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  1. Article ; Online: Eye-tracking as a tool to evaluate defibrillator handling.

    Buehler, Philipp K / Wendel-Garcia, Pedro David / Hofmaenner, Daniel A

    Resuscitation plus

    2024  Volume 17, Page(s) 100566

    Language English
    Publishing date 2024-03-25
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-5204
    ISSN (online) 2666-5204
    DOI 10.1016/j.resplu.2024.100566
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: "Dosis sola facit venenum"-Evidence for causality in the association between ketamine and cholestatic liver injury.

    Wendel-Garcia, Pedro David / Andermatt, Rea / Bode, Christian / David, Sascha / Stahl, Klaus

    Hepatology international

    2024  

    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2270316-0
    ISSN 1936-0541 ; 1936-0533
    ISSN (online) 1936-0541
    ISSN 1936-0533
    DOI 10.1007/s12072-024-10646-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Low-Dose Anticoagulation to Prevent Intracranial Hemorrhage in COVID-19 Patients under Extracorporeal Membrane Oxygenation Support.

    Wendel-Garcia, Pedro David / Seeliger, Benjamin / Hofmaenner, Daniel / Bode, Christian / Stahl, Klaus / David, Sascha

    American journal of respiratory and critical care medicine

    2024  Volume 209, Issue 7, Page(s) 894–895

    MeSH term(s) Humans ; Extracorporeal Membrane Oxygenation ; COVID-19 ; Intracranial Hemorrhages/chemically induced ; Blood Coagulation ; Anticoagulants/adverse effects ; Retrospective Studies ; Heparin/pharmacology
    Chemical Substances Anticoagulants ; Heparin (9005-49-6)
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Letter
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202311-2090LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Eye-tracking during newborn intubations.

    Buehler, Philipp K / Wendel-Garcia, Pedro David / Hofmaenner, Daniel A

    Pediatric research

    2023  Volume 94, Issue 2, Page(s) 418–419

    MeSH term(s) Infant, Newborn ; Humans ; Eye-Tracking Technology ; Intubation, Intratracheal
    Language English
    Publishing date 2023-04-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-023-02630-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Current clinical practice in using adjunctive extracorporeal blood purification in sepsis and septic shock: results from the ESICM "EXPLORATION" survey.

    Stahl, Klaus / Bode, Christian / Seeliger, Benjamin / Wendel-Garcia, Pedro David / David, Sascha

    Intensive care medicine experimental

    2024  Volume 12, Issue 1, Page(s) 5

    Abstract: Background: Despite a lack of clear evidence extracorporeal blood purification (EBP) is increasingly used as an adjunctive treatment in septic shock based on its biological plausibility. However, current state of praxis and believes in both efficacy and ...

    Abstract Background: Despite a lack of clear evidence extracorporeal blood purification (EBP) is increasingly used as an adjunctive treatment in septic shock based on its biological plausibility. However, current state of praxis and believes in both efficacy and level of evidence are very heterogeneous.
    Methods: The "EXPLORATION" (Current Clinical Practice in using adjunctive extracorporeal blood purification in septic shock), a web-based survey endorsed by the European Society of Intensive Care Medicine (ESICM), questioned both the current local clinical practices as well as future perspectives of EBP in sepsis and septic shock.
    Results: One hundred and two people participated in the survey. The majority of three quarters of participants (74.5%) use adjunctive EBP in their clinical routine with a varying frequency of description. Unselective cytokine adsorption (CA) (37.5%) and therapeutic plasma exchange (TPE) (34.1%) were by far the most commonly used modalities. While the overall theoretical rational was found to be moderate to high by the majority of the participants (74%), the effectively existing clinical evidence was acknowledged to be rather low (66%). Although CA was used most frequently in clinical practice, both the best existing clinical evidence endorsing its current use (45%) as well the highest potential to be explored in future clinical trials (51.5%) was attributed to TPE.
    Conclusions: Although the majority of participants use EBP techniques in their clinical practice and acknowledge a subjective good theoretical rationale behind it, the clinical evidence is assessed to be limited. While both CA and TPE are by far the most common used technique, both clinical evidence as well as future potential for further exploration in clinical trials was assessed to be the highest for TPE.
    Language English
    Publishing date 2024-01-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2740385-3
    ISSN 2197-425X
    ISSN 2197-425X
    DOI 10.1186/s40635-023-00592-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Effect of vertical stopcock position on start-up fluid delivery in syringe pumps used for microinfusions.

    Weiss, Markus / Wendel-Garcia, Pedro David / Grass, Beate / Kleine-Brueggeney, Maren

    Journal of clinical monitoring and computing

    2024  

    Abstract: The purpose of this in vitro study was to evaluate the impact of the vertical level of the stopcock connecting the infusion line to the central venous catheter on start-up fluid delivery in microinfusions. Start-up fluid delivery was measured under ... ...

