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Article: Usefulness of Cardiac Computed Tomography in Coronary Risk Prediction: A Five-Year Follow-Up of the SPICA Study (Secure Prevention with Imaging of the Coronary Arteries).

Viladés-Medel, David / Dégano, Irene R / Subirana, Isaac / Descalzo, Martin / Padilla, Mireia / Mundet, Xavier / Carreras Costa, Francesc / Alomar Serrallach, Xavier / Camps, Anna / Elosua, Roberto / Marrugat, Jaume / Leta Petracca, Rubén

Journal of clinical medicine

2022 Volume 11, Issue 3

Abstract: Accurate identification of individuals at high coronary risk would reduce acute coronary syndrome incidence and morbi-mortality. We analyzed the effect on coronary risk prediction of adding coronary artery calcification (CAC) and Segment Involvement ... ...

Abstract	Accurate identification of individuals at high coronary risk would reduce acute coronary syndrome incidence and morbi-mortality. We analyzed the effect on coronary risk prediction of adding coronary artery calcification (CAC) and Segment Involvement Score (SIS) to cardiovascular risk factors. This was a prospective cohort study of asymptomatic patients recruited between 2013-2017. All participants underwent a coronary computed tomography angiography to determine CAC and SIS. The cohort was followed-up for a composite endpoint of myocardial infarction, coronary angiography and/or revascularization (median = five years). Discrimination and reclassification of the REGICOR function with CAC/SIS were examined with the Sommer's D index and with the Net reclassification index (NRI). Nine of the 251 individuals included had an event. Of the included participants, 94 had a CAC = 0 and 85 a SIS = 0, none of them had an event. The addition of SIS or of SIS and CAC to the REGICOR risk function significantly increased the discrimination capacity from 0.74 to 0.89. Reclassification improved significantly when SIS or both scores were included. CAC and SIS were associated with five-year coronary event incidence, independently of cardiovascular risk factors. Discrimination and reclassification of the REGICOR risk function were significantly improved by both indexes, but SIS overrode the effect of CAC.
Language	English
Publishing date	2022-01-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11030533
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Article ; Online: A single-center prospective observational study on the effect of trimodal prehabilitation in colorectal surgery.

Mora López, L / Pallisera Llovera, A / Serra-Aracil, X / Serra Pla, S / Lucas Guerrero, V / Rebasa, P / Tremps Domínguez, C / Pujol Caballé, G / Martínez Castela, R / Subirana Giménez, L / Martínez Cabañero, J / Del Pino Zurita, C / Agudo Arcos, C / Carol Boeris, F G / Navarro Soto, S

Cirugia espanola

2020 Volume 98, Issue 10, Page(s) 605–611

Abstract: Introduction: A trimodal prehabilitation protocol was designed with the aim to evaluate whether it contributes to reducing postoperative morbidity, to evaluate the effect of prehabilitation on overall hospital stay, and to analyze the evolution of ... ...

