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Book: Head and neck

Brandwein-Gensler, Margaret

(Cambridge illustrated surgical pathology)

2010

Author's details	Margaret Brandwein-Gensler
Series title	Cambridge illustrated surgical pathology
Keywords	Head and Neck Neoplasms / pathology ; Head / pathology ; Neck / pathology
Language	English
Size	XV, 630 S. : überw. Ill.
Publisher	Cambridge Univ. Press
Publishing place	Cambridge u.a.
Publishing country	Great Britain
Document type	Book
Note	Formerly CIP Uk. - Includes bibliographical references and index
Accompanying material	1 CD-ROM (12 cm)
HBZ-ID	HT016255284
ISBN	978-0-521-87999-6 ; 0-521-87999-X
Database	Catalogue ZB MED Medicine, Health

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2010 A 993	order for loan	Magazin
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Article ; Online: Envisioning the next WHO head and neck classification.

Brandwein-Gensler, Margaret / Wei, Shi

Head and neck pathology

2014 Volume 8, Issue 1, Page(s) 1–15

Abstract: The next WHO classification should abandon "salivary duct carcinoma"; conventional salivary duct carcinoma should be classified as "high-grade salivary duct carcinoma". Low-grade salivary duct carcinoma should replace the current nosology of "low-grade ... ...

Abstract	The next WHO classification should abandon "salivary duct carcinoma"; conventional salivary duct carcinoma should be classified as "high-grade salivary duct carcinoma". Low-grade salivary duct carcinoma should replace the current nosology of "low-grade cribriform cystadenocarcinoma". Cystadenocarcinoma should be classified with the descriptor "Not Otherwise Specified" and should be considered an exclusionary diagnostic category. On the other hand, "Not Otherwise Specified" does not fit for hyalinizing clear cell carcinoma (HCCC). The EWSR1-ATF1 fusion is specific for HCCC within the context of salivary neoplasia. We recommend adding "hyalinizing" even though this feature is not present in all cases; the benefit of which is the mental association with a salivary clear cell malignancy. Sinonasal Renal Cell-like Adenocarcinoma (SNRCLA) is a distinct clear cell neoplasm and should be added to the next WHO classification. Future studies will bear out whether SNRCLA is even a low-grade carcinoma, or may be reclassified as "adenoma". Lastly, the next WHO monograph should include the Risk Model in the general introductory statements on oral squamous cell carcinoma, under a subheading of "Histological Prognosticators". The positive predictive value for developing locoregional recurrence in patients with low-stage oral cavity squamous carcinoma (OSCC) and "worst pattern of invasion type-5" (WPOI-5) is 42 %. Low-stage high-risk OSCC with a combination of features other than WPOI-5 is associated with 32 % likelihood for locoregional progression. WPOI-5 also predicts occult metastatic disease (p = 0.0001, Chi squared, 2 DF). Thus the Risk Model can also be used to make decisions regarding staged elective neck dissections.
MeSH term(s)	Head and Neck Neoplasms/classification ; Humans ; World Health Organization
Language	English
Publishing date	2014-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2407834-7
ISSN	1936-0568 ; 1936-055X
ISSN (online)	1936-0568
ISSN	1936-055X
DOI	10.1007/s12105-014-0529-5
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Book: Head and neck

Brandwein-Gensler, Margaret

(Cambridge illustrated surgical pathology)

2010

Author's details	Margaret Brandwein-Gensler
Series title	Cambridge illustrated surgical pathology
MeSH term(s)	Head and Neck Neoplasms/pathology ; Head/pathology ; Neck/pathology
Language	English
Size	xv, 630 p. :, ill. +
Publisher	Cambridge University Press
Publishing place	Cambridge ; New York
Document type	Book
Accompanying material	1 CD-ROM (4 3/4 in.).
ISBN	9780521879996 ; 052187999X
Database	Catalogue of the US National Library of Medicine (NLM)

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Article ; Online: Micro-RNA Profiling as a Predictor of Clinical Outcomes for Head and Neck Cancer Patients.

Isayeva, Tatyana / Brandwein-Gensler, Margaret / Somarathna, Maheshika / Moore-Smith, Lakisha D / Lee, Timmy

Current pharmaceutical design

2017 Volume 23, Issue 32, Page(s) 4729–4744

Abstract: Head and neck cancer is one of the leading malignancies worldwide. Due to the lack of symptoms in the early stage of the disease, about two thirds of patients present with locally advanced disease at the time of diagnosis. Even with significantly ... ...

