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Article ; Online: Multidisciplinary Strategies for Preventing Opioid Misuse and Escalation by Targeting Mental Health Symptoms and Conditions.

Yule, Amy M / Fernandes, Claudia-Santi F / Stormshak, Elizabeth A / Yang, Yang / Shelley, Lillyan / Fiellin, Lynn E / Larkin, Kaitlin / Ridenour, Ty A / Saavedra, Lissette M / Kelleher, Kelly / Feng, Xin / Walton, Maureen A / Bonar, Erin E

Prevention science : the official journal of the Society for Prevention Research

2023 Volume 24, Issue Suppl 1, Page(s) 77–87

Abstract: We aim to review the association between childhood-onset mental health conditions and increased risk for early substance use including opioid misuse and opioid use disorders (OUD). The association between mental health conditions and opioid misuse ... ...

Abstract	We aim to review the association between childhood-onset mental health conditions and increased risk for early substance use including opioid misuse and opioid use disorders (OUD). The association between mental health conditions and opioid misuse suggests youth with mental health conditions may benefit from opioid prevention efforts that concurrently address mental health. To aid in the identification of youth with mental health conditions who could benefit from interventions, we will review opportunities and challenges associated with screening for mental health symptoms or substance use in settings where youth at high risk for mental health conditions present. We will also review how research projects within the National Institutes of Health's Helping to End Addiction Long-term (HEAL) Prevention Cooperative are addressing mental health within opioid misuse and OUD prevention interventions for youth.
MeSH term(s)	Adolescent ; Humans ; Child ; Mental Health ; Opioid-Related Disorders/prevention & control ; Opioid-Related Disorders/diagnosis ; Opioid-Related Disorders/etiology ; Analgesics, Opioid ; Behavior, Addictive
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2023-06-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2251270-6
ISSN	1573-6695 ; 1389-4986
ISSN (online)	1573-6695
ISSN	1389-4986
DOI	10.1007/s11121-023-01556-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: In Vitro

Mounsey, Kate E / Walton, Shelley F / Innes, Ashlee / Cash-Deans, Skye / McCarthy, James S

Antimicrobial agents and chemotherapy

2017 Volume 61, Issue 8

Abstract: Moxidectin is under consideration for development as a treatment for human scabies. As some arthropods show decreased sensitivity to moxidectin relative to ivermectin, it was important to assess this ... ...

Abstract	Moxidectin is under consideration for development as a treatment for human scabies. As some arthropods show decreased sensitivity to moxidectin relative to ivermectin, it was important to assess this for
Language	English
Publishing date	2017-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.00381-17
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Article ; Online: Host immune responses to the itch mite, Sarcoptes scabiei, in humans.

Bhat, Sajad A / Mounsey, Kate E / Liu, Xiaosong / Walton, Shelley F

Parasites & vectors

2017 Volume 10, Issue 1, Page(s) 385

Abstract: Scabies is a parasitic disease due to infestation of skin by the burrowing mite Sarcoptes scabiei. Scabies is a major public health problem and endemic in resource poor communities worldwide affecting over 100 million people. Associated bacterial ... ...

Abstract	Scabies is a parasitic disease due to infestation of skin by the burrowing mite Sarcoptes scabiei. Scabies is a major public health problem and endemic in resource poor communities worldwide affecting over 100 million people. Associated bacterial infections cause substantial morbidity, and in severe cases can lead to renal and cardiac diseases. Mite infestation of the skin causes localised cutaneous inflammation, pruritus, skin lesions, and allergic and inflammatory responses are mounted by the host against the mite and its products. Our current understanding of the immune and inflammatory responses associated with the clinical manifestations in scabies is far outweighed by the significant global impact of the disease. This review aims to provide a better understanding of human immune responses to S. scabiei in ordinary and crusted scabies phenotypes.
MeSH term(s)	Animals ; Cytokines/immunology ; Host-Parasite Interactions ; Humans ; Immunity, Humoral ; Immunity, Innate ; Sarcoptes scabiei/immunology ; Scabies/immunology ; Scabies/parasitology ; Skin/immunology ; Skin/parasitology
Chemical Substances	Cytokines
Language	English
Publishing date	2017-08-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2409480-8
ISSN	1756-3305 ; 1756-3305
ISSN (online)	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-017-2320-4
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Article ; Online: Immunology of scabies and translational outcomes: identifying the missing links.

