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  1. Article ; Online: Global Production of Active Pharmaceutical Ingredients for US Generic Drugs Experiencing Shortages.

    Socal, Mariana P / Crane, Matthew A / Anderson, Gerard F

    JAMA

    2024  

    Language English
    Publishing date 2024-04-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2024.5296
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  2. Article ; Online: False or Misleading Claims in Online Direct-to-Consumer Ketamine Advertising in Maryland.

    Crane, Matthew A / DiStefano, Michael J / Moore, Thomas J

    JAMA network open

    2023  Volume 6, Issue 11, Page(s) e2342210

    MeSH term(s) Humans ; Maryland ; Ketamine ; Advertising
    Chemical Substances Ketamine (690G0D6V8H)
    Language English
    Publishing date 2023-11-01
    Publishing country United States
    Document type Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.42210
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  3. Article: Transcranial Focused Ultrasound Remotely Modulates Extrastriate Visual Cortex with Subregion Specificity.

    Yu, Kai / Schmitt, Samantha / Ni, Yunruo / Crane, Emily C / Smith, Matthew A / He, Bin

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Low-intensity transcranial focused ultrasound (tFUS) has emerged as a powerful neuromodulation tool characterized by its deep penetration and precise spatial targeting to influence neural activity. Our study directed low-intensity tFUS stimulation onto a ...

    Abstract Low-intensity transcranial focused ultrasound (tFUS) has emerged as a powerful neuromodulation tool characterized by its deep penetration and precise spatial targeting to influence neural activity. Our study directed low-intensity tFUS stimulation onto a region of prefrontal cortex (the frontal eye field, or FEF) of a rhesus macaque to examine its impact on a remote site, the extrastriate visual cortex (area V4). This pair of cortical regions form a top-down modulatory circuit that has been studied extensively with electrical microstimulation. To measure the impact of tFUS stimulation, we recorded local field potentials (LFPs) and multi-unit spiking activities from a multi-electrode array implanted in the visual cortex. To deliver tFUS stimulation, we leveraged a customized 128-element random array ultrasound transducer with improved spatial targeting. We observed that tFUS stimulation in FEF produced modulation of V4 neuronal activity, either through enhancement or suppression, dependent on the pulse repetition frequency of the tFUS stimulation. Electronically steering the transcranial ultrasound focus through the targeted FEF cortical region produced changes in the level of modulation, indicating that the tFUS stimulation was spatially targeted within FEF. Modulation of V4 activity was confined to specific frequency bands, and this modulation was dependent on the presence or absence of a visual stimulus during tFUS stimulation. A control study targeting the insula produced no effect, emphasizing the region-specific nature of tFUS neuromodulation. Our findings shed light on the capacity of tFUS to modulate specific neural pathways and provide a comprehensive understanding of its potential applications for neuromodulation within brain networks.
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.20.576476
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  4. Article: COVID-19 and working from home-related changes in physical activity in Sydney, Australia.

    Cobbold, Alec / Crane, Melanie / Greaves, Stephen / Standen, Christopher / Beck, Matthew / Rissel, Chris

    Health promotion journal of Australia : official journal of Australian Association of Health Promotion Professionals

    2024  

    Abstract: Issues addressed: Evidence on how COVID-19 lockdowns impacted physical activity (PA) is mixed. This study explores changes in PA following initial mobility restrictions, and their subsequent relaxation, in a sample of Sydney (Australia) residents using ... ...

    Abstract Issues addressed: Evidence on how COVID-19 lockdowns impacted physical activity (PA) is mixed. This study explores changes in PA following initial mobility restrictions, and their subsequent relaxation, in a sample of Sydney (Australia) residents using a natural experiment methodology.
    Methods: Participants' health and travel behaviours were collected pre-pandemic in late 2019 (n = 1937), with follow-up waves during the pandemic in 2020 (n = 1706) and 2021 (n = 1514). Linear mixed-effects models were used to analyse changes in weekly duration of PA between the three waves.
    Results: Compared with pre-pandemic, average weekly PA increased in 2021 by 42.6 min total PA (p = .001), 16 min walking PA (p = .02), and 26.4 min moderate-vigorous PA (MVPA) (p = .003). However, average weekly sessions of PA decreased in 2020 and remained lower in 2021. For participants who were sufficiently active in 2019, weekly total PA (-66.3 min) MVPA (-43.8 min) decreased in 2020 compared to pre-pandemic. Conversely, among participants who were insufficiently active in 2019, average weekly PA increased in both 2020 (total PA, +99.1 min; walking PA, +46.4 min; MVPA +52.8 min) and 2021 (total PA, +117.8 min; walking PA, +58.4 min; MVPA +59.2 min), compared to 2019. Participants who did more work from home increased their average weekly total PA in 2021 compared to pre-pandemic (+45.3 min).
    Conclusion: These findings reveal the complex variability in PA behaviour brought about by the pandemic. SO WHAT?: Strategies to support the population in achieving sufficient PA must focus on maintaining an appetite for PA as we move out of the pandemic and on promoting more frequent PA sessions.
    Language English
    Publishing date 2024-01-09
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2250864-8
    ISSN 2201-1617 ; 1036-1073
    ISSN (online) 2201-1617
    ISSN 1036-1073
    DOI 10.1002/hpja.838
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    Zs.A 6384: Show issues Location:
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  5. Article ; Online: Epidemiology of mortality attributed to falls in older adults in the US, 1999-2020.

