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  1. Article ; Online: Genetic divergence of Influenza A(H3N2) amino acid substitutions mark the beginning of the 2016-2017 winter season in Israel.

    Glatman-Freedman, Aharona / Drori, Yaron / Beni, Sharon Alexandra / Friedman, Nehemya / Pando, Rakefet / Sefty, Hanna / Tal, Ilana / McCauley, John / Rahav, Galia / Keller, Nathan / Shohat, Tamy / Mendelson, Ella / Hindiyeh, Musa / Mandelboim, Michal

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

    2017  Volume 93, Page(s) 71–75

    Abstract: ... surveillance period in Israel has been marked by the dominance of influenza A(H3N2).: Objectives ...

    Abstract Background: Influenza vaccine composition is reevaluated each year due to the frequency and accumulation of genetic changes that influenza viruses undergo. The beginning of the 2016-2017 influenza surveillance period in Israel has been marked by the dominance of influenza A(H3N2).
    Objectives: To evaluate the type, subtype, genetic evolution and amino acid substitutions of influenza A(H3N2) viruses detected among community patients with influenza-like illness (ILI) and hospitalized patients with respiratory illness in the first weeks of the 2016-2017 influenza season.
    Study design: Respiratory samples from community patients with influenza-like illness and from hospitalized patients underwent identification, subtyping and molecular characterization. Hemagglutinin sequences were compared to the vaccine strain, phylogenetic tree was created, and amino acid substitutions were determined.
    Results: Influenza A(H3N2) predominated during the early stages of the 2016-2017 influenza season. Noticeably, approximately 20% of community patients and 36% of hospitalized patients, positive for influenza
    Conclusions: Characterization of the 2016-2017 A(H3N2) influenza viruses is imperative for determining the future influenza vaccine composition.
    MeSH term(s) Amino Acid Sequence ; Amino Acid Substitution ; Animals ; Dogs ; Genetic Drift ; Hemagglutinin Glycoproteins, Influenza Virus/chemistry ; Hemagglutinin Glycoproteins, Influenza Virus/genetics ; Humans ; Influenza A Virus, H3N2 Subtype/genetics ; Influenza, Human/epidemiology ; Influenza, Human/virology ; Israel/epidemiology ; Madin Darby Canine Kidney Cells ; Models, Molecular ; Molecular Diagnostic Techniques ; Molecular Epidemiology ; Phylogeny ; Seasons
    Chemical Substances Hemagglutinin Glycoproteins, Influenza Virus
    Language English
    Publishing date 2017-06-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1446080-4
    ISSN 1873-5967 ; 1386-6532
    ISSN (online) 1873-5967
    ISSN 1386-6532
    DOI 10.1016/j.jcv.2017.05.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3790: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: DNA stretching as a probe for nucleic acid interactions: Reply to Comments on "Biophysical characterization of DNA binding from single molecule force measurements" by Kathy R. Chaurasiya, Thayaparan Paramanathan, Micah J. McCauley, Mark C. Williams.

    McCauley, Micah J / Chaurasiya, Kathy R / Paramanathan, Thayaparan / Rouzina, Ioulia / Williams, Mark C

    Physics of life reviews

    2010  Volume 7, Issue 3, Page(s) 358–361

    Language English
    Publishing date 2010-09-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2148883-6
    ISSN 1873-1457 ; 1571-0645
    ISSN (online) 1873-1457
    ISSN 1571-0645
    DOI 10.1016/j.plrev.2010.07.008
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  3. Article ; Online: Myofilament dysfunction in diastolic heart failure.

    Aboonabi, Anahita / McCauley, Mark D

    Heart failure reviews

    2023  Volume 29, Issue 1, Page(s) 79–93

    Abstract: Diastolic heart failure (DHF), in which impaired ventricular filling leads to typical heart failure symptoms, represents over 50% of all heart failure cases and is linked with risk factors, including metabolic syndrome, hypertension, diabetes, and aging. ...

    Abstract Diastolic heart failure (DHF), in which impaired ventricular filling leads to typical heart failure symptoms, represents over 50% of all heart failure cases and is linked with risk factors, including metabolic syndrome, hypertension, diabetes, and aging. A substantial proportion of patients with this disorder maintain normal left ventricular systolic function, as assessed by ejection fraction. Despite the high prevalence of DHF, no effective therapeutic agents are available to treat this condition, partially because the molecular mechanisms of diastolic dysfunction remain poorly understood. As such, by focusing on the underlying molecular and cellular processes contributing to DHF can yield new insights that can represent an exciting new avenue and propose a novel therapeutic approach for DHF treatment. This review discusses new developments from basic and clinical/translational research to highlight current knowledge gaps, help define molecular determinants of diastolic dysfunction, and clarify new targets for treatment.
    MeSH term(s) Humans ; Heart Failure, Diastolic/diagnosis ; Myofibrils ; Heart Failure ; Hypertension/complications ; Risk Factors ; Diastole ; Stroke Volume ; Ventricular Dysfunction, Left
    Language English
    Publishing date 2023-10-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1336499-6
    ISSN 1573-7322 ; 1382-4147
    ISSN (online) 1573-7322
    ISSN 1382-4147
    DOI 10.1007/s10741-023-10352-z
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Tachycardia and Atrial Fibrillation-Related Cardiomyopathies: Potential Mechanisms and Current Therapies.

