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  1. Article: Iron deficiency in heart failure: diagnosis and clinical implications.

    Del Pinto, Rita / Ferri, Claudio

    European heart journal supplements : journal of the European Society of Cardiology

    2022  Volume 24, Issue Suppl I, Page(s) I96–I99

    Abstract: Iron deficiency is a widely prevalent finding in patients with heart failure, observed on average in 50% of outpatients and up to 80% of acute patients, regardless of the ejection fraction and the presence of anaemia, being an independent predictor of ... ...

    Abstract Iron deficiency is a widely prevalent finding in patients with heart failure, observed on average in 50% of outpatients and up to 80% of acute patients, regardless of the ejection fraction and the presence of anaemia, being an independent predictor of worst functional capacity and reduced survival. The definition of iron deficiency in heart failure considers the state of chronic inflammation that characterizes the pathology, recognizing a discriminating role for transferrin saturation. The studies conducted so far, which focused on the patient with heart failure with at least moderately reduced ejection fraction, have shown clinical benefit with intravenous supplementation of ferric carboxymaltose in terms of functional capacity, quality of life, laboratory markers of disease and inflammation, and possible reduction of re-hospitalizations, but not in terms of mortality. Based on this evidence, guidelines recommend intravenous ferric carboxymaltose in decompensated and iron-deficient patients, while research is at work to investigate the clinical impact of supplementation in contexts not yet examined, such as that of decompensation in patients with heart failure and preserved ejection fraction.
    Language English
    Publishing date 2022-11-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1463769-8
    ISSN 1554-2815 ; 1520-765X
    ISSN (online) 1554-2815
    ISSN 1520-765X
    DOI 10.1093/eurheartjsupp/suac080
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    Zs.A 1563 -Suppl.-: Show issues Location:
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  2. Article ; Online: Long-term BP variability: open questions in clinical practice.

    Del Pinto, Rita / Ferri, Claudio

    International Journal of Cardiology. Hypertension

    2020  Volume 7, Page(s) 100064

    Language English
    Publishing date 2020-11-03
    Document type Journal Article
    ISSN 2590-0862
    ISSN (online) 2590-0862
    DOI 10.1016/j.ijchy.2020.100064
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Recurrent pericarditis is less scary: the new therapeutic solutions.

    Del Pinto, Rita / Ferri, Claudio

    European heart journal supplements : journal of the European Society of Cardiology

    2021  Volume 23, Issue Suppl E, Page(s) E83–E86

    Abstract: Pericarditis is a common inflammatory disease affecting the pericardial sac, resulting from a variety of stimuli that trigger a stereotyped immune response. Generally self-limiting, this condition can be burdened by a significant risk of acute ... ...

    Abstract Pericarditis is a common inflammatory disease affecting the pericardial sac, resulting from a variety of stimuli that trigger a stereotyped immune response. Generally self-limiting, this condition can be burdened by a significant risk of acute complications and relapses, with recurrence rates affecting up to 30% of patients, especially in the case of diagnostic and therapeutic delay. Therapeutic options in recurrent forms, initially based only on the use of traditional drugs such as colchicine, non-steroidal anti-inflammatory drugs, and corticosteroids, have recently been enriched with new molecules, such as interleukin 1 blockers anakinra and rilonacept, particularly indicated in refractory forms dependent on corticosteroids. Other medically relevant therapeutic possibilities in refractory disease include azathioprine, methotrexate, and intravenous immunoglobulins. This brief review aims to summarize the treatment strategies of recurrent pericarditis in light of the most up-to-date evidence and recommendations.
    Language English
    Publishing date 2021-10-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1463769-8
    ISSN 1554-2815 ; 1520-765X
    ISSN (online) 1554-2815
    ISSN 1520-765X
    DOI 10.1093/eurheartj/suab097
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563 -Suppl.-: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  4. Article ; Online: Oral health as a modifiable risk factor for cardiovascular diseases.

