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  1. Article ; Online: Prioritising 'already-scarce' intensive care unit resources in the midst of COVID-19: a call for regional triage committees in South Africa.

    Naidoo, Reshania / Naidoo, Kantharuben

    BMC medical ethics

    2021  Volume 22, Issue 1, Page(s) 28

    Abstract: Background: The worsening COVID-19 pandemic in South Africa poses multiple challenges for clinical decision making in the context of already-scarce ICU resources. Data from national government and the last published national audit of ICU resources ... ...

    Abstract Background: The worsening COVID-19 pandemic in South Africa poses multiple challenges for clinical decision making in the context of already-scarce ICU resources. Data from national government and the last published national audit of ICU resources indicate gross shortages. While the Critical Care Society of Southern Africa (CCSSA) guidelines provide a comprehensive guideline for triage in the face of overwhelmed ICU resources, such decisions present massive ethical and moral dilemmas for triage teams. It is therefore important for the health system to provide clinicians and critical care facilities with as much support and resources as possible in the face of impending pandemic demand. Following a discussion of the ethical considerations and potential challenges in applying the CCSSA guidelines, the authors propose a framework for regional triage committees adapted to the South African context.
    Discussion: Beyond the national CCSSA guidelines, the clinician has many additional ethical and clinical considerations. No single ethical approach to decision-making is sufficient, instead one which considers multiple contextual factors is necessary. Scores such as the Clinical Frailty Score and Sequential Organ Failure Assessment are of limited use in patients with COVID-19. Furthermore, the clinician is fully justified in withdrawing ICU care based on medical futility decisions and to reallocate this resource to a patient with a better prognosis. However, these decisions bear heavy emotional and moral burden compounded by the volume of clinical work and a fear of litigation.
    Conclusion: We propose the formation of Provincial multi-disciplinary Critical Care Triage Committees to alleviate the emotional, moral and legal burden on individual ICU teams and co-ordinate inter-facility collaboration using an adapted framework. The committee would provide an impartial, broader and ethically-sound viewpoint which has time to consider broader contextual factors such as adjusting rationing criteria according to different levels of pandemic demand and the latest clinical evidence. Their functioning will be strengthened by direct feedback to national level and accountability to a national monitoring committee. The potential applications of these committees are far-reaching and have the potential to enable a more effective COVID-19 health systems response in South Africa.
    MeSH term(s) COVID-19 ; Cooperative Behavior ; Critical Care/ethics ; Decision Making/ethics ; Emotions ; Ethics, Medical ; Health Care Rationing/ethics ; Health Resources ; Humans ; Intensive Care Units ; Medical Futility ; Pandemics ; Prognosis ; SARS-CoV-2 ; South Africa ; Triage/ethics ; Triage/methods
    Language English
    Publishing date 2021-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041552-7
    ISSN 1472-6939 ; 1472-6939
    ISSN (online) 1472-6939
    ISSN 1472-6939
    DOI 10.1186/s12910-021-00596-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Decision to self-isolate during the COVID-19 pandemic in the UK: a rapid scoping review.

    Keene, Claire Marriott / Dickinson, Sophie / Naidoo, Reshania / Andersen-Waine, Billie / Ferguson-Lewis, Angus / Polner, Anastasia / Amswych, Ma'ayan / White, Lisa / Molyneux, Sassy / Wanat, Marta

    BMJ open

    2024  Volume 14, Issue 3, Page(s) e084437

    Abstract: Objective: Testing for COVID-19 was a key component of the UK's response to the COVID-19 pandemic. This strategy relied on positive individuals self-isolating to reduce transmission, making isolation the lynchpin in the public health approach. Therefore, ...

