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Article: Choosing the Right Treatment Option for the Right R/M HNSCC Patient: Should We Adhere to PFE for First-Line Therapy?

Lübbers, Katharina / Pavlychenko, Mykola / Wald, Theresa / Wiegand, Susanne / Dietz, Andreas / Zebralla, Veit / Wichmann, Gunnar

Frontiers in oncology

2021 Volume 11, Page(s) 715297

Abstract: ... as first-line chemotherapy (1L-ChT) for recurrent/metastatic head and neck squamous cell carcinoma (R/M ... HNSCC). We were interested in outcome differences of R/M HNSCC in 1L-ChT and factors influencing outcome ... regimens to provide real world evidence (RWE).: Methods: For this retrospective monocentric study, 124 R ...

Abstract	Background: The landmark EXTREME trial established cisplatin, 5-fluorouracil and cetuximab (PFE) as first-line chemotherapy (1L-ChT) for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC). We were interested in outcome differences of R/M HNSCC in 1L-ChT and factors influencing outcome in certain subgroups, especially patients receiving PFE, and the value of PFE compared to other 1L-ChT regimens to provide real world evidence (RWE). Methods: For this retrospective monocentric study, 124 R/M HNSCC patients without curative surgical or radiotherapy options receiving at least one cycle of 1L-ChT were eligible. We analyzed their outcome using Kaplan-Meier plot and Cox regression to identify predictors for prolonged survival. Results: Subgroups benefiting significantly from PFE were patients suffering from an index HNSCC outside the oropharynx. The PFE regimen proved to be superior to all other 1L-ChT regimens in clinical routine. Significant outcome differences between PFE treatment within or outside controlled trials were not seen. Conclusion: This retrospective analysis provides RWE for factors linked to improved outcome. Subgroup analyses highlight the lasting value of PFE among the growing spectrum of 1L-ChT. Importantly, fit smokers with high level alcohol consumption benefit from PFE; considering the patient's lifestyle factors, PFE should not be ignored in decision-making.
Language	English
Publishing date	2021-07-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.715297
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Article ; Online: Surgical Treatment of Developmental Dysplastic Lumbosacral Spondylolisthesis: Additional Help from an Intervertebral Distraction, Correction, and Reduction Device.

Lübbers, Thomas / Sandvoss, Gerd / Baalmann, Rainer / Wigt, Peter

Journal of neurological surgery. Part A, Central European neurosurgery

2023 Volume 85, Issue 3, Page(s) 322–329

Abstract: Background: In mid- to high-grade adult dysplastic spondylolisthesis, surgeons are faced with three underlying components: angular, translational, and collapse of the disk. In extremely narrow intervertebral spaces, it is difficult to distract and lift ...