Walton, Shelley F / Oprescu, Florin I

Current opinion in infectious diseases

2013 Volume 26, Issue 2, Page(s) 116–122

Abstract: Purpose of review: We propose that a major gap in the control, prevention, diagnosis and treatment of scabies exists because of lack of key translational understandings related to the immunopathology of scabies and the associated severe form of the ... ...

Abstract	Purpose of review: We propose that a major gap in the control, prevention, diagnosis and treatment of scabies exists because of lack of key translational understandings related to the immunopathology of scabies and the associated severe form of the disease, crusted scabies. Understanding the complex network of innate and adaptive immune responses, including the long lag period from infection to clinical symptoms, is fundamental to developing early interventions and decreasing transmission. Such interventions must be driven by clinical need and include user-friendly translational outcomes for improved control in endemic and resource-poor settings. Recent findings: In the last few years, we have seen an increase in the molecular characterization of scabies mite proteins. However, owing to limited capacity in scabies immunology-related research, little is still known regarding the immunological effects of the mite or mite products on disease progression or protection. Summary: Detailing the skin immunopathogenesis in relation to scabies, including the role of macrophages, mast cells and eosinophils, as well as the immunomodulatory effects of parasite evasion mechanisms are essential for the rational design of future therapeutic, diagnostic and preventative tools. Resolving this knowledge gap could ultimately lead to significant improvements in clinical and public health interventions. This article proposes a conceptual model for capacity building to inform future research activities in the field.
MeSH term(s)	Adaptive Immunity ; Cytokines/immunology ; Host-Parasite Interactions/immunology ; Humans ; Immune Evasion/immunology ; Immunity, Innate ; Scabies/immunology ; Skin/immunology ; T-Lymphocytes/immunology ; Vaccines/immunology
Chemical Substances	Cytokines ; Vaccines
Language	English
Publishing date	2013-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	645085-4
ISSN	1473-6527 ; 1535-3877 ; 0951-7375 ; 1355-834X
ISSN (online)	1473-6527 ; 1535-3877
ISSN	0951-7375 ; 1355-834X
DOI	10.1097/QCO.0b013e32835eb8a6
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Zs.A 2462: Show issues

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Article ; Online: The interplay between diet and emerging allergy: what can we learn from Indigenous Australians?

Walton, Shelley F / Weir, Christopher

International reviews of immunology

2012 Volume 31, Issue 3, Page(s) 184–201

Abstract: The pathophysiology of atopic diseases, including asthma and allergy, is the result of complex gene-environment interactions. Since European colonization the Indigenous population of Australia has undergone significant changes with respect to their ... ...

Abstract	The pathophysiology of atopic diseases, including asthma and allergy, is the result of complex gene-environment interactions. Since European colonization the Indigenous population of Australia has undergone significant changes with respect to their lifestyle as hunter-gatherers. These changes have had a detrimental effect on Aboriginal health, in part due to immunological modification. This review provides a comparative look at both the traditional Aboriginal/Indigenous diet and modern Western diets, examines some common allergies increasingly reported in contemporary Indigenous populations, and reviews concepts such the effect of vitamin deficiencies and changes in gut microbiota on immune function.
MeSH term(s)	Asthma/immunology ; Australia ; Diet ; Food Hypersensitivity/immunology ; Gastrointestinal Tract/immunology ; Gastrointestinal Tract/microbiology ; Humans ; Models, Immunological ; Oceanic Ancestry Group ; Vitamin D Deficiency/immunology
Language	English
Publishing date	2012-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	632825-8
ISSN	1563-5244 ; 1545-5858 ; 0883-0185
ISSN (online)	1563-5244 ; 1545-5858
ISSN	0883-0185
DOI	10.3109/08830185.2012.667180
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Zs.A 2156: Show issues

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Article ; Online: Early immune suppression leads to uncontrolled mite proliferation and potent host inflammatory responses in a porcine model of crusted versus ordinary scabies.