Abstract	Head and neck cancer is one of the leading malignancies worldwide. Due to the lack of symptoms in the early stage of the disease, about two thirds of patients present with locally advanced disease at the time of diagnosis. Even with significantly improved survival rates over the past two decades due to advanced imaging and treatment modalities, locoregional recurrence rates in patients with advanced disease ranges from 16% to 35%. Alternative therapeutic targets are being developed to improve survival outcomes. MicroRNAs (miRNA or miRs) are a family of small non-coding RNA species that have been demonstrated to regulate all cellular, physiological and developmental processes. Recently, there has been an exponential increase in the number of studies suggesting that miRNA is involved in regulating tumor metastasis, chemoresistance, radioresistance and survival outcomes. MiRNA candidates have been identified as potential prognostic biomarkers to diagnose cancer stages and progression, as well as to monitor follow-up treatment. In this review, we will discuss the miRNA profile in each stage of head and neck patients' therapy, with an emphasis on its application to clinical outcome prognosis.
MeSH term(s)	Animals ; Biomarkers, Tumor/genetics ; Disease Progression ; Head and Neck Neoplasms/genetics ; Head and Neck Neoplasms/pathology ; Head and Neck Neoplasms/therapy ; Humans ; MicroRNAs/genetics ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Outcome Assessment (Health Care) ; Prognosis
Chemical Substances	Biomarkers, Tumor ; MicroRNAs
Language	English
Publishing date	2017-06-02
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	1304236-1
ISSN	1873-4286 ; 1381-6128
ISSN (online)	1873-4286
ISSN	1381-6128
DOI	10.2174/1381612823666170601100633
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Article ; Online: Striking pathology gold: a singular experience with daily reverberations: sinonasal hemangiopericytoma (glomangiopericytoma) and oncogenic osteomalacia.

Brandwein-Gensler, Margaret / Siegal, Gene P

Head and neck pathology

2012 Volume 6, Issue 1, Page(s) 64–74

Abstract: Sinonasal hemangiopericytoma-like tumors(SNHPC)(glomangiopericytomas)were originally conceived as histologically similar to, but biologically distinct from, their soft tissue counterparts. Re-evaluation of "hemangiopericytiomas" has determined that SNHPC ...

Abstract	Sinonasal hemangiopericytoma-like tumors(SNHPC)(glomangiopericytomas)were originally conceived as histologically similar to, but biologically distinct from, their soft tissue counterparts. Re-evaluation of "hemangiopericytiomas" has determined that SNHPC (glomangiopericytomas) represent bona-fide pericyte-derived tumors, whereas most soft tissue neoplasms previously designated as hemangiopericytomas represent cellular variants of solitary fibrous tumors or other lesions with a hemangiopericytomalike growth pattern. We present an interesting case of a woman with SNHPC (glomangiopericytomas) causing oncogenic osteomalacia, and discuss the recent advances in our understanding of phosphaturic mesenchymal tumors. This particular case is an example of "Striking Pathology Gold"-a situation where the pathologist actively guides the diagnostic process, and witnesses its repercussions. "Striking Pathology Gold" may be a rare event in one's career. However it serves to remind us of our place in the world as physicians. Working behind the scenes, we quietly change the course of countless individual destinies for the better.
MeSH term(s)	Aged ; Diagnosis, Differential ; Familial Hypophosphatemic Rickets/metabolism ; Familial Hypophosphatemic Rickets/pathology ; Female ; Hemangiopericytoma/metabolism ; Hemangiopericytoma/pathology ; Hemangiopericytoma/therapy ; Humans ; Meningeal Neoplasms/pathology ; Nasopharyngeal Neoplasms/metabolism ; Nasopharyngeal Neoplasms/pathology ; Nasopharyngeal Neoplasms/therapy ; Osteomalacia/metabolism ; Osteomalacia/pathology ; Solitary Fibrous Tumor, Pleural/pathology
Language	English
Publishing date	2012-03-20
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2407834-7
ISSN	1936-0568 ; 1936-055X
ISSN (online)	1936-0568
ISSN	1936-055X
DOI	10.1007/s12105-012-0337-8
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Article ; Online: Frozen section: guiding the hands of surgeons?

McIntosh, Eleanor R / Harada, Shuko / Drwiega, Joseph / Brandwein-Gensler, Margaret S / Gordetsky, Jennifer

Annals of diagnostic pathology

2015 Volume 19, Issue 5, Page(s) 326–329

Abstract: Frozen section (FS) analysis is a powerful tool that can provide a rapid diagnosis, directing operative management. However, FSs can also be misused. We consider an FS to be "inappropriate" when it does not influence operative management or immediate ... ...