Abstract	Background: In mid- to high-grade adult dysplastic spondylolisthesis, surgeons are faced with three underlying components: angular, translational, and collapse of the disk. In extremely narrow intervertebral spaces, it is difficult to distract and lift the vertebral bodies by the pedicle screw system alone. In this prospective case control study, we analyzed the efficacy of the latest prototypes (distraction, correction, and reduction [DCR] instrument) with intervertebral application in terms of distraction, correction of segmental kyphosis, and slip reduction. Methods: Twelve adult patients (5 male and 7 female patients) were enrolled in this study. The average age was 42 years (range: 17-67 years) and in all cases the maneuver was documented during the surgery. The amount of slip reduction, the lumbosacral angle according to the Spinal Deformity Study Group dysplastic angle (dys-SDGG), and the disk height were measured preoperatively, intraoperatively, 3 months after surgery, and during the latest follow-up (range: 3-44 months). The relative height of the lumbosacral disk was determined in relation to the disk height in L3/L4. Results: Slippage ranged from 17 to 67%. Overall, the average slippage was 45% preoperatively and 4.8% after the reduction maneuver. The average ratio of the disk height was 0.3 preoperatively, 1.0 intraoperatively, and 0.9 at the latest follow-up. Two patients showed significant kyphotic changes, and these patients had an 18- and 21-degree lordotic improvement. From those who had a lumbosacral kyphosis >20 degrees, only one patient did not show any lordotic improvement. All other patients had a significant lordotic improvement. In total, the lumbosacral angle changed from 15 to 23 degrees. Conclusion: The application of an intervertebral distractor with a mobile thigh has a good clinical and radiologic outcome for mid- to high-grade adult dysplastic spondylolisthesis in terms of distraction, kyphosis correction, and reduction of underlying slippage. The described hardware failures and the complications were not related to the DCR device.
MeSH term(s)	Adult ; Humans ; Male ; Female ; Spondylolisthesis/diagnostic imaging ; Spondylolisthesis/surgery ; Case-Control Studies ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/surgery ; Spinal Fusion ; Kyphosis/diagnostic imaging ; Kyphosis/surgery ; Kyphosis/complications ; Treatment Outcome ; Retrospective Studies
Language	English
Publishing date	2023-05-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2651663-9
ISSN	2193-6323 ; 2193-6315
ISSN (online)	2193-6323
ISSN	2193-6315
DOI	10.1055/a-2091-6921
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Article ; Online: Application and Interpretation of Antimicrobial Susceptibility Testing.

Fajt, Virginia R / Lubbers, Brian V

The Veterinary clinics of North America. Food animal practice

2022 Volume 39, Issue 1, Page(s) 115–128

Abstract: Antimicrobial susceptibility testing (AST) is an important component of antimicrobial stewardship. This article discusses how AST methods and breakpoints are developed, describes when AST may or may not be useful in clinical practice, and discusses how ... ...

Abstract	Antimicrobial susceptibility testing (AST) is an important component of antimicrobial stewardship. This article discusses how AST methods and breakpoints are developed, describes when AST may or may not be useful in clinical practice, and discusses how to interpret AST results from bacterial isolates from cattle, sheep, and goats. Discussion of when AST is not appropriate or when veterinarians should have low confidence in AST results is also included. Applicability of genomic testing for antimicrobial susceptibility is briefly addressed.
MeSH term(s)	Animals ; Cattle ; Sheep ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Microbial Sensitivity Tests/veterinary
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-11-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	286086-7
ISSN	1558-4240 ; 0749-0720
ISSN (online)	1558-4240
ISSN	0749-0720
DOI	10.1016/j.cvfa.2022.09.001
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Article: Surgical Treatment of Developmental Dysplastic Lumbosacral Spondylolisthesis: Additional Help from an Intervertebral Distraction, Correction, and Reduction Device

