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Book: Teaching atlas of nuclear medicine

Donohoe, Kevin J.

2000

Author's details	ed. by Kevin J. Donohoe
Keywords	Szintigraphie
Subject	Szintigrafie ; Nukleardiagnostik ; Isotopendiagnostik
Language	English
Size	XVII, 490 S. : zahlr. Ill., graph. Darst.
Publisher	Thieme
Publishing place	New York u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT012744504
ISBN	0-86577-775-6 ; 3-13-108611-4 ; 978-0-86577-775-0 ; 978-3-13-108611-2
Database	Catalogue ZB MED Medicine, Health

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2000 C 47	order for loan	Magazin

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Article ; Online: Antitumor Immunity Mediated by Photodynamic Therapy Using Injectable Chitosan Hydrogels for Intratumoral and Sustained Drug Delivery.

Gierlich, Piotr / Donohoe, Claire / Behan, Kevin / Kelly, Daniel J / Senge, Mathias O / Gomes-da-Silva, Lígia C

Biomacromolecules

2023 Volume 25, Issue 1, Page(s) 24–42

Abstract: Photodynamic therapy (PDT) is an anticancer therapy with proven efficacy; however, its application is often limited by prolonged skin photosensitivity and solubility issues associated with the phototherapeutic agents. Injectable hydrogels which can ... ...

Abstract	Photodynamic therapy (PDT) is an anticancer therapy with proven efficacy; however, its application is often limited by prolonged skin photosensitivity and solubility issues associated with the phototherapeutic agents. Injectable hydrogels which can effectively provide intratumoral delivery of photosensitizers with sustained release are attracting increased interest for photodynamic cancer therapies. However, most of the hydrogels for PDT applications are based on systems with high complexity, and often, preclinical validation is not provided. Herein, we provide a simple and reliable pH-sensitive hydrogel formulation that presents appropriate rheological properties for intratumoral injection. For this,
MeSH term(s)	Mice ; Animals ; Hydrogels/chemistry ; Photosensitizing Agents/pharmacology ; Chitosan/chemistry ; Delayed-Action Preparations/pharmacology ; Neoplasms/drug therapy ; Photochemotherapy
Chemical Substances	Hydrogels ; Photosensitizing Agents ; Chitosan (9012-76-4) ; Delayed-Action Preparations
Language	English
Publishing date	2023-10-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1526-4602
ISSN (online)	1526-4602
DOI	10.1021/acs.biomac.3c00591
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Article ; Online: Nuclear Medicine Imaging of Infection.

Connolly, Caitlin M / Donohoe, Kevin J

Seminars in roentgenology

2016 Volume 52, Issue 2, Page(s) 114–119

MeSH term(s)	Aneurysm, Infected/diagnostic imaging ; Bone Diseases, Infectious/diagnostic imaging ; Humans ; Nuclear Medicine/methods ; Radioisotopes ; Radionuclide Imaging/methods ; Radiopharmaceuticals ; Vasculitis/diagnostic imaging
Chemical Substances	Radioisotopes ; Radiopharmaceuticals
Language	English
Publishing date	2016-07-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80310-8
ISSN	1558-4658 ; 0037-198X
ISSN (online)	1558-4658
ISSN	0037-198X
DOI	10.1053/j.ro.2016.07.001
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Article: A hidden pandemic? An umbrella review of global evidence on mental health in the time of COVID-19.

Bower, Marlee / Smout, Scarlett / Donohoe-Bales, Amarina / O'Dean, Siobhan / Teesson, Lily / Boyle, Julia / Lim, Denise / Nguyen, Andre / Calear, Alison L / Batterham, Philip J / Gournay, Kevin / Teesson, Maree

Frontiers in psychiatry

2023 Volume 14, Page(s) 1107560

Abstract: Background: The mental health impacts of the COVID-19 pandemic remain a public health concern. High quality synthesis of extensive global literature is needed to quantify this impact and identify factors associated with adverse outcomes.: Methods: We ...

