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  1. Book ; Online: paq'batlh

    Schönfeld, Floris / Schönfeld, Floris / Ligtelijn, Kees / van Gerven Oei, Vincent W.J. / Yonge-Mallo, David

    The Klingon Epic (second expanded edition)

    2022  

    Keywords Artificial languages ; Space opera ; conlang;epic literature;Kahless the Unforgettable;Klingon;mythology;space opera;Star Trek
    Language 0|e
    Size 1 electronic resource (205 pages)
    Publisher punctum books
    Publishing place Brooklyn, NY
    Document type Book ; Online
    Note English ; tlhIngan-Hol ; Open Access
    HBZ-ID HT021616300
    ISBN 9781685710941 ; 1685710948
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Update on Biomarkers in Renal Cell Carcinoma.

    Saliby, Renée M / Saad, Eddy / Kashima, Soki / Schoenfeld, David A / Braun, David A

    American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

    2024  Volume 44, Issue 2, Page(s) e430734

    Abstract: Immune checkpoint inhibitors have significantly transformed the treatment paradigm for metastatic renal cell carcinoma (RCC), offering prolonged overall survival and achieving remarkable deep and durable responses. However, given the multiple ICI- ... ...

    Abstract Immune checkpoint inhibitors have significantly transformed the treatment paradigm for metastatic renal cell carcinoma (RCC), offering prolonged overall survival and achieving remarkable deep and durable responses. However, given the multiple ICI-containing, standard-of-care regimens approved for RCC, identifying biomarkers that predict therapeutic response and resistance is of critical importance. Although tumor-intrinsic features such as pathological characteristics, genomic alterations, and transcriptional signatures have been extensively investigated, they have yet to provide definitive, robust predictive biomarkers. Current research is exploring host factors through in-depth characterization of the immune system. Additionally, innovative technological approaches are being developed to overcome challenges presented by existing techniques, such as tumor heterogeneity. Promising avenues in biomarker discovery include the study of the microbiome, radiomics, and spatial transcriptomics.
    MeSH term(s) Humans ; Carcinoma, Renal Cell/diagnosis ; Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/genetics ; Kidney Neoplasms/diagnosis ; Kidney Neoplasms/genetics ; Kidney Neoplasms/therapy ; Biomarkers ; Biomedical Research ; Gene Expression Profiling
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2431126-1
    ISSN 1548-8756 ; 1548-8748
    ISSN (online) 1548-8756
    ISSN 1548-8748
    DOI 10.1200/EDBK_430734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Comment on: Progression-Free Survival as a Surrogate for Overall Survival in Clinical Trials of Targeted Therapy in Advanced Solid Tumors.

    Schoenfeld, David A

    Drugs

    2017  Volume 77, Issue 10, Page(s) 1137–1138

    Language English
    Publishing date 2017-07
    Publishing country New Zealand
    Document type Letter
    ZDB-ID 120316-2
    ISSN 1179-1950 ; 0012-6667
    ISSN (online) 1179-1950
    ISSN 0012-6667
    DOI 10.1007/s40265-017-0760-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 762: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Designing a longitudinal clinical trial based on a composite endpoint: Sample size, monitoring, and adaptation.

    Schoenfeld, David A / Ramchandani, Ritesh / Finkelstein, Dianne M

    Statistics in medicine

    2022  Volume 41, Issue 24, Page(s) 4745–4755

    Abstract: ... on a composite of multiple endpoints referred to as the Finkelstein-Schoenfeld (FS) test (Finkelstein and ... Schoenfeld. Stat Med. 1999;18(11):1341-1354.). More recently, an estimate of the treatment comparison based ...

    Abstract Longitudinal clinical trials are often designed to compare treatments on the basis of multiple outcomes. For example in the case of cardiac trials, the outcomes of interest include mortality as well as cardiac events and hospitalization. For a COVID-19 trial, the outcomes of interest include mortality, time on ventilator, and time in hospital. Earlier work by these authors proposed a non-parametric test based on a composite of multiple endpoints referred to as the Finkelstein-Schoenfeld (FS) test (Finkelstein and Schoenfeld. Stat Med. 1999;18(11):1341-1354.). More recently, an estimate of the treatment comparison based on multiple endpoints (related to the FS test) was proposed (Pocock et al. Eur Heart J. 2011;33(2):176-182.). This estimate, which summarized the ratio of the number of patients who fared better vs worse on the experimental arm was coined the win ratio. The aim of this article is to provide guidance in the design of a trial that will use the FS test or the win ratio. The issues that will be considered are the sample size, sequential monitoring, and adaptive designs.
    MeSH term(s) COVID-19 ; Hospitalization ; Humans ; Research Design ; Sample Size
    Language English
    Publishing date 2022-07-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 843037-8
    ISSN 1097-0258 ; 0277-6715
    ISSN (online) 1097-0258
    ISSN 0277-6715
    DOI 10.1002/sim.9416
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1756: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: First-Pass Success of Intubations Using Video Versus Direct Laryngoscopy in Children With Limited Neck Mobility.

