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  1. Article: Etiko-deontologicheskie problemy terapii psikhicheskikh rasstroistv.

    Mosolov, S N

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

    2023  Volume 123, Issue 9, Page(s) 7–14

    Abstract: In recent decades, psychiatric ethics has been an area of intensive research and reconsideration of established regulations. Basic principles of medical deontology do not cover ethical issues of modern psychiatric science and practice. The fundamental ... ...

    Title translation Ethical-deontological problems of therapy of mental disorders.
    Abstract In recent decades, psychiatric ethics has been an area of intensive research and reconsideration of established regulations. Basic principles of medical deontology do not cover ethical issues of modern psychiatric science and practice. The fundamental principle of ethical relationship between a physician and a patient in psychiatric practice is a voluntary informed consent that is based on three main criteria: voluntarism, decision-making capacity and information disclosure about proposed medical procedure. The principle of voluntary informed consent implies a dialogue between a psychiatrist and a patient that rely on the principles of patient's autonomy and does not allow the priority of the paternalistic approach. The physician is obliged to provide all available information on the proposed intervention in a comprehensive way and assess the degree of patient's awareness of this information. The main objective is to determine patient's ability to make decisions as accurately as possible. Many mental disorders affect cognitive processes of decision making and may impact patient's autonomy. It is unacceptable to consider psychiatric patients as incapable of making decisions in advance.
    MeSH term(s) Humans ; Mental Disorders/therapy ; Physicians
    Language Russian
    Publishing date 2023-10-05
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 1201462-x
    ISSN 2309-4729 ; 1997-7298 ; 0044-4588
    ISSN (online) 2309-4729
    ISSN 1997-7298 ; 0044-4588
    DOI 10.17116/jnevro20231230917
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Problemy psikhicheskogo zdorov'ya v usloviyakh pandemii COVID-19.

    Mosolov, S N

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

    2020  Volume 120, Issue 5, Page(s) 7–15

    Abstract: The WHO declared COVID-19 pandemic, the deterioration of the epidemic situation in Russia, the lockdown and the growing fear in society caused by panic rumors and misinformation spread on social networks and the media pose urgent organizational and ... ...

    Title translation Problems of mental health in the situation of COVID-19 pandemic.
    Abstract The WHO declared COVID-19 pandemic, the deterioration of the epidemic situation in Russia, the lockdown and the growing fear in society caused by panic rumors and misinformation spread on social networks and the media pose urgent organizational and medical tasks for our psychiatric service. Based on the experience of other countries that have already encountered the massive spread of COVID-19, the author presents a review of the proposed urgent and preventive organizational and treatment measures and suggests practical recommendations on urgent temporary reorganization of the psychiatric service, and the provision of psychological and psychotherapeutic support to the most vulnerable groups of the population, including medical personnel working with patients with COVID-19, and the management of mentally ill patients with severe acute respiratory syndrome. As the primary goals, it is proposed to separate the flows of people in need of psychological support and psychiatric care, and organize the remote provision of these services (hotline phones and telemedicine consultations). Particular attention is paid to the management of mentally ill patients with coronavirus respiratory syndrome and the characteristics of psychopharmacological therapy with an overview of the potential risks of side-effects and complications related primarily to respiratory function, including those due to adverse drug interactions.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Mental Health ; Pandemics ; Pneumonia, Viral ; Russia ; SARS-CoV-2
    Keywords covid19
    Language Russian
    Publishing date 2020-07-04
    Publishing country Russia (Federation)
    Document type Journal Article ; Review
    ZDB-ID 1201462-x
    ISSN 2309-4729 ; 1997-7298 ; 0044-4588
    ISSN (online) 2309-4729
    ISSN 1997-7298 ; 0044-4588
    DOI 10.17116/jnevro20201200517
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [The risk of developing cardiovascular disease in bipolar disorder. Biological factors and therapy].

    Mosolov, S N / Fedorova, E Y

    Terapevticheskii arkhiv

    2022  Volume 94, Issue 4, Page(s) 579–583

    Abstract: Background: Bipolar disorder (BD) is one of the most common mental disorders characterized by alternating episodes of mania/hypomania and depression, as well as the possibility of developing mixed conditions. Correct and timely diagnosis of BD is ... ...

