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Article ; Online: Contrast flow in CT-guided lumbar interlaminar epidural steroid injections: does needle position effect the laterality of contrast flow?

Mojarrad, Mohammadali / Wieschhoff, Ged G / Mandell, Jacob C

2024

Abstract: Purpose: To evaluate the effect of needle position on the laterality of contrast flow in CT-guided lumbar interlaminar epidural steroid injections.: Materials and methods: A retrospective review of consecutive CT-guided interlaminar lumbar epidural ... ...

Abstract	Purpose: To evaluate the effect of needle position on the laterality of contrast flow in CT-guided lumbar interlaminar epidural steroid injections. Materials and methods: A retrospective review of consecutive CT-guided interlaminar lumbar epidural steroid injections was performed. The terminal needle tip position (midline or lateral) and the laterality of epidural contrast were evaluated by two readers. Contrast flow pattern was classified as ipsilateral to needle trajectory, bilateral, or contralateral. Bilateral flow was further divided into asymmetric, symmetrical, or asymmetric to the contralateral side. Inter-reader agreement was calculated with the kappa statistic. The relationship of needle position to contrast laterality was calculated with the chi statistic. Pain scores were compared for bilateral and unilateral flows with a two-tailed T test for independent means. Results: A total of 250 injections were included in 204 patients, with an age range of 24 to 93 years. The most commonly injected level (145/250) was L4-L5. Agreement between the two readers was almost perfect and substantial (kappa 0.751-0.880). The majority of injections (154/250) demonstrated contrast flow ipsilateral to the needle trajectory, 90/250 demonstrated bilateral flow, and 6/250 had contralateral flow. Of the 90 cases with bilateral flow, 80% were performed with a midline terminal needle position (p < 0.001). There was no difference in immediate post-procedure pain scores between patients with ipsilateral or bilateral contrast flow. Conclusion: For interlaminar epidural steroid injections, a midline terminal needle tip position has a greater probability of producing bilateral contrast flow compared to a lateral terminal needle tip position.
Language	English
Publishing date	2024-01-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	527592-1
ISSN	1432-2161 ; 0364-2348
ISSN (online)	1432-2161
ISSN	0364-2348
DOI	10.1007/s00256-024-04588-5
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Article ; Online: Degree of articular injury as measured by CT cross sectional area is associated with physical function following the treatment of bicondylar tibial plateau fractures.

von Keudell, Arvind / Huebner, Kyla D / Mandell, Jacob / O'Brien, Matthew / Harris, Mitchel B / Esposito, John G / Caton, Tyler / Weaver, Michael J

Journal of orthopaedic surgery (Hong Kong)

2024 Volume 31, Issue 3, Page(s) 10225536231217148

Abstract: Background: Bicondylar tibial plateau fractures are complex injuries that commonly require surgical repair. Long-term clinical outcome has been associated with discrepancies in leg alignment, instability and condylar width abnormalities. While intuitive, ...

Abstract	Background: Bicondylar tibial plateau fractures are complex injuries that commonly require surgical repair. Long-term clinical outcome has been associated with discrepancies in leg alignment, instability and condylar width abnormalities. While intuitive, the degree of articular damage at time of injury has not been linked to outcomes in patients with bicondylar tibial plateau fractures. The aim of this study was to quantify percentage of articular surface cross sectional area disruption and assess for correlation between the degree of articular injury and patient reported physical function. Methods: Retrospective cohort study at two level 1 trauma centers. 57 consecutive patients undergoing surgical repair for bicondylar tibial plateau fractures between 2013 and 2016. Main outcome measure: Preoperative CT scans were reviewed, and the percentage of articular surface disruption cross sectional area was calculated. PROMIS Results: 57 patients with an average age of 58 ± 14.3 years were included. The average PROMIS Conclusion: Our method for calculating articular surface disruption on CT is a simple, reproducible and accurate method for assessing the degree of articular damage in patients with bicondylar tibial plateau fractures. We found that the percentage of cross-sectional articular surface disruption correlates with patient reported outcomes and physical function.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Aged ; Tibial Plateau Fractures ; Retrospective Studies ; Tibial Fractures/diagnostic imaging ; Tibial Fractures/surgery ; Tomography, X-Ray Computed ; Fracture Fixation, Internal/methods
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	1493368-8
ISSN	2309-4990 ; 1022-5536
ISSN (online)	2309-4990
ISSN	1022-5536
DOI	10.1177/10225536231217148
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Article ; Online: The Reply.