    Abstract Objective: Testing for COVID-19 was a key component of the UK's response to the COVID-19 pandemic. This strategy relied on positive individuals self-isolating to reduce transmission, making isolation the lynchpin in the public health approach. Therefore, we scoped evidence to systematically identify and categorise barriers and facilitators to compliance with self-isolation guidance during the COVID-19 pandemic in the UK, to inform public health strategies in future pandemics.
    Design: A rapid scoping review was conducted.
    Search strategy: Key terms were used to search literature databases (PubMed, Scopus and the WHO COVID-19 Research Database, on 7 November 2022), Google Scholar and stakeholder-identified manuscripts, ultimately including evidence published in English from UK-based studies conducted between 2020 and 2022.
    Data extraction and synthesis: Data were extracted and synthesised into themes, organised broadly into capability, opportunity and motivation, and reviewed with key stakeholders from the UK Health Security Agency (UKHSA).
    Results: We included 105 sources, with 63 identified from UKHSA and used to inform their decision-making during the pandemic. Influences on the decision to comply with isolation guidance were categorised into six themes: perceived ability to isolate; information and guidance; logistics; social influences, including trust; perceived value; and perceived consequences. Individuals continuously assessed these factors in deciding whether or not to comply with guidance and self-isolate.
    Conclusions: Decisions to self-isolate after a positive test were influenced by multiple factors, including individuals' beliefs, concerns, priorities and personal circumstances. Future testing strategies must facilitate meaningful financial, practical and mental health support to allow individuals to overcome the perceived and actual negative consequences of isolating. Clear, consistent communication of the purpose and procedures of isolating will also be critical to support compliance with self-isolation guidance, and should leverage people's perceived value in protecting others. Building public trust is also essential, but requires investment before the next pandemic starts.
    MeSH term(s) Humans ; COVID-19/epidemiology ; COVID-19/prevention & control ; Pandemics/prevention & control ; SARS-CoV-2 ; COVID-19 Testing ; United Kingdom/epidemiology
    Language English
    Publishing date 2024-03-29
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2024-084437
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Combined robotic transorbital and transnasal approach to the nasopharynx and anterior skull base: Feasibility study.

    Faulkner, Jack / Naidoo, Reshania / Arora, Asit / Jeannon, Jean Pierre / Hopkins, Claire / Surda, Pavol

    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery

    2020  Volume 45, Issue 4, Page(s) 630–633

    MeSH term(s) Cadaver ; Feasibility Studies ; Humans ; Nasopharynx/anatomy & histology ; Nasopharynx/surgery ; Orbit/anatomy & histology ; Orbit/surgery ; Robotic Surgical Procedures ; Skull Base/anatomy & histology ; Skull Base/surgery
    Language English
    Publishing date 2020-05-11
    Publishing country England
    Document type Letter
    ZDB-ID 2205891-6
    ISSN 1749-4486 ; 1749-4478 ; 0307-7772 ; 1365-2273
    ISSN (online) 1749-4486
    ISSN 1749-4478 ; 0307-7772 ; 1365-2273
    DOI 10.1111/coa.13550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A multistage mixed-methods evaluation of the UKHSA testing response during the COVID-19 pandemic in England

    Naidoo, Reshania / Andersen-Waine, Billie / Dahal, Prabin / Dickinson, Sophie / Lambert, Ben / Mills, Melinda C / Molyneux, Catherine / Rowe, Emily / Pinto-Duschinsky, Sarah / Stepniewska, Kasia / Shretta, Rima / Voysey, Merryn / Wanat, Marta / Yenidogan, Gulsen / White, Lisa J / the EY-Oxford Health Analytics Consortium

    medRxiv

    Abstract: Introduction: In 2020, the UK Health Security Agency (UKHSA) established a large-scale testing programme to rapidly identify individuals in England who were infected with SARS-CoV-2 and had COVID-19. This comprised part of the UK government′s COVID-19 ... ...