    Abstract Background: Bipolar disorder (BD) is one of the most common mental disorders characterized by alternating episodes of mania/hypomania and depression, as well as the possibility of developing mixed conditions. Correct and timely diagnosis of BD is important due to the presence of a high suicidal risk and a high predisposition to the development of cardiovascular disease (CVD). The risk of CVD is higher in ВD than in other mental disorders.
    Materials and methods: A sample assessment was made of current studies focusing on the vascular-bipolar link. The search was carried out in the PubMed and eLIBRARY databases for the following keywords: bipolar disorder, psychopharmacology, cardiovascular disease, biological mediators.
    Results: There are several biological factors which explain the close association and common pathogenetic mechanisms of BD and CVD. The most interesting of them are inflammation, oxidative stress, and brain-derived neurotrophic factor. Neuroimaging methods have shown similar structural brain changes in people with BD and with CVD. There is some evidence of the efficacy of statins and angiotensin-converting enzyme inhibitors in reducing cardio-vascular risk factors in BD patients.
    Conclusion: The predisposition of patients of BD to CVD is beyond doubt. It is necessary to consider the peculiarities of the course of BD and conduct active monitoring and preventive measures to reduce the risk of developing life-threatening CVDs. Further research focused on the pathogenetic relationship between BD and CVD could provide more insight into this area.
    MeSH term(s) Humans ; Bipolar Disorder/diagnosis ; Bipolar Disorder/drug therapy ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Brain-Derived Neurotrophic Factor/therapeutic use ; Biological Factors/therapeutic use ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Risk Factors ; Angiotensin-Converting Enzyme Inhibitors
    Chemical Substances Brain-Derived Neurotrophic Factor ; Biological Factors ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Angiotensin-Converting Enzyme Inhibitors
    Language Russian
    Publishing date 2022-05-26
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 40718-5
    ISSN 2309-5342 ; 0040-3660
    ISSN (online) 2309-5342
    ISSN 0040-3660
    DOI 10.26442/00403660.2022.04.201455
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [The risk of developing cardiovascular disease in bipolar disorder. Clinical and social factors].

    Mosolov, S N / Fedorova, E Y

    Terapevticheskii arkhiv

    2021  Volume 93, Issue 12, Page(s) 1556–1561

    Abstract: Bipolar disorder (BD) is one of the most common mental disorders in the world with high mortality and a hard economic burden. Although suicide is the leading cause of death in BD, cardiovascular disease (CVD) also contributes significantly to this rate, ... ...

    Abstract Bipolar disorder (BD) is one of the most common mental disorders in the world with high mortality and a hard economic burden. Although suicide is the leading cause of death in BD, cardiovascular disease (CVD) also contributes significantly to this rate, the risk of which is seriously underestimated in BD. A sample assessment was made of current studies focusing on the link between BD and CVD. The search was carried out in the PubMed and eLIBRARY databases for the following keywords: bipolar disorder, psychopharmacology, cardiovascular disease, metabolic syndrome. The association between BD and vascular disease is large. The analysis of adjusted mortality estimates in patients with bipolar disorder showed a significant contribution of CVD. A detailed study of the mutual influence of bipolar disorder BD and CVD is difficult due to the earlier manifestation of BD in comparison with CVD. Most of the studies have focused on cardiovascular risk factors (CVRFs), which are more common in BD than in the general population. Metabolic syndrome (MS) plays a significant role among CVRFs. The reasons for the development of MS in patients with BD are currently not known for sure, however, the instigated factors are certainly a disturbance of the diet, decreased physical activity, pharmacological therapy, and the lack of early preventive and medical care. Patients with hyperuricemia had a higher risk of developing MS. Lifestyle correction and a reduction of CVFRs, as well as the rational use of certain cardiac drugs can improve the better prognosis of the disease and reduce mortality in patients with BD. The predisposition of patients with BD to CVD is undeniable. It is necessary to consider the high frequency of CVRFs in people with BD, and promptly recommend appropriate treatment and special rehabilitation programs for the prevention of CVD complications, considering the change in affective phases and the applied mood-stabilizing drugs.
    MeSH term(s) Humans ; Bipolar Disorder/diagnosis ; Bipolar Disorder/epidemiology ; Bipolar Disorder/complications ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/prevention & control ; Social Factors ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/complications ; Life Style ; Risk Factors
    Language Russian
    Publishing date 2021-12-15
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article
    ZDB-ID 40718-5
    ISSN 2309-5342 ; 0040-3660
    ISSN (online) 2309-5342
    ISSN 0040-3660
    DOI 10.26442/00403660.2021.12.201175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Problemy psikhicheskogo zdorov'ya v usloviyakh pandemii COVID-19./ [Problems of mental health in the situation of COVID-19 pandemic]