    Keefe, Joshua A / Garber, Rebecca / McCauley, Mark D / Wehrens, Xander H T

    JACC. Heart failure

    2024  Volume 12, Issue 4, Page(s) 605–615

    Abstract: Atrial fibrillation (AF) is associated with an increased risk of new-onset ventricular contractile dysfunction, termed arrhythmia-induced cardiomyopathy (AIC). Although cardioembolic stroke remains the most feared and widely studied complication of AF, ... ...

    Abstract Atrial fibrillation (AF) is associated with an increased risk of new-onset ventricular contractile dysfunction, termed arrhythmia-induced cardiomyopathy (AIC). Although cardioembolic stroke remains the most feared and widely studied complication of AF, AIC is also a clinically important consequence of AF that portends significant morbidity and mortality to patients with AF. Current treatments are aimed at restoring sinus rhythm through catheter ablation and rate and rhythm control, but these treatments do not target the underlying molecular mechanisms driving the progression from AF to AIC. Here, we describe the clinical features of the various AIC subtypes, discuss the pathophysiologic mechanisms driving the progression from AF to AIC, and review the evidence surrounding current treatment options. In this review, we aim to identify key knowledge gaps that will enable the development of more effective AIC therapies that target cellular and molecular mechanisms.
    MeSH term(s) Humans ; Atrial Fibrillation/therapy ; Atrial Fibrillation/drug therapy ; Heart Failure/complications ; Cardiomyopathies/etiology ; Cardiomyopathies/therapy ; Tachycardia/complications ; Tachycardia/surgery ; Catheter Ablation/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2023.11.016
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  5. Article ; Online: Multicellular species environmental DNA (eDNA) research constrained by overfocus on mitochondrial DNA.

    McCauley, Mark / Koda, Samantha A / Loesgen, Sandra / Duffy, David J

    The Science of the total environment

    2023  Volume 912, Page(s) 169550

    Abstract: Environmental DNA (eDNA) is becoming an established tool across the biological and medical sciences. Despite the evident successes and wide adoption of eDNA approaches, some fundamental questions remain. For instance, there is almost a dogma in the field ...

    Abstract Environmental DNA (eDNA) is becoming an established tool across the biological and medical sciences. Despite the evident successes and wide adoption of eDNA approaches, some fundamental questions remain. For instance, there is almost a dogma in the field around the superiority of mitochondrial DNA for use in eDNA studies, however robust comparison with nuclear eDNA is widely lacking. The dominance of mitochondrial-based eDNA for animal and plant studies appears to be largely settled, despite a widespread lack of rigorous nuclear eDNA testing. Outside of the source organism the protections conferred on eDNA by the cell, mitochondrial and nuclear membranes are poorly understood, including the contribution of each to eDNA persistence and degradation. Utilizing shotgun sequencing to unbiasedly assess the level of nuclear and mitochondrial eDNA across samples, we reveal stark differences in nuclear versus mitochondrial eDNA persistence and abundance. By focusing too heavily on mitochondrial DNA alone the field is underutilizing eDNA's full potential.
    MeSH term(s) Animals ; DNA, Mitochondrial ; DNA, Environmental ; Mitochondria ; Plants ; Environmental Monitoring
    Chemical Substances DNA, Mitochondrial ; DNA, Environmental
    Language English
    Publishing date 2023-12-21
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.169550
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Ranking the biases: The choice of OTUs vs. ASVs in 16S rRNA amplicon data analysis has stronger effects on diversity measures than rarefaction and OTU identity threshold.

    Chiarello, Marlène / McCauley, Mark / Villéger, Sébastien / Jackson, Colin R

    PloS one

    2022  Volume 17, Issue 2, Page(s) e0264443

    Abstract: Advances in the analysis of amplicon sequence datasets have introduced a methodological shift in how research teams investigate microbial biodiversity, away from sequence identity-based clustering (producing Operational Taxonomic Units, OTUs) to ... ...