    Khanam, Dilruba / Schoenfeld, Elizabeth / Ginsberg-Peltz, Julien / Lutfy-Clayton, Lucienne / Schoenfeld, David A / Spirko, Blake / Brown, Calvin A / Nishisaki, Akira

    Pediatric emergency care

    2023  

    Abstract: Objective: It is not clear whether video laryngoscopy (VL) is associated with a higher first-pass success rate in pediatric patients with limited neck mobility when compared with direct laryngoscopy (DL). We sought to determine the association between ... ...

    Abstract Objective: It is not clear whether video laryngoscopy (VL) is associated with a higher first-pass success rate in pediatric patients with limited neck mobility when compared with direct laryngoscopy (DL). We sought to determine the association between the laryngoscopy method and first-pass success.
    Methods: In this retrospective cohort study, we examined intubation data extracted from 2 prospectively collected, multicenter, airway management safety databases (National Emergency Airway Registry and the National Emergency Airway Registry for children), obtained during the years 2013-2018 in the emergency department. Intubations were included if patients were aged younger than 18 and had limited neck mobility. We compared first-pass success rates for ED intubations that were performed using VL versus DL. We built a structural causal model to account for potential confounders such as age, disease category (medical or trauma condition), other difficult airway characteristics, use of sedatives/paralytics, and laryngoscopist training level. We also analyzed adverse events as a secondary outcome.
    Results: Of 34,239 intubations (19,071 in the National Emergency Airway Registry and 15,168 in the National Emergency Airway Registry for children), a total of 341 intubations (1.0%) met inclusion criteria; 168 were performed via VL and 173 were performed via DL. The median age of patients was 124 months (interquartile range, 48-204). There was no difference in first-pass success between VL and DL (79.8% vs 75.7%, P = 0.44). Video laryngoscopy was not associated with higher first-pass success (odds ratio, 1.11; 95% confidence interval 0.84-1.47, with DL as a comparator) when a structural causal model was used to account for confounders. There was no difference in the adverse events between VL and DL groups (13.7% vs 8.7%, P = 0.19).
    Conclusion: In children with limited neck mobility receiving tracheal intubation in the ED, neither VL nor DL was associated with a higher first-pass success rate.
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632588-9
    ISSN 1535-1815 ; 0749-5161
    ISSN (online) 1535-1815
    ISSN 0749-5161
    DOI 10.1097/PEC.0000000000003058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2083: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Digital spatial proteomic profiling reveals immune checkpoints as biomarkers in lymphoid aggregates and tumor microenvironment of desmoplastic melanoma.

    Su, David G / Schoenfeld, David A / Ibrahim, Wael / Cabrejo, Raysa / Djureinovic, Dijana / Baumann, Raymond / Rimm, David L / Khan, Sajid A / Halaban, Ruth / Kluger, Harriet M / Olino, Kelly / Galan, Anjela / Clune, James

    Journal for immunotherapy of cancer

    2024  Volume 12, Issue 3

    Abstract: Background: Desmoplastic melanoma (DM) is a rare melanoma subtype characterized by dense fibrous stroma, a propensity for local recurrence, and a high response rate to programmed cell death protein 1 (PD-1) blockade. Occult sentinel lymph node ... ...