    Mosolov, S N

    Zh Nevrol Psikhiatr Im S S Korsakova

    Abstract: The WHO declared COVID-19 pandemic, the deterioration of the epidemic situation in Russia, the lockdown and the growing fear in society caused by panic rumors and misinformation spread on social networks and the media pose urgent organizational and ... ...

    Abstract The WHO declared COVID-19 pandemic, the deterioration of the epidemic situation in Russia, the lockdown and the growing fear in society caused by panic rumors and misinformation spread on social networks and the media pose urgent organizational and medical tasks for our psychiatric service. Based on the experience of other countries that have already encountered the massive spread of COVID-19, the author presents a review of the proposed urgent and preventive organizational and treatment measures and suggests practical recommendations on urgent temporary reorganization of the psychiatric service, and the provision of psychological and psychotherapeutic support to the most vulnerable groups of the population, including medical personnel working with patients with COVID-19, and the management of mentally ill patients with severe acute respiratory syndrome. As the primary goals, it is proposed to separate the flows of people in need of psychological support and psychiatric care, and organize the remote provision of these services (hotline phones and telemedicine consultations). Particular attention is paid to the management of mentally ill patients with coronavirus respiratory syndrome and the characteristics of psychopharmacological therapy with an overview of the potential risks of side-effects and complications related primarily to respiratory function, including those due to adverse drug interactions.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #634786
    Database COVID19

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  6. Article: Ispol'zovanie piatifaktornoĭ dimensional'noĭ shkaly simptomov shizofrenii dlia otsenki terapevticheskogo deĭstviia Lurazidona: ob''edinennyĭ analiz dannykh dvukh kratkosrochnykh randomizirovannykh dvoĭnykh slepykh platsebo-kontroliruemykh issledovaniĭ na populiatsii patsientov Rossii i Ukrainy.

    Mosolov, S N / Malyutin, A V / Pikalov, A A

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

    2020  Volume 119, Issue 12, Page(s) 29–37

    Abstract: ... score, CGI-S score and five established PANSS factors were assessed using mixed-model repeated measures ... analysis.: Results: Lurasidone (n=162, dose groups pooled) compared with placebo (n=68), significantly ...

    Title translation Effect of Lurasidone on symptoms of schizophrenia in five-factor dimensional model: pooled analysis of two short-term, randomized, double-blind, placebo-controlled studies in patients from Russia and Ukraine.
    Abstract Aim: Evaluation of a new five-factor dimensional model of schizophrenia in recent revisions of classifications of mental disorders (DSM-5 and ICD-11) dictates the need to use this approach in conducting a comprehensive assessment of the effectiveness of new antipsychotic agents, including ethnically homogeneous populations of patients.
    Material and methods: Post-hoc analysis of pooled data from two randomized, double-blind, placebo-controlled, 6-week clinical studies (RCTs) of lurasidone (fixed doses, 40, 80, 120 or 160 mg/d) in patients experiencing an acute exacerbation of schizophrenia. Changes in PANSS total score, CGI-S score and five established PANSS factors were assessed using mixed-model repeated measures analysis.
    Results: Lurasidone (n=162, dose groups pooled) compared with placebo (n=68), significantly improved the PANSS total score at Week 6 (-23.0 vs. -10.5; p<0.001; effect size 0.82) as well as all PANSS factor scores: positive symptoms (-8.5 vs. -4.2; p<0.001; effect size 0.88), negative symptoms (-4.4 vs. -2.8; p=0.011, effect size 0.44), disorganized thoughts (-4.4 vs. -2.1; p<0.001; effect size 0.70), hostility/excitement (-2.7 vs. -0.7; p<0.001; effect size 0.66), and depression/anxiety (-3.5 vs. -2.2; p=0.002; effect size 0.53).
    Conclusion: Lurasidone demonstrated significant improvement for both PANSS total score and each of the five PANSS factor scores, indicating effectiveness across the broad spectrum of schizophrenia symptoms. Effect size for both PANSS total score and each of the five PANSS factor scores for the local population was higher than for the wider population, which included patients from various countries.
    MeSH term(s) Antipsychotic Agents/therapeutic use ; Double-Blind Method ; Humans ; Lurasidone Hydrochloride/therapeutic use ; Psychiatric Status Rating Scales ; Russia ; Schizophrenia/drug therapy ; Treatment Outcome ; Ukraine
    Chemical Substances Antipsychotic Agents ; Lurasidone Hydrochloride (O0P4I5851I)
    Language Russian
    Publishing date 2020-01-28
    Publishing country Russia (Federation)
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 1201462-x
    ISSN 2309-4729 ; 1997-7298 ; 0044-4588
    ISSN (online) 2309-4729
    ISSN 1997-7298 ; 0044-4588
    DOI 10.17116/jnevro201911912129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: [Current biological hypotheses of recurrent depression (review)].