Lübbers, Thomas / Sandvoss, Gerd / Baalmann, Rainer / Wigt, Peter

Journal of Neurological Surgery Part A: Central European Neurosurgery

2023 Volume 85, Issue 03, Page(s) 322–329

Abstract	Background: In mid- to high-grade adult dysplastic spondylolisthesis, surgeons are faced with three underlying components: angular, translational, and collapse of the disk. In extremely narrow intervertebral spaces, it is difficult to distract and lift the vertebral bodies by the pedicle screw system alone. In this prospective case control study, we analyzed the efficacy of the latest prototypes (distraction, correction, and reduction [DCR] instrument) with intervertebral application in terms of distraction, correction of segmental kyphosis, and slip reduction. Methods: Twelve adult patients (5 male and 7 female patients) were enrolled in this study. The average age was 42 years (range: 17–67 years) and in all cases the maneuver was documented during the surgery. The amount of slip reduction, the lumbosacral angle according to the Spinal Deformity Study Group dysplastic angle (dys-SDGG), and the disk height were measured preoperatively, intraoperatively, 3 months after surgery, and during the latest follow-up (range: 3–44 months). The relative height of the lumbosacral disk was determined in relation to the disk height in L3/L4. Results: Slippage ranged from 17 to 67%. Overall, the average slippage was 45% preoperatively and 4.8% after the reduction maneuver. The average ratio of the disk height was 0.3 preoperatively, 1.0 intraoperatively, and 0.9 at the latest follow-up. Two patients showed significant kyphotic changes, and these patients had an 18- and 21-degree lordotic improvement. From those who had a lumbosacral kyphosis >20 degrees, only one patient did not show any lordotic improvement. All other patients had a significant lordotic improvement. In total, the lumbosacral angle changed from 15 to 23 degrees. Conclusion: The application of an intervertebral distractor with a mobile thigh has a good clinical and radiologic outcome for mid- to high-grade adult dysplastic spondylolisthesis in terms of distraction, kyphosis correction, and reduction of underlying slippage. The described hardware failures and the complications were not related to the DCR device.
Keywords	dysplastic spondylolisthesis ; lumbosacral kyphosis ; reduction of spondylolisthesis ; posterior lumbar interbody fusion
Language	English
Publishing date	2023-05-11
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2651663-9
ISSN	2193-6323 ; 2193-6315
ISSN (online)	2193-6323
ISSN	2193-6315
DOI	10.1055/a-2091-6921
Database	Thieme publisher's database

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Book: Gastroenterologie

Lankisch, Paul G. / Lübbers, H. / Mahlke, R. / Müller, Claus-Heinrich

vom Symptom zur Diagnose : ein Leitfaden für Klinik und Praxis

2015

Institution	Falk Foundation
Author's details	P. G. Lankisch, H. Lübbers, R. Mahlke, C.-H. Müller, Städtisches Klinikum Lüneburg ; Herausgeber Falk Foundation e.V
Subject code	616.33075
Language	German
Size	99 Seiten, Illustrationen, 21 cm
Edition	10. Auflage
Publisher	Falk Foundation e.V
Publishing place	Freiburg
Publishing country	Germany
Document type	Book
Note	Literaturangaben
HBZ-ID	HT019054187
Database	Catalogue ZB MED Medicine, Health

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2016 A 1983	available for loan (reading room)	Lesesaal EG

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Article ; Online: Revision of fluoroquinolone breakpoints used for interpretation of antimicrobial susceptibility testing of canine bacterial isolates.

Papich, Mark G / Gunnett, Lacie A / Lubbers, Brian V

American journal of veterinary research

2023 Volume 84, Issue 11

Abstract: ... susceptible (S), ≤ 0.5 µg/mL, intermediate (I) 1-2 µg/mL, and resistant (R) ≥ 4 µg/mL. The new breakpoints are ... of 20 mg/kg, and R ≥ 0.5 µg/mL. The breakpoints of 0.12 and 0.25 µg/mL represent a new susceptible-dose ... dependent (SDD) category. For marbofloxacin, previous breakpoints were S, ≤ 1 µg/mL, I 2 µg/mL, and R ≥ 4 µg ...

