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  1. Article ; Online: Prevalence and management of proteinuria associated with vascular endothelial growth factor receptor-targeted tyrosine kinase inhibitor treatment in advanced renal cell carcinoma, hepatocellular carcinoma, and thyroid cancer.

    Kato, Taigo / Mizuno, Ryuichi / Miyake, Hideaki

    International journal of urology : official journal of the Japanese Urological Association

    2024  

    Abstract: Vascular endothelial growth factor receptor-targeted tyrosine kinase inhibitors (VEGFR-TKIs) are often used for treatment of several types of cancer; however, they are associated with an increased risk of proteinuria, sometimes leading to treatment ... ...

    Abstract Vascular endothelial growth factor receptor-targeted tyrosine kinase inhibitors (VEGFR-TKIs) are often used for treatment of several types of cancer; however, they are associated with an increased risk of proteinuria, sometimes leading to treatment discontinuation. We searched PubMed and Scopus to identify clinical studies examining the incidence and risk factors for proteinuria caused by VEGFR-TKIs in patients with renal cell carcinoma, thyroid cancer, and hepatocellular carcinoma. The global incidence of proteinuria ranged from 6% to 34% for all grades of proteinuria, and from 1% to 10% for grade ≥3 proteinuria. The incidence of proteinuria did not differ significantly by cancer type, but in all three cancer types, there was a trend toward a higher incidence of proteinuria with lenvatinib than with other VEGFR-TKIs. In terms of risk factors, the incidence of proteinuria was significantly higher among Asians (including Japanese) compared with non-Asian populations. Other risk factors included diabetes mellitus, hypertension, and previous nephrectomy. When grade 3/4 proteinuria occurs, patients should be treated according to the criteria for dose reduction or withdrawal specified for each drug. For grade 2 proteinuria, treatment should be continued when the benefits outweigh the risks. Referral to a nephrologist should be considered for symptoms related to decreased renal function or when proteinuria has not improved after medication withdrawal. These management practices should be implemented universally, regardless of the cancer type.
    Language English
    Publishing date 2024-02-06
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 1328401-0
    ISSN 1442-2042 ; 0919-8172
    ISSN (online) 1442-2042
    ISSN 0919-8172
    DOI 10.1111/iju.15409
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Single-Cell NanoBRET Imaging with Green-Range HaloTag Acceptor.

    Thirukkumaran, Ovia / Mizuno, Hideaki

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2525, Page(s) 207–218

    Abstract: Bioluminescence resonance energy transfer (BRET) has gained impetus to monitor protein interactions in proximity. BRET involves the energy transfer from a bioluminescent donor (luciferases) to a fluorescent acceptor. Since bioluminescence is an intrinsic ...

    Abstract Bioluminescence resonance energy transfer (BRET) has gained impetus to monitor protein interactions in proximity. BRET involves the energy transfer from a bioluminescent donor (luciferases) to a fluorescent acceptor. Since bioluminescence is an intrinsic phenomenon, BRET excludes the need for external illumination and serves as a powerful alternative to fluorescence-based systems. However, BRET has not been widely adopted for single-cell imaging applications, mainly due to the low signal output resulting in poor signal-to-noise ratio. In this chapter, we describe a protocol to optimize spatiotemporal BRET imaging by adopting fluorescent HaloTag acceptors, adapting cell culture conditions and microscopic setup.
    MeSH term(s) Diagnostic Imaging ; Energy Transfer ; Fluorescence Resonance Energy Transfer/methods ; Hydrolases ; Luciferases/metabolism ; Luminescent Measurements/methods
    Chemical Substances Luciferases (EC 1.13.12.-) ; Hydrolases (EC 3.-) ; haloalkane dehalogenase (EC 3.8.1.5)
    Language English
    Publishing date 2022-07-15
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2473-9_15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correction to "Atomic-Scale Observations of Oxygen Release Degradation in Sulfide-Based All-Solid-State Batteries with Layered Oxide Cathodes".

    Kobayashi, Shunsuke / Watanabe, Hideaki / Kato, Takeharu / Mizuno, Fuminori / Kuwabara, Akihide

    ACS applied materials & interfaces

    2023  Volume 15, Issue 5, Page(s) 7635–7637

    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Published Erratum
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c19943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction: Untangling the complexity of market competition in consumer goods - A complex Hilbert PCA analysis.