    Abstract Advances in the analysis of amplicon sequence datasets have introduced a methodological shift in how research teams investigate microbial biodiversity, away from sequence identity-based clustering (producing Operational Taxonomic Units, OTUs) to denoising methods (producing amplicon sequence variants, ASVs). While denoising methods have several inherent properties that make them desirable compared to clustering-based methods, questions remain as to the influence that these pipelines have on the ecological patterns being assessed, especially when compared to other methodological choices made when processing data (e.g. rarefaction) and computing diversity indices. We compared the respective influences of two widely used methods, namely DADA2 (a denoising method) vs. Mothur (a clustering method) on 16S rRNA gene amplicon datasets (hypervariable region v4), and compared such effects to the rarefaction of the community table and OTU identity threshold (97% vs. 99%) on the ecological signals detected. We used a dataset comprising freshwater invertebrate (three Unionidae species) gut and environmental (sediment, seston) communities sampled in six rivers in the southeastern USA. We ranked the respective effects of each methodological choice on alpha and beta diversity, and taxonomic composition. The choice of the pipeline significantly influenced alpha and beta diversities and changed the ecological signal detected, especially on presence/absence indices such as the richness index and unweighted Unifrac. Interestingly, the discrepancy between OTU and ASV-based diversity metrics could be attenuated by the use of rarefaction. The identification of major classes and genera also revealed significant discrepancies across pipelines. Compared to the pipeline's effect, OTU threshold and rarefaction had a minimal impact on all measurements.
    MeSH term(s) Animals ; Bias ; Biodiversity ; Bivalvia/microbiology ; Cluster Analysis ; DNA, Bacterial ; Data Analysis ; Datasets as Topic ; Gastrointestinal Microbiome ; Genetic Variation ; Invertebrates/microbiology ; RNA, Ribosomal, 16S/genetics ; Rivers/microbiology ; Sequence Analysis, DNA
    Chemical Substances DNA, Bacterial ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2022-02-24
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0264443
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  7. Article: Gut Microbiomes of Freshwater Mussels (Unionidae) Are Taxonomically and Phylogenetically Variable across Years but Remain Functionally Stable.

    McCauley, Mark / Chiarello, Marlène / Atkinson, Carla L / Jackson, Colin R

    Microorganisms

    2021  Volume 9, Issue 2

    Abstract: Freshwater mussels perform essential ecosystem functions, yet we have no information on how their microbiomes fluctuate over time. In this study, we examined temporal variation in the microbiome of six mussel species ( ...

    Abstract Freshwater mussels perform essential ecosystem functions, yet we have no information on how their microbiomes fluctuate over time. In this study, we examined temporal variation in the microbiome of six mussel species (
    Language English
    Publishing date 2021-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms9020411
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  8. Article: Microbiomes of Caribbean Octocorals Vary Over Time but Are Resistant to Environmental Change.

    McCauley, Mark / Jackson, Colin R / Goulet, Tamar L

    Frontiers in microbiology

    2020  Volume 11, Page(s) 1272

    Abstract: The bacterial microbiome is an essential component of many corals, although knowledge of the microbiomes in scleractinian corals far exceeds that for octocorals. This study characterized the bacterial communities present in shallow water Caribbean ... ...

    Abstract The bacterial microbiome is an essential component of many corals, although knowledge of the microbiomes in scleractinian corals far exceeds that for octocorals. This study characterized the bacterial communities present in shallow water Caribbean gorgonian octocorals over time and space, in addition to determining the bacterial assemblages in gorgonians exposed to environmental perturbations. We found that seven shallow water Caribbean gorgonian species maintained distinct microbiomes and predominantly harbored two bacterial genera,
    Language English
    Publishing date 2020-06-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2020.01272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Metabolomics-Guided Discovery, Isolation, Structure Elucidation, and Bioactivity of Myropeptins C-E from

    Jagels, Annika / Adpressa, Donovon A / Kaweesa, Elizabeth N / McCauley, Mark / Philmus, Benjamin / Strother, James A / Loesgen, Sandra

    Journal of natural products

    2023  Volume 86, Issue 7, Page(s) 1723–1735

    Abstract: The saprotrophic filamentous ... ...

    Abstract The saprotrophic filamentous fungus
    MeSH term(s) Animals ; Methicillin-Resistant Staphylococcus aureus ; Zebrafish ; Hypocreales/chemistry ; Metabolomics ; Molecular Structure
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/acs.jnatprod.3c00148
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: The Pharmacogenomics of a Mutation 'Hotspot' for the Short QT Syndrome.

    Darbar, Dawood / McCauley, Mark

    JACC. Clinical electrophysiology

    2017  Volume 3, Issue 7, Page(s) 744–746

    MeSH term(s) Arrhythmias, Cardiac ; Humans ; Mutation ; Pharmacogenetics
    Language English
    Publishing date 2017-09-29
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2846739-5
    ISSN 2405-500X ; 2405-5018 ; 2405-500X
    ISSN (online) 2405-500X ; 2405-5018
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2016.12.024
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