Abstract	The fluoroquinolone antimicrobial agents, enrofloxacin and marbofloxacin, were US Food and Drug Administration (FDA) approved in the United States for use in dogs in 1988 and 1999, respectively. There have been many advances since then concerning the pharmacokinetic-pharmacodynamic (PK-PD) evaluation of fluoroquinolones, and there are data available on the susceptibility of targeted pathogens since the original approval. Using this information, the Clinical and Laboratory Standards Institute (CLSI) Veterinary Antimicrobial Susceptibility Testing Subcommittee (VAST) revised its antimicrobial susceptibility testing breakpoints. The previous breakpoints (used in older editions of CLSI standards) for enrofloxacin in dogs were susceptible (S), ≤ 0.5 µg/mL, intermediate (I) 1-2 µg/mL, and resistant (R) ≥ 4 µg/mL. The new breakpoints are S ≤ 0.06 µg/mL for a dose of 5 mg/kg, 0.12 µg/mL for a dose of 10 mg/kg, 0.25 µg/mL for a high dose of 20 mg/kg, and R ≥ 0.5 µg/mL. The breakpoints of 0.12 and 0.25 µg/mL represent a new susceptible-dose dependent (SDD) category. For marbofloxacin, previous breakpoints were S, ≤ 1 µg/mL, I 2 µg/mL, and R ≥ 4 µg/mL. The new breakpoints are S ≤ 0.12 µg/mL for a dose of 2.8 mg/kg, 0.25 µg/mL for a dose of 5.5 mg/kg (SDD), and R ≥ 0.5 µg/mL. The new breakpoints will be published in the next edition of CLSI-Vet01(S) and deviate considerably from the prior breakpoints. Laboratories are encouraged to revise their testing standards. These changes will likely reduce the unnecessary use of these fluoroquinolones in dogs.
MeSH term(s)	Dogs ; Animals ; Enrofloxacin/pharmacology ; Fluoroquinolones/pharmacology ; Anti-Infective Agents ; Microbial Sensitivity Tests/veterinary ; Anti-Bacterial Agents/pharmacology
Chemical Substances	Enrofloxacin (3DX3XEK1BN) ; Fluoroquinolones ; Anti-Infective Agents ; Anti-Bacterial Agents
Language	English
Publishing date	2023-09-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	390796-x
ISSN	1943-5681 ; 0002-9645
ISSN (online)	1943-5681
ISSN	0002-9645
DOI	10.2460/ajvr.23.07.0159
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Article ; Online: Latent Dirichlet Allocation modeling of environmental microbiomes.

Kim, Anastasiia / Sevanto, Sanna / Moore, Eric R / Lubbers, Nicholas

PLoS computational biology

2023 Volume 19, Issue 6, Page(s) e1011075

Abstract: Interactions between stressed organisms and their microbiome environments may provide new routes for understanding and controlling biological systems. However, microbiomes are a form of high-dimensional data, with thousands of taxa present in any given ... ...

Abstract	Interactions between stressed organisms and their microbiome environments may provide new routes for understanding and controlling biological systems. However, microbiomes are a form of high-dimensional data, with thousands of taxa present in any given sample, which makes untangling the interaction between an organism and its microbial environment a challenge. Here we apply Latent Dirichlet Allocation (LDA), a technique for language modeling, which decomposes the microbial communities into a set of topics (non-mutually-exclusive sub-communities) that compactly represent the distribution of full communities. LDA provides a lens into the microbiome at broad and fine-grained taxonomic levels, which we show on two datasets. In the first dataset, from the literature, we show how LDA topics succinctly recapitulate many results from a previous study on diseased coral species. We then apply LDA to a new dataset of maize soil microbiomes under drought, and find a large number of significant associations between the microbiome topics and plant traits as well as associations between the microbiome and the experimental factors, e.g. watering level. This yields new information on the plant-microbial interactions in maize and shows that LDA technique is useful for studying the coupling between microbiomes and stressed organisms.
MeSH term(s)	Microbiota ; Microbial Interactions ; Phenotype
Language	English
Publishing date	2023-06-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2193340-6
ISSN	1553-7358 ; 1553-734X
ISSN (online)	1553-7358
ISSN	1553-734X
DOI	10.1371/journal.pcbi.1011075
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Article ; Online: OrthoCalc: The six degrees of freedom measurement workflow of rotational and displacement changes for maxilla positioning evaluation.

Gao, Yao / Gu, Yifei / Dessel, Jeroen Van / Lübbers, Heinz-Theo / Tian, Lei / Politis, Constantinus / Bila, Michel / Willaert, Robin / Chen, Xiaojun / Sun, Yi

Computer methods and programs in biomedicine

2024 Volume 247, Page(s) 108083

Abstract: Background: This study is undertaken to establish the accuracy and reliability of OrthoCalc, a 3D application designed for the evaluation of maxillary positioning.: Methods: We registered target virtual planned models, maxillary models from pre- ... ...