Abstract	Frozen section (FS) analysis is a powerful tool that can provide a rapid diagnosis, directing operative management. However, FSs can also be misused. We consider an FS to be "inappropriate" when it does not influence operative management or immediate patient care. Not only can inappropriate FSs compromise diagnostic material, they can impact turnaround time of other FSs. We evaluated the utilization of FSs at our institution and assessed influence on intraoperative management. Frozen sections performed at the University of Alabama at Birmingham Hospital in 2013 were stratified by surgical subspecialty. Operative, clinical, and pathology notes were reviewed to determine the rationale for sending each FS and to determine impact on intraoperative management. Cases lacking operative notes were excluded. A total of 4104 FSs were performed in 1896 cases. Surgical subspecialties included cardiothoracic, otolaryngology, breast, surgical oncology, gynecology, gastrointestinal, hepatobiliary, urology, transplant, and orthopedics. 42.5% of FSs evaluated margin status, 34.8% confirmed or excluded malignancy, 9.5% were for tumor classification, 6.7% assessed adequacy for diagnosis, 1.9% were to confirm or exclude infection, 2.8% were for transplant, and 1.8% were for lymphoma workup. Twelve percent (491/4104) of FSs did not influence operative management. This was most common among cardiothoracic surgeries (34%). No inappropriate FSs were sent for any transplant surgeries. Otolaryngology used the most FSs and had less than 1% that were inappropriate. Most FSs influence operative management. The rationale for sending an FS and its influence on operative management was subspecialty dependent. Interdepartmental discussions of FS utilization might be helpful in the elimination of unnecessary FSs.
MeSH term(s)	Frozen Sections/methods ; Frozen Sections/statistics & numerical data ; Humans ; Intraoperative Care/methods ; Intraoperative Care/statistics & numerical data ; Quality Assurance, Health Care ; Retrospective Studies ; Surgical Procedures, Operative/methods ; Surgical Procedures, Operative/statistics & numerical data
Language	English
Publishing date	2015-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1440011-x
ISSN	1532-8198 ; 1092-9134
ISSN (online)	1532-8198
ISSN	1092-9134
DOI	10.1016/j.anndiagpath.2015.07.004
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Zs.A 5463: Show issues

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Article ; Online: Characterization of estrogen receptor-negative/progesterone receptor-positive breast cancer.

Shen, Tiansheng / Brandwein-Gensler, Margaret / Hameed, Omar / Siegal, Gene P / Wei, Shi

Human pathology

2015 Volume 46, Issue 11, Page(s) 1776–1784

Abstract: Despite the controversies, estrogen receptor-negative/progesterone receptor-positive (ER-/PR+) breast cancers have a reported incidence of 1% to 4%. These tumors are less well defined, and it is unclear whether ER-/PR+ represents a distinct subtype. Thus, ...

Abstract	Despite the controversies, estrogen receptor-negative/progesterone receptor-positive (ER-/PR+) breast cancers have a reported incidence of 1% to 4%. These tumors are less well defined, and it is unclear whether ER-/PR+ represents a distinct subtype. Thus, we analyzed 5374 consecutive breast cancers to characterize the clinicopathological features of this underrecognized subset of tumors. The ER-/PR+ tumors, constituting 2.3% of the total, were mostly high grade and significantly seen in younger patients and African American women when compared with the ER+/PR+ and ER+/PR- groups, but similar to that of ER-/PR- phenotype (P < .0001). A significantly prolonged relapse-free survival (RFS) was associated with the ER+/PR+ subtype when compared with the ER+/PR- (P = .0002) or ER-/PR+ (P = .0004) tumors, whereas all 3 groups showed a superior outcome to that of the ER-/PR- phenotype. In the subset of patients receiving endocrine therapy, those with ER+/PR+ tumors had a significantly prolonged RFS (P = .001) and disease-specific survival (P = .005) when compared with the group with an ER+/PR- phenotype, but did not significantly differ from those with ER-/PR+ tumors. No significant survival advantage was found between the ER+/PR- and ER-/PR+ tumors in any group of patients analyzed. Furthermore, a higher PR expression was associated with a favorable RFS and disease-specific survival in the patients with ER-/PR+ tumors. Therefore, the ER-/PR+ tumors demonstrate a similar, if not higher than, response rate to endocrine therapy when compared with the ER+/PR- tumors and thus are important to identify. Routine PR testing remains necessary in assisting clinical decision making in the pursuit of precision medicine.
MeSH term(s)	African Americans ; Age Factors ; Aged ; Breast Neoplasms/metabolism ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; European Continental Ancestry Group ; Female ; Humans ; Middle Aged ; Neoplasm Recurrence, Local/metabolism ; Neoplasm Recurrence, Local/mortality ; Neoplasm Recurrence, Local/pathology ; Prognosis ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism ; Survival Rate
Chemical Substances	Receptors, Estrogen ; Receptors, Progesterone
Language	English
Publishing date	2015-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	207657-3
ISSN	1532-8392 ; 0046-8177
ISSN (online)	1532-8392
ISSN	0046-8177
DOI	10.1016/j.humpath.2015.07.019
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Article ; Online: Prognostic indicators in head and neck oncology including the new 7th edition of the AJCC staging system.