Mangione, Salvatore / Mandell, Brian F / Post, Stephen G

The American journal of medicine

2022 Volume 135, Issue 7, Page(s) e224

Language	English
Publishing date	2022-05-01
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2022.02.027
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Article: Community-Acquired Pneumonia in Canada During Coronavirus Disease 2019.

Mandell, Lionel A / Zhanel, George G / Rotstein, Coleman / Muscedere, John / Loeb, Mark / Johnstone, Jennie

Open forum infectious diseases

2022 Volume 9, Issue 3, Page(s) ofac043

Abstract: Dealing with coronavirus disease 2019 (COVID-19) has been a monumental test of medical skills and resources worldwide. The management of community-acquired pneumonia (CAP) can at times be difficult, but treating CAP in the setting of COVID-19 can be ... ...

Abstract	Dealing with coronavirus disease 2019 (COVID-19) has been a monumental test of medical skills and resources worldwide. The management of community-acquired pneumonia (CAP) can at times be difficult, but treating CAP in the setting of COVID-19 can be particularly trying and confusing and raises a number of challenging questions relating to etiology, diagnosis, and treatment. This article is based on the authors' experiences and presents an overview of how CAP during COVID-19 is handled in Canada. We touch on the issues of microbial etiology in patients with CAP in the setting of COVID-19 as well as diagnostic, site of care, and treatment approaches. Published guidelines are the basis of management of CAP and are discussed in the context of Canadian data. We also outline the usual treatment approaches to COVID-19, particularly in patients who have been hospitalized.
Language	English
Publishing date	2022-02-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2757767-3
ISSN	2328-8957
ISSN	2328-8957
DOI	10.1093/ofid/ofac043
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Article ; Online: Incidence of congenital complications related to COVID-19 infection during pregnancy.

Reppucci, M L / Kaizer, A M / Prendergast, C / Acker, S N / Mandell, E W / Euser, A G / Diaz-Miron, J

Journal of neonatal-perinatal medicine

2023 Volume 16, Issue 2, Page(s) 227–234

Abstract: Purpose: Infection with COVID-19 during pregnancy has been associated with a hypercoagulable state. It is unknown if maternal COVID-19 infection results in congenital anomalies secondary to intrauterine vascular accidents. This study sought to determine ...

Abstract	Purpose: Infection with COVID-19 during pregnancy has been associated with a hypercoagulable state. It is unknown if maternal COVID-19 infection results in congenital anomalies secondary to intrauterine vascular accidents. This study sought to determine if the rate of in-utero vascular complications (intestinal atresia and limb abnormalities) that may be attributable to the hypercoagulable states associated with COVID-19 and pregnancy increased after the onset of the pandemic. Methods: Pregnancy, neonatal, and congenital defect data from a single academic medical center and the partner's children's hospital were collected and compared to the period prior to onset of the pandemic. A subanalysis including pregnant woman 18 years or greater with documented COVID-19 infection during gestation between March 2020-2021 was performed. Results: Rates of intestinal atresia did not differ prior to or after the onset of the pandemic (3.78% vs 7.23%, p = 0.21) nor did rates of limb deficiency disorders (4.41% vs 9.65%, p = 0.09). On subanalysis, there were 194 women with COVID-19 infection included in analysis: 135 (69.6%) were positive during delivery admission and 59 (30.4%) were positive earlier in their pregnancy. There was one infant born with intestinal atresia. Conclusion: We report a low incidence of congenital anomalies in infants born to mothers with COVID-19 infection. It remains unclear if the impact of COVID-19 on the coagulative state augments the normal pro-thrombotic state of pregnancy; ongoing surveillance is warranted.
MeSH term(s)	Pregnancy ; Infant, Newborn ; Infant ; Child ; Humans ; Female ; COVID-19/complications ; COVID-19/epidemiology ; Incidence ; Intestinal Atresia ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Outcome
Language	English
Publishing date	2023-05-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2435387-5
ISSN	1878-4429 ; 1934-5798
ISSN (online)	1878-4429
ISSN	1934-5798
DOI	10.3233/NPM-221122
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Article: Cefiderocol is an effective topical monotherapy for experimental extensively-drug resistant