    Abstract The purpose of this in vitro study was to evaluate the impact of the vertical level of the stopcock connecting the infusion line to the central venous catheter on start-up fluid delivery in microinfusions. Start-up fluid delivery was measured under standardized conditions with the syringe outlet and liquid flow sensors positioned at heart level (0 cm) and exposed to a simulated CVP of 10 mmHg at a set flow rate of 1 ml/h. Flow and intraluminal pressures were measured with the infusion line connected to the stopcock primarily placed at vertical levels of 0 cm, + 30 cm and - 30 cm or primarily placed at 0 cm and secondarily, after connecting the infusion line, displaced to + 30 cm and - 30 cm. Start-up fluid delivery 10 s after opening the stopcock placed at zero level and after opening the stopcock primarily connected at zero level and secondary displaced to vertical levels of + 30 cm and - 30 cm were similar (- 10.52 [- 13.85 to - 7.19] µL; - 8.84 [- 12.34 to - 5.33] µL and - 11.19 [- 13.71 to - 8.67] µL (p = 0.469)). Fluid delivered at 360 s related to 65% (zero level), 71% (+ 30 cm) and 67% (- 30 cm) of calculated infusion volume (p = 0.395). Start-up fluid delivery with the stopcock primarily placed at + 30 cm and - 30 cm resulted in large anterograde and retrograde fluid volumes of 34.39 [33.43 to 35.34] µL and - 24.90 [- 27.79 to - 22.01] µL at 10 s, respectively (p < 0.0001). Fluid delivered with the stopcock primarily placed at + 30 cm and - 30 cm resulted in 140% and 35% of calculated volume at 360 s, respectively (p < 0.0001). Syringe infusion pumps should ideally be connected to the stopcock positioned at heart level in order to minimize the amounts of anterograde and retrograde fluid volumes after opening of the stopcock.
    Language English
    Publishing date 2024-04-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1418733-4
    ISSN 1573-2614 ; 1387-1307 ; 0748-1977
    ISSN (online) 1573-2614
    ISSN 1387-1307 ; 0748-1977
    DOI 10.1007/s10877-024-01156-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The authors reply.

    Seeliger, Benjamin / Stahl, Klaus / Wendel-Garcia, Pedro David / Hofmaenner, Daniel / Bode, Christian / David, Sascha

    Critical care medicine

    2022  Volume 50, Issue 7, Page(s) e651–e652

    Language English
    Publishing date 2022-06-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The authors reply.

    Seeliger, Benjamin / Stahl, Klaus / Wendel-Garcia, Pedro David / Hofmaenner, Daniel / Bode, Christian / David, Sascha

    Critical care medicine

    2022  Volume 50, Issue 9, Page(s) e723–e724

    Language English
    Publishing date 2022-08-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000005599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Where is the imperceptible difference?

    Wendel-Garcia, Pedro D / Seeliger, Benjamin / Stahl, Klaus / Bode, Christian / David, Sascha

    Intensive care medicine

    2022  Volume 48, Issue 7, Page(s) 975–976

    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-022-06710-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Carboxyhemoglobin predicts oxygenator performance and imminent oxygenator change in extracorporeal membrane oxygenation.

    Erlebach, Rolf / Buhlmann, Alix / Andermatt, Rea / Seeliger, Benjamin / Stahl, Klaus / Bode, Christian / Schuepbach, Reto / Wendel-Garcia, Pedro David / David, Sascha

    Intensive care medicine experimental

    2024  Volume 12, Issue 1, Page(s) 41

    Abstract: Background: The continuous exposure of blood to a non-biological surface during extracorporeal membrane oxygenation (ECMO) may lead to progressive thrombus formation in the oxygenator, hemolysis and consequently impaired gas exchange. In most centers ... ...

    Abstract Background: The continuous exposure of blood to a non-biological surface during extracorporeal membrane oxygenation (ECMO) may lead to progressive thrombus formation in the oxygenator, hemolysis and consequently impaired gas exchange. In most centers oxygenator performance is monitored only on a once daily basis. Carboxyhemoglobin (COHb) is generated upon red cell lysis and is routinely measured with any co-oximetry performed to surveille gas exchange and acid-base homeostasis every couple of hours. This retrospective cohort study aims to evaluate COHb in the arterial blood gas as a novel marker of oxygenator dysfunction and its predictive value for imminent oxygenator change.
    Results: Out of the 484 screened patients on ECMO 89, cumulatively requiring 116 oxygenator changes within 1833 patient days, including 19,692 arterial COHb measurements were analyzed. Higher COHb levels were associated with lower post-oxygenator pO
    Conclusion: COHb correlates with oxygenator performance and can be predictive of imminent oxygenator change. Therefore, longitudinal measurements of COHb in clinical routine might be a cheap and more granular candidate for ECMO surveillance that should be further analyzed in a controlled prospective trial design.
    Language English
    Publishing date 2024-04-24
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2740385-3
    ISSN 2197-425X
    ISSN 2197-425X
    DOI 10.1186/s40635-024-00626-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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