Title translation	Estudio observacional prospectivo unicéntrico sobre el efecto de la prehabilitación trimodal en cirugía colorrectal.
Abstract	Introduction: A trimodal prehabilitation protocol was designed with the aim to evaluate whether it contributes to reducing postoperative morbidity, to evaluate the effect of prehabilitation on overall hospital stay, and to analyze the evolution of functional capacity before and after surgery. Methods: A single-center observational study of patients with colorectal cancer who underwent surgery with curative intent after a trimodal prehabilitation protocol. We collected data for postoperative morbidity according to the Comprehensive Complication Index and hospital stay, which were compared with a historical matrix. Functional capacity data were also collected before and after the application of the prehabilitation protocol. Results: Compared to the historical population, the overall Comprehensive Complication Index was reduced from 13.2 to 11.5, which was statistically significant. Analyzed by morbidity type, all decreased in percentage, although without achieving significance (surgical site infection from 11.7% to 8.4%, nosocomial infection 15.8 to 10% and medical morbidity 8.6% to 4.2%). The overall hospital stay went from 6 to 4 days, and the decrease in the percentage of patients who prepared at home was statistically significant in both cases. Conclusions: Trimodal prehabilitation can contribute to lowering the postoperative morbidity and overall hospital stay of patients undergoing colorectal cancer surgery.
MeSH term(s)	Aged ; Colorectal Neoplasms/rehabilitation ; Colorectal Neoplasms/surgery ; Colorectal Surgery/methods ; Colorectal Surgery/statistics & numerical data ; Cross Infection/epidemiology ; Female ; Humans ; Length of Stay/statistics & numerical data ; Length of Stay/trends ; Male ; Middle Aged ; Morbidity/trends ; Physical Functional Performance ; Physical Therapy Modalities/adverse effects ; Physical Therapy Modalities/statistics & numerical data ; Postoperative Complications/mortality ; Postoperative Complications/prevention & control ; Preoperative Exercise/physiology ; Prospective Studies ; Surgical Wound Infection/epidemiology
Language	Spanish
Publishing date	2020-05-17
Publishing country	Spain
Document type	Comparative Study ; Journal Article ; Observational Study
ISSN	2173-5077
ISSN (online)	2173-5077
DOI	10.1016/j.ciresp.2020.03.023
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Article ; Online: Prospective association of physical activity and inflammatory biomarkers in older adults from the PREDIMED-Plus study with overweight or obesity and metabolic syndrome.

Fuentes, Gabriela Cárdenas / Castañer, Olga / Warnberg, Julia / Subirana, Isaac / Buil-Cosiales, Pilar / Salas-Salvadó, Jordi / Corella, Dolores / Serra-Majem, Lluis / Romaguera, Dora / Estruch, Ramón / Martínez, J Alfredo / Pintó, Xavier / Vázquez, Clotilde / Vidal, Josep / Tur, Josep A / Arós, Fernando / Bullo, Mònica / Fitó, Montserrat / Schröder, Helmut

Clinical nutrition (Edinburgh, Scotland)

2020 Volume 39, Issue 10, Page(s) 3092–3098

Abstract: Background: There is limited prospective evidence on the association between physical activity (PA) and inflammation in older adults. Our aim was to assess the associations between changes in PA and changes in the inflammatory profile in older ... ...

Abstract	Background: There is limited prospective evidence on the association between physical activity (PA) and inflammation in older adults. Our aim was to assess the associations between changes in PA and changes in the inflammatory profile in older individuals who are overweight or obese. Methods: This prospective study included 489 men and women, aged 55-75 years, from the PREDIMED-Plus trial. Levels of interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 18 (IL-18), monocyte chemo-attractant protein-1 (MCP-1), C-peptide, high-sensitivity C-reactive protein (hs-CRP), leptin, and regulated on activation, normal T-cell expressed and secreted chemokine (RANTES) were obtained from fasting blood samples and a composite inflammatory score based on these biomarkers was calculated. Physical activity was measured by a validated questionnaire. All measures were taken at baseline and one-year follow-up. Results: Multiple linear regression models showed an association between an increase in total PA and a decrease in the inflammatory score (p = 0.012), which was particularly driven by a decrease in C-peptide (p = 0.037). Similarly, the inflammatory score decreased with increasing moderate PA (p = 0.001), and moderate-to-vigorous PA (p = 0.006). Conclusions: Increases in total PA, moderate and moderate-to-vigorous PA were associated with a decrease in the inflammatory profile of obese or overweight older individuals. This finding is relevant for PA recommendations and public health strategies. Clinical trial registry: Clinical trial identifier: International Standard Randomized Controlled Trial 89898870.
MeSH term(s)	Age Factors ; Aged ; Biomarkers/blood ; Cytokines/blood ; Diet, Healthy ; Diet, Mediterranean ; Exercise ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Inflammation Mediators/blood ; Male ; Metabolic Syndrome/blood ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/epidemiology ; Metabolic Syndrome/therapy ; Middle Aged ; Obesity/blood ; Obesity/diagnosis ; Obesity/epidemiology ; Obesity/therapy ; Patient Education as Topic ; Prospective Studies ; Risk Assessment ; Risk Factors ; Spain/epidemiology ; Time Factors ; Treatment Outcome
Chemical Substances	Biomarkers ; Cytokines ; Inflammation Mediators
Language	English
Publishing date	2020-02-03
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	604812-2
ISSN	1532-1983 ; 0261-5614
ISSN (online)	1532-1983
ISSN	0261-5614
DOI	10.1016/j.clnu.2020.01.015
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Article ; Online: Structure of a stacked anthraquinone-DNA complex.

De Luchi, Daniela / Usón, Isabel / Wright, Glenford / Gouyette, Catherine / Subirana, Juan A

Acta crystallographica. Section F, Structural biology and crystallization communications

2010 Volume 66, Issue Pt 9, Page(s) 1019–1022

Abstract: The crystal structure of the telomeric sequence d(UBrAGG) interacting with an anthraquinone derivative has been solved by MAD. In all previously studied complexes of intercalating drugs, the drug is usually sandwiched between two DNA base pairs. Instead, ...

Abstract	The crystal structure of the telomeric sequence d(UBrAGG) interacting with an anthraquinone derivative has been solved by MAD. In all previously studied complexes of intercalating drugs, the drug is usually sandwiched between two DNA base pairs. Instead, the present structure looks like a crystal of stacked anthraquinone molecules in which isolated base pairs are intercalated. Unusual base pairs are present in the structure, such as G.G and A.UBr reverse Watson-Crick base pairs.
MeSH term(s)	Anthraquinones/chemistry ; Crystallography, X-Ray ; DNA/chemistry ; Models, Molecular ; Molecular Conformation ; Nucleic Acid Conformation ; Stereoisomerism
Chemical Substances	Anthraquinones ; DNA (9007-49-2)
Language	English
Publishing date	2010-08-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1744-3091
ISSN (online)	1744-3091
DOI	10.1107/S1744309110030034
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Article ; Online: Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes.

Bustamante, M / Danileviciute, A / Espinosa, A / Gonzalez, J R / Subirana, I / Cordier, S / Chevrier, C / Chatzi, L / Grazuleviciene, R / Sunyer, J / Ibarluzea, J / Ballester, F / Villanueva, C M / Nieuwenhuijsen, M / Estivill, X / Kogevinas, M

BJOG : an international journal of obstetrics and gynaecology

2012 Volume 119, Issue 9, Page(s) 1141–1146

Abstract: A nested case-control association study was designed to investigate the influence of maternal and fetal copy number variants (CNVs) on reproductive outcomes. Genotypes of ten CNVs encompassing GST and CYP genes were assessed. Significant associations ... ...

Abstract	A nested case-control association study was designed to investigate the influence of maternal and fetal copy number variants (CNVs) on reproductive outcomes. Genotypes of ten CNVs encompassing GST and CYP genes were assessed. Significant associations were only found for child CNV genotypes. In particular, the child GSTM1 insertion allele was associated with prematurity protection (odds ratio, 95% CI: 0.67, 0.51-0.89; P < 0.01), whereas the child GSTT2B insertion allele was associated with an increased risk of being small for gestational age (odds ratio, 95% CI: 1.33, 1.07-1.67; P = 0.01). The study highlights the role of the fetal genome in prenatal development and also the need to analyse CNVs in a systematic manner.
MeSH term(s)	Case-Control Studies ; Cytochrome P-450 Enzyme System/genetics ; DNA Copy Number Variations/genetics ; Female ; Fetus/enzymology ; Genotype ; Glutathione Transferase/genetics ; Haplotypes ; Humans ; Polymorphism, Single Nucleotide/genetics ; Pregnancy ; Pregnancy Outcome ; Premature Birth/genetics
Chemical Substances	Cytochrome P-450 Enzyme System (9035-51-2) ; GSTT2 protein, human (EC 2.5.1.-) ; Glutathione Transferase (EC 2.5.1.18) ; glutathione S-transferase M1 (EC 2.5.1.18)
Language	English
Publishing date	2012-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2000931-8
ISSN	1471-0528 ; 0306-5456 ; 1470-0328
ISSN (online)	1471-0528
ISSN	0306-5456 ; 1470-0328
DOI	10.1111/j.1471-0528.2012.03400.x
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Article ; Online: Multiple approaches to associations of physical activity and adherence to the Mediterranean diet with all-cause mortality in older adults: the PREvención con DIeta MEDiterránea study.

Cárdenas-Fuentes, Gabriela / Subirana, Isaac / Martinez-Gonzalez, Miguel A / Salas-Salvadó, Jordi / Corella, Dolores / Estruch, Ramon / Fíto, Montserrat / Muñoz-Bravo, Carlos / Fiol, Miguel / Lapetra, José / Aros, Fernando / Serra-Majem, Luis / Tur, Josep A / Pinto, Xavier / Ros, Emilio / Coltell, Oscar / Díaz-López, Andres / Ruiz-Canela, Miguel / Schröder, Helmut

European journal of nutrition

2018 Volume 58, Issue 4, Page(s) 1569–1578

Abstract: Purpose: Although evidence indicates that both physical activity and adherence to the Mediterranean diet (MedDiet) reduce the risk of all-cause mortality, a little is known about optimal intensities of physical activity and their combined effect with ... ...

Abstract	Purpose: Although evidence indicates that both physical activity and adherence to the Mediterranean diet (MedDiet) reduce the risk of all-cause mortality, a little is known about optimal intensities of physical activity and their combined effect with MedDiet in older adults. We assessed the separate and combined associations of leisure-time physical activity (LTPA) and MedDiet adherence with all-cause mortality. Methods: We prospectively studied 7356 older adults (67 ± 6.2 years) at high vascular risk from the PREvención con DIeta MEDiterránea study. At baseline and yearly thereafter, adherence to the MedDiet and LTPA were measured using validated questionnaires. Results: After 6.8 years of follow-up, we documented 498 deaths. Adherence to the MedDiet and total, light, and moderate-to-vigorous LTPA were inversely associated with all-cause mortality (p < 0.01 for all) in multiple adjusted Cox regression models. The adjusted hazard of all-cause mortality was 73% lower (hazard ratio 0.27, 95% confidence interval 0.19-0.38, p < 0.001) for the combined category of highest adherence to the MedDiet (3rd tertile) and highest total LTPA (3rd tertile) compared to lowest adherence to the MedDiet (1st tertile) and lowest total LTPA (1st tertile). Reductions in mortality risk did not meaningfully differ between total, light intensity, and moderate-to-vigorous LTPA. Conclusions: We found that higher levels of LTPA, regardless of intensity (total, light and moderate-to-vigorous), and greater adherence to the MedDiet were associated separately and jointly with lower all-cause mortality. The finding that light LTPA was inversely associated with mortality is relevant because this level of intensity is a feasible option for older adults.
MeSH term(s)	Aged ; Aged, 80 and over ; Cohort Studies ; Diet, Mediterranean/statistics & numerical data ; Exercise ; Female ; Follow-Up Studies ; Geriatric Assessment/statistics & numerical data ; Humans ; Male ; Middle Aged ; Mortality ; Patient Compliance/statistics & numerical data ; Prospective Studies ; Risk Factors ; Spain ; Surveys and Questionnaires
Language	English
Publishing date	2018-04-25
Publishing country	Germany
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	1466536-0
ISSN	1436-6215 ; 1436-6207
ISSN (online)	1436-6215
ISSN	1436-6207
DOI	10.1007/s00394-018-1689-y
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Article ; Online: Detección y cuantificación de la fibrosis miocárdica en la miocardiopatía hipertrófica mediante cardiorresonancia magnética con contraste.

Pujadas, Sandra / Carreras, Francesc / Arrastio, Xabier / Leta, Rubén / Vila, Montserrat / Subirana, María Teresa / Bayés-Genís, Antoni / Pons-Lladó, Guillem

Revista espanola de cardiologia

2007 Volume 60, Issue 1, Page(s) 10–14

Abstract: Introduction and objectives: Severity of hypertrophic cardiomyopathy has been associated with the amount of myocardial fibrosis in autopsy studies. Cardio-vascular magnetic resonance allows, by means of the delayed contrast-enhancement technique, an in ... ...

Title translation	Detection and quantification of myocardial fibrosis in hypertrophic cardiomyopathy by contrast-enhanced cardiovascular magnetic resonance.
Abstract	Introduction and objectives: Severity of hypertrophic cardiomyopathy has been associated with the amount of myocardial fibrosis in autopsy studies. Cardio-vascular magnetic resonance allows, by means of the delayed contrast-enhancement technique, an in vivo detection of focal myocardial fibrosis. Our aim was to study myocardial fibrosis in patients with hypertrophic cardiomyopathy by means of contrast-enhance cardio-vascular magnetic resonance. Methods: 43 patients (30 males; mean age 47 [18] years) were studied by cardio-vascular magnetic resonance. In all patients left ventricular function and mass was analyzed. Total mass of myocardial fibrosis, as identified by delayed contrast-enhancement, was also calculated. Results: In 63% of patients some degree of myocardial delayed contrast-enhancement was observed, total mass of myocardial fibrosis ranging between 1 and 59 g (mean: 17 g). There was a positive correlation between the amount of myocardial fibrosis and the degree of hypertrophy. Maximal wall thickness was higher in patients with myocardial fibrosis (23 [7] vs 18 [4] mm, respectively, P=.04). Familial cases were also more prevalent among this group (48% vs 13%, respectively), as well as conventional clinical risk factors. Conclusions: Myocardial fibrosis as detected by contrast-enhanced cardio-vascular magnetic resonance is highly prevalent in hypertrophic cardiomyopathy patients, particularly in familial cases with severe hypertrophy and associated risk factors.
MeSH term(s)	Cardiomyopathy, Hypertrophic/diagnosis ; Cardiomyopathy, Hypertrophic/pathology ; Contrast Media/pharmacokinetics ; Female ; Fibrosis/diagnosis ; Fibrosis/pathology ; Humans ; Magnetic Resonance Imaging, Cine/methods ; Male ; Middle Aged ; Myocardium/pathology ; Organometallic Compounds/pharmacokinetics ; Statistics, Nonparametric
Chemical Substances	Contrast Media ; Organometallic Compounds ; gadobutrol (1BJ477IO2L)
Language	Spanish
Publishing date	2007-01
Publishing country	Spain
Document type	English Abstract ; Journal Article
ZDB-ID	128925-1
ISSN	1579-2242 ; 0300-8932
ISSN (online)	1579-2242
ISSN	0300-8932
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Article ; Online: Direct-acting antivirals are effective and safe in HCV/HIV-coinfected liver transplant recipients who experience recurrence of hepatitis C: A prospective nationwide cohort study.

Manzardo, Christian / Londoño, Maria C / Castells, LLuís / Testillano, Milagros / Luis Montero, José / Peñafiel, Judit / Subirana, Marta / Moreno, Ana / Aguilera, Victoria / Luisa González-Diéguez, María / Calvo-Pulido, Jorge / Xiol, Xavier / Salcedo, Magdalena / Cuervas-Mons, Valentin / Manuel Sousa, José / Suarez, Francisco / Serrano, Trinidad / Ignacio Herrero, Jose / Jiménez, Miguel /

Fernandez, José R / Giménez, Carlos / Del Campo, Santos / Esteban-Mur, Juan I / Crespo, Gonzalo / Moreno, Asunción / de la Rosa, Gloria / Rimola, Antoni / Miro, Jose M

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2018 Volume 18, Issue 10, Page(s) 2513–2522

Abstract: Direct-acting antivirals have proved to be highly efficacious and safe in monoinfected liver transplant (LT) recipients who experience recurrence of hepatitis C virus (HCV) infection. However, there is a lack of data on effectiveness and tolerability of ... ...

Abstract	Direct-acting antivirals have proved to be highly efficacious and safe in monoinfected liver transplant (LT) recipients who experience recurrence of hepatitis C virus (HCV) infection. However, there is a lack of data on effectiveness and tolerability of these regimens in HCV/HIV-coinfected patients who experience recurrence of HCV infection after LT. In this prospective, multicenter cohort study, the outcomes of 47 HCV/HIV-coinfected LT patients who received DAA therapy (with or without ribavirin [RBV]) were compared with those of a matched cohort of 148 HCV-monoinfected LT recipients who received similar treatment. Baseline characteristics were similar in both groups. HCV/HIV-coinfected patients had a median (IQR) CD4 T-cell count of 366 (256-467) cells/µL. HIV-RNA was <50 copies/mL in 96% of patients. The DAA regimens administered were SOF + LDV ± RBV (34%), SOF + SMV ± RBV (31%), SOF + DCV ± RBV (27%), SMV + DCV ± RBV (5%), and 3D (3%), with no differences between the groups. Treatment was well tolerated in both groups. Rates of SVR (negative serum HCV-RNA at 12 weeks after the end of treatment) were high and similar for coinfected and monoinfected patients (95% and 94%, respectively; P = .239). Albeit not significant, a trend toward lower SVR rates among patients with advanced fibrosis (P = .093) and genotype 4 (P = .088) was observed. In conclusion, interferon-free regimens with DAAs for post-LT recurrence of HCV infection in HIV-infected individuals were highly effective and well tolerated, with results comparable to those of HCV-monoinfected patients.
MeSH term(s)	Antiviral Agents/therapeutic use ; Coinfection/drug therapy ; Coinfection/virology ; Drug Therapy, Combination ; Female ; Follow-Up Studies ; HIV/drug effects ; HIV Infections/drug therapy ; HIV Infections/virology ; Hepacivirus/drug effects ; Hepatitis C/drug therapy ; Hepatitis C/virology ; Humans ; Liver Transplantation/methods ; Male ; Middle Aged ; Prognosis ; Prospective Studies ; Recurrence ; Transplant Recipients
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2018-08-13
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.14996
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Article: Leishmaniasis nasal en paciente HIV+

Grasa, J M / Lorente, J / Crego, F / Naches, S / Subirana, F X / Calderón, J R / Pollán, C / Encarnación, L F / Quesada, P

Acta otorrinolaringologica espanola

2000 Volume 51, Issue 2, Page(s) 169–173

Abstract: Leishmania is currently one of the most clinically important protozoa in otorhinolaryngology. Mediterranean countries, including Spain, have endemic HIV and L. infantum. Dogs are the most important Leishmania reservoir. Leishmaniasis is transmitted ... ...

Title translation	Nasal leishmaniasis in an HIV-positive patient.
Abstract	Leishmania is currently one of the most clinically important protozoa in otorhinolaryngology. Mediterranean countries, including Spain, have endemic HIV and L. infantum. Dogs are the most important Leishmania reservoir. Leishmaniasis is transmitted basically by the bite of infected female Phlebotomus sandflies. Its clinical development depends mainly on the host's cellular immunity (TCD4+ lymphocyte count). About 400 cases of HIV-visceral leishmaniasis have been reported in Spain. However, exclusively cutaneous presentation of HIV-leishmaniasis coinfection has been observed in only 2-3% of cases. We report the case of a female HIV+ patient who developed cutaneous leishmaniasis of the nasal vestibule by L. infantum. The patient was treated satisfactorily with a combination of parenteral Pentostam (sodium stilbogluconate) and periodic intralesional injections of Pentostam. The patient was included in a secondary prophylaxis protocol for visceral leishmaniasis with a monthly dose of Glucantime (meglumine antimoniate) for life.
MeSH term(s)	Animals ; Female ; HIV Seropositivity/complications ; Humans ; Leishmania infantum ; Leishmaniasis/drug therapy ; Leishmaniasis/parasitology ; Middle Aged ; Nasal Obstruction/parasitology ; Nose Diseases/drug therapy ; Nose Diseases/parasitology
Language	Spanish
Publishing date	2000-03
Publishing country	Spain
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	730022-0
ISSN	0001-6519
ISSN	0001-6519
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Article ; Online: Prueba de esfuerzo con función cardiopulmonar en niños operados de cardiopatía congénita. Recomendaciones de ejercicio físico en el ámbito escolar.

Serra-Grima, Ricard / Doñate, Maite / Borrás, Xavier / Rissech, Miquel / Puig, Teresa / Albert, Dimpna C / Bartrons, Joaquim / Gran, Ferran / Manso, Begoña / Ferrer, Queralt / Girona, Josep / Casaldáliga, Jaume / Subirana, Maite

Revista espanola de cardiologia

2011 Volume 64, Issue 9, Page(s) 780–787

Abstract: Introduction and objectives: To analyze and discover if stress testing with exhaled gases in children who have had congenital heart surgery is useful so we could make physical exercise recommendations according to heart disease, type of surgery ... ...

Title translation	Cardiopulmonary stress testing in children who have had congenital heart disease surgery. Physical exercise recommendations during school hours.
Abstract	Introduction and objectives: To analyze and discover if stress testing with exhaled gases in children who have had congenital heart surgery is useful so we could make physical exercise recommendations according to heart disease, type of surgery performed, present hemodynamic state and level of exercise practiced. Methods: Prospective study of 108 children, who performed stress testing with exhaled gases, electrocardiogram monitoring and blood pressure. A questionnaire was used to obtain variables concerning heart disease, surgery, present functional condition and level of exercise practiced. Exercise recommendations were given after stress testing, and after a year 35 patients answered a questionnaire. Results: There were significant differences between lesion severity and heart rate at rest and during effort, systolic pressure at rest and during effort, oxygen uptake, oxygen pulse, carbon dioxide production and test duration. A relationship was observed between level of weekly exercise and greater oxygen uptake and test duration, but this was not observed with the underlying heart disease. We observed that best performance occurred with fast repairing for 59 children with cyanotic heart disease. Increased exercise level was recommended for 48 children. Conclusions: The cardiopulmonary function study allows us to examine the physical performance of children who have had congenital heart surgery and provides us with important data so that we can recommend better physical exercise planning.
MeSH term(s)	Analysis of Variance ; Blood Pressure ; Carbon Dioxide/metabolism ; Cardiac Surgical Procedures ; Child ; Cyanosis/physiopathology ; Electrocardiography ; Exercise ; Exercise Test/methods ; Female ; Heart Defects, Congenital/physiopathology ; Heart Defects, Congenital/surgery ; Heart Rate ; Hemodynamics ; Humans ; Male ; Oxygen Consumption ; Prospective Studies ; Surveys and Questionnaires
Chemical Substances	Carbon Dioxide (142M471B3J)
Language	Spanish
Publishing date	2011-09
Publishing country	Spain
Document type	English Abstract ; Journal Article
ZDB-ID	128925-1
ISSN	1579-2242 ; 0300-8932
ISSN (online)	1579-2242
ISSN	0300-8932
DOI	10.1016/j.recesp.2011.05.007
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