    Mosolov, S N

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

    2012  Volume 112, Issue 11 Pt 2, Page(s) 29–40

    Abstract: A review of the recent data on the biological mechanisms of depression, including the мonoamine hypothesis, the diathesis-stress model and the chronobiological model, is presented. These and other biological hypotheses are viewed in the aspect of the ... ...

    Abstract A review of the recent data on the biological mechanisms of depression, including the мonoamine hypothesis, the diathesis-stress model and the chronobiological model, is presented. These and other biological hypotheses are viewed in the aspect of the current genetic, neurochemical and neuroimaging studies as well as in relation to different treatment approaches. Depression seems not to be a homogenous disease and may be caused by different factors. Genetic factors and stressful life events play an important role in the young age. Chronic stress, chronobiological disturbances and comorbid somatic disease are relevant to middle-aged and elderly people. Moreover, recurrent and chronic depression are accompanied by cognitive impairment, social dysfunction and neurodegeneration. All these factors should be taken into consideration in the development of personalized complex treatment programs.
    MeSH term(s) Biogenic Monoamines/metabolism ; Circadian Rhythm ; Cognition Disorders/metabolism ; Cognition Disorders/physiopathology ; Depressive Disorder/genetics ; Depressive Disorder/metabolism ; Depressive Disorder/physiopathology ; Humans ; Hypothalamo-Hypophyseal System/metabolism ; Hypothalamo-Hypophyseal System/physiopathology ; Nerve Growth Factors/metabolism ; Pituitary-Adrenal System/metabolism ; Pituitary-Adrenal System/physiopathology ; Recurrence ; Stress, Psychological/genetics ; Stress, Psychological/metabolism ; Stress, Psychological/physiopathology
    Chemical Substances Biogenic Monoamines ; Nerve Growth Factors
    Language Russian
    Publishing date 2012
    Publishing country Russia (Federation)
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 1201462-x
    ISSN 2309-4729 ; 1997-7298 ; 0044-4588
    ISSN (online) 2309-4729
    ISSN 1997-7298 ; 0044-4588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Incidence of the Diagnosis of Anxiety Disorders in the Russian Federation: Results of a Web-Based Survey of Psychiatrists.

    Mosolov, Sergey N / Martynikhin, Ivan A / Syunyakov, Timur S / Galankin, Timofey L / Neznanov, Nikolay G

    Neurology and therapy

    2021  Volume 10, Issue 2, Page(s) 971–984

    Abstract: Introduction: According to the official Russian source, in 2017 only 0.27% of the population of Russia was diagnosed with International Classification of Diseases, tenth revision (ICD-10) F4 category disorders (neurotic, stress-related and somatoform ... ...

