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Article ; Online: Reply to M.S. Rajagopalan et al and P.G. Rose.

Morice, Philippe / Gouy, Sebastien / Querleu, Denis / Leblanc, Eric

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2014 Volume 32, Issue 4, Page(s) 358–359

MeSH term(s)	Female ; Humans ; Positron-Emission Tomography/methods ; Uterine Cervical Neoplasms/diagnostic imaging ; Uterine Cervical Neoplasms/therapy
Language	English
Publishing date	2014-02-01
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.2013.53.7191
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 650: Show issues

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Article ; Online: Keratitis-Ichthyosis-Deafness Syndrome: Early Death Caused by the GJB2 Mutation p.Gly12Arg.

Godillot, Clothilde / Severino-Freire, Maella / Michaud, Vincent / Boralevi, Franck / Labrèze, Christine / Guigonis, Vincent / Onnis, Giuliana / Morice-Picard, Fanny / Mazereeuw-Hautier, Juliette

Acta dermato-venereologica

2019 Volume 99, Issue 10, Page(s) 921–922

MeSH term(s)	Child ; Connexins/genetics ; Deafness/diagnosis ; Deafness/genetics ; Deafness/therapy ; Disease Progression ; Fatal Outcome ; Genetic Predisposition to Disease ; Humans ; Ichthyosis/diagnosis ; Ichthyosis/genetics ; Ichthyosis/therapy ; Keratitis/diagnosis ; Keratitis/genetics ; Keratitis/therapy ; Male ; Mutation ; Phenotype
Chemical Substances	Connexins ; GJB2 protein, human
Language	English
Publishing date	2019-05-16
Publishing country	Sweden
Document type	Case Reports
ZDB-ID	80007-7
ISSN	1651-2057 ; 0001-5555
ISSN (online)	1651-2057
ISSN	0001-5555
DOI	10.2340/00015555-3218
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Ui VI Zs.101: Show issues

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Article ; Online: Hereditary Mucoepithelial Dysplasia Results from Heterozygous Variants at p.Arg557 Mutational Hotspot in SREBF1, Encoding a Transcription Factor Involved in Cholesterol Homeostasis.

Morice-Picard, Fanny / Michaud, Vincent / Lasseaux, Eulalie / Rezvani, Hamid Reza / Plaisant, Claudio / Bessis, Didier / Leauté-Labrèze, Christine / Arveiler, Benoit / Taieb, Alain / Trimouille, Aurélien / Boralevi, Franck

The Journal of investigative dermatology

2019 Volume 140, Issue 6, Page(s) 1289–1292.e2

MeSH term(s)	Alopecia/diagnosis ; Alopecia/genetics ; Alopecia/metabolism ; Alopecia/pathology ; Arginine/genetics ; Cholesterol/metabolism ; DNA Mutational Analysis ; Female ; Heterozygote ; Humans ; Keratosis/diagnosis ; Keratosis/genetics ; Keratosis/metabolism ; Keratosis/pathology ; Lipid Metabolism/genetics ; Male ; Mucous Membrane/metabolism ; Mucous Membrane/pathology ; Mutation ; Pedigree ; Polymorphism, Single Nucleotide ; Skin/pathology ; Skin Abnormalities/diagnosis ; Skin Abnormalities/genetics ; Skin Abnormalities/metabolism ; Skin Abnormalities/pathology ; Sterol Regulatory Element Binding Protein 1/genetics ; Sterol Regulatory Element Binding Protein 1/metabolism
Chemical Substances	SREBF1 protein, human ; Sterol Regulatory Element Binding Protein 1 ; Arginine (94ZLA3W45F) ; Cholesterol (97C5T2UQ7J)
Language	English
Publishing date	2019-11-29
Publishing country	United States
Document type	Letter
ZDB-ID	80136-7
ISSN	1523-1747 ; 0022-202X
ISSN (online)	1523-1747
ISSN	0022-202X
DOI	10.1016/j.jid.2019.10.014
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Ui VI Zs.124: Show issues

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Article ; Online: Reply to 'Rituximab in CD20 positive multiple myeloma' by P Moreau et al.

