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Article ; Online: Prioritizing COVID-19 tests based on participatory surveillance and spatial scanning.

Leal-Neto, O B / Santos, F A S / Lee, J Y / Albuquerque, J O / Souza, W V

International journal of medical informatics

2020 Volume 143, Page(s) 104263

Abstract: Objectives: This study aimed to identify, describe and analyze priority areas for COVID-19 testing combining participatory surveillance and traditional surveillance.: Design: It was carried out a descriptive transversal study in the city of Caruaru, ... ...

Abstract	Objectives: This study aimed to identify, describe and analyze priority areas for COVID-19 testing combining participatory surveillance and traditional surveillance. Design: It was carried out a descriptive transversal study in the city of Caruaru, Pernambuco state, Brazil, within the period of 20/02/2020 to 05/05/2020. Data included all official reports for influenza-like illness notified by the municipality health department and the self-reports collected through the participatory surveillance platform Brasil Sem Corona. Methods: We used linear regression and loess regression to verify a correlation between Participatory Surveillance (PS) and Traditional Surveillance (TS). Also a spatial scanning approach was deployed in order to identify risk clusters for COVID-19. Results: In Caruaru, the PS had 861 active users, presenting an average of 1.2 reports per user per week. The platform Brasil Sem Corona started on March 20th and since then, has been officially used by the Caruaru health authority to improve the quality of information from the traditional surveillance system. Regarding the respiratory syndrome cases from TS, 1588 individuals were positive for this clinical outcome. The spatial scanning analysis detected 18 clusters and 6 of them presented statistical significance (p-value < 0.1). Clusters 3 and 4 presented an overlapping area that was chosen by the local authority to deploy the COVID-19 serology, where 50 individuals were tested. From there, 32 % (n = 16) presented reagent results for antibodies related to COVID-19. Conclusion: Participatory surveillance is an effective epidemiological method to complement the traditional surveillance system in response to the COVID-19 pandemic by adding real-time spatial data to detect priority areas for COVID-19 testing.
MeSH term(s)	Adolescent ; Adult ; Algorithms ; Brazil/epidemiology ; COVID-19/diagnosis ; COVID-19 Testing ; Coronavirus Infections/diagnosis ; Humans ; Linear Models ; Middle Aged ; Pandemics ; Population Surveillance ; SARS-CoV-2 ; Self Report ; Spatial Analysis ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-08-27
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	1466296-6
ISSN	1872-8243 ; 1386-5056
ISSN (online)	1872-8243
ISSN	1386-5056
DOI	10.1016/j.ijmedinf.2020.104263
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prioritizing COVID-19 tests based on participatory surveillance and spatial scanning

Leal-Neto, O.B / Santos, F.A.S / Lee, J.Y / Albuquerque, J.O / Souza, W.V

International Journal of Medical Informatics

2020 Volume 143, Page(s) 104263

Keywords	Health Informatics ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	1466296-6
ISSN	1872-8243 ; 1386-5056
ISSN (online)	1872-8243
ISSN	1386-5056
DOI	10.1016/j.ijmedinf.2020.104263
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Prioritizing COVID-19 tests based on participatory surveillance and spatial scanning

Leal-Neto, O B / Santos, F A S / Lee, J Y / Albuquerque, J O / Souza, W V

Int J Med Inform

Abstract: OBJECTIVES: This study aimed to identify, describe and analyze priority areas for COVID-19 testing combining participatory surveillance and traditional surveillance. DESIGN: It was carried out a descriptive transversal study in the city of Caruaru, ... ...

Abstract	OBJECTIVES: This study aimed to identify, describe and analyze priority areas for COVID-19 testing combining participatory surveillance and traditional surveillance. DESIGN: It was carried out a descriptive transversal study in the city of Caruaru, Pernambuco state, Brazil, within the period of 20/02/2020 to 05/05/2020. Data included all official reports for influenza-like illness notified by the municipality health department and the self-reports collected through the participatory surveillance platform Brasil Sem Corona. METHODS: We used linear regression and loess regression to verify a correlation between Participatory Surveillance (PS) and Traditional Surveillance (TS). Also a spatial scanning approach was deployed in order to identify risk clusters for COVID-19. RESULTS: In Caruaru, the PS had 861 active users, presenting an average of 1.2 reports per user per week. The platform Brasil Sem Corona started on March 20th and since then, has been officially used by the Caruaru health authority to improve the quality of information from the traditional surveillance system. Regarding the respiratory syndrome cases from TS, 1588 individuals were positive for this clinical outcome. The spatial scanning analysis detected 18 clusters and 6 of them presented statistical significance (p-value < 0.1). Clusters 3 and 4 presented an overlapping area that was chosen by the local authority to deploy the COVID-19 serology, where 50 individuals were tested. From there, 32 % (nâ¯=â¯16) presented reagent results for antibodies related to COVID-19. CONCLUSION: Participatory surveillance is an effective epidemiological method to complement the traditional surveillance system in response to the COVID-19 pandemic by adding real-time spatial data to detect priority areas for COVID-19 testing.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #731790
Database	COVID19

