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  1. Book ; Thesis: Infection- related complications in paediatric acute lymphoblastic leukemia

    Teshome, Sarah / Simon, Tim-Philipp / Borchmann, Peter

    2020  

    Institution Klinik und Poliklinik für Kinder- und Jugendmedizin
    Author's details vorgelegt von Sarah Teshome ; 1. Gutachterin oder Gutachter: Professor Dr. med. T. Simon, 2. Gutachterin oder Gutachter: Professor Dr. med. P. Borchmann ; aus dem Zentrum für Kinder- und Jugendmedizin der Universität zu Köln, Klinik und Poliklinik für Kinder- und Jugendmedizin
    Subject code 610
    Language German ; English
    Size 80 Seiten, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2020
    Note Zusammenfassung in deutscher und englischer Sprache
    HBZ-ID HT020876859
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2021 D 196 order for loan Magazin

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  2. Book ; Thesis: Einfluss diagnostischer und therapeutischer Strategien zur Reduktion der Organdysfunktion in der Sepsis

    Simon, Tim-Philipp

    2018  

    Author's details vorgelegt von Dr. med. Tim-Philipp Simon
    Language German ; English
    Size II, 113 Blätter, Diagramme
    Publishing place Aachen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Habilitationsschrift, Rheinisch-Westfälische Technische Hochschule Aachen, 2018
    Note Die Habilitationsschrift besteht aus einem Text und 5 Aufsätzen in englischer Sprache
    HBZ-ID HT019761937
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 E 1107 order for loan Magazin

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  3. Book ; Thesis: Entwicklung eines Schilddrüsen-Score zur Semiquantitativen Erfassung der Iod-Anreicherung in der Shcilddrüse bei der 123I-mIBG-Szintigraphie von Patienten mit Neuroblastom oder Ganglioneurom

    David, Christian / Simon, Tim-Philipp / Pfaff, Heinrich Wilhelm

    2020  

    Institution Klinik und Poliklinik für Kinder- und Jugendmedizin
    Author's details vorgelegt von Christian David ; 1. Gutachter: Professor Dr. med. T. Simon, 2. Gutachter: Universitätsprofessor Dr. phil. H. Pfaff ; aus dem Zentrum für Kinder- und Jugendmedizin der Universität zu Köln, Klinik und Poliklinik für Kinder- und Jugendmedizin
    Subject code 610
    Language German ; English
    Size 71 Seiten, Diagramme
    Publishing place Köln
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität zu Köln, 2020
    Note Enthält Sonderabdruck aus Zeitschrift in englischer Sprache
    HBZ-ID HT020562424
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 D 574 order for loan Magazin

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  4. Book ; Online ; Thesis: Analyse extrazellulärer Vesikel in Zusammenhang mit der ARDS-Induktion im Polytrauma-Großtiermodell

    Hauser, Anna-Lena [Verfasser] / Hildebrand, Frank [Akademischer Betreuer] / Simon, Tim-Philipp [Akademischer Betreuer]

    2023  

    Author's details Anna-Lena Hauser ; Frank Hildebrand, Tim-Philipp Simon
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der RWTH Aachen
    Publishing place Aachen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  5. Article ; Online: Haemoglobin value and red blood cell transfusions in prolonged weaning from mechanical ventilation

    Gernot Marx / Michael Dreher / Johannes Bickenbach / Sebastian Johannes Fritsch / Tim-Philipp Simon

    BMJ Open Respiratory Research, Vol 9, Iss

    a retrospective observational study

    2022  Volume 1

    Keywords Medicine ; R ; Diseases of the respiratory system ; RC705-779
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Book ; Thesis: Evaluation der transpulmonalen Doppelindikatormethode zur Messung des Blutvolumens und des Herzzeitvolumens in der Sepsis beim Schwein

    Simon, Tim-Philipp

    2005  

    Author's details vorgelegt von Tim-Philipp Simon
    Language German
    Size 92 Bl. : graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Hannover, Med. Hochsch., Diss., 2005
    HBZ-ID HT014674773
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2006 E 551 order for loan Magazin

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  7. Article ; Online: Haemoglobin value and red blood cell transfusions in prolonged weaning from mechanical ventilation: a retrospective observational study.

    Fritsch, Sebastian Johannes / Dreher, Michael / Simon, Tim-Philipp / Marx, Gernot / Bickenbach, Johannes

    BMJ open respiratory research

    2022  Volume 9, Issue 1

    Abstract: Introduction: The role of haemoglobin (Hb) value and red blood cell (RBC) transfusions in prolonged weaning from mechanical ventilation (MV) is still controversial. Pathophysiological considerations recommend a not too restrictive transfusion strategy, ... ...