Greipp, P T / Kapoor, P / Morice, W G / Witzig, T E / Greipp, P R

Leukemia

2008 Volume 22, Issue 1, Page(s) 214–215

MeSH term(s)	Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Murine-Derived ; Antigens, CD20/metabolism ; Antineoplastic Agents/therapeutic use ; Gene Expression Regulation, Neoplastic/immunology ; Humans ; Multiple Myeloma/drug therapy ; Multiple Myeloma/immunology ; Rituximab
Chemical Substances	Antibodies, Monoclonal ; Antibodies, Monoclonal, Murine-Derived ; Antigens, CD20 ; Antineoplastic Agents ; Rituximab (4F4X42SYQ6)
Language	English
Publishing date	2008-01
Publishing country	England
Document type	Comment ; Letter
ZDB-ID	807030-1
ISSN	1476-5551 ; 0887-6924
ISSN (online)	1476-5551
ISSN	0887-6924
DOI	10.1038/sj.leu.2404972
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Zs.A 2295: Show issues

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Article: Characterization of mitotane (o,p'-DDD)--cyclodextrin inclusion complexes: phase-solubility method and NMR.

Alfonsi, R / Attivi, D / Astier, A / Socha, M / Morice, S / Gibaud, S

Annales pharmaceutiques francaises

2013 Volume 71, Issue 3, Page(s) 186–192

Abstract: ... experiments. To elucidate the inclusion mechanism, o,p'-DDD was compared to its regioisomer (i.e. p,p'-DDD ... Mitotane (o,p'-dichlorodimethyl dichloroethane [o,p'-DDD]) is used for the treatment ...

Abstract	Mitotane (o,p'-dichlorodimethyl dichloroethane [o,p'-DDD]) is used for the treatment of adrenocortical cancer and occasionally Cushing's syndrome. This drug is very poorly soluble in water, and following oral administration, approximately 60% of the dose is recovered in the feces unaltered. The preparation of a soluble formulation (i.e. by complexation with cyclodextrins) with improved bioavailability is the aim of this work. The inclusion of mitotane in methyl-ß-cyclodextrins was studied using both phase-solubility methods and NMR experiments. To elucidate the inclusion mechanism, o,p'-DDD was compared to its regioisomer (i.e. p,p'-DDD). It was demonstrated that two dimethyl-ß-cyclodextrins (DMßCD) can complex with the aromatic rings. From the phase-solubility diagrams, we observe that both cases are very different: K(1:1) is between 37 000 and 85 000 mol.l(-1), whereas K(1:2) is between 5.3 and 32 mol.l(-1). The NMR experiments confirmed the inclusion but it also gave an insight into the kinetics of the dissociation: the ortho-chloro moiety is in slow exchange on the NMR time scale, whereas the para-chloro moiety is in fast exchange rate.
MeSH term(s)	Algorithms ; Antineoplastic Agents/chemistry ; Cyclodextrins/chemistry ; Freeze Drying ; Magnetic Resonance Spectroscopy ; Mitotane/chemistry ; Solubility
Chemical Substances	Antineoplastic Agents ; Cyclodextrins ; Mitotane (78E4J5IB5J)
Language	English
Publishing date	2013-05
Publishing country	France
Document type	Journal Article
ZDB-ID	307-4
ISSN	0003-4509
ISSN	0003-4509
DOI	10.1016/j.pharma.2013.02.001
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Zs.A 223: Show issues

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Article: Inhibitory effect of the substance P and its derivative on erythropoietin-independent growth of erythroid progenitors in polycythemia vera.

Le Gall, Christelle / Ianotto, Jean-Christophe / Hardy, Elisabeth / Ugo, Valérie / Eveillard, Jean-Richard / Ngo-Sack, Françoise / Bourquard, Pascal / Morice, Patrick / Berthou, Christian

Leukemia research

2008 Volume 32, Issue 5, Page(s) 743–754

Abstract: Regulation of normal hematopoiesis by neuropeptide substance P (SP) and its amino terminal fragment ...

Abstract	Regulation of normal hematopoiesis by neuropeptide substance P (SP) and its amino terminal fragment, SP(1-4), has been reported. Endogenous erythroid colony (EEC) formation without erythropoietin is characteristic of polycythemia vera (PV), a chronic myeloproliferative disorder. We investigated the effect(s) of SP and SP(1-4) on EEC formation from PV BM mononuclear cells (BMMCs) and purified CD36+ erythroid progenitors. We found a potent in vitro inhibitory effect of SP and SP(1-4) on PV EEC formation for both BMMCs and CD36+ erythroid progenitors. The influence of SP and SP(1-4) on PV progenitor erythroid differentiation and cell viability was also investigated, and the impact of neurokinin receptors and G proteins in the inhibition were analyzed by quantitative PCR and with specific inhibitors. This progenitor inhibition was: (1) not mediated by accessory cells; (2) characterized by an increase in cell death and inhibition of the EPOindependent terminal erythroid differentiation; and (3) not mediated by the same neurokinin receptor. NK-1R and NK-2R antagonists completely abrogated the SP inhibitory effect but not SP(1-4)-induced inhibition. Furthermore, the truncated form of the NK-1R was predominant over the full-length mRNA and could mediated the SP inhibitory effect on PV CD36+ erythroid progenitors. Different G proteins were also implicated according to the erythroid differentiation stage of the PV cells. The observation of an inhibitory effect of SP and its related peptide, SP(1-4), on PV EEC formation at physiological concentrations (10-8M) suggests that neuropeptides represent a way to downregulate pathologic expansion of PV progenitors.
MeSH term(s)	Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Erythroid Precursor Cells/drug effects ; Erythroid Precursor Cells/physiology ; Erythropoietin/physiology ; GTP-Binding Proteins/physiology ; Humans ; Peptide Fragments/pharmacology ; Polycythemia Vera/blood ; Polycythemia Vera/drug therapy ; RNA, Messenger/analysis ; Receptors, Tachykinin/genetics ; Substance P/pharmacology
Chemical Substances	Peptide Fragments ; RNA, Messenger ; Receptors, Tachykinin ; Erythropoietin (11096-26-7) ; Substance P (33507-63-0) ; substance P (1-4) (69355-89-1) ; GTP-Binding Proteins (EC 3.6.1.-)
Language	English
Publishing date	2008-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752396-8
ISSN	1873-5835 ; 0145-2126
ISSN (online)	1873-5835
ISSN	0145-2126
DOI	10.1016/j.leukres.2007.09.011
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Zs.A 1321: Show issues

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Article ; Online: CHIP : l’âge de raison.

Evrard, Serge / Morice, Philippe

Bulletin du cancer

2023 Volume 111, Issue 3, Page(s) 237–238

Title translation	HIPEC: The age of reason.
MeSH term(s)	Humans ; Hyperthermic Intraperitoneal Chemotherapy ; Combined Modality Therapy ; Chemotherapy, Adjuvant ; Hyperthermia, Induced
Language	French
Publishing date	2023-05-12
Publishing country	France
Document type	Editorial
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2023.04.002
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Article ; Online: A multi-scale analysis of basketball throw in virtual reality for tracking perceptual-motor expertise.

Soltani, Pooya / Morice, Antoine H P

Scandinavian journal of medicine & science in sports

2022 Volume 33, Issue 2, Page(s) 178–188

Abstract: To benefit from virtual reality (VR) as a complementary tool for training, coaches must determine the proper tools and variables for tracking sports performance. We explored the basketball shooting at several scales (basket-ball, ball-player, and player ... ...

