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  1. Article: Engineering cerebral folding in brain organoids.

    Scott, Glen / Huang, Yu

    Neural regeneration research

    2022  Volume 17, Issue 11, Page(s) 2420–2422

    Language English
    Publishing date 2022-04-30
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.335789
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Bioinformatics in MicroRNA research

    Tan, Ming / Huang, Jingshan / Borchert, Glen M. / Dou, Deijing / Huan, Jun (Luke) / Lan, Wenjun / Wu, Bin

    (Methods in molecular biology ; 1617 ; Springer protocols)

    2017  

    Author's details editors Jingshan Huan, Glen M. Borchert, Dejing Dou, Jun (Luke) Huan, Wenjun Lan, Ming Tan, Bin Wu
    Series title Methods in molecular biology ; 1617
    Springer protocols
    Collection
    Keywords miRNA targets ; miR regulation mechanisms ; Non-coding RNAs ; Computational techniques ; Databases
    Subject code 570
    Language English
    Size x, 285 Seiten, Illustrationen, Diagramme, 25.4 cm x 17.8 cm
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT019355234
    ISBN 978-1-4939-7044-5 ; 1-4939-7044-5 ; 9781493970469 ; 1493970461
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1617- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Lessons from CanSpotASF: Moving towards risk-based African Swine Fever surveillance with rule-out testing in Western Canada.

    Christensen, Jette / Huang, Yanyun / Duizer, Glen

    Preventive veterinary medicine

    2024  Volume 226, Page(s) 106196

    Abstract: African swine fewer (ASF) is a serious disease present in Africa, Eurasia, and the Caribbean but not in continental North America. CanSpotASF describes the ASF surveillance in Canada as a phased in approach. The first enhancement to the passive ... ...

    Abstract African swine fewer (ASF) is a serious disease present in Africa, Eurasia, and the Caribbean but not in continental North America. CanSpotASF describes the ASF surveillance in Canada as a phased in approach. The first enhancement to the passive surveillance was the risk-based early detection testing (rule-out testing) where eligible cases were tested for ASF virus (ASFv). The objective was to describe how the eligibility criteria were applied to cases in western Canada. In particular, to assess if cases tested for ASFv had eligible conditions and if pathology cases with eligible conditions were tested for ASFv based on the data collated by Canada West Swine Health Intelligence Network (CWSHIN) from British Columbia, Alberta, Saskatchewan, and Manitoba. The study period was August 2020 to December 2022 and the data included two study laboratories. We found that over 90% of cases tested for ASFv had eligible conditions as defined in CanSpotASF. The eligibility criteria were applied at three stages of the disease investigation process: 1) the clinical presentation in the herd; 2) at the initial laboratory assessment; and 3) the final pathology diagnosis. At the two study laboratories the proportion of all submitted cases (culture, serology, PCR, pathology) tested for ASFv was very low 1%. However, in the pathology cases specifically targeted in CanSpotASF, and the proportion of tested cases was 12%. In addition, for eligible pathology cases (eligible diagnosis or test) the proportion tested was higher 15%. These results indicated that CanSpotASF targeted herds with submissions for pathological examination and to some degree eligible conditions which would be herds with health issues (known or unknown). We interpret this as a first step towards risk-based surveillance with health as the defining factor.
    MeSH term(s) Swine ; Animals ; African Swine Fever/diagnosis ; African Swine Fever/epidemiology ; African Swine Fever Virus ; Africa ; Alberta ; Swine Diseases
    Language English
    Publishing date 2024-04-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 43399-8
    ISSN 1873-1716 ; 0167-5877
    ISSN (online) 1873-1716
    ISSN 0167-5877
    DOI 10.1016/j.prevetmed.2024.106196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 5367: Show issues

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  4. Article ; Online: REPLY.

    Kovalic, Alexander J / Huang, Glen / Thuluvath, Paul J / Satapathy, Sanjaya K

    Hepatology (Baltimore, Md.)

    2021  Volume 73, Issue 5, Page(s) 2080–2081

    Keywords covid19
    Language English
    Publishing date 2021-04-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.31542
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1660: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Granule formation mechanism, key influencing factors, and resource recycling in aerobic granular sludge (AGS) wastewater treatment: A review.