Abstract	Background: The mental health impacts of the COVID-19 pandemic remain a public health concern. High quality synthesis of extensive global literature is needed to quantify this impact and identify factors associated with adverse outcomes. Methods: We conducted a rigorous umbrella review with meta-review and present (a) pooled prevalence of probable depression, anxiety, stress, psychological distress, and post-traumatic stress, (b) standardised mean difference in probable depression and anxiety pre-versus-during the pandemic period, and (c) comprehensive narrative synthesis of factors associated with poorer outcomes. Databases searched included Scopus, Embase, PsycINFO, and MEDLINE dated to March 2022. Eligibility criteria included systematic reviews and/or meta-analyses, published post-November 2019, reporting data in English on mental health outcomes during the COVID-19 pandemic. Findings: Three hundred and thirty-eight systematic reviews were included, 158 of which incorporated meta-analyses. Meta-review prevalence of anxiety symptoms ranged from 24.4% (95%CI: 18-31%, Conclusion: This is the first meta-review to synthesise the longitudinal mental health impacts of the pandemic. Findings show that probable depression and anxiety were significantly higher than pre-COVID-19, and provide some evidence that that adolescents, pregnant and postpartum people, and those hospitalised with COVID-19 experienced heightened adverse mental health. Policymakers can modify future pandemic responses accordingly to mitigate the impact of such measures on public mental health.
Language	English
Publishing date	2023-03-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564218-2
ISSN	1664-0640
ISSN	1664-0640
DOI	10.3389/fpsyt.2023.1107560
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Article ; Online: Spectral power ratio as a measure of EEG changes in mild cognitive impairment due to Alzheimer's disease: a case-control study.

Flores-Sandoval, Aimee A / Davila-Pérez, Paula / Buss, Stephanie S / Donohoe, Kevin / O'Connor, Margaret / Shafi, Mouhsin M / Pascual-Leone, Alvaro / Benwell, Christopher S Y / Fried, Peter J

Neurobiology of aging

2023 Volume 130, Page(s) 50–60

Abstract: Adopting preventive strategies in individuals with subclinical Alzheimer's disease (AD) has the potential to delay dementia onset and reduce healthcare costs. Thus, it is extremely important to identify inexpensive, scalable, sensitive, and specific ... ...

Abstract	Adopting preventive strategies in individuals with subclinical Alzheimer's disease (AD) has the potential to delay dementia onset and reduce healthcare costs. Thus, it is extremely important to identify inexpensive, scalable, sensitive, and specific markers to track disease progression. The electroencephalography spectral power ratio (SPR: the fast to slow spectral power ratio), a measure of the shift in power distribution from higher to lower frequencies, holds potential for aiding clinical practice. The SPR is altered in patients with AD, correlates with cognitive functions, and can be easily implemented in clinical settings. However, whether the SPR is sensitive to pathophysiological changes in the prodromal stage of AD is unclear. We explored the SPR of individuals diagnosed with amyloid-positive amnestic mild cognitive impairment (Aβ+aMCI) and its association with both cognitive function and amyloid load. The SPR was lower in Aβ+aMCI than in the cognitively unimpaired individuals and correlated with executive function scores but not with amyloid load. Hypothesis-generating analyses suggested that aMCI participants with a lower SPR had an increased probability of a positive amyloid positron emission tomography. Future research may explore the potential of this measure to classify aMCI individuals according to their AD biomarker status.
MeSH term(s)	Humans ; Alzheimer Disease/psychology ; Amyloid beta-Peptides ; Case-Control Studies ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/complications ; Electroencephalography ; Positron-Emission Tomography ; Amyloid ; Neuropsychological Tests
Chemical Substances	Amyloid beta-Peptides ; Amyloid
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	604505-4
ISSN	1558-1497 ; 0197-4580
ISSN (online)	1558-1497
ISSN	0197-4580
DOI	10.1016/j.neurobiolaging.2023.05.010
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Zs.A 1685: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: MRI staging of upper extremity secondary lymphedema: correlation with clinical measurements.

Kim, Geunwon / Smith, Martin P / Donohoe, Kevin J / Johnson, Anna Rose / Singhal, Dhruv / Tsai, Leo L

European radiology

2020 Volume 30, Issue 8, Page(s) 4686–4694

Abstract: Objectives: Staging of upper extremity lymphedema is needed to guide surgical management, but is not standardized due to lack of accessible, quantitative, or precise measures. Here, we established an MRI-based staging system for lymphedema and validate ... ...

