, North Africans, Europeans). The outcomes were in-hospital mortality (IHM), intensive care unit (ICU) admission, and the use of invasive mechanical ventilation (IMV). Associations between ethnic groups and clinical outcomes adjusted for patient characteristics and baseline Charlson Comorbidity Index values and wave were evaluated using logistic regression. (3) Results: Of 23,953 patients (median age 69.5 years, 42.9% women), 7.0% were Latin American, 1.2% were North African, 0.5% were Asian, 0.5% were Sub-Saharan African, and 89.7% were European. Ethnic minority patients were significantly younger than European patients (median (IQR) age 49.1 (40.5−58.9) to 57.1 (44.1−67.1) vs. 71.5 (59.5−81.4) years, p < 0.001). The unadjusted IHM was higher in European (21.6%) versus North African (11.4%), Asian (10.9%), Latin American (7.1%), and Sub-Saharan African (3.2%) patients. After further adjustment, the IHM was lower in Sub-Saharan African (OR 0.28 (0.10−0.79), p = 0.017) versus European patients, while ICU admission rates were higher in Latin American and North African versus European patients (OR (95%CI) 1.37 (1.17−1.60), p < 0.001) and (OR (95%CI) 1.74 (1.26−2.41), p < 0.001). Moreover, Latin American patients were 39% more likely than European patients to use IMV (OR (95%CI) 1.43 (1.21−1.71), p < 0.001). (4) Conclusion: The adjusted IHM was similar in all groups except for Sub-Saharan Africans, who had lower IHM. Latin American patients were admitted to the ICU and required IMV more often.
    Language English
    Publishing date 2022-03-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11071949
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  8. Article ; Online: Long-term dietary adherence and changes in dietary intake in coronary patients after intervention with a Mediterranean diet or a low-fat diet: the CORDIOPREV randomized trial.

    Quintana-Navarro, Gracia Maria / Alcala-Diaz, Juan Francisco / Lopez-Moreno, Javier / Perez-Corral, Isabel / Leon-Acuña, Ana / Torres-Peña, Jose David / Rangel-Zuñiga, Oriol Alberto / Arenas de Larriva, Antonio Pablo / Corina, Andreea / Camargo, Antonio / Yubero-Serrano, Elena Maria / Rodriguez-Cantalejo, Fernando / Garcia-Rios, Antonio / Luque, Raul Miguel / Ordovas, Jose Maria / Perez-Martinez, Pablo / Lopez-Miranda, Jose / Delgado-Lista, Javier

    European journal of nutrition

    2019  Volume 59, Issue 5, Page(s) 2099–2110

    Abstract: Purpose: Adherence to a healthy dietary pattern positively influences clinical outcomes in cardiovascular prevention, but long-term adherence is difficult to maintain. We evaluated 5-year changes in dietary habits, adherence achieved, and its ... ...

    Abstract Purpose: Adherence to a healthy dietary pattern positively influences clinical outcomes in cardiovascular prevention, but long-term adherence is difficult to maintain. We evaluated 5-year changes in dietary habits, adherence achieved, and its maintenance in a cohort of coronary patients from the CORDIOPREV study.
    Methods: 1002 coronary patients were randomized to a Mediterranean diet (n = 502) or a low-fat diet (n = 500) and received individual-group-telephone visits and personalized dietary advice. A validated food-frequency questionnaire, a 14-point Mediterranean diet adherence screener, and a 9-point low-fat diet adherence score were used. Dietary adherence was categorized into Low, Medium, and High Adherence. Changes in nutrient intake, food consumption, and adherence were analyzed on a yearly basis. The maintenance of long-term dietary adherence was evaluated using data after the first year and fifth year.
    Results: From baseline to 5 years, significant increases were observed in overall dietary adherence (Mediterranean diet from 8.9 to 11.4; low-fat diet from 3.9 to 7.1) and in the percentage of patients considered High Adherence (Mediterranean diet from 41 to 89%; low-fat diet from 4 to 67%). When we evaluated the maintenance of adherence, patients considered Low and Medium Adherence at 1 year increased their adherence at the 5 years with both diets and patients considered High Adherence maintained their adherence with a Mediterranean diet, but decreased their adherence with a low-fat diet.
    Conclusions: A comprehensive dietary intervention results in an overall long-term improvement and maintenance of adherence to the Mediterranean and low-fat diets. In our population, the Mediterranean diet group achieved a high level of adherence in the short term which was maintained in the long term.
    MeSH term(s) Diet, Fat-Restricted ; Diet, Mediterranean ; Eating ; Energy Intake ; Feeding Behavior ; Humans
    Language English
    Publishing date 2019-07-24
    Publishing country Germany
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 1466536-0
    ISSN 1436-6215 ; 1436-6207
    ISSN (online) 1436-6215
    ISSN 1436-6207
    DOI 10.1007/s00394-019-02059-5
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  9. Article: Association of Hypertension with All-Cause Mortality among Hospitalized Patients with COVID-19.

