LIVIVO - Search results -

Search results

Result 1 - 10 of total 180

Search options

Article: Exploration of Novel Urolithin C Derivatives as Non-Competitive Inhibitors of Liver Pyruvate Kinase.

Battisti, Umberto Maria / Monjas, Leticia / Akladios, Fady / Matic, Josipa / Andresen, Eric / Nagel, Carolin H / Hagkvist, Malin / Håversen, Liliana / Kim, Woonghee / Uhlen, Mathias / Borén, Jan / Mardinoğlu, Adil / Grøtli, Morten

Pharmaceuticals (Basel, Switzerland)

2023 Volume 16, Issue 5

Abstract: ... to cirrhosis. Recently, urolithin C has been reported as a new scaffold for the development of allosteric ... of urolithin C was carried out. More than 50 analogues were synthesized and tested regarding the chemical ...

Abstract	The inhibition of liver pyruvate kinase could be beneficial to halt or reverse non-alcoholic fatty liver disease (NAFLD), a progressive accumulation of fat in the liver that can lead eventually to cirrhosis. Recently, urolithin C has been reported as a new scaffold for the development of allosteric inhibitors of liver pyruvate kinase (PKL). In this work, a comprehensive structure-activity analysis of urolithin C was carried out. More than 50 analogues were synthesized and tested regarding the chemical features responsible for the desired activity. These data could pave the way to the development of more potent and selective PKL allosteric inhibitors.
Language	English
Publishing date	2023-04-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph16050668
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Interview with Prof. Chérif Akladios: Sentinel lymph node in gynaecologic malignancy, the beginning of a new area in lymph node surgery.

Akladios, Chérif / Liao, Annabel / Zeng, Yixuan

Chinese clinical oncology

2023 Volume 11, Issue 6, Page(s) 51

MeSH term(s)	Humans ; Sentinel Lymph Node/surgery ; Sentinel Lymph Node/pathology ; Sentinel Lymph Node Biopsy ; Lymph Nodes/pathology ; Lymphatic System ; Neoplasms/pathology ; Lymph Node Excision
Language	English
Publishing date	2023-01-09
Publishing country	China
Document type	Journal Article
ZDB-ID	2828547-5
ISSN	2304-3873 ; 2304-3873
ISSN (online)	2304-3873
ISSN	2304-3873
DOI	10.21037/cco-22-99
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Establishing sentinel lymph node as a standard of care in gynecologic cancer?

Querleu, Denis / Akladios, Chérif

Chinese clinical oncology

2021 Volume 10, Issue 2, Page(s) 13

MeSH term(s)	Female ; Genital Neoplasms, Female/surgery ; Humans ; Sentinel Lymph Node ; Sentinel Lymph Node Biopsy ; Standard of Care
Language	English
Publishing date	2021-02-23
Publishing country	China
Document type	Journal Article
ZDB-ID	2828547-5
ISSN	2304-3873 ; 2304-3873
ISSN (online)	2304-3873
ISSN	2304-3873
DOI	10.21037/cco-21-11
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Therapeutic role of para-aortic lymphadenectomy in patients with intermediate- and high-risk endometrial cancer: a systematic review and meta-analysis.

Pavone, Matteo / Jochum, Floriane / Lecointre, Lise / Fanfani, Francesco / Scambia, Giovanni / Querleu, Denis / Akladios, Chérif

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2024 Volume 34, Issue 4, Page(s) 519–527

Abstract: Objective: Lymph nodal involvement is a prognostic factor in endometrial cancer. The added value of para-aortic lymphadenectomy compared with pelvic nodal evaluation alone remains a matter of debate in the management of patients with intermediate- and ... ...