    Abstract Introduction: According to the official Russian source, in 2017 only 0.27% of the population of Russia was diagnosed with International Classification of Diseases, tenth revision (ICD-10) F4 category disorders (neurotic, stress-related and somatoform disorders), despite these disorders being among the most prevalent mental disorders worldwide. Here we report the results of a large-scale survey among Russian psychiatrists with the primary objective to assess the proportion of psychiatrists who use the diagnoses of interest (mixed anxiety and depression disorder [MADD], adjustment disorder [AdD], panic disorder [PD], agoraphobia, generalized anxiety disorder [GAD], social phobia, simple phobia, acute stress disorder and posttraumatic stress disorder) and compare results with those of a recent World Psychiatric Association (WPA) and World Health Organization (WHO) survey. We also compared the incidence of these diagnoses between state and non-state psychiatric services in Russia.
    Methods: Mean proportions and distribution of proportions of participants who made diagnoses of interest at different rates were calculated and compared with the results of the recent WPA and WHO survey. Risk ratios (RR) of the incidence of these diagnoses made at a frequency of at least once a week were calculated to compare state and non-state psychiatric services. The 95% confidence intervals of the RRs were calculated using the Koopman asymptotic score method.
    Results: Responses of 960 Russian psychiatrists were included in the analysis. Of these 95, 89 and 87% reported making diagnoses of MADD, AdD and PD, respectively, during the preceding 12 months, a far larger proportion compared to other disorders of interest. In general, a significantly smaller proportion of participants in our survey made diagnoses of anxiety disorders compared to respondents in the international WPA-WHO survey. Based on RRs, diagnoses of MADD, AdD, PD, GAD and acute stress disorder were less frequently made in the state-operated psychiatric service.
    Conclusion: Our survey revealed a serious underdiagnosis of anxiety disorders in Russia that may be associated with complex factors that include, but are not limited to the current stigma associated with the state-operated psychiatric service, which is still the exclusive source of official statistical data in Russia.
    Language English
    Publishing date 2021-08-30
    Publishing country New Zealand
    Document type Journal Article
    ISSN 2193-8253
    ISSN 2193-8253
    DOI 10.1007/s40120-021-00277-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [Actual theoretical problems of diagnostic, classification, neurobiology and therapy of schizophrenia: a comparison of international and Russian experience].

    Mosolov, S N

    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

    2010  Volume 110, Issue 6, Page(s) 4–11

    MeSH term(s) Humans ; Russia ; Schizophrenia/classification ; Schizophrenia/diagnosis ; Schizophrenia/drug therapy ; Schizophrenia/genetics
    Language Russian
    Publishing date 2010
    Publishing country Russia (Federation)
    Document type Journal Article
    ZDB-ID 1201462-x
    ISSN 2309-4729 ; 1997-7298 ; 0044-4588
    ISSN (online) 2309-4729
    ISSN 1997-7298 ; 0044-4588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Patients selection for psychiatric neurosurgery: pitfalls and considerations.

    Zaitsev, Oleg S / Poddubskaya, Anna A / Tomskiy, Alexey A / Gamaleya, Anna A / Maksakova, Olga A / Potapov, Igor V / Tsukarzi, Eduard E / Mosolov, Sergey N

    Progress in brain research

    2022  Volume 272, Issue 1, Page(s) 173–183

    Abstract: Neurosurgical interventions (destructive or neuromodulation) are considered as a therapeutic option for patients with treatment resistant mental disorders. However, the issues of indications and contraindications for psychiatric surgery, method and ... ...

    Abstract Neurosurgical interventions (destructive or neuromodulation) are considered as a therapeutic option for patients with treatment resistant mental disorders. However, the issues of indications and contraindications for psychiatric surgery, method and patient selection remain unresolved. This article discusses possible problems and contradictions in the selection of patients, the need for an interdisciplinary team to work to solve the question of the feasibility of using neurosurgical methods. The authors have identified the main problems that increase the risks of selection and lead to a lack of results or low efficiency of neurosurgical intervention, namely: (1) diagnostic errors or inaccuracies; (2) inconclusive data on therapeutic resistance; (3) lack of a common understanding of the goals and desired results among participants in the selection of patients for neurosurgery. Possible predictors of surgical outcome and ethical issues are also discussed. Neurosurgical interventions as a treatment option for psychiatric disorders are not officially approved in most countries. So an appropriate algorithm for patient selection and clear criteria for outcome measures are needed.
    MeSH term(s) Humans ; Mental Disorders/surgery ; Neurosurgery ; Neurosurgical Procedures ; Patient Selection
    Language English
    Publishing date 2022-05-18
    Publishing country Netherlands
    Document type Journal Article
    ISSN 1875-7855 ; 0079-6123
    ISSN (online) 1875-7855
    ISSN 0079-6123
    DOI 10.1016/bs.pbr.2022.03.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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