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Article ; Online: Digital SARS-CoV-2 Detection Among Hospital Employees: Participatory Surveillance Study.

Leal-Neto, Onicio / Egger, Thomas / Schlegel, Matthias / Flury, Domenica / Sumer, Johannes / Albrich, Werner / Babouee Flury, Baharak / Kuster, Stefan / Vernazza, Pietro / Kahlert, Christian / Kohler, Philipp

JMIR public health and surveillance

2021 Volume 7, Issue 11, Page(s) e33576

Abstract: Background: The implementation of novel techniques as a complement to traditional disease surveillance systems represents an additional opportunity for rapid analysis.: Objective: The objective of this work is to describe a web-based participatory ... ...

Abstract	Background: The implementation of novel techniques as a complement to traditional disease surveillance systems represents an additional opportunity for rapid analysis. Objective: The objective of this work is to describe a web-based participatory surveillance strategy among health care workers (HCWs) in two Swiss hospitals during the first wave of COVID-19. Methods: A prospective cohort of HCWs was recruited in March 2020 at the Cantonal Hospital of St. Gallen and the Eastern Switzerland Children's Hospital. For data analysis, we used a combination of the following techniques: locally estimated scatterplot smoothing (LOESS) regression, Spearman correlation, anomaly detection, and random forest. Results: From March 23 to August 23, 2020, a total of 127,684 SMS text messages were sent, generating 90,414 valid reports among 1004 participants, achieving a weekly average of 4.5 (SD 1.9) reports per user. The symptom showing the strongest correlation with a positive polymerase chain reaction test result was loss of taste. Symptoms like red eyes or a runny nose were negatively associated with a positive test. The area under the receiver operating characteristic curve showed favorable performance of the classification tree, with an accuracy of 88% for the training data and 89% for the test data. Nevertheless, while the prediction matrix showed good specificity (80.0%), sensitivity was low (10.6%). Conclusions: Loss of taste was the symptom that was most aligned with COVID-19 activity at the population level. At the individual level-using machine learning-based random forest classification-reporting loss of taste and limb/muscle pain as well as the absence of runny nose and red eyes were the best predictors of COVID-19.
MeSH term(s)	COVID-19 ; Child ; Hospitals ; Humans ; Personnel, Hospital ; Prospective Studies ; SARS-CoV-2
Language	English
Publishing date	2021-11-22
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2369-2960
ISSN (online)	2369-2960
DOI	10.2196/33576
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Symptoms Compatible With Long Coronavirus Disease (COVID) in Healthcare Workers With and Without Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection-Results of a Prospective Multicenter Cohort.

Strahm, Carol / Seneghini, Marco / Güsewell, Sabine / Egger, Thomas / Leal-Neto, Onicio / Brucher, Angela / Lemmenmeier, Eva / Meier Kleeb, Dorette / Möller, J Carsten / Rieder, Philip / Ruetti, Markus / Rutz, Remus / Schmid, Hans Ruedi / Stocker, Reto / Vuichard-Gysin, Danielle / Wiggli, Benedikt / Besold, Ulrike / Kuster, Stefan P / McGeer, Allison /

Risch, Lorenz / Friedl, Andrée / Schlegel, Matthias / Schmid, Dagmar / Vernazza, Pietro / Kahlert, Christian R / Kohler, Philipp

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2022 Volume 75, Issue 1, Page(s) e1011–e1019

Abstract: Background: The burden of long-term symptoms (ie, long COVID) in patients after mild COVID-19 is debated. Within a cohort of healthcare workers (HCWs), frequency and risk factors for symptoms compatible with long COVID are assessed.: Methods: ... ...