    Mizuno, Makoto / Aoyama, Hideaki / Fujiwara, Yoshi

    PloS one

    2021  Volume 16, Issue 10, Page(s) e0258600

    Abstract: This corrects the article DOI: 10.1371/journal.pone.0245531.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pone.0245531.].
    Language English
    Publishing date 2021-10-08
    Publishing country United States
    Document type Published Erratum
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0258600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Correction

    Makoto Mizuno / Hideaki Aoyama / Yoshi Fujiwara

    PLoS ONE, Vol 16, Iss 10, p e

    Untangling the complexity of market competition in consumer goods - A complex Hilbert PCA analysis.

    2021  Volume 0258600

    Abstract: This corrects the article DOI:10.1371/journal.pone.0245531.]. ...

    Abstract [This corrects the article DOI:10.1371/journal.pone.0245531.].
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Atomic-Scale Observations of Oxygen Release Degradation in Sulfide-Based All-Solid-State Batteries with Layered Oxide Cathodes.

    Kobayashi, Shunsuke / Watanabe, Hideaki / Kato, Takeharu / Mizuno, Fuminori / Kuwabara, Akihide

    ACS applied materials & interfaces

    2022  Volume 14, Issue 34, Page(s) 39459–39466

    Abstract: All-solid-state batteries exhibit considerable potential for applications in electric vehicles. Understanding and controlling the oxygen release from the layered cathode active material are essential in achieving long-term operation of all-solid-state ... ...

    Abstract All-solid-state batteries exhibit considerable potential for applications in electric vehicles. Understanding and controlling the oxygen release from the layered cathode active material are essential in achieving long-term operation of all-solid-state batteries because the oxygen release degrades the cathode material and the solid electrolyte, triggering capacity degradation. In this study, we verified the specific interface where the oxygen release is accelerated by atomic-scale scanning transmission electron microscopy and electron energy loss spectroscopy analyses. Oxygen release is suppressed at the interface where the LiNbO
    Language English
    Publishing date 2022-08-18
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c06950
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: High-glycemic index meal acutely potentiates blood pressure response to static handgrip exercise in healthy humans.

    Kashima, Hideaki / Endo, Masako Yamaoka / Kanda, Masako / Miura, Akira / Fukuba, Yoshiyuki / Mizuno, Masaki

    Journal of applied physiology (Bethesda, Md. : 1985)

    2023  Volume 135, Issue 3, Page(s) 609–620

    Abstract: Blood glucose levels acutely increase postprandially depending on the type of meal consumed. However, it remains unclear whether postprandial hyperglycemia temporally affects cardiovascular responses to static handgrip exercise (SHG-ex). Thus, this study ...

    Abstract Blood glucose levels acutely increase postprandially depending on the type of meal consumed. However, it remains unclear whether postprandial hyperglycemia temporally affects cardiovascular responses to static handgrip exercise (SHG-ex). Thus, this study aimed to examine whether increased blood glucose induced by consumption of a high-glycemic index (HGI) meal affects pressor response to SHG-ex. A total of 14 healthy participants (7 women and 7 men) consumed an HGI meal, a low-glycemic index (LGI) meal, or no meal (control). Participants performed 30% maximal voluntary contraction SHG-ex followed by a postexercise muscle ischemia (PEMI) test before the meal and 60 min after consuming the meal. Blood glucose, plasma insulin, and plasma triglyceride levels were measured, and the area under the curve until 60 min (AUC
    MeSH term(s) Male ; Young Adult ; Humans ; Female ; Glycemic Index/physiology ; Blood Glucose ; Blood Pressure ; Hand Strength ; Dietary Carbohydrates ; Insulin ; Hyperglycemia ; Postprandial Period ; Cross-Over Studies
    Chemical Substances Blood Glucose ; Dietary Carbohydrates ; Insulin
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 219139-8
    ISSN 1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
    ISSN (online) 1522-1601
    ISSN 0021-8987 ; 0161-7567 ; 8750-7587
    DOI 10.1152/japplphysiol.00703.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.249: Show issues Location:
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  8. Article ; Online: A Case of

    Mizuno, Yuta / Ichikawa, Yasuhiro / Kawai, Shun / Wakamiya, Takuya / Murakami, Hiroaki / Kurosawa, Kenji / Ueda, Hideaki

    CJC pediatric and congenital heart disease

    2022  Volume 1, Issue 6, Page(s) 270–273

    Abstract: NAA10 is an enzyme involved in the N-terminal acetylation of proteins. ...

    Abstract NAA10 is an enzyme involved in the N-terminal acetylation of proteins.
    Language English
    Publishing date 2022-10-07
    Publishing country United States
    Document type Case Reports
    ISSN 2772-8129
    ISSN (online) 2772-8129
    DOI 10.1016/j.cjcpc.2022.10.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Untangling the complexity of market competition in consumer goods-A complex Hilbert PCA analysis.