Bhat, Sajad A / Walton, Shelley F / Ventura, Tomer / Liu, Xiaosong / McCarthy, James S / Burgess, Stewart T G / Mounsey, Kate E

PLoS neglected tropical diseases

2020 Volume 14, Issue 9, Page(s) e0008601

Abstract: Scabies is a neglected tropical disease of global significance. Our understanding of host-parasite interactions has been limited, particularly in crusted scabies (CS), a severe clinical manifestation involving hyper-infestation of Sarcoptes scabiei mites. ...

Abstract	Scabies is a neglected tropical disease of global significance. Our understanding of host-parasite interactions has been limited, particularly in crusted scabies (CS), a severe clinical manifestation involving hyper-infestation of Sarcoptes scabiei mites. Susceptibility to CS may be associated with immunosuppressive conditions but CS has also been seen in cases with no identifiable risk factor or immune deficit. Due to ethical and logistical difficulties with undertaking research on clinical patients with CS, we adopted a porcine model which parallels human clinical manifestations. Transcriptomic analysis using microarrays was used to explore scabies pathogenesis, and to identify early events differentiating pigs with ordinary (OS) and crusted scabies. Pigs with OS (n = 4), CS (n = 4) and non-infested controls (n = 4) were compared at pre-infestation, weeks 1, 2, 4 and 8 post-infestation. In CS relative to OS, there were numerous differentially expressed genes including pro-inflammatory cytokines (IL17A, IL8, IL19, IL20 and OSM) and chemokines involved in immune cell activation and recruitment (CCL20, CCL27 and CXCL6). The influence of genes associated with immune regulation (CD274/PD-L1 and IL27), immune signalling (TLR2, TLR8) and antigen presentation (RFX5, HLA-5 and HLA-DOB) were highlighted in the early host response to CS. We observed similarities with gene expression profiles associated with psoriasis and atopic dermatitis and confirmed previous observations of Th2/17 pronounced responses in CS. This is the first comprehensive study describing transcriptional changes associated with the development of CS and significantly, the distinction between OS and CS. This provides a basis for clinical follow-up studies, potentially identifying new control strategies for this severely debilitating disease.
MeSH term(s)	Animals ; Cytokines/genetics ; Cytokines/immunology ; Gene Expression Profiling ; Gene Expression Regulation/genetics ; Host-Parasite Interactions/immunology ; Immunomodulation/immunology ; Sarcoptes scabiei/immunology ; Scabies/immunology ; Scabies/pathology ; Scabies/veterinary ; Skin/immunology ; Skin/parasitology ; Skin/pathology ; Sus scrofa/immunology ; Sus scrofa/parasitology ; Swine ; Swine Diseases/immunology ; Swine Diseases/parasitology ; Th17 Cells/immunology ; Th2 Cells/immunology ; Transcriptome/genetics
Chemical Substances	Cytokines
Language	English
Publishing date	2020-09-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2429704-5
ISSN	1935-2735 ; 1935-2727
ISSN (online)	1935-2735
ISSN	1935-2727
DOI	10.1371/journal.pntd.0008601
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Article ; Online: Characterization of

Naz, Shumaila / Desclozeaux, Marion / Mounsey, Kate E / Chaudhry, Farhana Riaz / Walton, Shelley F

The American journal of tropical medicine and hygiene

2017 Volume 97, Issue 3, Page(s) 851–860

Abstract: Scabies is a human skin disease due to the burrowing ... ...

Abstract	Scabies is a human skin disease due to the burrowing ectoparasite
MeSH term(s)	Allergens/metabolism ; Animals ; Cloning, Molecular ; DNA, Complementary/genetics ; Gene Expression Regulation/physiology ; Immunoglobulin G/immunology ; Phylogeny ; Protein Binding ; Sarcoptes scabiei/genetics ; Sarcoptes scabiei/metabolism ; Scabies/parasitology ; Tropomyosin/genetics ; Tropomyosin/metabolism
Chemical Substances	Allergens ; DNA, Complementary ; Immunoglobulin G ; Tropomyosin
Language	English
Publishing date	2017-07-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.16-0976
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Article: Host-Defense Peptides Caerin 1.1 and 1.9 Stimulate TNF-Alpha-Dependent Apoptotic Signals in Human Cervical Cancer HeLa Cells.

Ni, Guoying / Chen, Shu / Chen, Mo / Wu, Jialing / Yang, Binbin / Yuan, Jianwei / Walton, Shelley F / Li, Hejie / Wei, Ming Q / Wang, Yuejian / Chen, Guoqiang / Liu, Xiaosong / Wang, Tianfang

Frontiers in cell and developmental biology

2020 Volume 8, Page(s) 676

Abstract: Host defense caerin 1.1 and 1.9 peptides, isolated from the glandular secretion of Australian tree frogs, the ... ...

Abstract	Host defense caerin 1.1 and 1.9 peptides, isolated from the glandular secretion of Australian tree frogs, the genus
Language	English
Publishing date	2020-07-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2020.00676
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Article: Host immune responses to the itch mite, Sarcoptes scabiei, in humans

Bhat, SajadA / Kate E. Mounsey / Xiaosong Liu / Shelley F. Walton

Parasites & vectors. 2017 Dec., v. 10, no. 1

2017

Abstract	Scabies is a parasitic disease due to infestation of skin by the burrowing mite Sarcoptes scabiei. Scabies is a major public health problem and endemic in resource poor communities worldwide affecting over 100 million people. Associated bacterial infections cause substantial morbidity, and in severe cases can lead to renal and cardiac diseases. Mite infestation of the skin causes localised cutaneous inflammation, pruritus, skin lesions, and allergic and inflammatory responses are mounted by the host against the mite and its products. Our current understanding of the immune and inflammatory responses associated with the clinical manifestations in scabies is far outweighed by the significant global impact of the disease. This review aims to provide a better understanding of human immune responses to S. scabiei in ordinary and crusted scabies phenotypes.
Keywords	Sarcoptes scabiei ; bacterial infections ; heart diseases ; humans ; immune response ; inflammation ; mites ; morbidity ; people ; phenotype ; pruritus ; public health ; scabies ; skin lesions
Language	English
Dates of publication	2017-12
Size	p. 385.
Publishing place	BioMed Central
Document type	Article
Note	Review
ZDB-ID	2409480-8
ISSN	1756-3305
ISSN	1756-3305
DOI	10.1186/s13071-017-2320-4
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Early immune suppression leads to uncontrolled mite proliferation and potent host inflammatory responses in a porcine model of crusted versus ordinary scabies.

Sajad A Bhat / Shelley F Walton / Tomer Ventura / Xiaosong Liu / James S McCarthy / Stewart T G Burgess / Kate E Mounsey

PLoS Neglected Tropical Diseases, Vol 14, Iss 9, p e

2020 Volume 0008601

Abstract	Scabies is a neglected tropical disease of global significance. Our understanding of host-parasite interactions has been limited, particularly in crusted scabies (CS), a severe clinical manifestation involving hyper-infestation of Sarcoptes scabiei mites. Susceptibility to CS may be associated with immunosuppressive conditions but CS has also been seen in cases with no identifiable risk factor or immune deficit. Due to ethical and logistical difficulties with undertaking research on clinical patients with CS, we adopted a porcine model which parallels human clinical manifestations. Transcriptomic analysis using microarrays was used to explore scabies pathogenesis, and to identify early events differentiating pigs with ordinary (OS) and crusted scabies. Pigs with OS (n = 4), CS (n = 4) and non-infested controls (n = 4) were compared at pre-infestation, weeks 1, 2, 4 and 8 post-infestation. In CS relative to OS, there were numerous differentially expressed genes including pro-inflammatory cytokines (IL17A, IL8, IL19, IL20 and OSM) and chemokines involved in immune cell activation and recruitment (CCL20, CCL27 and CXCL6). The influence of genes associated with immune regulation (CD274/PD-L1 and IL27), immune signalling (TLR2, TLR8) and antigen presentation (RFX5, HLA-5 and HLA-DOB) were highlighted in the early host response to CS. We observed similarities with gene expression profiles associated with psoriasis and atopic dermatitis and confirmed previous observations of Th2/17 pronounced responses in CS. This is the first comprehensive study describing transcriptional changes associated with the development of CS and significantly, the distinction between OS and CS. This provides a basis for clinical follow-up studies, potentially identifying new control strategies for this severely debilitating disease.
Keywords	Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
Subject code	610
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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