    Crane, Matthew A / Lam, Audrey / Christmas, Colleen / Gemmill, Alison / Romley, John A

    Journal of the American Geriatrics Society

    2023  Volume 72, Issue 1, Page(s) 303–307

    MeSH term(s) Humans ; Aged ; Accidental Falls ; Risk Factors
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.18600
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  6. Article ; Online: Does trocar puncture of the bladder during midurethral sling impact postoperative urinary storage and voiding symptoms?

    Crane, Erin A / Moss, Matthew / Frilot, Clifton F / Gomelsky, Alex

    International urogynecology journal

    2023  Volume 34, Issue 8, Page(s) 1915–1921

    Abstract: Introduction and hypothesis: The incidence of trocar bladder puncture during midurethral sling (MUS) surgery varies widely. We aim to further characterize risk factors for bladder puncture and examine its long-term impact on storage and emptying.: ... ...

    Abstract Introduction and hypothesis: The incidence of trocar bladder puncture during midurethral sling (MUS) surgery varies widely. We aim to further characterize risk factors for bladder puncture and examine its long-term impact on storage and emptying.
    Methods: This is an Institutional Review Board-approved, retrospective chart review of women who underwent MUS surgery at our institution from 2004 to 2018 with ≥12 months of follow-up. Unless prolonged catheterization was necessary, a voiding trial was performed prior to discharge, or the next morning in outpatients, regardless of puncture. Preoperative and postoperative details were obtained from office charts and operative records.
    Results: Of 1,500 women, 1,063 (71%) had retropubic (RP) and 437 (29%) had transobturator MUS surgery. Mean follow-up was 34 months. Thirty-five women (2.3%) sustained a bladder puncture. RP approach and lower BMI were significantly associated with puncture. No statistical association was found between bladder puncture and age, previous pelvic surgery, or concomitant surgery. Mean day of discharge and day of successful voiding trial were not statistically different between the puncture and nonpuncture groups. There was no statistically significant difference in de novo storage and emptying symptoms between the two groups. Fifteen women in the puncture group had cystoscopy during follow-up and none had bladder exposure. Level of the resident performing trocar passage was not associated with bladder puncture.
    Conclusions: Lower BMI and RP approach are associated with bladder puncture during MUS surgery. Bladder puncture is not associated with additional perioperative complications, long-term urinary storage/voiding sequelae, or delayed bladder sling exposure. Standardized training minimizes bladder punctures in trainees of all levels.
    MeSH term(s) Female ; Humans ; Urinary Bladder ; Retrospective Studies ; Urinary Incontinence, Stress/surgery ; Urinary Incontinence, Stress/complications ; Suburethral Slings/adverse effects ; Surgical Instruments/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2023-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 1050631-7
    ISSN 1433-3023 ; 0937-3462
    ISSN (online) 1433-3023
    ISSN 0937-3462
    DOI 10.1007/s00192-023-05484-7
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    Zs.A 3070: Show issues Location:
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  7. Article ; Online: Mortality Due to Hyperglycemic Crises in the US, 1999-2022.

    Crane, Matthew A / Lam, Audrey / Ekanayake, Emil / Alshawkani, Yazan Y / Christmas, Colleen / Gemmill, Alison / Romley, John A

    JAMA

    2024  Volume 331, Issue 5, Page(s) 440–442

    MeSH term(s) Humans ; Diabetic Ketoacidosis/epidemiology ; Diabetic Ketoacidosis/mortality ; Insulin ; United States/epidemiology ; Hyperglycemic Hyperosmolar Nonketotic Coma/epidemiology ; Hyperglycemic Hyperosmolar Nonketotic Coma/mortality
    Chemical Substances Insulin
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.26174
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    Ua VI Zs.88: Show issues Location:
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  8. Article ; Online: Change in Epidemiology of Creutzfeldt-Jakob Disease in the US, 2007-2020.