    Mizuno, Makoto / Aoyama, Hideaki / Fujiwara, Yoshi

    PloS one

    2021  Volume 16, Issue 2, Page(s) e0245531

    Abstract: Today's consumer goods markets are rapidly evolving with significant growth in the number of information media as well as the number of competitive products. In this environment, obtaining a quantitative grasp of heterogeneous interactions of firms and ... ...

    Abstract Today's consumer goods markets are rapidly evolving with significant growth in the number of information media as well as the number of competitive products. In this environment, obtaining a quantitative grasp of heterogeneous interactions of firms and customers, which have attracted interest of management scientists and economists, requires the analysis of extremely high-dimensional data. Existing approaches in quantitative research could not handle such data without any reliable prior knowledge nor strong assumptions. Alternatively, we propose a novel method called complex Hilbert principal component analysis (CHPCA) and construct a synchronization network using Hodge decomposition. CHPCA enables us to extract significant comovements with a time lead/delay in the data, and Hodge decomposition is useful for identifying the time-structure of correlations. We apply this method to the Japanese beer market data and reveal comovement of variables related to the consumer choice process across multiple products. Furthermore, we find remarkable customer heterogeneity by calculating the coordinates of each customer in the space derived from the results of CHPCA. Lastly, we discuss the policy and managerial implications, limitations, and further development of the proposed method.
    MeSH term(s) Beer/economics ; Consumer Behavior ; Economic Competition ; Humans ; Japan ; Marketing
    Language English
    Publishing date 2021-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0245531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pulmonary Vein Stump Thrombosis and Cerebral Infarction after Left Upper Lobectomy.

    Yasuura, Yoshiyuki / Kayata, Hiroyuki / Konno, Hayato / Kojima, Hideaki / Mizuno, Tetsuya / Isaka, Mitsuhiro / Ohde, Yasuhisa

    The Thoracic and cardiovascular surgeon

    2023  Volume 71, Issue 7, Page(s) 589–594

    Abstract: Background: Pulmonary vein stump thrombosis may occur after left upper lobectomy (LUL) and is a potential risk factor for cerebral infarction. However, there are few reports on the role of pulmonary vein stump thrombosis in the development of cerebral ... ...

    Abstract Background: Pulmonary vein stump thrombosis may occur after left upper lobectomy (LUL) and is a potential risk factor for cerebral infarction. However, there are few reports on the role of pulmonary vein stump thrombosis in the development of cerebral infarction. We aimed to clarify the correlation between pulmonary vein stump thrombosis and cerebral infarction following LUL.
    Methods: We evaluated 296 patients who underwent contrast-enhanced computed tomography (CT) after LUL for lung cancer at the Shizuoka Cancer Center Hospital in Shizuoka, Japan, between September 2002 and December 2015. The cerebral infarction in patients with pulmonary vein stump thrombosis was examined, and the risk factors for cerebral infarction were identified via a univariate analysis of the clinicopathological and surgical variables.
    Results: Overall, 179 men and 117 women (median age: 68 years; range: 36-88 years) were included. The median observation period was 68 months. Pulmonary vein stump thrombosis occurred in 21 (7%) patients and cerebral infarction occurred in 15 (5%) patients. None of the 21 patients with pulmonary vein stump thrombosis developed cerebral infarction. Most cerebral infarctions (12/15) were diagnosed in the late phase (> 3 months). The pathological stage of cancer was found to be the only significant risk factor for cerebral infarction by the univariate analysis.
    Conclusion: Pulmonary vein stump thrombosis following LUL was not necessarily associated with cerebral infarction, including the late phase. A prospective observational study with contrast-enhanced chest CT would be required to investigate the risk factors for cerebral infarction in each phase of the postoperative period.
    MeSH term(s) Male ; Humans ; Female ; Aged ; Pulmonary Veins/diagnostic imaging ; Pulmonary Veins/surgery ; Pneumonectomy/adverse effects ; Pneumonectomy/methods ; Retrospective Studies ; Treatment Outcome ; Venous Thrombosis/etiology ; Venous Thrombosis/complications ; Cerebral Infarction/etiology ; Cerebral Infarction/complications ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/surgery
    Language English
    Publishing date 2023-02-03
    Publishing country Germany
    Document type Observational Study ; Journal Article
    ZDB-ID 800050-5
    ISSN 1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
    ISSN (online) 1439-1902
    ISSN 0171-6425 ; 0946-4778 ; 0172-6137
    DOI 10.1055/s-0043-1761274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.186: Show issues Location:
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