Abstract	Objectives: Staging of upper extremity lymphedema is needed to guide surgical management, but is not standardized due to lack of accessible, quantitative, or precise measures. Here, we established an MRI-based staging system for lymphedema and validate it against existing clinical measures. Methods: Bilateral upper extremity MRI and lymphoscintigraphy were performed on 45 patients with unilateral secondary lymphedema, due to surgical intervention, who were referred to our multidisciplinary lymphedema clinic between March 2017 and October 2018. MRI short-tau inversion recovery (STIR) images were retrospectively reviewed. A grading system was established based on the cross-sectional circumferential extent of subcutaneous fluid infiltration at three locations, labeled MRI stage 0-3, and was compared to L-Dex®, ICG lymphography, volume, lymphedema quality of life (LYMQOL), International Society of Lymphology (ISL) stage, and lymphoscintigraphy. Linear weighted Cohen's kappa was calculated to compare MRI staging by two readers. Results: STIR images on MRI revealed a predictable pattern of fluid infiltration centered on the elbow and extending along the posterior aspect of the upper arm and the ulnar side of the forearm. Patients with higher MRI stage were more likely to be in ISL stage 2 (p = 0.002) or to demonstrate dermal backflow on lymphoscintigraphy (p = 0.0002). No correlation was found between MRI stages and LYMQOL. Higher MRI stage correlated with abnormal ICG lymphography pattern (r Conclusion: An MRI staging system for upper extremity lymphedema offers an improved non-invasive precision marker for lymphedema for therapeutic planning. Key points: • Diagnosis and staging of patients with secondary upper extremity lymphedema may be performed with non-contrast MRI, which is non-invasive and more readily accessible compared to lymphoscintigraphy and evaluation by lymphedema specialists. • MRI-based staging of secondary upper extremity lymphedema is highly reproducible and could be used for long-term follow-up of patients. • In patients with borderline clinical measurements, MRI can be used to identify patients with early-stage lymphedema.
MeSH term(s)	Cross-Sectional Studies ; Female ; Humans ; Lymphedema/diagnosis ; Lymphedema/etiology ; Lymphography/methods ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Quality of Life ; Retrospective Studies ; Severity of Illness Index ; Upper Extremity
Language	English
Publishing date	2020-03-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-020-06790-0
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Zs.A 3300: Show issues

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Book: Case based nuclear medicine

Donohoe, Kevin J. / Van den Abbeele, Annick

2011

Title variant	Case-based nuclear medicine
Author's details	Kevin J. Donohoe ; Annick D. Van den Abbeele
Keywords	Radionuclide Imaging
Language	English
Size	XVIII, 581 S. : zahlr. Ill., graph. Darst., 280 mm x 216 mm
Edition	2. ed.
Publisher	Thieme
Publishing place	New York u.a.
Publishing country	United States
Document type	Book
Accompanying material	Zeitlich befristeter Zugang zu zusätzlichem Internetmaterial über Code
HBZ-ID	HT016911496
ISBN	978-1-58890-652-6 ; 1-58890-652-3
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Summary: Appropriate Use Criteria for Lymphoscintigraphy in Sentinel Node Mapping and Lymphedema/Lipedema.

Donohoe, Kevin J / Carroll, Brett J / Chung, David K V / Dibble, Elizabeth H / Diego, Emilia / Giammarile, Francesco / Grant, Frederick D / Lai, Stephen Y / Linden, Hannah / Miller, Megan E / Pandit-Taskar, Neeta / Tawa, Nicholas E / Vidal-Sicart, Sergi

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2023 Volume 64, Issue 4, Page(s) 525–528

Abstract: Expert representatives from 11 professional societies, as part of an autonomous work group, researched and developed appropriate use criteria (AUC) for lymphoscintigraphy in sentinel lymph node mapping and lymphedema. The complete findings and ... ...

Abstract	Expert representatives from 11 professional societies, as part of an autonomous work group, researched and developed appropriate use criteria (AUC) for lymphoscintigraphy in sentinel lymph node mapping and lymphedema. The complete findings and discussions of the work group, including example clinical scenarios, were published on October 8, 2022, and are available at https://www.snmmi.org/ClinicalPractice/content.aspx?ItemNumber=42021 The complete AUC document includes clinical scenarios for scintigraphy in patients with breast, cutaneous, and other cancers, as well as for mapping lymphatic flow in lymphedema. Pediatric considerations are addressed. These AUC are intended to assist health care practitioners considering lymphoscintigraphy. Presented here is a brief overview of the AUC, including the rationale and methodology behind development of the document. For detailed findings of the work group, the reader should refer to the complete AUC document online.
MeSH term(s)	Humans ; Child ; Female ; Lymphoscintigraphy ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology ; Lipedema/pathology ; Radionuclide Imaging ; Lymphedema/diagnostic imaging ; Lymphedema/pathology ; Sentinel Lymph Node Biopsy/methods ; Breast Neoplasms/pathology
Language	English
Publishing date	2023-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.123.265560
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Zs.A 114: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Superficial and functional imaging of the tricipital lymphatic pathway: a modern reintroduction.

