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  1. Article ; Online: The representation of vulnerable populations in quality improvement studies.

    Rolnitsky, Asaph / Kirtsman, Maksim / Goldberg, Hanna R / Dunn, Michael / Bell, Chaim M

    International journal for quality in health care : journal of the International Society for Quality in Health Care

    2018  Volume 30, Issue 4, Page(s) 244–249

    Abstract: Purpose: A mapping review to quantify representation of vulnerable populations, who suffer from disparity and often inequitable healthcare, in quality improvement (QI) research.: Data sources: Studies published in 2004-2014 inclusive from Medline, ... ...

    Abstract Purpose: A mapping review to quantify representation of vulnerable populations, who suffer from disparity and often inequitable healthcare, in quality improvement (QI) research.
    Data sources: Studies published in 2004-2014 inclusive from Medline, Embase and Cochrane databases for English language research with the terms 'quality improvement' or 'quality control' or 'QI' and 'plan-do-study-act' or 'PDSA' in the years 2004-2014 inclusively.
    Study selection: Published clinical research that was a QI-themed, as identified by its declared search terms, MESH terms, abstract or title.
    Data extraction: Three reviewers identified the eligible studies independently. Excluded were publications that were not trials, evaluations or analyses.
    Results of data synthesis: Of 2039 results, 1660 were eligible for inclusion. There were 586 (33.5%) publications that targeted a specific vulnerable population: children (184, 10.54%), mental health patients (125, 7.16%), the elderly (100, 5.73%), women (57, 3.27%), the poor (30, 1.72%), rural residents (29, 1.66%), visible minorities (27, 1.55%), the terminally ill (17, 0.97%), adolescents (16, 0.92%) and prisoners (1 study). Seventy-four articles targeted two or more vulnerable populations, and 11 targeted three population categories. On average, there were 158 QI research studies published per year, increasing from 69 in 2004 to 396 in 2014 (R2 = 0.7, P < 0.001). The relative representation of vulnerable populations had a mean of 33.58% and was stable over the time period (standard deviation (SD) = 5.9%, R2 = 0.001). Seven countries contributed to over 85% of the publications targeting vulnerable populations, with the USA contributing 62% of the studies.
    Conclusions: Over 11 years, there has been a marked increase in QI publications. Roughly one-third of all published QI research is on vulnerable populations, a stable proportion over time. Nevertheless, some vulnerable populations are under-represented. Increased education, resources and attention are encouraged to improve the health of vulnerable populations through focused QI initiatives.
    MeSH term(s) Female ; Humans ; Male ; Minority Groups ; Quality Improvement/statistics & numerical data ; Quality of Health Care/standards ; Quality of Health Care/statistics & numerical data ; Vulnerable Populations
    Language English
    Publishing date 2018-02-05
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1194150-9
    ISSN 1464-3677 ; 1353-4505
    ISSN (online) 1464-3677
    ISSN 1353-4505
    DOI 10.1093/intqhc/mzy016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: [No title information]

    Kirtsman, Maksim / Diambomba, Yenge / Poutanen, Susan M / Malinowski, Ann K / Vlachodimitropoulou, Evangelia / Parks, W Tony / Erdman, Laura / Morris, Shaun K / Shah, Prakesh S

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2020  Volume 192, Issue 45, Page(s) E1419–E1422

    Title translation Infection congénitale probable au SRAS-CoV-2 chez le nouveau-né d’une femme atteinte de COVID-19 active.
    Keywords covid19
    Language French
    Publishing date 2020-11-09
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.200821-f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection.

    Kirtsman, Maksim / Diambomba, Yenge / Poutanen, Susan M / Malinowski, Ann K / Vlachodimitropoulou, Evangelia / Parks, W Tony / Erdman, Laura / Morris, Shaun K / Shah, Prakesh S

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2020  Volume 192, Issue 24, Page(s) E647–E650

    MeSH term(s) Adult ; Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Cesarean Section ; Clinical Laboratory Techniques ; Coronavirus Infections/congenital ; Coronavirus Infections/diagnosis ; Coronavirus Infections/transmission ; Female ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Male ; Nasopharynx/virology ; Pandemics ; Placenta/pathology ; Placenta/virology ; Pneumonia, Viral/congenital ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/transmission ; Pregnancy ; Pregnancy Complications, Infectious ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-14
    Publishing country Canada
    Document type Case Reports ; Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.200821
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection

    Kirtsman, Maksim / Diambomba, Yenge / Poutanen, Susan M / Malinowski, Ann K / Vlachodimitropoulou, Evangelia / Parks, W Tony / Erdman, Laura / Morris, Shaun K / Shah, Prakesh S

    CMAJ

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32409520
    Database COVID19

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  5. Article ; Online: Nil-per-os days and necrotizing enterocolitis in extremely preterm infants.

    Kirtsman, Maksim / Yoon, Eugene W / Ojah, Cecil / Cieslak, Zenon / Lee, Shoo K / Shah, Prakesh S

    American journal of perinatology

    2015  Volume 32, Issue 8, Page(s) 785–794

    Abstract: Objective: This study aims to evaluate the association between nil-per-os (NPO) days and development of necrotizing enterocolitis (NEC) in extremely preterm neonates (<29 weeks gestational age).: Study design: A case-control study of 234 extremely ... ...

    Abstract Objective: This study aims to evaluate the association between nil-per-os (NPO) days and development of necrotizing enterocolitis (NEC) in extremely preterm neonates (<29 weeks gestational age).
    Study design: A case-control study of 234 extremely preterm neonates who developed stage II or III NEC and 467 matched control infants admitted to participating sites in the Canadian Neonatal Network between 2010 and 2011 was conducted. The number and percentage of NPO days before the development of NEC was compared with the equivalent period in control infants using logistic regression.
    Results: Infants with NEC were NPO on average 5.6 days (28% of days before NEC) versus 3.7 days (19% of equivalent days; p < 0.01) among controls. NEC cases required more days of inotropic support, antibiotic use, and had higher rates of patent ductus arteriosus (PDA). After adjusting for inotrope use, PDA, antibiotics, and severity of illness, for each additional NPO day the adjusted odds for NEC increased by 1.08 (95% confidence interval: 1.04-1.12).
    Conclusion: Among extremely preterm neonates, those who developed NEC were NPO for a longer period of time than control infants who were NEC-free. We speculate that delayed initiation or interruption of feeding may be a potent risk factor for NEC.
    MeSH term(s) Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Canada ; Case-Control Studies ; Ductus Arteriosus, Patent/drug therapy ; Enterocolitis, Necrotizing/drug therapy ; Fasting/adverse effects ; Female ; Gestational Age ; Humans ; Indomethacin/therapeutic use ; Infant, Extremely Premature ; Infant, Newborn ; Intensive Care Units, Neonatal ; Logistic Models ; Male ; Risk Factors
    Chemical Substances Anti-Inflammatory Agents, Non-Steroidal ; Indomethacin (XXE1CET956)
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0034-1396687
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Nil-Per-Os Days and Necrotizing Enterocolitis in Extremely Preterm Infants

    Kirtsman, Maksim / Yoon, Eugene W. / Ojah, Cecil / Cieslak, Zenon / Lee, Shoo K. / Shah, Prakesh S.

    American Journal of Perinatology

    2014  Volume 32, Issue 08, Page(s) 785–794

    Abstract: Objective: This study aims to evaluate the association between nil-per-os (NPO) days and development of necrotizing enterocolitis (NEC) in extremely preterm neonates (<29 weeks gestational age).: Study Design: A case–control study of 234 extremely ... ...

    Abstract Objective: This study aims to evaluate the association between nil-per-os (NPO) days and development of necrotizing enterocolitis (NEC) in extremely preterm neonates (<29 weeks gestational age).
    Study Design: A case–control study of 234 extremely preterm neonates who developed stage II or III NEC and 467 matched control infants admitted to participating sites in the Canadian Neonatal Network between 2010 and 2011 was conducted. The number and percentage of NPO days before the development of NEC was compared with the equivalent period in control infants using logistic regression.
    Results: Infants with NEC were NPO on average 5.6 days (28% of days before NEC) versus 3.7 days (19% of equivalent days; p  < 0.01) among controls. NEC cases required more days of inotropic support, antibiotic use, and had higher rates of patent ductus arteriosus (PDA). After adjusting for inotrope use, PDA, antibiotics, and severity of illness, for each additional NPO day the adjusted odds for NEC increased by 1.08 (95% confidence interval: 1.04–1.12).
    Conclusion: Among extremely preterm neonates, those who developed NEC were NPO for a longer period of time than control infants who were NEC-free. We speculate that delayed initiation or interruption of feeding may be a potent risk factor for NEC.
    Keywords enteral nutrition ; gut colonization ; infant ; premature ; intestinal microbiome
    Language English
    Publishing date 2014-12-29
    Publisher Thieme Medical Publishers
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 605671-4
    ISSN 1098-8785 ; 0735-1631
    ISSN (online) 1098-8785
    ISSN 0735-1631
    DOI 10.1055/s-0034-1396687
    Database Thieme publisher's database

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  7. Article ; Online: Annotating the Mycobacterium avium Genome

    David D. Shersher / Maksim Kirtsman / Mikael Katz-Lavigne / Marcel A. Behr / Makeda Semret

    McGill Journal of Medicine, Vol 7, Iss

    A Project in Bioinformatics

    2004  Volume 2

    Abstract: Bioinformatic tools facilitate efficient processing and formatting of experimental data and are becoming essential to research in the biological sciences. Whole genome sequencing projects, combined with DNA microarray technology, have allowed genomic ... ...

    Abstract Bioinformatic tools facilitate efficient processing and formatting of experimental data and are becoming essential to research in the biological sciences. Whole genome sequencing projects, combined with DNA microarray technology, have allowed genomic comparisons between and within species of microorganisms. The genome of Mycobacterium avium subsp. avium (MAA) has been sequenced by The Institute for Genomic Research (TIGR), but a final and annotated version has not yet been made available. The goal of this project was to annotate the sequence of MAA as a foundation for microarray-based genomic comparisons. We used software to identify and predict open reading frames (ORFs) present in this organism. The ORFs were then compared to those catalogued in two large, online genetic databases for other microorganisms and matched to homologous sequences, allowing the determination of putative functions for each predicted gene. The genome of MAA was determined to contain 4480 genes, the majority of which are homologous to genes found in other Mycobacterial species.
    Keywords mycobacterium avium complex ; annotation ; genomics ; blast ; Medicine ; R
    Language English
    Publishing date 2004-12-01T00:00:00Z
    Publisher McGill University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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