    Rodilla, Enrique / Saura, Alberto / Jiménez, Iratxe / Mendizábal, Andrea / Pineda-Cantero, Araceli / Lorenzo-Hernández, Elizabeth / Fidalgo-Montero, Maria Del Pilar / López-Cuervo, Joaquín Fernandez / Gil-Sánchez, Ricardo / Rabadán-Pejenaute, Elisa / Abella-Vázquez, Lucy / Giner-Galvañ, Vicente / Solís-Marquínez, Marta Nataya / Boixeda, Ramon / Peña-Fernández, Andrés de la / Carrasco-Sánchez, Francisco Javier / González-Moraleja, Julio / Torres-Peña, José David / Guisado-Espartero, María Esther /
    Escobar-Sevilla, Joaquín / Guzmán-García, Marcos / Martín-Escalante, María Dolores / Martínez-González, Ángel Luis / Casas-Rojo, José Manuel / Gómez-Huelgas, Ricardo

    Journal of clinical medicine

    2020  Volume 9, Issue 10

    Abstract: It is unclear to which extent the higher mortality associated with hypertension in the coronavirus disease (COVID-19) is due to its increased prevalence among older patients or to specific mechanisms. Cross-sectional, observational, retrospective ... ...

    Abstract It is unclear to which extent the higher mortality associated with hypertension in the coronavirus disease (COVID-19) is due to its increased prevalence among older patients or to specific mechanisms. Cross-sectional, observational, retrospective multicenter study, analyzing 12226 patients who required hospital admission in 150 Spanish centers included in the nationwide SEMI-COVID-19 Network. We compared the clinical characteristics of survivors versus non-survivors. The mean age of the study population was 67.5 ± 16.1 years, 42.6% were women. Overall, 2630 (21.5%) subjects died. The most common comorbidity was hypertension (50.9%) followed by diabetes (19.1%), and atrial fibrillation (11.2%). Multivariate analysis showed that after adjusting for gender (males, OR: 1.5,
    Keywords covid19
    Language English
    Publishing date 2020-09-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm9103136
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  10. Article: The Fluid Aspect of the Mediterranean Diet in the Prevention and Management of Cardiovascular Disease and Diabetes: The Role of Polyphenol Content in Moderate Consumption of Wine and Olive Oil

    Ditano-Vázquez, Paola / Torres-Peña, José David / Galeano-Valle, Francisco / Pérez-Caballero, Ana Isabel / Demelo-Rodríguez, Pablo / Lopez-Miranda, José / Katsiki, Niki / Delgado-Lista, Javier / Alvarez-Sala-Walther, Luis A

    Nutrients. 2019 Nov. 19, v. 11, no. 11

    2019  

    Abstract: A growing interest has emerged in the beneficial effects of plant-based diets for the prevention of cardiovascular disease, diabetes and obesity. The Mediterranean diet, one of the most widely evaluated dietary patterns in scientific literature, includes ...

    Abstract A growing interest has emerged in the beneficial effects of plant-based diets for the prevention of cardiovascular disease, diabetes and obesity. The Mediterranean diet, one of the most widely evaluated dietary patterns in scientific literature, includes in its nutrients two fluid foods: olive oil, as the main source of fats, and a low-to-moderate consumption of wine, mainly red, particularly during meals. Current mechanisms underlying the beneficial effects of the Mediterranean diet include a reduction in inflammatory and oxidative stress markers, improvement in lipid profile, insulin sensitivity and endothelial function, as well as antithrombotic properties. Most of these effects are attributable to bioactive ingredients including polyphenols, mono- and poly-unsaturated fatty acids. Polyphenols are a heterogeneous group of phytochemicals containing phenol rings. The principal classes of red wine polyphenols include flavonols (quercetin and myricetin), flavanols (catechin and epicatechin), anthocyanin and stilbenes (resveratrol). Olive oil has at least 30 phenolic compounds. Among them, the main are simple phenols (tyrosol and hydroxytyrosol), secoroids and lignans. The present narrative review focuses on phenols, part of red wine and virgin olive oil, discussing the evidence of their effects on lipids, blood pressure, atheromatous plaque and glucose metabolism.
    Keywords Mediterranean diet ; anthocyanins ; blood pressure ; cardiovascular diseases ; catechin ; diabetes ; eating habits ; epicatechin ; glucose ; ingredients ; insulin resistance ; lignans ; lipid composition ; metabolism ; myricetin ; nutrients ; obesity ; oxidative stress ; phenol ; plant-based diet ; polyphenols ; polyunsaturated fatty acids ; quercetin ; red wines ; resveratrol ; virgin olive oil
    Language English
    Dates of publication 2019-1119
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2518386-2
    ISSN 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu11112833
    Database NAL-Catalogue (AGRICOLA)

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