Abstract	Objective: Lymph nodal involvement is a prognostic factor in endometrial cancer. The added value of para-aortic lymphadenectomy compared with pelvic nodal evaluation alone remains a matter of debate in the management of patients with intermediate- and high-risk endometrial cancer. A systematic review and meta-analysis was conducted to assess the prognostic value of para-aortic lymphadenectomy in terms of overall survival and disease-free survival in patients with intermediate- and high-risk endometrial cancer. Methods: The study adhered to the PRISMA guidelines. PubMed, Google Scholar and ClinicalTrials.gov were searched from January 2000 to April 2023. Studies on intermediate- and high-risk patients who underwent pelvic versus pelvic and para-aortic dissection were included in the analysis. The Methodological Index for Nonrandomized Studies (MINORS) and the Quality Assessment of Diagnostic Accuracy Studies 2 tool (QUADAS-2) were used for quality assessment of the selected articles. Results: Fourteen studies were identified, encompassing 9415 patients with a median age of 62 years (IQR 56.5-66.5). The majority had International Federation of Gynecology and Obstetrics stage I-II disease (76%) and endometrioid histology (89%). The 72% of patients who underwent only pelvic nodal evaluation and the 87% who underwent pelvic and para-aortic lymphadenectomy received adjuvant treatment (p=0.44). Pelvic and para-aortic lymphadenectomy was associated with a significant improvement in 5-year overall survival (RR=0.71, 95% CI 0.57 to 0.88, p<0.01), translating to a 41% reduction in the risk of overall death. However, no significant differences were observed in the 5-year risk of recurrence (RR=1.12, 95% CI 0.94 to 1.34, p=0.15). Additionally, patients undergoing pelvic and para-aortic lymphadenectomy experienced a 26% increased risk of post-operative complications (RR=1.26, 95% CI 1.04 to 1.53, p=0.03) and prolonged operative times (MD=56.27, 95% CI 15.94 to 96.60, p<0.01). Conclusion: Pelvic and para-aortic lymphadenectomy appears to confer a prognostic benefit in patients with intermediate- and high-risk endometrial cancer. Robust prospective studies are needed to further validate these findings and elucidate the precise role of para-aortic lymphadenectomy in the optimal management of these patients.
MeSH term(s)	Female ; Humans ; Middle Aged ; Aged ; Lymph Node Excision/adverse effects ; Lymph Nodes/surgery ; Lymph Nodes/pathology ; Endometrial Neoplasms/pathology ; Endometrium/pathology ; Disease-Free Survival ; Neoplasm Staging ; Retrospective Studies
Language	English
Publishing date	2024-04-01
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1136/ijgc-2023-005134
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3198: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Deep infiltrating endometriosis: Laparoscopic nerve-sparing surgery and use of neutral argon plasma.

Buttignol, Megane / Faller, Emilie / Lecointre, Lise / Boisrame, Thomas / Akladios, Cherif

Journal of gynecology obstetrics and human reproduction

2023 Volume 52, Issue 5, Page(s) 102573

Abstract: Objective: To present a minimally approach to the management of deep pelvic endometriosis by nerve-sparing surgery and use of neutral argon plasma for extensive endometriotic lesions.: Design: This is a clinical case video of a 29 years-old patient, ... ...

Abstract	Objective: To present a minimally approach to the management of deep pelvic endometriosis by nerve-sparing surgery and use of neutral argon plasma for extensive endometriotic lesions. Design: This is a clinical case video of a 29 years-old patient, affected by deep pelvic endometriosis with primary dysmenorrhea, deep dyspareunia, chronic pelvic pain and dyschezia. Pelvic MRI shows a right ovarian endometrioma measuring 5 cm, a thickening of the right uterosacral ligament and a uterine torus nodule. Setting: Laparoscopy video. Intervention: This laparoscopic surgery begins by an adhesiolysis of the sigmoid and a blue tube test to check the correct permeability of the tubes. A bilateral ureterolysis is performed before the excision of a torus lesion and adhesiolysis of the rectovaginal septum. A fine dissection of the uterosacral ligament by nerve-sparing surgery is realized to respect the hypogastric nerve in the Okabayashi space. Endometriosis nodules of the lumbo-ovarian ligaments and multiples endometriosis peritoneal implants, inaccessible to a complete excision, are destroyed by argon plasma vaporization. A cystectomy of the right endometrioma and an appendectomy are performed at the end. Conclusion: The surgical management of deep infiltrating endometriosis is complex, with the recent contribution of new technical procedures such as nerve-sparing surgery to reduce postoperative urinary complications, or argon plasma for ablation of extended peritoneal implants or endometrioma to preserve ovarian function.
MeSH term(s)	Female ; Humans ; Adult ; Endometriosis/complications ; Plasma Gases ; Laparoscopy/methods ; Uterus/pathology ; Pelvic Pain/etiology ; Pelvic Pain/surgery
Chemical Substances	Plasma Gases
Language	English
Publishing date	2023-03-11
Publishing country	France
Document type	Case Reports
ISSN	2468-7847
ISSN (online)	2468-7847
DOI	10.1016/j.jogoh.2023.102573
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Bilateral posterior Richter sacrospinous fixation with native tissue: Anatomical and functional results and quality of life assessment over 10 years.

Gaultier, Victor / Martel, Camille / Boisramé, Thomas / Faller, Emilie / Lecointre, Lise / Akladios, Cherif

Journal of gynecology obstetrics and human reproduction

2023 Volume 52, Issue 6, Page(s) 102575

Abstract: Introduction: Pelvic organ prolapse (POP) is a common condition that affects 50% of women who have given birth in their lifetime. With stop of vaginal mesh sale in 2019, the sacrospinous fixation technique according to Richter with native tissue has ... ...