    Altamura, Serena / Del Pinto, Rita / Pietropaoli, Davide / Ferri, Claudio

    Trends in cardiovascular medicine

    2023  

    Abstract: Cardiovascular diseases (CVDs) are a leading cause of morbidity and mortality worldwide with a high socioeconomic burden. Increasing evidence supports a convincing connection with increased cardiovascular risk of periodontal diseases (PD), a group of ... ...

    Abstract Cardiovascular diseases (CVDs) are a leading cause of morbidity and mortality worldwide with a high socioeconomic burden. Increasing evidence supports a convincing connection with increased cardiovascular risk of periodontal diseases (PD), a group of widespread, debilitating, and costly dysbiotic relapsing-remitting inflammatory diseases of the tissues supporting the teeth. Herein, we ensembled the best available evidence on the connection between CVDs and PD to review the recently emerging concept of the latter as a non-traditional risk factor for CVDs. We focused on oral dysbiosis, inflammation-associated molecular and cellular mechanisms, and epigenetic changes as potential causative links between PD and CVDs. The available evidence on the effects of periodontal treatment on cardiovascular risk factors and diseases was also described.
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2023.03.003
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    Zs.A 3419: Show issues Location:
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  5. Article ; Online: Correction to: Impact of 2021 ESC Guidelines for Cardiovascular Disease Prevention on Hypertensive Patients Risk: Secondary Analysis of Save Your Heart Study.

    Del Pinto, Rita / Giua, Corrado / Keber, Enrico / Grippa, Eleonora / Tilotta, Marco / Ferri, Claudio

    High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension

    2023  Volume 30, Issue 5, Page(s) 487

    Language English
    Publishing date 2023-09-13
    Publishing country New Zealand
    Document type Published Erratum
    ZDB-ID 1236337-6
    ISSN 1179-1985 ; 1120-9879
    ISSN (online) 1179-1985
    ISSN 1120-9879
    DOI 10.1007/s40292-023-00599-w
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4289: Show issues Location:
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  6. Article: Is there a connection among atrial fibrillation, anticoagulant treatment, and dementia?

    Ferri, Claudio / Del Pinto, Rita

    European heart journal supplements : journal of the European Society of Cardiology

    2020  Volume 22, Issue Suppl E, Page(s) E79–E81

    Abstract: It is well-known that atrial fibrillation carries an increased risk of stroke and dementia. The connecting pathogenic common mechanism is the thromboembolic state provided by atrial fibrillation, which is responsible for the acute cerebral events, as ... ...

    Abstract It is well-known that atrial fibrillation carries an increased risk of stroke and dementia. The connecting pathogenic common mechanism is the thromboembolic state provided by atrial fibrillation, which is responsible for the acute cerebral events, as well as more saddle anatomic lesions, which accumulating over time, could lead to a progressive cognitive decline. It is plausible, instinctively, that oral anticoagulation could decrease this risk, although the possibility of micro-haemorrhages, which cannot be ignored, could make anticoagulation in this contest even dangerous. In this regard, whether there are firm, well established, evidences documenting a significant reduction in stroke occurrence with anticoagulant treatment in atrial fibrillation, the same level of evidences are not supporting the treatment in preventing dementia. Bringing some more clarity to this issue could have some considerable advantages, also in term of healthcare cost containment, considering the high prevalence of atrial fibrillation and dementia in the elderly.
    Language English
    Publishing date 2020-03-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1463769-8
    ISSN 1554-2815 ; 1520-765X
    ISSN (online) 1554-2815
    ISSN 1520-765X
    DOI 10.1093/eurheartj/suaa066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563 -Suppl.-: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: The role of Immunity in Fabry Disease and Hypertension: A Review of a Novel Common Pathway.

    Del Pinto, Rita / Ferri, Claudio

    High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension

    2020  Volume 27, Issue 6, Page(s) 539–546

    Abstract: Fabry disease is a progressive, X-linked inherited lysosomal storage disorder where accumulation of glycosphingolipids increases the risk for early cardiovascular complications, including heart failure, stroke, and end stage renal disease. Besides ... ...