    Crane, Matthew A / Nair-Desai, Sameer / Gemmill, Alison / Romley, John A / Probasco, John C

    JAMA neurology

    2023  Volume 81, Issue 2, Page(s) 195–197

    MeSH term(s) Humans ; Creutzfeldt-Jakob Syndrome/epidemiology ; United States
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2702023-X
    ISSN 2168-6157 ; 2168-6149
    ISSN (online) 2168-6157
    ISSN 2168-6149
    DOI 10.1001/jamaneurol.2023.4678
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    Ui II Zs.191: Show issues Location:
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  9. Article ; Online: Disparities In County COVID-19 Vaccination Rates Linked To Disadvantage And Hesitancy.

    Crane, Matthew A / Faden, Ruth R / Romley, John A

    Health affairs (Project Hope)

    2021  Volume 40, Issue 11, Page(s) 1792–1796

    Abstract: We analyzed trends in adult COVID-19 vaccine coverage over time based on COVID-19 vaccine hesitancy and social vulnerability. We found that each of these variables carries an independent association with disparities across counties in COVID-19 vaccine ... ...

    Abstract We analyzed trends in adult COVID-19 vaccine coverage over time based on COVID-19 vaccine hesitancy and social vulnerability. We found that each of these variables carries an independent association with disparities across counties in COVID-19 vaccine coverage. Counties that score high on both hesitancy and vulnerability are especially likely to have lower COVID-19 vaccination rates compared with the rest of the country.
    MeSH term(s) Adult ; COVID-19 ; COVID-19 Vaccines ; Humans ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-11-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632712-6
    ISSN 1544-5208 ; 0278-2715
    ISSN (online) 1544-5208
    ISSN 0278-2715
    DOI 10.1377/hlthaff.2021.01092
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    Zs.A 2118: Show issues Location:
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  10. Article ; Online: Mortality Rates Among U.S. Women of Reproductive Age, 1999-2019.

    Gemmill, Alison / Berger, Blair O / Crane, Matthew A / Margerison, Claire E

    American journal of preventive medicine

    2022  Volume 62, Issue 4, Page(s) 548–557

    Abstract: Introduction: High and increasing levels of pregnancy-related mortality and morbidity in the U.S. indicate that the underlying health status of reproductive-aged women may be far from optimal, yet few studies have examined mortality trends and ... ...

    Abstract Introduction: High and increasing levels of pregnancy-related mortality and morbidity in the U.S. indicate that the underlying health status of reproductive-aged women may be far from optimal, yet few studies have examined mortality trends and disparities exclusively among this population.
    Methods: All-cause and cause-specific mortality data for 1999-2019 were obtained from the Centers for Disease Control and Prevention WONDER Underlying Cause of Death database. Levels and trends in mortality between 1999 and 2019 for women aged 15-44 years stratified by age, race/ethnicity, and state were examined. Given the urgent need to address pregnancy-related health disparities, the correlation between all-cause and pregnancy-related mortality rates across states for the years 2015-2019 was also examined.
    Results: Age-adjusted, all-cause mortality rates among women aged 15-44 years improved between 2003 and 2011 but worsened between 2011 and 2019. The recent increase in mortality among this age group was not driven solely by increases in external causes of death. Patterns differed by age, race/ethnicity, and geography, with non-Hispanic American Indian and Alaskan Native women having 2.3 and non-Hispanic Black women having 1.4 times the risk of all-cause mortality in 2019 compared with that of non-Hispanic White women. Age-adjusted all-cause mortality rates and pregnancy-related mortality rates were strongly correlated at the state level (r=0.75).
    Conclusions: Increasing mortality among reproductive-aged women has substantial implications for maternal, women's, and children's health. Given the high correlation between pregnancy-related mortality and all-cause mortality at the state level, addressing the structural factors that shape mortality risks may have the greatest likelihood of improving women's health outcomes across the life course.
    MeSH term(s) Adolescent ; Adult ; Age Distribution ; Centers for Disease Control and Prevention, U.S. ; Ethnicity/statistics & numerical data ; Female ; Health Status Disparities ; Humans ; Mortality/ethnology ; Mortality/trends ; Pregnancy ; United States/epidemiology ; Women's Health/ethnology ; Women's Health/statistics & numerical data ; Young Adult
    Language English
    Publishing date 2022-02-05
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632646-8
    ISSN 1873-2607 ; 0749-3797
    ISSN (online) 1873-2607
    ISSN 0749-3797
    DOI 10.1016/j.amepre.2021.10.009
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