Abstract	Introduction: Pelvic organ prolapse (POP) is a common condition that affects 50% of women who have given birth in their lifetime. With stop of vaginal mesh sale in 2019, the sacrospinous fixation technique according to Richter with native tissue has seen its incidence tripled in 15 years. Classically, sacrospinous fixation according to Richter is performed unilaterally, however its unilateral or bilateral character is controversial. Objective of this work is to evaluate the efficacy and safety of bilateral sacrospinous fixation according to Richter by the posterior approach with native tissue (SSB). Methods: We performed a retrospective single-center study. From March 12, 2010 to March 23, 2020, all first-time operated patients who underwent SSB in CHU Strasbourg gynecological surgery unit for symptomatic POP management were included. The main endpoint of our work is the anatomical and functional success rate at 12 and 24 months. The secondary judgment criteria of our work were based on the postoperative evaluation of patient's quality of life according to the PFDI-20 score as well as the rate of postoperative complications. Results: 77 patients were included in our work. The anatomical success rate at 12 months is 94 and 81% at 24 months regardless of the compartment affected. The functional success rate is 94% at 12 months and 82% at 24 months. Quality of life evaluation through the PFDI-20 scale revealed a clear improvement in the symptomatology related to POP: 127/300 +/- 27.3. preoperatively and 59.8 ± 14.7 postoperatively. Conclusion: Bilateral sacrospinous fixation according to Richter by posterior approach with native tissue is a safe and effective surgical technique allowing a clear improvement in patients quality of life.
MeSH term(s)	Humans ; Female ; Treatment Outcome ; Quality of Life ; Retrospective Studies ; Vagina/surgery ; Pelvic Organ Prolapse/surgery ; Pelvic Organ Prolapse/etiology
Language	English
Publishing date	2023-03-26
Publishing country	France
Document type	Journal Article
ISSN	2468-7847
ISSN (online)	2468-7847
DOI	10.1016/j.jogoh.2023.102575
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Intérêt des réunions de concertation pluridisciplinaires dédiées à l’endométriose : à partir d’une série de 682 patientes.

Osada, Marine / Faller, Emilie / Lecointre, Lise / Boisrame, Thomas / Martel, Camille / Gabriele, Victor / Akladios, Cherif / Host, Aline

Gynecologie, obstetrique, fertilite & senologie

2024

Abstract: Objective: We decided to conduct a study based on these multidisciplinary team (MDT) in order to investigate their impact at the University Hospitals of Strasbourg and look for ways to improve this MDT.: Methods: This is a retrospective study of the ... ...

Title translation	Interest of multidisciplinary consultation meetings dedicated to endometriosis: From a series of 682 patients.
Abstract	Objective: We decided to conduct a study based on these multidisciplinary team (MDT) in order to investigate their impact at the University Hospitals of Strasbourg and look for ways to improve this MDT. Methods: This is a retrospective study of the 682 patients presented to endometriosis MDT from its inception in March 2017 to December 2020. Results: The MDT decision was different from that initially proposed by the patient's referent for 406 patients (60%). Surgery was chosen for 417 patients (61%) and assisted reproduction for 261 patients (38%). A review of the MRI by a referring radiologist was carried out for 348 cases (51%), with a modification of the results for 255 patients (73%). Initial underestimation of lesions was noted in 198 cases. Conclusion: Our study has shown the importance of MDT in endometriosis since the therapeutic proposal was modified in 60% of cases. In addition, we supported the importance of radiologists specializing in this field since they made a modification in two-thirds of the MRIs reread. These results show the importance of collegial discussions, which can modify the decisions of medical teams. This underlines the importance of setting up endometriosis networks.
Language	French
Publishing date	2024-01-17
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	2887456-0
ISSN	2468-7189
ISSN (online)	2468-7189
DOI	10.1016/j.gofs.2024.01.005
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 1937: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The saga of lymph node surgery in malignant melanoma: a history repeating itself in gynecologic oncology.

Bund, Virginie / Lecointre, Lise / Akladios, Chérif

Chinese clinical oncology

2021 Volume 10, Issue 2, Page(s) 21

Abstract: In view of the high morbidity to complete lymphadenectomy, the sentinel node procedure is currently being investigated in different cancers with the aim of reducing morbidity and of achieving oncological outcomes similar to complete lymphadenectomy. In ... ...

