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Article ; Online: The NFκB Dif is required for behavioral and molecular correlates of sleep homeostasis in Drosophila.

O'Hara, Michael K / Saul, Christopher / Handa, Arun / Cho, Bumsik / Zheng, Xiangzhong / Sehgal, Amita / Williams, Julie A

Sleep

2024

Abstract: The nuclear factor binding the κ light chain in B-cells (NFκB) is involved in a wide range of cellular processes including development, growth, innate immunity, and sleep. However, genetic studies of the role of specific NFκB transcription factors in ... ...

Abstract	The nuclear factor binding the κ light chain in B-cells (NFκB) is involved in a wide range of cellular processes including development, growth, innate immunity, and sleep. However, genetic studies of the role of specific NFκB transcription factors in sleep have been limited. Drosophila fruit flies carry three genes encoding NFκB transcription factors, Dorsal, Dorsal Immunity Factor (Dif), and Relish. We previously found that loss of the Relish gene from fat body suppressed daily nighttime sleep, and abolished infection-induced sleep. Here we show that Dif regulates daily sleep and recovery sleep following prolonged wakefulness. Mutants of Dif showed reduced daily sleep and suppressed recovery in response to sleep deprivation. Pan-neuronal knockdown of Dif strongly suppressed daily sleep, indicating that in contrast to Relish, Dif functions from the central nervous system to regulate sleep. Based on the unique expression pattern of a Dif- GAL4 driver, we hypothesized that its effects on sleep were mediated by the pars intercerebralis (PI). While RNAi knock-down of Dif in the PI reduced daily sleep, it had no effect on the recovery response to sleep deprivation. However, recovery sleep was suppressed when RNAi knock-down of Dif was distributed across a wider range of neurons. Induction of the nemuri (nur) antimicrobial peptide by sleep deprivation was reduced in Dif mutants and pan-neuronal over-expression of nur also suppressed the Dif mutant phenotype by significantly increasing sleep and reducing nighttime arousability. Together, these findings indicate that Dif functions from brain to target nemuri and to promote deep sleep.
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	424441-2
ISSN	1550-9109 ; 0161-8105
ISSN (online)	1550-9109
ISSN	0161-8105
DOI	10.1093/sleep/zsae096
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Article: New Insight Into the Structure-Activity Relationship of Sweet-Tasting Proteins: Protein Sector and Its Role for Sweet Properties.

Zhao, Xiangzhong / Wang, Congrui / Zheng, Yue / Liu, Bo

Frontiers in nutrition

2021 Volume 8, Page(s) 691368

Abstract: Sweet-tasting protein is a kind of biomacromolecule that has remarkable sweetening power and is regarded as the promising sugar replacer in the future. Some sweet-tasting proteins has been used in foods and beverages. However, the structure and function ... ...

Abstract	Sweet-tasting protein is a kind of biomacromolecule that has remarkable sweetening power and is regarded as the promising sugar replacer in the future. Some sweet-tasting proteins has been used in foods and beverages. However, the structure and function relationship of these proteins is still elusive, and guidelines for their protein engineering is limited. It is well-known that the sweet-tasting proteins bind to and activate the sweet taste receptor T1R2/T1R3, thus eliciting their sweetness. The "wedge-model" for describing the interaction between sweet-tasting proteins and sweet taste receptor to elucidate their sweetness has been reported. In this perspective article, we revealed that the intramolecular interaction forces in sweet-tasting proteins is directly correlated to their properties (sweetness and stability). This intramolecular interaction pattern, named as "protein sector," refers to a small subset of residues forming physically connections, which cooperatively affect the function of the proteins. Based on the analysis of previous experimental data, we suggest that "protein sector" of sweet-tasting proteins is pivotal for their sweet properties, which are meaningful guidelines for the future protein engineering.
Language	English
Publishing date	2021-06-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2021.691368
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Article ; Online: De-Toring high fat for a healthy heart.

Zheng, Xiangzhong

Expert review of cardiovascular therapy

2011 Volume 9, Issue 3, Page(s) 299–302

Language	English
Publishing date	2011-03
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	2192343-7
ISSN	1744-8344 ; 1477-9072
ISSN (online)	1744-8344
ISSN	1477-9072
DOI	10.1586/erc.11.18
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Zs.A 6107: Show issues

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Article ; Online: Revealing the role of hydrogen bond coupling structure for enhanced performance of the solid-state electrolyte.

Cai, Minghui / Zheng, Changyong / Li, Jixiao / Shi, Chuan / Yin, Ruonan / Ren, Zhiheng / Hu, Jiangtao / Li, Yongliang / He, Chuanxin / Zhang, Qianling / Ren, Xiangzhong

Journal of colloid and interface science

2023 Volume 652, Issue Pt A, Page(s) 529–539

Abstract: Achieving practical applications of PEO-based composite solid electrolyte (CPE) batteries requires the precise design of filler structures at the molecular level to form stable composite interfacial phases, which in turn improve the conductivity of ... ...

Abstract	Achieving practical applications of PEO-based composite solid electrolyte (CPE) batteries requires the precise design of filler structures at the molecular level to form stable composite interfacial phases, which in turn improve the conductivity of Li
Language	English
Publishing date	2023-08-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.08.046
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Article ; Online: Revealing the role of hydrogen bond coupling structure for enhanced performance of the solid-state electrolyte

Cai, Minghui / Zheng, Changyong / Li, Jixiao / Shi, Chuan / Yin, Ruonan / Ren, Zhiheng / Hu, Jiangtao / Li, Yongliang / He, Chuanxin / Zhang, Qianling / Ren, Xiangzhong

Journal of Colloid And Interface Science. 2023 Aug. 09,

2023

Abstract	Achieving practical applications of PEO-based composite solid electrolyte (CPE) batteries requires the precise design of filler structures at the molecular level to form stable composite interfacial phases, which in turn improve the conductivity of Li⁺ and inhibit the nucleation growth of lithium dendrites. Some functional fillers suffer from severe agglomeration due to poor compatibility with the polymer base or grain boundary migration, resulting in limited improvement in cell performance. In this paper, ILs@KAP1 is reported as a filler to enhance the performance of PEO-based batteries. Thereinto, the hypercrosslinked phosphorus ligand polymer-containing KAP1, designed at the molecular level, has an abundant porous structure, hydrogen bonding network, and a rigid skeleton structure of benzene rings. These can be used both to improve the flammability with PEO-based and to reduce the crystallinity of the polymer electrolyte. Ionic liquids (ILs) are encapsulated in the nanochannels of KAP1, and thus a 3D Li⁺ conducting framework could be formed. In this case, it could not only facilitate the wettability of the contact interface with the electrode, significantly promoting its compatibility and providing a fast Li⁺ transport path, but also facilitate the formation of LiF, Li₃N and Li₂O rich SEI components, further fostering the uniform deposition/exfoliation of lithium. The LFP\|\|CPE\|\|Li battery assembled with ILs@KAP1-PEO-CPE has a high initial discharge specific capacity about 156 mAh/g at 1 C and a remaining capacity about 121.8 mAh/g after 300 cycles (capacity retention of 78.07%).
Keywords	batteries ; benzene ; crosslinking ; crystal structure ; electrodes ; electrolytes ; flammability ; hydrogen ; hydrogen bonding ; ligands ; lithium ; phosphorus ; polymers ; wettability ; Solid-state polymer electrolytes ; hypercrosslinked ; hydrogen bonds ; ionic liquids ; solid-state lithium metal batteries
Language	English
Dates of publication	2023-0809
Publishing place	Elsevier Inc.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.08.046
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: N-Acetylglucosamine mitigates lung injury and pulmonary fibrosis induced by bleomycin.

Li, Jinyu / Xu, Xiaohui / Liu, Jiane / Chen, Yunqing / Jin, Shengxi / Zhang, Guangmin / Yin, Shulan / Wang, Jingqi / Tian, Kangqi / Luan, Xiaoyang / Tan, Xiaohua / Zhao, Xiangzhong / Zhang, Na / Wang, Zheng

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 166, Page(s) 115069

Abstract: Lung injury and pulmonary fibrosis contribute to morbidity and mortality, and, in particular, are characterized as leading cause on confirmed COVID-19 death. To date, efficient therapeutic approach for such lung diseases is lacking. N-Acetylglucosamine ( ... ...

Abstract	Lung injury and pulmonary fibrosis contribute to morbidity and mortality, and, in particular, are characterized as leading cause on confirmed COVID-19 death. To date, efficient therapeutic approach for such lung diseases is lacking. N-Acetylglucosamine (NAG), an acetylated derivative of glucosamine, has been proposed as a potential protector of lung function in several types of lung diseases. The mechanism by which NAG protects against lung injury, however, remains unclear. Here, we show that NAG treatment improves pulmonary function in bleomycin (BLM)-induced lung injury model measured by flexiVent system. At early phase of lung injury, NAG treatment results in silenced immune response by targeting ARG1
MeSH term(s)	Humans ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/drug therapy ; Pulmonary Fibrosis/prevention & control ; Lung Injury/chemically induced ; Lung Injury/drug therapy ; Acetylglucosamine ; Bleomycin/toxicity ; COVID-19
Chemical Substances	Acetylglucosamine (V956696549) ; Bleomycin (11056-06-7)
Language	English
Publishing date	2023-08-24
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115069
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Ud II Zs.198: Show issues

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Article: A 1,400-year eolian dust activity record from Lake Erhai in the northeastern Tibetan Plateau

Wang, Min / Shen, Caiming / Wu, Xudong / Liu, Guangxin / Zhao, Jiaju / Sun, Qifa / Zheng, Hongbo / Li, Xiangzhong

Catena. 2022 May, v. 212

2022

Abstract: Dust raised from Arid Central Asia (ACA) affects the global climate, global biogeochemical cycles, and human health. Studies on the ACA dust activities thus are crucial for understanding dust forcing mechanisms and the mitigation of hazardous storms. ... ...

Abstract	Dust raised from Arid Central Asia (ACA) affects the global climate, global biogeochemical cycles, and human health. Studies on the ACA dust activities thus are crucial for understanding dust forcing mechanisms and the mitigation of hazardous storms. Located at the downwind margin of the ACA, the Lake Qinghai basin is an ideal trap for dust activities documentation. However, isolating eolian dust signals from Lake Qinghai sediments is difficult as the dust signals are well-mixed with riverine input signals. As a satellite of Lake Qinghai, Lake Erhai is much smaller and has only one inflow river. Lake Erhai, therefore, is much less sensitive to riverine input and its sediments theoretically contain more explicit dust signals. In this study, a 111.5-cm core was taken from Lake Erhai in 2016. The sediments’ grain size distribution (GSD) of this core was analyzed, and end-member (EM) analyses were applied to the GSDs to detect dust signals. Sediment carbonate content and carbonate oxygen isotopes (δ¹⁸Ocₐᵣb) were also measured to provide independent climate background information. Our results showed that the first EM is attributed to lake level dynamics due to its resemblances with carbonate content and δ¹⁸Ocₐᵣb records; the third EM, which peaked in the coarser grain size, is attributed to the riverine input; the remaining second EM likely captures the changes of regional dust activity and suggests that the Lake Qinghai basin has experienced multiple intense eolian dust activity intervals, i.e., 1000–1110, 1180–1290, and 1450–1560 AD over the past 1400 years. A further comparison of EMs with well-established climatic records in the northeastern Tibetan Plateau suggests that the rise and fall of regional dust activities are likely mainly controlled by wetness conditions and are secondarily affected by human activities.
Keywords	basins ; carbonates ; catenas ; climate ; dust ; human health ; humans ; lakes ; oxygen ; particle size distribution ; riparian areas ; rivers ; satellites ; sediments ; Central Asia ; China
Language	English
Dates of publication	2022-05
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	519608-5
ISSN	1872-6887 ; 0008-7769 ; 0341-8162
ISSN (online)	1872-6887 ; 0008-7769
ISSN	0341-8162
DOI	10.1016/j.catena.2022.106050
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Atmospheric dryness reduces photosynthesis along a large range of soil water deficits

Zheng Fu / Philippe Ciais / I. Colin Prentice / Pierre Gentine / David Makowski / Ana Bastos / Xiangzhong Luo / Julia K. Green / Paul C. Stoy / Hui Yang / Tomohiro Hajima

Nature Communications, Vol 13, Iss 1, Pp 1-

2022 Volume 10

Abstract: Using global flux tower observations, the authors show that atmospheric dryness always reduces photosynthesis, whereas soil dryness can increase photosynthesis if soil water stores are sufficient. ...