Abstract	Background: This study is undertaken to establish the accuracy and reliability of OrthoCalc, a 3D application designed for the evaluation of maxillary positioning. Methods: We registered target virtual planned models, maxillary models from pre-operative and post-operative CT scans, and post-operative intra-oral scans to a common reference system, allowing for digital evaluation. To assess rotational changes, we introduced a novel measurement method based on virtual cuboid models. Displacement errors were calculated based on proposed registration matrices. We also compared OrthoCalc to established commercial medical software as a benchmark. Results: Statistical significance calculated showed no significant differences between OrthoCalc and commercial software. the biggest error of 0.04 degree in rotation change was found in the yaw. A maximum displacement change of 0.75 mm was found in the X direction. Conclusions: Our study validates OrthoCalc as a precise and reliable tool for assessing maxillary position changes with six degrees of freedom in orthognathic surgery, endorsing its clinical utility.
MeSH term(s)	Orthognathic Surgical Procedures/methods ; Maxilla/diagnostic imaging ; Reproducibility of Results ; Workflow ; Software ; Imaging, Three-Dimensional/methods ; Surgery, Computer-Assisted/methods
Language	English
Publishing date	2024-02-16
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632564-6
ISSN	1872-7565 ; 0169-2607
ISSN (online)	1872-7565
ISSN	0169-2607
DOI	10.1016/j.cmpb.2024.108083
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Article: Ein extrem lateraler Bandscheibenvorfall L4/5

Lübbers, Thomas / Baalmann, Rainer / Sandvoss, Gerd

Die Wirbelsäule

2021 Volume 05, Issue 04, Page(s) 259–262

Language	German
Publishing date	2021-01-13
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ISSN	2509-825X ; 2509-8241
ISSN (online)	2509-825X
ISSN	2509-8241
DOI	10.1055/a-1240-9382
Database	Thieme publisher's database

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Article: Using telehealth clinical case vignettes to enhance clinical confidence and competence in veterinary students.

Lubbers, Brian V / Fajt, Virginia R / Teller, Lori M / Apley, Michael D / Stillisano, Jacqueline

Frontiers in veterinary science

2023 Volume 9, Page(s) 1075752

Abstract: Veterinarians contribute substantially to the health of their patients and enhance the communities in which they live. Delivery of veterinary curricula continues to evolve to ensure that veterinary graduates are prepared to meet their professional ... ...

Abstract	Veterinarians contribute substantially to the health of their patients and enhance the communities in which they live. Delivery of veterinary curricula continues to evolve to ensure that veterinary graduates are prepared to meet their professional obligations on Day One of their careers. In this study, veterinary practitioners were recruited to deliver telehealth case rounds to veterinary students at Kansas State University and Texas A&M University. Case discussions were hosted virtually once per month in the 2020-2021 and 2021-2022 academic years for a total of 16 sessions. Each presenting practitioner was instructed to develop a brief presentation for a case routinely seen in their practice, and to discuss important clinical decision points in diagnosis, treatment and management. Cases could also highlight important ethical or communication issues encountered in veterinary medicine. The overall goals of this project were to increase the quantity and diversity of clinical cases to which veterinary students were exposed during their professional training and to evaluate the feasibility and acceptability of telehealth technology as a teaching strategy. Student participants were surveyed to determine the effectiveness of telehealth sessions in increasing overall confidence and competence in case management, and veterinary presenters were surveyed to determine motivations for participating in the project and perceived value of the telehealth sessions. More than 95% of students indicated that participation in telehealth sessions increased their clinical confidence and competence. Presenting practitioners unanimously indicated that they would participate in similar instruction in the future. Recommendations are provided to improve the educational experience for future adopters of telehealth teaching sessions.
Language	English
Publishing date	2023-01-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2834243-4
ISSN	2297-1769
ISSN	2297-1769
DOI	10.3389/fvets.2022.1075752
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