    Abstract Introduction: In 2020, the UK Health Security Agency (UKHSA) established a large-scale testing programme to rapidly identify individuals in England who were infected with SARS-CoV-2 and had COVID-19. This comprised part of the UK government′s COVID-19 response strategy, to protect those at risk of severe COVID-19 disease and death and to reduce the burden on the health system. To assess the success of this approach, UKHSA commissioned an independent evaluation of the activities delivered by the NHS testing programme in England. The primary purpose of this evaluation is to capture key learnings from the rollout of testing to different target populations via various testing services between October 2020 and March 2022 and to use these insights to formulate recommendations for future pandemic preparedness strategy. Methods and analysis: The proposed study involves a stepwise mixed-methods approach, aligned with established methods for the evaluation of complex interventions in health, with retrospective and prospective components. A bottom-up approach will be taken, focusing on each of nine population-specific service settings. We will use a Theory of Change to understand the causal pathways and intended and unintended outcomes of each service, also exploring the effect of context on each individual service setting′s intended outcomes. Subsequently, the insights gained will be synthesised to identify process and outcome indicators to evaluate how the combined aims of the testing programme were achieved. A forward-looking, prospective component of this work will aim to inform testing strategy in preparation for future pandemics, through a participatory modelling simulation and policy analysis exercise. Disclaimer: This is a provisional draft protocol that represents research in progress. This research was commissioned and funded by UKHSA, to be performed between August 2022 and March 2023. The scope and depth of testing services and channels covered by this research were pre-agreed with UKHSA and are limited to the availability and provision of data available at the time this protocol was written.
    Keywords covid19
    Language English
    Publishing date 2022-10-27
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.10.27.22281604
    Database COVID19

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  5. Article ; Online: A multistage mixed-methods evaluation of the UKHSA testing response during the COVID-19 pandemic in England

    Naidoo, Reshania / Andersen-waine, Billie / Dahal, Prabin / Dickinson, Sophie / Lambert, Ben / Mills, Melinda / Molyneux, Catherine / Rowe, Emily / Pinto-Duschinsky, Sarah / Stepniewska, Kasia / Shretta, Rima / Voysey, Merryn / Wanat, Marta / Yenidogan, Gulsen / White, Lisa J / EY-Oxford Health Analytics Consortium

    medRxiv

    Abstract: Introduction: In 2020, the UK Health Security Agency (UKHSA) established a large-scale testing programme to rapidly identify individuals in England who were infected with SARS-CoV-2 and had COVID-19. This comprised part of the UK government′s COVID-19 ... ...

    Abstract Introduction: In 2020, the UK Health Security Agency (UKHSA) established a large-scale testing programme to rapidly identify individuals in England who were infected with SARS-CoV-2 and had COVID-19. This comprised part of the UK government′s COVID-19 response strategy, to protect those at risk of severe COVID-19 disease and death and to reduce the burden on the health system. To assess the success of this approach, UKHSA commissioned an independent evaluation of the activities delivered by the NHS testing programme in England. The primary purpose of this evaluation is to capture key learnings from the rollout of testing to different target populations via various testing services between October 2020 and March 2022 and to use these insights to formulate recommendations for future pandemic preparedness strategy. Methods and analysis: The proposed study involves a stepwise mixed-methods approach, aligned with established methods for the evaluation of complex interventions in health, with retrospective and prospective components. A bottom-up approach will be taken, focusing on each of nine population-specific service settings. We will use a Theory of Change to understand the causal pathways and intended and unintended outcomes of each service, also exploring the effect of context on each individual service setting′s intended outcomes. Subsequently, the insights gained will be synthesised to identify process and outcome indicators to evaluate how the combined aims of the testing programme were achieved. A forward-looking, prospective component of this work will aim to inform testing strategy in preparation for future pandemics, through a participatory modelling simulation and policy analysis exercise. Disclaimer: This is a provisional draft protocol that represents research in progress. This research was commissioned and funded by UKHSA, to be performed between August 2022 and March 2023. The scope and depth of testing services and channels covered by this research were pre-agreed with UKHSA and are limited to the availability and provision of data available at the time this protocol was written.
    Keywords covid19
    Language English
    Publishing date 2022-10-27
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.10.27.22281604
    Database COVID19