Friedman, Rosie / Bustos, Valeria P / Pardo, Jaime / Tillotson, Elizabeth / Donohoe, Kevin / Chatterjee, Abhishek / Ciucci, José Luis / Singhal, Dhruv

Breast cancer research and treatment

2022 Volume 197, Issue 1, Page(s) 235–242

Abstract: Purpose: The tricipital, or Caplan's, lymphatic pathway has been previously identified in cadavers and described as a potential compensatory pathway for lymphatic drainage of the upper extremity, as it may drain lymphatic fluid directly to the scapular ... ...

Abstract	Purpose: The tricipital, or Caplan's, lymphatic pathway has been previously identified in cadavers and described as a potential compensatory pathway for lymphatic drainage of the upper extremity, as it may drain lymphatic fluid directly to the scapular lymph nodes, avoiding the axillary lymph node groups. The aim of this study was to map the anatomy of the tricipital pathway in vivo in patients without lymphatic disease. Methods: A retrospective review was performed to identify patients with unilateral breast cancer undergoing preoperative Indocyanine green (ICG) lymphography prior to axillary lymph node dissection from May 2021 through January 2022. Exclusion criteria were evidence or known history of upper extremity lymphedema or non-linear channels visualized on ICG. Demographic, oncologic, and ICG imaging data were extracted from a Lymphatic Surgery Database. The primary outcome of this study was the presence and absence of the tricipital pathway. The secondary outcome was major anatomical variations among those with a tricipital pathway. Results: Thirty patients underwent preoperative ICG lymphography in the study period. The tricipital pathway was visualized in the posterior upper arm in 90% of patients. In 63% of patients, the pathway had a functional connection to the forearm (long bundle variant) and in 27%, the pathway was isolated to the upper arm without a connection to the forearm (short bundle variant). In those with a long bundle, the contribution was predominantly from the posterior ulnar lymphosome. Anatomic destinations of the tricipital pathway included the deltotricipital groove and the medial upper arm channel, which drains to the axilla. Conclusion: When present, the tricipital pathway coursed along the posterior upper arm with variability in its connections to the forearm distally, and the torso proximally. Long-term follow-up studies will help determine the significance of these anatomic variations in terms of individual risk of lymphedema after axillary nodal dissection.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/surgery ; Breast Neoplasms/pathology ; Lymphatic Vessels/diagnostic imaging ; Lymphatic Vessels/pathology ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/pathology ; Lymph Node Excision/methods ; Axilla ; Lymphedema/diagnostic imaging ; Lymphedema/etiology ; Lymphedema/pathology ; Indocyanine Green
Chemical Substances	Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2022-11-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	604563-7
ISSN	1573-7217 ; 0167-6806
ISSN (online)	1573-7217
ISSN	0167-6806
DOI	10.1007/s10549-022-06777-z
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Zs.A 1655: Show issues

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Article ; Online: Delayed hospital discharges and the trolley crisis.

Burke, Conor / Dolan, Eamon / Faul, John / Donohoe, Kevin / Ogbebor, Estella / O'Carroll, Orla / Tormey, William

Irish journal of medical science

2022 Volume 192, Issue 1, Page(s) 11–14

Abstract: We audited use of acute hospital beds in Connolly Hospital over a 3-month period (January-March 2020) which coincided with increased provision of step-down (nursing home) beds. Our results show both ineffective and inefficient baseline uses of these ... ...

Abstract	We audited use of acute hospital beds in Connolly Hospital over a 3-month period (January-March 2020) which coincided with increased provision of step-down (nursing home) beds. Our results show both ineffective and inefficient baseline uses of these acute beds. Increased step-down beds improve patient care by reducing the trolley count, shortening average length of stay and reducing waiting lists. These data confirm that more step-down beds are a high priority for our Health Service to improve the effectiveness and efficiency of our hospitals i.e. better care at less cost.
MeSH term(s)	Humans ; Patient Discharge ; Hospitals ; Nursing Homes ; Waiting Lists ; Length of Stay ; Bed Occupancy
Language	English
Publishing date	2022-02-19
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	390895-1
ISSN	1863-4362 ; 0021-1265
ISSN (online)	1863-4362
ISSN	0021-1265
DOI	10.1007/s11845-022-02924-z
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