    Liu, Shuli / Zhou, Miao / Daigger, Glen T / Huang, Jianping / Song, Gangfu

    Journal of environmental management

    2023  Volume 338, Page(s) 117771

    Abstract: The high-efficiency and additionally economic benefits generated from aerobic granular sludge (AGS) wastewater treatment have led to its increasing popularity among academics and industrial players. The AGS process can recycle high value-added ... ...

    Abstract The high-efficiency and additionally economic benefits generated from aerobic granular sludge (AGS) wastewater treatment have led to its increasing popularity among academics and industrial players. The AGS process can recycle high value-added biomaterials including extracellular polymeric substances (EPS), sodium alginate-like external polymer (ALE), polyhydroxyfatty acid (PHA), and phosphorus (P), etc., which can serve various fields including agriculture, construction, and chemical while removing pollutants from wastewaters. The effects of various key operation parameters on formation and structural stability of AGS are comprehensively summarized. The degradable metabolism of typical pollutants and corresponding microbial diversity and succession in the AGS wastewater treatment system are also discussed, especially with a focus on emerging contaminants removal. In addition, recent attempts for potentially effective production of high value-added biomaterials from AGS are proposed, particularly concerning improving the yield, quality, and application of these biomaterials. This review aims to provide a reference for in-depth research on the AGS process, suggesting a new alternative for wastewater treatment recycling.
    MeSH term(s) Wastewater ; Sewage/chemistry ; Waste Disposal, Fluid ; Aerobiosis ; Bioreactors
    Chemical Substances Wastewater ; Sewage
    Language English
    Publishing date 2023-03-31
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2023.117771
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7556: Show issues

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  6. Article ; Online: Material biosynthesis, mechanism regulation and resource recycling of biomass and high-value substances from wastewater treatment by photosynthetic bacteria: A review.

    Liu, Shuli / Li, Heng / Daigger, Glen T / Huang, Jianping / Song, Gangfu

    The Science of the total environment

    2022  Volume 820, Page(s) 153200

    Abstract: The environmental-friendly and economic benefits generated from photosynthetic bacteria (PSB) wastewater treatment have attracted significant attention. This process of resource recovery can produce PSB biomass and high-value substances including single ... ...

    Abstract The environmental-friendly and economic benefits generated from photosynthetic bacteria (PSB) wastewater treatment have attracted significant attention. This process of resource recovery can produce PSB biomass and high-value substances including single cell protein, Coenzyme Q
    MeSH term(s) Biomass ; Bioreactors/microbiology ; Gram-Negative Bacteria ; Photosynthesis ; Waste Disposal, Fluid/methods ; Waste Water/chemistry ; Water Purification/methods
    Chemical Substances Waste Water
    Language English
    Publishing date 2022-01-19
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2022.153200
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Granule formation mechanism, key influencing factors, and resource recycling in aerobic granular sludge (AGS) wastewater treatment: A review

    Liu, Shuli / Zhou, Miao / Daigger, Glen T. / Huang, Jianping / Song, Gangfu

    Journal of Environmental Management. 2023 July, v. 338 p.117771-

    2023  

    Abstract: The high-efficiency and additionally economic benefits generated from aerobic granular sludge (AGS) wastewater treatment have led to its increasing popularity among academics and industrial players. The AGS process can recycle high value-added ... ...

    Abstract The high-efficiency and additionally economic benefits generated from aerobic granular sludge (AGS) wastewater treatment have led to its increasing popularity among academics and industrial players. The AGS process can recycle high value-added biomaterials including extracellular polymeric substances (EPS), sodium alginate-like external polymer (ALE), polyhydroxyfatty acid (PHA), and phosphorus (P), etc., which can serve various fields including agriculture, construction, and chemical while removing pollutants from wastewaters. The effects of various key operation parameters on formation and structural stability of AGS are comprehensively summarized. The degradable metabolism of typical pollutants and corresponding microbial diversity and succession in the AGS wastewater treatment system are also discussed, especially with a focus on emerging contaminants removal. In addition, recent attempts for potentially effective production of high value-added biomaterials from AGS are proposed, particularly concerning improving the yield, quality, and application of these biomaterials. This review aims to provide a reference for in-depth research on the AGS process, suggesting a new alternative for wastewater treatment recycling.
    Keywords biocompatible materials ; metabolism ; phosphorus ; polymers ; sludge ; sodium ; value added ; wastewater ; wastewater treatment ; Aerobic granular sludge ; Granulation mechanism ; Structural stability ; High value-added biomaterials ; Resource recycling
    Language English
    Dates of publication 2023-07
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2023.117771
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  8. Article ; Online: Traumatic dorsal spondyloptosis of upper thoracic spine: case report and novel open reduction technique.