Abstract	In view of the high morbidity to complete lymphadenectomy, the sentinel node procedure is currently being investigated in different cancers with the aim of reducing morbidity and of achieving oncological outcomes similar to complete lymphadenectomy. In this review, a parallel will be drawn between the evolutions of the place of lymph node surgery in the management of melanoma and gynecologic cancers. Currently, in the case of cutaneous melanoma, the indications of lymph node surgery are becoming increasingly rare. In contrast with the scarce available evidence in gynecologic cancer, this trend is supported by multicenter randomized studies with a large number of patients for cutaneous melanoma. The second difference is the demonstrated therapeutic benefit of immunotherapies and targeted therapies in cutaneous melanoma, which are less significant in gynecological cancers for which the mainstay of treatment is surgery. According to this review, it seems that in gynecologic oncology, we could in the next decades follow the same pathway currently taken in the management of lymph nodes in malignant melanoma.
MeSH term(s)	Female ; Genital Neoplasms, Female/surgery ; Humans ; Lymph Nodes ; Lymphatic Metastasis ; Melanoma/surgery ; Multicenter Studies as Topic ; Randomized Controlled Trials as Topic ; Sentinel Lymph Node Biopsy ; Skin Neoplasms/surgery
Language	English
Publishing date	2021-03-23
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2828547-5
ISSN	2304-3873 ; 2304-3873
ISSN (online)	2304-3873
ISSN	2304-3873
DOI	10.21037/cco-20-227
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Fostering Cardio-Endometriosis: A Call to Action for a Comprehensive Understanding of Cardiovascular Disease in Endometriosis.

Marchandot, Benjamin / Faller, Emilie / Akladios, Cherif / Matsushita, Kensuke / Bäck, Magnus / Jesel, Laurence / Schini-Kerth, Valérie / Morel, Olivier

European journal of preventive cardiology

2024

Abstract: Recently, a growing body of evidence has highlighted a concerning link between endometriosis and cardiovascular disease. Endometriosis, a chronic, inflammatory hormone-dependent condition affecting 5 to 10% of reproductive-aged women worldwide, has long ... ...

Abstract	Recently, a growing body of evidence has highlighted a concerning link between endometriosis and cardiovascular disease. Endometriosis, a chronic, inflammatory hormone-dependent condition affecting 5 to 10% of reproductive-aged women worldwide, has long been associated with reproductive and gynecological consequences. However, emerging research has suggested that it may also contribute to adverse cardiovascular outcomes. This paper aims to shed light on the importance of recognizing cardio-endometriosis as a new and developing sphere of research in the field of cardiology, thereby urging the medical community to address this pressing issue.
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2626011-6
ISSN	2047-4881 ; 2047-4873
ISSN (online)	2047-4881
ISSN	2047-4873
DOI	10.1093/eurjpc/zwae087
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4686: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Laparoscopic-Assisted Vaginal Trachelectomy with Prophylactic Cerclage: A Safe Fertility-Sparing Treatment for Early Stage Cervical Cancer.

Pavone, Matteo / Goglia, Marta / Scambia, Giovanni / Querleu, Denis / Akladios, Cherif / Lecointre, Lise

Annals of surgical oncology

2023 Volume 31, Issue 3, Page(s) 1804–1805

Abstract: Background: In recent years fertility-sparing treatments are increasingly developing in patients with early stage cervical cancer.: Results: The first laparoscopic time is dedicated to the safe opening of the vesicouterine and rectovaginal spaces ... ...

Abstract	Background: In recent years fertility-sparing treatments are increasingly developing in patients with early stage cervical cancer. Results: The first laparoscopic time is dedicated to the safe opening of the vesicouterine and rectovaginal spaces until the medial pararectal fossa. Ureters are found and bilateral ureterolysis performed under vision. Colpotomy is then vaginally achieved, and the cervix is closed in a vaginal cuff to avoid tumor spread. Careful dissection of the anterior and posterior septa is carried out until reunification with laparoscopic dissection. Bilateral parametrectomy is performed. Vaginal trachelectomy is finalized with a negative deep margin at the frozen section. In the second laparoscopic time a monofilament polypropylene sling cerclage is bilaterally positioned from posterior to anterior through the broad ligaments and fixed anteriorly on the uterine isthmus to prevent an eventual preterm delivery. Conclusion: Laparoscopic-assisted vaginal trachelectomy is a feasible procedure combining the conservative advantages of the vaginal approach and the oncological safety of laparoscopic spaces dissection with possible good obstetric outcomes.
MeSH term(s)	Humans ; Female ; Pregnancy ; Infant, Newborn ; Adult ; Trachelectomy/methods ; Cervix Uteri/pathology ; Uterine Cervical Neoplasms/pathology ; Positron Emission Tomography Computed Tomography ; Laparoscopy/methods ; Fertility Preservation/methods ; Neoplasm Staging
Language	English
Publishing date	2023-12-10
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-023-14737-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4042: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito