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  1. Article ; Online: Oocyte cryopreservation for non-medical reasons: Ethical and regulatory concerns in China.

    Lanyi, Yu / Xiaomei, Zhai

    Developing world bioethics

    2023  

    Abstract: Assisted reproductive technology is a complex medical intervention with many potential social sensitivities. Within this domain, oocyte cryopreservation has emerged as an important research area for preserving female fertility. Against the backdrop of ... ...

    Abstract Assisted reproductive technology is a complex medical intervention with many potential social sensitivities. Within this domain, oocyte cryopreservation has emerged as an important research area for preserving female fertility. Against the backdrop of the hotly debated first legal case in China of a single woman wishing to freeze her eggs, and the implementation of the 'three-child policy' in China, there is an urgent need to evaluate policies and address ethical considerations surrounding oocyte cryopreservation for non-medical reasons. This review examines current policies, explores China's practices and research, and examines the latest ethical challenges surrounding non-medical oocyte cryopreservation. It develops strategies and recommendations that will be relevant in China and other developing countries seeking to navigate this complex landscape.
    Language English
    Publishing date 2023-08-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2049034-3
    ISSN 1471-8847 ; 1471-8731
    ISSN (online) 1471-8847
    ISSN 1471-8731
    DOI 10.1111/dewb.12418
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5461: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Metabolism of Phenolic Compounds and Antioxidant Activity in Different Tissue Parts of Post-Harvest Chive (

    Dai, Xiaomei / Jia, Chonglei / Lu, Jiaqi / Yu, Zhifang

    Antioxidants (Basel, Switzerland)

    2024  Volume 13, Issue 3

    Abstract: Chive ( ...

    Abstract Chive (
    Language English
    Publishing date 2024-02-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13030279
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Multiple Effects of High Surface Area Hollow Nanospheres Assembled by Nickel Cobaltate Nanosheets on Soluble Lithium Polysulfides.

    Pu, Jun / Zhu, Xiaomei / Wang, Jie / Yu, Shaomeng

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 4

    Abstract: Inhibiting the shuttle effect of soluble polysulfides and improving slow reaction kinetics are key factors for the future development of Li-S batteries. Herein, edelweiss shaped ... ...

    Abstract Inhibiting the shuttle effect of soluble polysulfides and improving slow reaction kinetics are key factors for the future development of Li-S batteries. Herein, edelweiss shaped NiCo
    MeSH term(s) Nanospheres ; Lithium ; Nickel ; Binding Sites
    Chemical Substances polysulfide (9080-49-3) ; Lithium (9FN79X2M3F) ; Nickel (7OV03QG267)
    Language English
    Publishing date 2023-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28041539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  4. Article ; Online: Metformin Increases the Response of Cholangiocarcinoma Cells to Gemcitabine by Suppressing Pyruvate Kinase M2 to Activate Mitochondrial Apoptosis.

    Deng, Haishan / Qian, Xiaomei / Zhang, Yongtao / Yu, Wenlong / Yang, Ping

    Digestive diseases and sciences

    2024  Volume 69, Issue 2, Page(s) 476–490

    Abstract: Background: Cholangiocarcinoma (CCA) is a malignant tumor with a high mortality rate. Resistance to chemotherapy remains a major challenge related to cancer treatment, and increasing the sensitivity of cancer cells to therapeutic drugs is a major focus ... ...

    Abstract Background: Cholangiocarcinoma (CCA) is a malignant tumor with a high mortality rate. Resistance to chemotherapy remains a major challenge related to cancer treatment, and increasing the sensitivity of cancer cells to therapeutic drugs is a major focus of cancer treatment.
    Aims: We purposed to explore the role of Metformin in CCA involved in chemotherapeutic sensitivity and Pyruvate kinase M2 (PKM2) through regulating mitochondrial apoptosis in the present study.
    Methods: CCA cell lines of HCC9810 and RBE were treated with Metformin companied with antagonists or agonists of PKM2, cells sensitivity to Gemcitabine, cell migration and invasion along with apoptosis, which is mediated by JC-1 and LDH were assayed.
    Results: Our results indicated that Metformin and Gemcitabine exhibit synergistic effect on inhibition of cholangiocarcinoma cell viability, cell migration and invasion as well as promotion apoptosis of cholangiocarcinoma cells. In vivo, Metformin combined with Gemcitabine has cooperation in inhibiting the growth of cholangiocarcinoma cell-derived tumors. Moreover, Metformin and Gemcitabine inhibited expression of PKM2 and PDHB in HCC9810 and RBE.
    Conclusion: Our study suggested that Metformin may increase the response of cholangiocarcinoma cells to Gemcitabine by suppressing PKM2 to activate mitochondrial apoptosis.
    MeSH term(s) Humans ; Gemcitabine ; Metformin/pharmacology ; Metformin/therapeutic use ; Pyruvate Kinase/pharmacology ; Pyruvate Kinase/therapeutic use ; Cell Line, Tumor ; Bile Duct Neoplasms/pathology ; Cholangiocarcinoma/pathology ; Apoptosis ; Bile Ducts, Intrahepatic/pathology ; Cell Proliferation
    Chemical Substances Gemcitabine ; Metformin (9100L32L2N) ; Pyruvate Kinase (EC 2.7.1.40)
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-023-08210-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ui V Zs.35: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Odorant Receptors Expressing and Antennal Lobes Architecture Are Linked to Caste Dimorphism in Asian Honeybee,

    Ke, Haoqin / Chen, Yu / Zhang, Baoyi / Duan, Shiwen / Ma, Xiaomei / Ren, Bingzhong / Wang, Yinliang

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: Insects heavily rely on the olfactory system for food, mating, and predator evasion. However, the caste-related olfactory differences ... ...

    Abstract Insects heavily rely on the olfactory system for food, mating, and predator evasion. However, the caste-related olfactory differences in
    MeSH term(s) Bees/genetics ; Animals ; Hymenoptera ; Sex Characteristics ; Cell Communication ; Food ; Receptors, Odorant/genetics
    Chemical Substances Receptors, Odorant
    Language English
    Publishing date 2024-04-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25073934
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  6. Article: [Clinical phenotype and genetic analysis of six Chinese patients affected with Acromicric dysplasia due to variants of FBN1 gene].

    Yu, Meiyan / Liu, Xiaomei / Ran, Ni / Yang, Zhaochuan / Shan, Yanchun

    Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

    2024  Volume 41, Issue 3, Page(s) 271–277

    Abstract: Objective: To retrospectively analyze the clinical and genetic characteristics of six patients with Acromicric dysplasia due to variants of the FBN1 gene.: Methods: Six patients who had visited the Affiliated Hospital of Qingdao University between ... ...

    Abstract Objective: To retrospectively analyze the clinical and genetic characteristics of six patients with Acromicric dysplasia due to variants of the FBN1 gene.
    Methods: Six patients who had visited the Affiliated Hospital of Qingdao University between February 2018 and October 2020 were selected as the study subjects. Clinical data of the patients were collected. High-throughput sequencing was carried out. And candidate variants were verified by Sanger sequencing.
    Results: All of the six patients had presented with severe short stature (< 3s), brachydactyly, short and broad hands and feet. Other manifestations included joint stiffness, facial dysmorphism, delayed bone age, liver enlargement, coracoid femoral head, and lumbar lordosis. Genetic testing revealed that all had harbored heterozygous variants of the FBN1 gene. Patient 1 had harbored a c.5183C>T (p.A1728V) missense variant in exon 42, which had derived from his father (patient 2). Patient 3 had harbored a c.5284G>A (p.G1762S) missense variant in exon 43, which had derived from her mother (patient 4). Patient 5 had harbored a c.5156G>T (p.C1719F) missense variant in exon 42, which was de novo in origin. Patient 6 had harbored a c.5272G>T (p.D1758Y) missense variant in exon 43, which was also de novo in origin. The variants carried by patients 1, 3 and 6 were known to be pathogenic. Based on the guidelines from the American College of Medical Genetics and Genomics (ACMG), the FBN1: c.5156G>T was rated as a pathogenic variant (PS2+PM1+PM2_Supporting +PM5+PP3).
    Conclusion: All of the six patients had severe short stature and a variety of other clinical manifestations, which may be attributed to the variants of the FBN1 gene.
    MeSH term(s) Humans ; Female ; Animals ; Retrospective Studies ; Limb Deformities, Congenital ; Dwarfism ; Phenotype ; China ; Fibrillin-1/genetics ; Adipokines ; Bone Diseases, Developmental
    Chemical Substances FBN1 protein, human ; Fibrillin-1 ; Adipokines
    Language Chinese
    Publishing date 2024-03-06
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1003-9406
    ISSN 1003-9406
    DOI 10.3760/cma.j.cn511734-20221212-00865
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Extramed: Show issues

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  7. Article: Effects of Nifedipine Tablets Combined With Magnesium Sulfate on Blood Coagulation Index, Oxidative Stress, NO and ET-1 Levels in Patients With Pregnancy Hypertension.

    Yu, Xiaomei / Zhou, Qiang

    Frontiers in surgery

    2022  Volume 9, Page(s) 862676

    Abstract: Objective: To explore the effects of nifedipine tablets combined with magnesium sulfate on blood coagulation indexes, oxidative stress and levels of NO and ET-1 in patients with Pregnancy-induced hypertension syndrome (PIH).: Methods: A total of 110 ... ...

    Abstract Objective: To explore the effects of nifedipine tablets combined with magnesium sulfate on blood coagulation indexes, oxidative stress and levels of NO and ET-1 in patients with Pregnancy-induced hypertension syndrome (PIH).
    Methods: A total of 110 patients with hypertension during pregnancy were admitted to our hospital from January 2020 to January 2021. According to the random number table method, 110 patients were divided into the control group and the therapy group, with 55 cases in each group. The blood pressure levels (systolic and diastolic blood pressure), coagulation indexes (TT, PT, APTT, Fib), oxidative stress indexes (LPO, MDA, SOD), vascular endothelial function (ET-1, NO), clinical efficacy and adverse reactions of the two groups were compared.
    Results: After therapy, the systolic blood pressure and diastolic blood pressure of the two groups were significantly decreased, and the therapy group was significantly lower than the control group (
    Conclusion: Nifedipine tablets combined with magnesium sulfate in the treatment of PIH can improve the blood coagulation function of patients, reduce oxidative stress damage, adjust the serum levels of ET-1 and NO, and improve the clinical efficacy.
    Language English
    Publishing date 2022-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.862676
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Reduction of obesity and hepatic adiposity in high-fat diet-induced rats by besunyen slimming tea.

    Yu, Chingwen / Wan, Xiaoning / Li, Dan / Guo, Xiaomei

    Heliyon

    2023  Volume 9, Issue 6, Page(s) e17383

    Abstract: Objective: Obesity is a significant risk factor for metabolic syndrome, type 2 diabetes mellitus, hypertension, nonalcoholic fatty liver disease, and cardiovascular disorders. As a well-known Chinese tea product, Besunyen Slimming Tea (BST) is believed ... ...

    Abstract Objective: Obesity is a significant risk factor for metabolic syndrome, type 2 diabetes mellitus, hypertension, nonalcoholic fatty liver disease, and cardiovascular disorders. As a well-known Chinese tea product, Besunyen Slimming Tea (BST) is believed to effectively reduce body weight (BW) and lipid profile. In this study, we aimed to elucidate the mechanisms and effects of BST on treating obesity and hepatic steatosis using a rat model fed with a high-fat diet (HFD).
    Methods: Sprague-Dawley rats were subjected to random separation into three categories: Animals were fed (1) a normal diet food (ND); (2) HFD, and (3) HFD
    Results: HFD
    Conclusions: The results of this study offer evidence supporting the potential health benefits of BST in the management of metabolic disorders and obesity.
    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e17383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Comments on the Oyster Aquaculture Industry in China: 1985-2020.

    Yu, Shu / Hou, Xiaomei / Huan, Changkun / Mu, Yongtong

    Thalassas : revista de ciencias del mar

    2023  , Page(s) 1–8

    Abstract: Since the 1980s, China's oyster aquaculture has grown quickly in the past four decades, and it became the top mariculture species in China with an annual production of 5.23 million in 2019. Understanding the growth of oyster aquaculture in China is ... ...

    Abstract Since the 1980s, China's oyster aquaculture has grown quickly in the past four decades, and it became the top mariculture species in China with an annual production of 5.23 million in 2019. Understanding the growth of oyster aquaculture in China is important to gain insights into successful long-term production. This paper attempts to decompose China's oyster aquaculture between trends and cycles by means of an HP filter, make a specific identification of the relevant factors according to the Cobb-Douglas production function, to summarize the objective law of yield fluctuations. Results suggest that from 1985 to 2011, China's oyster aquaculture experienced a development stage of "rapid rise - steady development". At this stage, it shows a slow growth trend, and the growth can persist for long periods of time. The improvement of consumption level driven by economic growth is the main facilitating factor to promote the oyster industry, export trade and oyster price are also critical, diseases and disasters did not exert much influence on the growth of China's oyster aquaculture. The biggest problem hindering sustainable development is the tragedy of the commons caused by the limitation of marine resources, the contradiction of development will become a thorny issue.
    Language English
    Publishing date 2023-05-09
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 2383320-8
    ISSN 2366-1674 ; 0212-5919
    ISSN (online) 2366-1674
    ISSN 0212-5919
    DOI 10.1007/s41208-023-00558-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Amorphous bismuth and GO co-doped WO

    Zheng, Jin You / Sun, Qimeng / Yang, Huijing / Yu, Shuang / Li, Mengsi / Yu, Xiaomei / Wang, Chengduo / Liu, Tiantian / Li, Songjie

    Dalton transactions (Cambridge, England : 2003)

    2024  Volume 53, Issue 6, Page(s) 2460–2464

    Abstract: The sol-gel process for fabricating electrochromic thin films is straightforward, offering advantages such as low cost and ease of compositional control. Herein we prepared GO-Bi- ... ...

    Abstract The sol-gel process for fabricating electrochromic thin films is straightforward, offering advantages such as low cost and ease of compositional control. Herein we prepared GO-Bi-WO
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt03805j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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