Abstract	Background: The burden of long-term symptoms (ie, long COVID) in patients after mild COVID-19 is debated. Within a cohort of healthcare workers (HCWs), frequency and risk factors for symptoms compatible with long COVID are assessed. Methods: Participants answered baseline (August/September 2020) and weekly questionnaires on SARS-CoV-2 nasopharyngeal swab (NPS) results and acute disease symptoms. In January 2021, SARS-CoV-2 serology was performed; in March, symptoms compatible with long COVID (including psychometric scores) were asked and compared between HCWs with positive NPS, seropositive HCWs without positive NPS (presumable asymptomatic/pauci-symptomatic infections), and negative controls. The effect of time since diagnosis and quantitative anti-spike protein antibodies (anti-S) was evaluated. Poisson regression was used to identify risk factors for symptom occurrence. Results: Of 3334 HCWs (median, 41 years; 80% female), 556 (17%) had a positive NPS and 228 (7%) were only seropositive. HCWs with positive NPS more frequently reported ≥1 symptom compared with controls (73% vs 52%, P < .001); seropositive HCWs without positive NPS did not score higher than controls (58% vs 52%, P = .13), although impaired taste/olfaction (16% vs 6%, P < .001) and hair loss (17% vs 10%, P = .004) were more common. Exhaustion/burnout was reported by 24% of negative controls. Many symptoms remained elevated in those diagnosed >6 months ago; anti-S titers correlated with high symptom scores. Acute viral symptoms in weekly questionnaires best predicted long-COVID symptoms. Physical activity at baseline was negatively associated with neurocognitive impairment and fatigue scores. Conclusions: Seropositive HCWs without positive NPS are only mildly affected by long COVID. Exhaustion/burnout is common, even in noninfected HCWs. Physical activity might be protective against neurocognitive impairment/fatigue symptoms after COVID-19.
MeSH term(s)	Asymptomatic Infections/epidemiology ; COVID-19/complications ; COVID-19/epidemiology ; Fatigue ; Female ; Health Personnel ; Humans ; Male ; Olfaction Disorders ; Prospective Studies ; SARS-CoV-2
Language	English
Publishing date	2022-01-28
Publishing country	United States
Document type	Journal Article ; Multicenter Study
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciac054
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Non-occupational and occupational factors associated with specific SARS-CoV-2 antibodies among Hospital Workers - a multicentre cross-sectional study

Abstract: Background Protecting healthcare workers (HCW) from Coronavirus Disease-19 (COVID-19) is critical to preserve the functioning of healthcare systems. We therefore assessed seroprevalence and identified risk factors for Severe Acute Respiratory Syndrome- ... ...

Abstract	Background Protecting healthcare workers (HCW) from Coronavirus Disease-19 (COVID-19) is critical to preserve the functioning of healthcare systems. We therefore assessed seroprevalence and identified risk factors for Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) seropositivity in this population. Methods Between June 22nd and August 15th 2020, employees from healthcare institutions in Northern/Eastern Switzerland were screened for SARS-CoV-2 antibodies. We recorded baseline characteristics, non-occupational and occupational risk factors. We used pairwise tests of associations and multivariable logistic regression to identify factors associated with seropositivity. Findings Among the 4664 included HCW from 23 healthcare facilities, 139 (3%) were seropositive. Non-occupational exposures independently associated with seropositivity were contact with a COVID-19 positive household (adjusted OR=54, 95%-CI: 31-97) and stay in a COVID 19 hotspot (aOR=2.2, 95%-CI: 1.1-3.9). Blood group 0 vs. non-0 (aOR=0.4, 95%-CI: 0.3-0.7), active smoking (aOR=0.5, 95%-CI: 0.3-0.9) and living with children <12 years (aOR=0.3, 95%-CI: 0.2-0.6) were associated with decreased risk. Occupational risk factors were close contact to COVID-19 patients (aOR=2.8, 95%-CI: 1.5-5.5), exposure to COVID-19 positive co-workers (aOR=2.0, 95%-CI: 1.2-3.1), poor knowledge of standard hygiene precautions (aOR=2.0, 95%-CI: 1.3-3.2), and frequent visits to the hospital canteen (aOR=1.9, 95%-CI: 1.2-3.1). Interpretation We identified several modifiable factors associated with SARS-CoV-2 seropositivity among our HCW. Living with COVID-19 positive households showed by far the strongest association. The lower risk among those living with children, even after correction for multiple confounders, is remarkable and merits further study. Funding Swiss National Sciences Foundation, Federal Office of Public Health, Health Department Canton of St. Gallen
Keywords	covid19
Publisher	MedRxiv; WHO
Document type	Article ; Online
DOI	10.1101/2020.11.10.20229005
Database	COVID19