    Abstract Fabry disease is a progressive, X-linked inherited lysosomal storage disorder where accumulation of glycosphingolipids increases the risk for early cardiovascular complications, including heart failure, stroke, and end stage renal disease. Besides disease-specific therapy, blood pressure (BP) control is of central importance in Fabry disease to reduce disease progression and improve prognosis. Both Fabry disease and hypertension are characterized by the activation of the innate component of the immune system, with Toll-like receptor 4 (TLR4) as a common trigger to the inflammatory cascade. The renin-angiotensin system (RAS) participates in the establishment of low-grade chronic inflammation and redox unbalance that contribute to organ damage in the long term. Besides exploiting the anti-inflammatory effects of RAS blockade and enzyme replacement therapy, targeted therapies acting on the immune system represent an appealing field of research in these conditions. The aim of this narrative review is to examine the issue of hypertension in the setting of Fabry disease, focusing on the possible determinants of their reciprocal relationship, as well as on the related clinical and therapeutic implications.
    MeSH term(s) Animals ; Anti-Inflammatory Agents/therapeutic use ; Antihypertensive Agents/therapeutic use ; Antioxidants/therapeutic use ; Blood Pressure ; Fabry Disease/drug therapy ; Fabry Disease/immunology ; Fabry Disease/metabolism ; Fabry Disease/physiopathology ; Humans ; Hypertension/drug therapy ; Hypertension/immunology ; Hypertension/metabolism ; Hypertension/physiopathology ; Immunity, Innate/drug effects ; Inflammation/drug therapy ; Inflammation/immunology ; Inflammation/metabolism ; Inflammation/physiopathology ; Inflammation Mediators/metabolism ; Oxidative Stress ; Renin-Angiotensin System ; Signal Transduction ; Toll-Like Receptor 4/metabolism
    Chemical Substances Anti-Inflammatory Agents ; Antihypertensive Agents ; Antioxidants ; Inflammation Mediators ; TLR4 protein, human ; Toll-Like Receptor 4
    Keywords covid19
    Language English
    Publishing date 2020-10-12
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1236337-6
    ISSN 1179-1985 ; 1120-9879
    ISSN (online) 1179-1985
    ISSN 1120-9879
    DOI 10.1007/s40292-020-00414-w
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4289: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  8. Article ; Online: Analysis of Aspirin Use and Cardiovascular Events and Mortality Among Adults With Hypertension and Controlled Systolic Blood Pressure.

    Del Pinto, Rita / Pietropaoli, Davide / Desideri, Giovambattista / Ferri, Claudio

    JAMA network open

    2022  Volume 5, Issue 4, Page(s) e226952

    MeSH term(s) Adult ; Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use ; Aspirin/pharmacology ; Aspirin/therapeutic use ; Blood Pressure/physiology ; Humans ; Hypertension/drug therapy ; Hypertension/epidemiology
    Chemical Substances Antihypertensive Agents ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2022-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2022.6952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Commentary to Angiotensin-Converting-Enzyme 2 and Renin-Angiotensin System Inhibitors in COVID-19: An Update.

    Ferri, Claudio / Desideri, Giovambattista / Del Pinto, Rita

    High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension

    2021  Volume 28, Issue 3, Page(s) 251–252

    MeSH term(s) Angiotensin-Converting Enzyme 2 ; Angiotensins ; COVID-19 ; Humans ; Renin-Angiotensin System ; SARS-CoV-2
    Chemical Substances Angiotensins ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2021-04-01
    Publishing country New Zealand
    Document type Letter ; Comment
    ZDB-ID 1236337-6
    ISSN 1179-1985 ; 1120-9879
    ISSN (online) 1179-1985
    ISSN 1120-9879
    DOI 10.1007/s40292-021-00446-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4289: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article ; Online: Long-term BP variability

    Rita Del Pinto / Claudio Ferri

    International Journal of Cardiology. Hypertension, Vol 7, Iss , Pp 100064- (2020)

    open questions in clinical practice

    2020  

    Keywords Blood pressure variability ; Cardiovascular risk ; Prognostic markers ; Precision medicine ; Diseases of the circulatory (Cardiovascular) system ; RC666-701
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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