Romanowski, Eric G / Mumper, Sonya M / Shanks, Hazel Q / Yates, Kathleen A / Mandell, Jonathan B / Zegans, Michael E / Shanks, Robert M Q

bioRxiv : the preprint server for biology

2023

Abstract: Purpose: To test cefiderocol, a siderophore-cephalosporin antibiotic for topical monotherapy treatment of experimental extensively drug resistant (XDR) : Design: Preclinical study.: Subjects and controls: Deidentified : Methods intervention or ... ...

Abstract	Purpose: To test cefiderocol, a siderophore-cephalosporin antibiotic for topical monotherapy treatment of experimental extensively drug resistant (XDR) Design: Preclinical study. Subjects and controls: Deidentified Methods intervention or testing: Cefiderocol antibacterial activity against Main outcome measures: MIC analysis for susceptibility, graded tests for ocular toxicity/tolerability, CFU analysis for bacterial burden, corneal cefiderocol concentrations. Results: 100% of Conclusions: These results demonstrate that cefiderocol is well tolerated on rabbit corneas and is effective against
Language	English
Publishing date	2023-09-02
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.08.31.555778
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Article ; Online: Cefiderocol Is an Effective Topical Monotherapy for Experimental Extensively Drug-Resistant

Romanowski, Eric G / Mumper, Sonya M / Shanks, Hazel Q / Yates, Kathleen A / Mandell, Jonathan B / Zegans, Michael E / Shanks, Robert M Q

Ophthalmology science

2023 Volume 4, Issue 4, Page(s) 100452

Abstract: Purpose: To test cefiderocol, a siderophore-cephalosporin antibiotic for topical monotherapy treatment of experimental extensively drug-resistant (XDR) : Design: Preclinical study.: Subjects and controls: Deidentified : Methods intervention or ... ...

Abstract	Purpose: To test cefiderocol, a siderophore-cephalosporin antibiotic for topical monotherapy treatment of experimental extensively drug-resistant (XDR) Design: Preclinical study. Subjects and controls: Deidentified Methods intervention or testing: Cefiderocol antibacterial activity against Main outcome measures: Minimum inhibitory concentration analysis for susceptibility, graded tests for ocular toxicity/tolerability, colony-forming unit (CFU) analysis for bacterial burden, corneal cefiderocol concentrations. Results: One hundred percent of Conclusions: These results demonstrate that cefiderocol is well tolerated on rabbit corneas and is effective against Financial disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
Language	English
Publishing date	2023-12-13
Publishing country	Netherlands
Document type	Journal Article
ISSN	2666-9145
ISSN (online)	2666-9145
DOI	10.1016/j.xops.2023.100452
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Article ; Online: The Language Game: We Are Physicians, Not Providers.

Mangione, Salvatore / Mandell, Brian F / Post, Stephen G

The American journal of medicine

2021 Volume 134, Issue 12, Page(s) 1444–1446

MeSH term(s)	Health Personnel/history ; History, 20th Century ; Humans ; National Socialism/history ; Physicians ; Terminology as Topic
Language	English
Publishing date	2021-07-21
Publishing country	United States
Document type	Editorial ; Historical Article
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2021.06.031
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Article ; Online: Deep learning discrimination of rheumatoid arthritis from osteoarthritis on hand radiography.