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Article ; Online: Impact of baseline SARS–CoV–2 antibody status on syndromic surveillance and the risk of subsequent Covid-19 — a prospective multicentre cohort study

medRxiv

Abstract: <b>Objectivesb> In a prospective healthcare worker (HCW) cohort, we assessed the risk of SARS-CoV ... 2 infection according to baseline serostatus. <b>Methodsb> Baseline serologies were performed ... without anti-nucleocapsid antibodies. <b>Resultsb> A total of 4′818 HCW participated, whereof 144 (3%) were ...

Abstract	<b>Objectives</<mark>b> In a prospective healthcare worker (HCW) cohort, we assessed the risk of SARS-CoV-2 infection according to baseline serostatus. <b>Methods</<mark>b> Baseline serologies were performed among HCW from 23 Swiss healthcare institutions between June and September 2020, before the second COVID-19 wave. Participants answered weekly electronic questionnaires covering information about nasopharyngeal swabs (PCR/rapid antigen tests) and symptoms compatible with Coronavirus Disease 2019 (COVID-19). Screening of symptomatic staff by nasopharyngeal swabs was routinely performed in participating facilities. We compared numbers of positive nasopharyngeal tests and occurrence of COVID-19 symptoms between HCW with and without anti-nucleocapsid antibodies. <b>Results</<mark>b> A total of 4′818 HCW participated, whereof 144 (3%) were seropositive at baseline. We analysed 107′820 questionnaires with a median follow-up of 7.9 months. Median number of answered questionnaires was similar (24 vs. 23 per person, P=0.83) between those with and without positive baseline serology. Among 2′713 HCW with ≥1 SARS-CoV-2 test during follow-up, 3/67 (4.5%) seropositive individuals reported a positive result (one of whom asymptomatic), compared to 547/2646 (20.7%) seronegative participants, 12 of whom asymptomatic (risk ratio [RR] 0.22; 95% confidence interval [CI] 0.07 to 0.66). Seropositive HCWs less frequently reported impaired olfaction/taste (6/144, 4.2% vs. 588/4674, 12.6%, RR 0.33, 95%-CI: 0.15-0.73), chills (19/144, 13.2% vs. 1040/4674, 22.3%, RR 0.59, 95%-CI: 0.39-0.90), and limb/muscle pain (28/144, 19.4% vs. 1335/4674, 28.6%, RR 0.68 95%-CI: 0.49-0.95). Impaired olfaction/taste and limb/muscle pain also discriminated best between positive and negative SARS-CoV-2 results. <b>Conclusions</<mark>b> Having SARS-CoV-2 anti-nucleocapsid antibodies provides almost 80% protection against SARS-CoV-2 re-infection for a period of at least eight months.
Keywords	covid19
Language	English
Publishing date	2021-06-12
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2021.06.09.21258422
Database	COVID19

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Article: Cattle tick and gastrointestinal nematodes strategic control in dairy 31/32 Gyr x Holstein and beef ½ Brangus: is the same way?

Trindade, A.S.N. / Couto, L.F.M. / Heller, L.M. / Zapa, D.M.B. / de Aquino, L.M. / Ferreira, L.L. / de Morais, I.M.L. / Salvador, V.F. / Leal, L.L.L.L. / Ruivo, M.A. / Scarpa, A.B. / Neto, O.P. / Soares, V.E. / Lopes, W.D.Z.

Livestock science

2023 Volume 268, Issue -, Page(s) 105154

Language	English
Document type	Article
ZDB-ID	2226176-X
ISSN	1871-1413
Database	Current Contents Nutrition, Environment, Agriculture

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Article ; Online: Prioritizing COVID-19 tests based in Participatory Surveillance and Spatial Scanning.

Leal Neto, O. B. / Santos, F. A. / Lee, J. Y. / Albuquerque, J. / Souza, W. V.

Abstract: Objectives The aim of this study was to describe and analyze the generation of priority areas for Covid-19 testing combining participatory surveillance and traditional surveillance. Design The study is a descriptive transversal, where was performed in ... ...