    Abstract Introduction: The role of haemoglobin (Hb) value and red blood cell (RBC) transfusions in prolonged weaning from mechanical ventilation (MV) is still controversial. Pathophysiological considerations recommend a not too restrictive transfusion strategy, whereas adverse effects of transfusions are reported. We aimed to investigate the association between Hb value, RBC transfusion and clinical outcome of patients undergoing prolonged weaning from MV.
    Methods: We performed a retrospective, single-centred, observational study including patients being transferred to a specialised weaning unit. Data on demographic characteristics, comorbidities, current and past medical history and the current course of treatment were collected. Weaning failure and mortality were chosen as primary and secondary endpoint, respectively. Differences between transfused and non-transfused patients were analysed. To evaluate the impact of different risk factors including Hb value and RBC transfusion on clinical outcome, a multivariate logistic regression analysis was used.
    Results: 184 patients from a specialised weaning unit were analysed, of whom 36 (19.6%) failed to be weaned successfully. In-hospital mortality was 18.5%. 90 patients (48.9%) required RBC transfusion during the weaning process, showing a significantly lower Hb value (g/L) (86.3±5.3) than the non-transfusion group (95.8±10.5). In the multivariate regression analysis (OR 3.24; p=0.045), RBC transfusion was associated with weaning failure. However, the transfusion group had characteristics indicating that these patients were still in a more critical state of disease.
    Conclusions: In our analysis, the need for RBC transfusion was independently associated with weaning failure. However, it is unclear whether the transfusion itself should be considered an independent risk factor or an additional symptom of a persistent critical patient condition.
    MeSH term(s) Erythrocyte Transfusion/adverse effects ; Hemoglobins/analysis ; Hospital Mortality ; Humans ; Respiration, Artificial/adverse effects ; Retrospective Studies
    Chemical Substances Hemoglobins
    Language English
    Publishing date 2022-06-14
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 2736454-9
    ISSN 2052-4439 ; 2052-4439
    ISSN (online) 2052-4439
    ISSN 2052-4439
    DOI 10.1136/bmjresp-2022-001228
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Proenkephalin A and bioactive adrenomedullin are useful for risk prognostication in cardiac surgery.

    Hill, Aileen / Bergmann, Deborah / Schulte, Janin / Zayat, Rashad / Marx, Gernot / Simon, Tim-Philipp / Mossanen, Jana / Brücken, Anne / Stoppe, Christian

    Frontiers in cardiovascular medicine

    2023  Volume 9, Page(s) 1017867

    Abstract: Introduction: Various clinical scores have been developed to predict organ dysfunction and mortality in patients undergoing cardiac surgery, but outcome prediction may be inaccurate for some patient groups. Proenkephalin A (penKid) and bioactive ... ...

    Abstract Introduction: Various clinical scores have been developed to predict organ dysfunction and mortality in patients undergoing cardiac surgery, but outcome prediction may be inaccurate for some patient groups. Proenkephalin A (penKid) and bioactive adrenomedullin (bio-ADM) have emerged as promising biomarkers correlating with shock and organ dysfunction. This imposes the question of whether they can be used as prognostic biomarkers for risk stratification in the perioperative setting of cardiac surgery.
    Methods: Patients undergoing cardiac surgery were prospectively enrolled in this observational study. PenKid and bio-ADM plasma levels, as well as markers evaluating inflammation and organ dysfunction, were measured at five perioperative time points from before the induction of anesthesia to up to 48 h postoperatively. Clinical data regarding organ dysfunction and patient outcomes were recorded during the intensive care unit (ICU)-stay with a special focus on acute kidney injury (AKI).
    Results: In 136 patients undergoing cardiac surgery, the bio-ADM levels increased and the penKid levels decreased significantly over time. PenKid was associated with chronic kidney disease (CKD), the incidence of AKI, and renal replacement therapy (RRT). Bio-ADM was associated with lactate and the need for vasopressors. PenKid was useful to predict an ICU-length of stay (LOS)>1 day and added prognostic value to the European System for Cardiac Operative Risk Evaluation Score (EuroSCORE) II when measured after the end of cardiopulmonary bypass and 24 h after cardiac surgery. For bio-ADM, the same was true when measured 24 h after surgery. PenKid also added prognostic value to the EuroSCORE II for the combined outcome "ICU length of stay >1 day and in-hospital mortality."
    Conclusion: The combination of preoperative EuroSCORE II and intraoperative measurement of penKid may be more useful to predict a prolonged ICU LOS and increased mortality than EuroSCORE II alone. Bio-ADM correlates with markers of shock. More research is encouraged for early risk stratification and validation of penKid and bio-ADM as a tool involved in clinical decisions, which may enable the early initiation of organ protective strategies.
    Language English
    Publishing date 2023-01-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.1017867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Potential Association between Ribonuclease 1 Dynamics in the Blood and the Outcome in COVID-19 Patients.