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  6. Article ; Online: Understanding COVID-19 testing behaviour in England through a sociodemographic lens

    Bajaj, Sumali / Chen, Siyu / Creswell, Richard / Naidoo, Reshania / L.-H. Tsui, Joseph / Kolade, Olumide / Nicholson, George / Lehmann, Brieuc / A. Hay, James / U.G. Kraemer, Moritz / Aguas, Ricardo / A. Donnelly, Christl / Fowler, Tom / Hopkins, Susan / Cantrell, Liberty / Dahal, Prabin / J. White, Lisa / Stepniewska, Kasia / Voysey, Merryn /
    Lambert, Ben / EY-Oxford Health Analytics Consortium

    medRxiv

    Abstract: Background Understanding underlying mechanisms of heterogeneity in test-seeking and reporting behaviour can help to protect the vulnerable and guide equity-driven interventions. Using COVID-19 testing data for England and data from community prevalence ... ...

    Abstract Background Understanding underlying mechanisms of heterogeneity in test-seeking and reporting behaviour can help to protect the vulnerable and guide equity-driven interventions. Using COVID-19 testing data for England and data from community prevalence surveillance surveys (REACT-1 and ONS-CIS) from October 2020 to March 2022, we investigated the relationship between sociodemographic factors and testing behaviours in England. Methods We used mass testing data for lateral flow device (LFD; data for 290 million tests performed and reported) and polymerase chain reaction (PCR) (data for 107 million tests performed and returned from the laboratory) tests made available for the general public, provided by date, self-reported age and ethnicity at lower tier local authority (LTLA) level.Using a mechanistic causal model to debias the PCR testing data, we obtained estimates of weekly SARS-CoV-2 prevalence by self-reported ethnic groups and age groups for LTLAs in England. This approach to debiasing the PCR (or LFD) testing data also estimated a testing bias parameter defined as the odds of testing in infected versus not infected individuals, which would be close to zero if the likelihood of test seeking (or seeking and reporting) was the same regardless of infection status. Using confirmatory PCR data, we estimated false positivity rates, sensitivity, specificity, and the rate of decline in detection probability by PCR by sociodemographic groups, We also estimated the daily incidence allowing us to determine the fraction of cases captured by the testing programme. Findings From March 2021 onwards, individuals in the most deprived regions reported approximately half as many LFD tests per-capita than those in the least deprived areas (Median ratio [Inter quartile range, IQR]: 0.50 [0.44, 0.54]). During October 2020 - June 2021, PCR testing patterns were in the opposite direction (Median ratio [IQR]: 1.8 [1.7, 1.9]). Infection prevalences in Asian or Asian British communities were considerably higher than those of other ethnic groups during the Alpha and Omicron BA.1 waves. Our estimates indicate that the England COVID-19 testing program detected 26% - 40% of all cases (including asymptomatic cases) over the study period with no consistent differences by deprivation levels or ethnic groups. PCR testing biases were generally higher than for LFDs, which was in line with the general policy of symptomatic and asymptomatic use of these tests. During the invasion phases of the Delta and Omicron variants of concern, the PCR testing bias in the most deprived populations was roughly double (ratio: 2.2 and 2.7 respectively) that in the least. We also determined that ethnic minorities and older individuals were less likely to use confirmatory PCR tests through most of the pandemic and that there was possibly a longer delay in reporting a positive LFD test in the Black populations. Interpretation Differences in testing behaviours across sociodemographic groups may be reflective of the relatively higher costs of self-isolation to vulnerable populations, differences in test accessibility, digital literacy, and differing perception about the utility of tests and risks posed by infection. Our work shows how mass testing data can be used in conjunction with surveillance surveys to identify gaps in the uptake of public health interventions at fine scale levels and by sociodemographic groups. It provides a framework for monitoring local interventions and yields valuable lessons for policy makers in ensuring an equitable response to future pandemics. Funding UK Health Security Agency.
    Keywords covid19
    Language English
    Publishing date 2023-10-28
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2023.10.26.23297608
    Database COVID19