    Abstract Background: Desmoplastic melanoma (DM) is a rare melanoma subtype characterized by dense fibrous stroma, a propensity for local recurrence, and a high response rate to programmed cell death protein 1 (PD-1) blockade. Occult sentinel lymph node positivity is significantly lower in both pure and mixed DM than in conventional melanoma, underscoring the need for better prognostic biomarkers to inform therapeutic strategies.
    Methods: We assembled a tissue microarray comprising various cores of tumor, stroma, and lymphoid aggregates from 45 patients with histologically confirmed DM diagnosed between 1989 and 2018. Using a panel of 62 validated immune-oncology markers, we performed digital spatial profiling using the NanoString GeoMx platform and quantified expression in three tissue compartments defined by fluorescence colocalization (tumor (S100+/PMEL+/SYTO+), leukocytes (CD45+/SYTO+), and non-immune stroma (S100-/PMEL-/CD45-/SYTO+)).
    Results: We observed higher expression of immune checkpoints (lymphocyte-activation gene 3 [LAG-3] and cytotoxic T-lymphocyte associated protein-4 [CTLA-4]) and cancer-associated fibroblast (CAF) markers (smooth muscle actin (SMA)) in the tumor compartments of pure DMs than mixed DMs. When comparing lymphoid aggregates (LA) to non-LA tumor cores, LAs were more enriched with CD20+B cells, but non-LA intratumoral leukocytes were more enriched with macrophage/monocytic markers (CD163, CD68, CD14) and had higher LAG-3 and CTLA-4 expression levels. Higher intratumoral PD-1 and LA-based LAG-3 expression appear to be associated with worse survival.
    Conclusions: Our proteomic analysis reveals an intra-tumoral population of SMA+CAFs enriched in pure DM. Additionally, increased expressions of immune checkpoints (LAG-3 and PD-1) in LA and within tumor were associated with poorer prognosis. These findings might have therapeutic implications and help guide treatment selection in addition to informing potential prognostic significance.
    MeSH term(s) Humans ; Melanoma/drug therapy ; Programmed Cell Death 1 Receptor/metabolism ; CTLA-4 Antigen/therapeutic use ; Tumor Microenvironment ; Actins/metabolism ; Proteomics ; Biomarkers, Tumor/metabolism
    Chemical Substances Programmed Cell Death 1 Receptor ; CTLA-4 Antigen ; Actins ; Biomarkers, Tumor
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2719863-7
    ISSN 2051-1426 ; 2051-1426
    ISSN (online) 2051-1426
    ISSN 2051-1426
    DOI 10.1136/jitc-2023-008646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Bacillus Cereus

    Schoenfeld, David / Lee, Dasom / Arrington, John A / Greene, John / Klinkova, Olga

    IDCases

    2022  Volume 29, Page(s) e01525

    Abstract: ... Bacillus ... ...

    Abstract Bacillus cereus
    Language English
    Publishing date 2022-06-06
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2022.e01525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Assessing the one-month mortality impact of civilian-setting prehospital transfusion: A systematic review and meta-analysis.

    Schoenfeld, David W / Rosen, Carlo L / Harris, Tim / Thomas, Stephen H

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

    2024  

    Abstract: Background: Based on convincing evidence for outcomes improvement in the military setting, the past decade has seen evaluation of prehospital transfusion (PHT) in the civilian emergency medical services (EMS) setting. Evidence synthesis has been ... ...

    Abstract Background: Based on convincing evidence for outcomes improvement in the military setting, the past decade has seen evaluation of prehospital transfusion (PHT) in the civilian emergency medical services (EMS) setting. Evidence synthesis has been challenging, due to study design variation with respect to both exposure (type of blood product administered) and outcome (endpoint definitions and timing). The goal of the current meta-analysis was to execute an overarching assessment of all civilian-arena randomized controlled trial (RCT) evidence focusing on administration of blood products compared to control of no blood products.
    Method: The review structure followed the Cochrane group's Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA). Using the Transfusion Evidence Library (transfusionevidencelibrary.com), the multidatabase (e.g. PubMed, EMBASE) Harvard On-Line Library Information System (HOLLIS), and GoogleScholar, we accessed many databases and gray literature sources. RCTs of PHT in the civilian setting with a comparison group receiving no blood products with 1-month mortality outcomes were identified.
    Results: In assessing a single patient-centered endpoint-1-month mortality-we calculated an overall risk ratio (RR) estimate. Analysis of three RCTs yielded a model with acceptable heterogeneity (I
    Conclusions: Current evidence does not demonstrate 1-month mortality benefit of civilian-setting PHT. This should give pause to EMS systems considering adoption of civilian-setting PHT programs. Further studies should not only focus on which formulations of blood products might improve outcomes but also focus on which patients are most likely to benefit from any form of civilian-setting PHT.
    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1329813-6
    ISSN 1553-2712 ; 1069-6563
    ISSN (online) 1553-2712
    ISSN 1069-6563
    DOI 10.1111/acem.14882
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4479: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Book ; Thesis: Durchmesservariabilität und Strömungswiderstand in Mikrogefäßen

    Schönfeld, David

    2000  

    Author's details vorgelegt von David Schönfeld
    Language German
    Size 60 S., Ill., graph. Darst., 21 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Freie Univ., Diss., 2000
    HBZ-ID HT013030585
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2001 D 1159 order for loan Magazin

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  10. Article: Sex differences in stretch-induced hypertrophy, maximal strength and flexibility gains.

    Warneke, Konstantin / Zech, Astrid / Wagner, Carl-Maximilian / Konrad, Andreas / Nakamura, Masatoshi / Keiner, Michael / Schoenfeld, Brad J / Behm, David George

    Frontiers in physiology

    2023  Volume 13, Page(s) 1078301

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.1078301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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