Abstract	Using global flux tower observations, the authors show that atmospheric dryness always reduces photosynthesis, whereas soil dryness can increase photosynthesis if soil water stores are sufficient.
Keywords	Science ; Q
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Shuttle-Free Solid-State Cu-Li Battery Based on a Sandwich-Structured Electrolyte.

Wang, Huimin / Wang, Changhong / Zheng, Matthew / Liang, Jianneng / Yang, Ming / Feng, Xingyu / Ren, Xiangzhong / Yu, Denis Y W / Li, Yongliang / Sun, Xueliang

Angewandte Chemie (International ed. in English)

2022 , Page(s) e202214117

Abstract: Cu-Li batteries leveraging the two-electron redox property of Cu can offer high energy density and low cost. However, Cu-Li batteries are plagued by limited solubility and a shuttle effect of Cu ions in traditional electrolytes, which leads to low energy ...

Abstract	Cu-Li batteries leveraging the two-electron redox property of Cu can offer high energy density and low cost. However, Cu-Li batteries are plagued by limited solubility and a shuttle effect of Cu ions in traditional electrolytes, which leads to low energy density and poor cycling stability. In this work, we rationally design a solid-state sandwich electrolyte for solid-state Cu-Li batteries, in which a deep-eutectic-solvent gel with high Cu-ion solubility is devised as a Cu-ion reservoir while a ceramic Li
Language	English
Publishing date	2022-11-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202214117
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Article ; Online: Chitosan oligosaccharide attenuates acute kidney injury and renal interstitial fibrosis induced by ischemia-reperfusion.

Yin, Shulan / Liu, Jiane / Zhao, Xiangzhong / Dong, Hanyu / Cao, Yanjing / Zhang, Sudan / Dong, Xiaolei / Zhang, Guangmin / Jin, Shengxi / Shi, Weiping / Xiang, Fenggang / Gong, Jizheng / Wang, Ziyi / Han, Baoqin / Zhang, Na / Tan, Xiaohua / Wang, Zheng

Renal failure

2023 Volume 45, Issue 1, Page(s) 2238831

Abstract: Acute kidney injury (AKI) and renal interstitial fibrosis are global clinical syndromes associated with high morbidity and mortality. Renal ischemia-reperfusion (I/R) injury, which commonly occurs during surgery, is one of the major causes of AKI. ... ...

Abstract	Acute kidney injury (AKI) and renal interstitial fibrosis are global clinical syndromes associated with high morbidity and mortality. Renal ischemia-reperfusion (I/R) injury, which commonly occurs during surgery, is one of the major causes of AKI. Nevertheless, an efficient therapeutic approach for AKI and the development of renal interstitial fibrosis is still lacking due to its elusive pathogenetic mechanism. Here, we showed that chitosan oligosaccharide (COS), a natural oligomer polysaccharide degraded from chitosan, significantly attenuates I/R-induced AKI and maintains glomerular filtration function by inhibiting oxidative stress, mitochondrial damage, and excessive endoplasmic reticulum stress both
MeSH term(s)	Humans ; Chitosan/pharmacology ; Chitosan/therapeutic use ; Chitosan/metabolism ; Acute Kidney Injury/drug therapy ; Acute Kidney Injury/etiology ; Acute Kidney Injury/prevention & control ; Kidney/pathology ; Ischemia ; Reperfusion Injury/complications ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism ; Reperfusion/adverse effects ; Fibrosis ; Oligosaccharides/pharmacology ; Oligosaccharides/therapeutic use ; Oligosaccharides/metabolism
Chemical Substances	Chitosan (9012-76-4) ; Oligosaccharides
Language	English
Publishing date	2023-07-24
Publishing country	England
Document type	Journal Article
ZDB-ID	632949-4
ISSN	1525-6049 ; 0886-022X
ISSN (online)	1525-6049
ISSN	0886-022X
DOI	10.1080/0886022X.2023.2238831
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