    Zechendorf, Elisabeth / Beckers, Christian / Frank, Nadine / Kraemer, Sandra / Neu, Carolina / Breuer, Thomas / Dreher, Michael / Dahl, Edgar / Marx, Gernot / Martin, Lukas / Simon, Tim-Philipp

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: The COVID-19 pandemic caused by the new SARS-CoV-2 coronavirus is the most recent and well-known outbreak of a coronavirus. RNase 1 is a small endogenous antimicrobial polypeptide that possesses antiviral activity against viral diseases. In this study, ... ...

    Abstract The COVID-19 pandemic caused by the new SARS-CoV-2 coronavirus is the most recent and well-known outbreak of a coronavirus. RNase 1 is a small endogenous antimicrobial polypeptide that possesses antiviral activity against viral diseases. In this study, we investigated a potential association between ribonuclease 1 and the outcome in COVID-19 patients and the impact of increased and decreased RNase 1 levels serum during the course of the disease. Therefore, two patient populations, Cohort A (
    Language English
    Publishing date 2023-08-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241512428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Standardized pharmacological management of delirium after on-pump cardiac surgery reduces ICU stay and ventilation in a retrospective pre-post study.

    Deininger, Matthias Manfred / Schnitzler, Stefan / Benstoem, Carina / Simon, Tim-Philipp / Marx, Gernot / Panagiotidis, Despina / Ziles, Dmitrij / Schnoering, Heike / Karasimos, Evangelos / Breuer, Thomas

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 3741

    Abstract: Cardiac surgery patients not only undergo a highly invasive procedure but are at risk for a diversity of postoperative complications. Up to 53% of these patients suffer from postoperative delirium (POD). This severe and common adverse event increases ... ...

    Abstract Cardiac surgery patients not only undergo a highly invasive procedure but are at risk for a diversity of postoperative complications. Up to 53% of these patients suffer from postoperative delirium (POD). This severe and common adverse event increases mortality and prolonged mechanical ventilation and extends the intensive care unit stay. The objective of this study was to test the hypothesis that standardized pharmacological management of delirium (SPMD) may reduce the length of stay in the intensive care unit (ICU), duration of postoperative mechanical ventilation, and the incidence of postoperative complications such as pneumonia or bloodstream infections in on-pump cardiac surgery ICU patients. In this retrospective, single-center observational cohort study, 247 patients were examined between May 2018 to June 2020, who underwent on-pump cardiac surgery, suffered from POD, and received pharmacological POD treatment. 125 were treated before and 122 after SPMD implementation in the ICU. The primary endpoint was a composite outcome, including the length of ICU stay, postoperative mechanical ventilation time, and ICU survival rate. The secondary endpoints were complications including postoperative pneumonia and bloodstream infections. Although the ICU survival rate was not significantly different between both groups, the length of ICU stay (control group: 23 ± 27 days; SPMD group: 16 ± 16 days; p = 0.024) and the duration of mechanical ventilation were significantly reduced in the SPMD-cohort (control group: 230 ± 395 h; SPMD group: 128 ± 268 h; p = 0.022). Concordantly, the pneumonic risk was reduced after SPMD introduction (control group: 44.0%; SPMD group: 27.9%; p = 0.012) as well as the incidence for bloodstream infections (control group: 19.2%; SPMD group: 6.6%; p = 0.004). Standardized pharmacological management of postoperative delirium in on-pump cardiac surgery ICU patients reduced the length of ICU stay and duration of mechanical ventilation significantly, leading to a decrease in pneumonic complications and bloodstream infections.
    MeSH term(s) Humans ; Retrospective Studies ; Emergence Delirium ; Respiration ; Cardiac Surgical Procedures/adverse effects ; Postoperative Complications/drug therapy ; Postoperative Complications/etiology ; Intensive Care Units
    Language English
    Publishing date 2023-03-06
    Publishing country England
    Document type Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-30781-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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