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  7. Article ; Online: Modelling the COVID-19 pandemic in context

    Ali Mirzazadeh / Hamid Sharifi / Proochista Ariana / Sunil Pokharel / Siyu Chen / Ricardo Aguas / Sudhir Venkatesan / Lisa White / Nathaniel Hupert / Rima Shretta / Wirichada Pan-Ngum / Olivier Celhay / Ainura Moldokmatova / Fatima Arifi / Keyrellous Adib / Mohammad Nadir Sahak / Caroline Franco / Renato Coutinho / Penny Hancock /
    Roberto A. Kraenkel / Sompob Saralamba / Nantasit Luangasanatip / Sheetal Prakash Silal / Jared Norman / Rachel Hounsell / Sai Tun / Yu Nandar Aung / A Bakare Emmanuel / Biniam Getachew / Sandra Adele / Semeeh A. Omoleke / Rashid U Zaman / Nicholas Letchford / Daniel M. Parker / Dipti Lata / Shwe Sin Kyaw / Inke N D Lubis / Ivana Alona / John Robert C. Medina / Chris Erwin G. Mercado / Sana Eybpoosh / Ibrahim Mamadu / Manar Marzouk / Nicole Feune de Colombi / Lorena Suárez-Idueta / Francisco Obando / Luzia Freitas / Michael G. Klein / David Scales / Dooronbekova Aizhan / Chynar Zhumalieva / Aida Estebesova / Aibek Mukambetov / Shamil Ibragimov / Aisuluu Kubatova / Phetsavanh Chanthavialy / Amel H. Salim / KC Sarin / Priyanka Shrestha / Sayed Ataullah Saeedzai / Jenny Hsieh / Mick Soukavong / Yuki Yunanda / Handoyo Harsono / Mahnaz Hossain Fariba / Viviana Mabombo / Nicole Advani / Nusrat Jabin / Reshania Naidoo / Parinda Wattanasri / Amen-Patrick Nwosu / Sopuruchukwu Obiesie

    BMJ Global Health, Vol 5, Iss

    an international participatory approach

    2020  Volume 12

    Abstract: The SARS-CoV-2 pandemic has had an unprecedented impact on multiple levels of society. Not only has the pandemic completely overwhelmed some health systems but it has also changed how scientific evidence is shared and increased the pace at which such ... ...

    Abstract The SARS-CoV-2 pandemic has had an unprecedented impact on multiple levels of society. Not only has the pandemic completely overwhelmed some health systems but it has also changed how scientific evidence is shared and increased the pace at which such evidence is published and consumed, by scientists, policymakers and the wider public. More significantly, the pandemic has created tremendous challenges for decision-makers, who have had to implement highly disruptive containment measures with very little empirical scientific evidence to support their decision-making process. Given this lack of data, predictive mathematical models have played an increasingly prominent role. In high-income countries, there is a long-standing history of established research groups advising policymakers, whereas a general lack of translational capacity has meant that mathematical models frequently remain inaccessible to policymakers in low-income and middle-income countries. Here, we describe a participatory approach to modelling that aims to circumvent this gap. Our approach involved the creation of an international group of infectious disease modellers and other public health experts, which culminated in the establishment of the COVID-19 Modelling (CoMo) Consortium. Here, we describe how the consortium was formed, the way it functions, the mathematical model used and, crucially, the high degree of engagement fostered between CoMo Consortium members and their respective local policymakers and ministries of health.
    Keywords Medicine (General) ; R5-920 ; Infectious and parasitic diseases ; RC109-216
    Subject code 360
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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