Abstract	Objectives The aim of this study was to describe and analyze the generation of priority areas for Covid-19 testing combining participatory surveillance and traditional surveillance. Design The study is a descriptive transversal, where was performed in the city of Caruaru, Pernambuco state, within the period of 20/02/2020 to 05/05/2020. It was considered all official reports for flu syndromes notified by municipality health department and the data collected through the participatory surveillance platform Brasil Sem Corona. Methods To verify a correlation between Participatory Surveillance (PS) and Traditional Surveillance (TS), it was carried out a linear regression. Results The PS has showed in Caruaru 861 active users, presenting an average of 1.2 report per user per week. It was started in March 20th and is officially used by the local health authority in order to improve the quality of information from traditional surveillance system. Regarding to the respiratory syndrome cases from TS, it was found out 1,588 individuals that were positive for this clinical outcome. The spatial scanning analysis has detected 18 clusters and 6 of them have presented statistical significance (p-value < 0.1). Clusters 3 and 4 presented an overlapping and this area was chosen by local authority to deploy the Covid-19 serology, where 50 individuals were tested. From there, 32% (n=16) presented reagent results for antibodies related to Covid-19. Conclusion The use of alternative methods as participatory surveillance showed a relevant role taking advantage on the insertion at community levels to complement traditional surveillance system.
Keywords	covid19
Publisher	MedRxiv; WHO
Document type	Article ; Online
DOI	10.1101/2020.05.25.20109058
Database	COVID19

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Article ; Online: Symptoms compatible with long-COVID in healthcare workers with and without SARS-CoV-2 infection - results of a prospective multicenter cohort

Strahm, Carol / Seneghini, Marco / Guesewell, Sabine / Egger, Thomas / Leal-Neto, Onicio / Brucher, Angela / Lemmenmaier, Eva / Meier Kleeb, Dorette / Moeller, Carsten / Rieder, Philip / Ruetti, Markus / Rutz, Remus / Schmid, Hans-Ruedi / Stocker, Reto / Vuichard-Gysin, Danelle / Wiggli, Benedikt / Besold, Ulrike / Kuster, Stefan P / McGeer, Allison /

Risch, Lorenz / Friedl, Andree / Schlegel, Matthias / Schmid, Dagmar / Vernazza, Pietro / Kahlert, Christian R. / Kohler, Philipp

medRxiv

Abstract: Background: The burden of long-term symptoms (i.e. long-COVID) in patients after mild COVID-19 is debated. Within a cohort of healthcare workers (HCW), frequency and risk factors for symptoms compatible with long-COVID are assessed. Methods: Participants ...

Abstract	Background: The burden of long-term symptoms (i.e. long-COVID) in patients after mild COVID-19 is debated. Within a cohort of healthcare workers (HCW), frequency and risk factors for symptoms compatible with long-COVID are assessed. Methods: Participants answered baseline (August/September 2020) and weekly questionnaires on SARS-CoV-2 nasopharyngeal swab (NPS) results and acute disease symptoms. In January 2021, SARS-CoV-2 serology was performed; in March, symptoms compatible with long-COVID (including psychometric scores) were asked and compared between HCW with positive NPS, seropositive HCW without positive NPS (presumable a-/pauci-symptomatic infections), and negative controls. Also, the effect of time since diagnosis and quantitative anti-S was evaluated. Poisson regression was used to identify risk factors for symptom occurrence. Results: Of 3334 HCW (median 41 years; 80% female), 556 (17%) had a positive NPS and 228 (7%) were only seropositive. HCW with positive NPS more frequently reported ≥1 symptom compared to controls (73%vs.52%, p<0.001); seropositive HCW without positive NPS did not score higher than controls (58%vs.52%, p=0.13), although impaired taste/olfaction (16%vs.6%, p<0.001) and hair loss (17%vs.10%, p=0.004) were more common. Exhaustion/burnout was reported by 24% of negative controls. Many symptoms remained elevated in those diagnosed >6 months ago; anti-S titers correlated with high symptom scores. Acute viral symptoms in weekly questionnaires best predicted long-COVID symptoms. Physical activity at baseline was negatively associated with neurocognitive impairment and fatigue scores. Conclusions: Seropositive HCW without positive NPS are only mildly affected by long-COVID. Exhaustion/burnout is common, even in non-infected HCW. Physical activity might be protective against neurocognitive impairment/fatigue symptoms after COVID-19.
Keywords	covid19
Language	English
Publishing date	2021-10-22
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2021.10.19.21265187
Database	COVID19

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