Abstract	To benefit from virtual reality (VR) as a complementary tool for training, coaches must determine the proper tools and variables for tracking sports performance. We explored the basketball shooting at several scales (basket-ball, ball-player, and player systems) by monitoring success-rate, and ball and body kinematics. We measured how these scales of analysis allowed tracking players' expertise and perceptual sensitivity to basket distance. Experienced and novice players were instructed to naturally throw and swish an instrumented ball in a stereoscopically rendered virtual basket. We challenged their perceptual-motor systems by manipulating the distance of the virtual basket while keeping the surrounding environment unchanged. The success-rate accounted for the players' shooting adjustments to the manipulation of basket distance and allowed tracking their expertise. Ball kinematics also reflected the manipulation of distance and allowed detecting gender, but did not reflect the players' expertise. Finally, body kinematics variables did not echo players' adjustments to the distance manipulation but reflected their expertise and gender. The results gained at each scale of analysis are discussed with regard to the simulator's construct, biomechanical, and psychological fidelity.
MeSH term(s)	Humans ; Basketball ; Athletic Performance/psychology ; Biomechanical Phenomena ; Virtual Reality
Language	English
Publishing date	2022-11-18
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1077418-x
ISSN	1600-0838 ; 0905-7188
ISSN (online)	1600-0838
ISSN	0905-7188
DOI	10.1111/sms.14250
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Zs.A 3247: Show issues

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Article ; Online: Reply: Saving the Kidneys Takes a Village.

Garot, Philippe / Morice, Marie-Claude

JACC. Cardiovascular interventions

2022 Volume 15, Issue 21, Page(s) 2231

MeSH term(s)	Humans ; Treatment Outcome ; Kidney
Language	English
Publishing date	2022-08-31
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2022.09.041
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Zs.A 6669: Show issues

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Article ; Online: Immunothérapies validées en oncogynécologie.

Nay, Paula / Morice, Philippe / Blanc-Durand, Felix

Bulletin du cancer

2023 Volume 110, Issue 4, Page(s) 395–401

Abstract: Immune checkpoint inhibitors have deeply changed treatment paradigm of many tumor types, notably by providing long-term remissions, even in the metastatic setting. These immunotherapies aim to restore T-cells activity against tumour cells, in particular ... ...

Title translation	Immunotherapy in oncogynaecology.
Abstract	Immune checkpoint inhibitors have deeply changed treatment paradigm of many tumor types, notably by providing long-term remissions, even in the metastatic setting. These immunotherapies aim to restore T-cells activity against tumour cells, in particular via the inhibition of PD1/PD-L1 interaction. As for lung or renal carcinomas, and melanomas, the management of endometrial and uterine cervical cancers has been disrupted by PD1/PD-L1 inhibitors efficacy. In locally advanced or metastatic cervical carcinomas, the combination of platinum-based chemotherapy with pembrolizumab demonstrated improved overall and progression-free survival in all subgroups of patients, and became the new standard of care. Regarding endometrial cancers, while single-agent immunotherapies have shown very limited activity in an unselected population, dostarlimab and pembrolizumab have been associated with remarkable antitumor activity in case of microsatellite instability (dMMR/MSI), detected in around 30% of patients. Finally, in endometrial cancer that has progressed after first-line chemotherapy, the association of pembrolizumab with an oral antiangiogenic kinase inhibitor (lenvatinib) has demonstrated its superiority over second-line chemotherapy regimens, regardless molecular subgroups, and has become the new standard of care in this indication.
MeSH term(s)	Female ; Humans ; Antineoplastic Agents/therapeutic use ; Melanoma/drug therapy ; Brain Neoplasms/drug therapy ; Endometrial Neoplasms/drug therapy ; Immune Checkpoint Inhibitors/therapeutic use ; Immunotherapy ; Microsatellite Instability
Chemical Substances	Antineoplastic Agents ; Immune Checkpoint Inhibitors
Language	French
Publishing date	2023-02-08
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2023.01.004
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