    Li, Yingda / Huang, Meng / Manzano, Glen

    British journal of neurosurgery

    2020  , Page(s) 1–5

    Abstract: Traumatic thoracic spondyloptosis represents a rare but potentially catastrophic spinal injury pattern. We present a unique case of a 37-year-old male who suffered a high-thoracic retroloptosis with resultant complete spinal cord injury following a motor ...

    Abstract Traumatic thoracic spondyloptosis represents a rare but potentially catastrophic spinal injury pattern. We present a unique case of a 37-year-old male who suffered a high-thoracic retroloptosis with resultant complete spinal cord injury following a motor vehicle accident. We describe a novel and effective method of open reduction utilising horizontally oriented temporary rods facilitating controlled, sequential sagittal distraction and unlocking, reversal of anteroposterior shear and restoration of alignment. Using our technique, successful reduction and realignment was achieved.
    Language English
    Publishing date 2020-10-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 639029-8
    ISSN 1360-046X ; 0268-8697
    ISSN (online) 1360-046X
    ISSN 0268-8697
    DOI 10.1080/02688697.2020.1828277
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2210: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Prognostic Value of Leukocytosis and Lymphopenia for Coronavirus Disease Severity

    Glen Huang / Alex J. Kovalic / Christopher J. Graber

    Emerging Infectious Diseases, Vol 26, Iss 8, Pp 1839-

    2020  Volume 1841

    Abstract: To evaluate lymphopenia as a marker for coronavirus disease severity, we conducted a meta-analysis of 10 studies. Severe illness was associated with lower lymphocyte and higher leukocyte counts. Using these markers for early identification of patients ... ...

    Abstract To evaluate lymphopenia as a marker for coronavirus disease severity, we conducted a meta-analysis of 10 studies. Severe illness was associated with lower lymphocyte and higher leukocyte counts. Using these markers for early identification of patients with severe disease may help healthcare providers prioritize the need to obtain therapy.
    Keywords 2019 novel coronavirus disease ; coronavirus disease ; COVID-19 ; severe acute respiratory syndrome coronavirus 2 ; SARS-CoV-2 ; viruses ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: RARG S427L attenuates the DNA repair response to doxorubicin in induced pluripotent stem cell-derived cardiomyocytes.

    Huang, Haojun / Christidi, Effimia / Shafaattalab, Sanam / Davis, Margot K / Tibbits, Glen F / Brunham, Liam R

    Stem cell reports

    2022  Volume 17, Issue 4, Page(s) 756–765

    Abstract: Doxorubicin is a commonly used chemotherapeutic drug, but its use is limited by doxorubicin-induced cardiotoxicity (DIC), which can lead to irreversible heart failure and death. A missense variant rs2229774 (p.S427L) in the retinoic acid receptor gamma ( ... ...

    Abstract Doxorubicin is a commonly used chemotherapeutic drug, but its use is limited by doxorubicin-induced cardiotoxicity (DIC), which can lead to irreversible heart failure and death. A missense variant rs2229774 (p.S427L) in the retinoic acid receptor gamma (RARG) gene is associated with increased susceptibility to DIC, but the precise mechanism underlying this association is incompletely understood. We performed molecular dynamic simulations to determine the effect of this variant on RARG structure and then validated these predictions using CRISPR-Cas9-genome-edited, induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). We found that this variant leads to reduced activation of its target genes in response to doxorubicin, including gene pathways involved in DNA repair and consequently an inability to mediate DNA repair after exposure to doxorubicin. Our findings establish a role of RARG p.S427L in attenuating DNA repair in DIC and provide insight into the pathogenesis of this cardiotoxic effect.
    MeSH term(s) Antibiotics, Antineoplastic/pharmacology ; Cardiotoxicity ; DNA Repair ; Doxorubicin/pharmacology ; Humans ; Induced Pluripotent Stem Cells ; Myocytes, Cardiac/metabolism
    Chemical Substances Antibiotics, Antineoplastic ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2022-03-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2022.03.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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