Ma, Yuntong / Pan, Ian / Kim, Stanley Y / Wieschhoff, Ged G / Andriole, Katherine P / Mandell, Jacob C

Skeletal radiology

2023 Volume 53, Issue 2, Page(s) 377–383

Abstract: Purpose: To develop a deep learning model to distinguish rheumatoid arthritis (RA) from osteoarthritis (OA) using hand radiographs and to evaluate the effects of changing pretraining and training parameters on model performance.: Materials and methods! ...

Abstract	Purpose: To develop a deep learning model to distinguish rheumatoid arthritis (RA) from osteoarthritis (OA) using hand radiographs and to evaluate the effects of changing pretraining and training parameters on model performance. Materials and methods: A convolutional neural network was retrospectively trained on 9714 hand radiograph exams from 8387 patients obtained from 2017 to 2021 at seven hospitals within an integrated healthcare network. Performance was assessed using an independent test set of 250 exams from 146 patients. Binary discriminatory capacity (no arthritis versus arthritis; RA versus not RA) and three-way classification (no arthritis versus OA versus RA) were evaluated. The effects of additional pretraining using musculoskeletal radiographs, using all views as opposed to only the posteroanterior view, and varying image resolution on model performance were also investigated. Area under the receiver operating characteristic curve (AUC) and Cohen's kappa coefficient were used to evaluate diagnostic performance. Results: For no arthritis versus arthritis, the model achieved an AUC of 0.975 (95% CI: 0.957, 0.989). For RA versus not RA, the model achieved an AUC of 0.955 (95% CI: 0.919, 0.983). For three-way classification, the model achieved a kappa of 0.806 (95% CI: 0.742, 0.866) and accuracy of 87.2% (95% CI: 83.2%, 91.2%) on the test set. Increasing image resolution increased performance up to 1024 × 1024 pixels. Additional pretraining on musculoskeletal radiographs and using all views did not significantly affect performance. Conclusion: A deep learning model can be used to distinguish no arthritis, OA, and RA on hand radiographs with high performance.
MeSH term(s)	Humans ; Deep Learning ; Retrospective Studies ; Radiography ; Osteoarthritis/diagnostic imaging ; Arthritis, Rheumatoid/diagnostic imaging
Language	English
Publishing date	2023-08-02
Publishing country	Germany
Document type	Journal Article
ZDB-ID	527592-1
ISSN	1432-2161 ; 0364-2348
ISSN (online)	1432-2161
ISSN	0364-2348
DOI	10.1007/s00256-023-04408-2
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Article: TBK1 is ubiquitinated by TRIM5α to assemble mitophagy machinery.

Saha, Bhaskar / Olsvik, Hallvard / Williams, Geneva L / Oh, Seeun / Evjen, Gry / Sjøttem, Eva / Mandell, Michael A

bioRxiv : the preprint server for biology

2023

Abstract: Ubiquitination of mitochondrial proteins provides a basis for the downstream recruitment of mitophagy machinery, yet whether ubiquitination of the machinery itself contributes to mitophagy is unknown. Here, we show that K63-linked polyubiquitination of ... ...

Abstract	Ubiquitination of mitochondrial proteins provides a basis for the downstream recruitment of mitophagy machinery, yet whether ubiquitination of the machinery itself contributes to mitophagy is unknown. Here, we show that K63-linked polyubiquitination of the key mitophagy regulator TBK1 is essential for its mitophagy functions. This modification is catalyzed by the ubiquitin ligase TRIM5α. Mitochondrial damage triggers TRIM5α's auto-ubiquitination and its interaction with ubiquitin-binding autophagy adaptors including NDP52, optineurin, and NBR1. Autophagy adaptors, along with TRIM27, enable TRIM5α to engage with TBK1. TRIM5α with intact ubiquitination function is required for the proper accumulation of active TBK1 on damaged mitochondria in Parkin-dependent and Parkin-independent mitophagy pathways. Additionally, we show that TRIM5α can directly recruit autophagy initiation machinery to damaged mitochondria. Our data support a model in which TRIM5α provides a self-amplifying, mitochondria-localized, ubiquitin-based, assembly platform for TBK1 and mitophagy adaptors that is ultimately required to recruit the core autophagy machinery.
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.10.19.563195
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