Brandwein-Gensler, Margaret / Smith, Richard V

Head and neck pathology

2010 Volume 4, Issue 1, Page(s) 53–61

MeSH term(s)	Carcinoma, Squamous Cell/classification ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/surgery ; Female ; Head and Neck Neoplasms/classification ; Head and Neck Neoplasms/diagnosis ; Head and Neck Neoplasms/surgery ; Humans ; Male ; Manuals as Topic ; Neoplasm Staging/methods ; Neoplasm Staging/standards ; Prognosis ; Societies, Medical ; Treatment Outcome
Language	English
Publishing date	2010-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2407834-7
ISSN	1936-0568 ; 1936-055X
ISSN (online)	1936-0568
ISSN	1936-055X
DOI	10.1007/s12105-010-0161-y
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Article ; Online: Human papillomavirus in non-oropharyngeal head and neck cancers: a systematic literature review.

Isayeva, Tatyana / Li, Yufeng / Maswahu, Daniel / Brandwein-Gensler, Margaret

Head and neck pathology

2012 Volume 6 Suppl 1, Page(s) S104–20

Abstract: Perhaps one of the most important developments in head and neck oncology of the past decade is the demonstration that patients with human papillomavirus (HPV)-mediated oropharyngeal cancers have significantly improved outcomes, compared to HPV-negative ... ...

Abstract	Perhaps one of the most important developments in head and neck oncology of the past decade is the demonstration that patients with human papillomavirus (HPV)-mediated oropharyngeal cancers have significantly improved outcomes, compared to HPV-negative counterpart patients. This has become the basis for clinical trials investigating the impact on "treatment deintensification" for patients with HPV-mediated oropharyngeal cancers. Unfortunately, the significance of HPV in non-oropharyngeal head and neck cancers is much less certain. Our goal is to systematically review the published data regarding the role HPV in carcinomas of the oral cavity, larynx, sinonasal tract and nasopharynx with respect to HPV detection frequency, viral activity, and association with outcome. We also present preliminary data on HPV16/18 transcriptional status in oral cavity carcinomas, as well as salivary gland neoplasia, as determined by nested reverse transcription PCR for HPV E6/E7 RNA. The weighted prevalence (WP) of HPV DNA detection in 4,195 oral cavity cancer patients is 20.2 %, (95 % CI 16.0 %, 25.2 %). HPV16 is the most common type detected. Importantly, no data currently demonstrates a significant association between the presence of HPV DNA and improved outcome. The WP of HPV DNA in 1,712 laryngeal cancer patients is 23.6 %, (95 % CI 18.7 %, 29.3 %). Similarly, no association has yet been demonstrated between HPV DNA status and outcome. The WP of HPV DNA detection in 120 sinonasal cancer patients is 29.6 % (95 % CI 17.8 %, 44.9 %), and in 154 nasopharyngeal carcinoma patients is 31.1 %, (95 % CI 20.3 %, 44.5 %). Recent preliminary data also suggests an association between HPV and certain salivary gland neoplasms. The clinical significance of these findings is unclear. The published data strongly support the need for studies on patients with oral and laryngeal carcinomas that will be powered to find any differences in clinical outcome with respect to HR-HPV and p16 overexpression.
MeSH term(s)	Head and Neck Neoplasms/epidemiology ; Head and Neck Neoplasms/virology ; Humans ; Papillomavirus Infections/complications ; Papillomavirus Infections/epidemiology ; Prognosis
Language	English
Publishing date	2012-07-03
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review
ZDB-ID	2407834-7
ISSN	1936-0568 ; 1936-055X
ISSN (online)	1936-0568
ISSN	1936-055X
DOI	10.1007/s12105-012-0368-1
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Article ; Online: Transoral robotic versus open surgical approaches to oropharyngeal squamous cell carcinoma by human papillomavirus status.

Ford, Samuel E / Brandwein-Gensler, Margaret / Carroll, William R / Rosenthal, Eben L / Magnuson, J Scott

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

2014 Volume 151, Issue 4, Page(s) 606–611

Abstract: Objectives: (1) Investigate oncologic survival outcomes and (2) analyze the impact of human papillomavirus status on prognosis in patients with oropharyngeal squamous cell carcinoma treated with transoral robotic versus open surgery.: Study design: ... ...

Abstract	Objectives: (1) Investigate oncologic survival outcomes and (2) analyze the impact of human papillomavirus status on prognosis in patients with oropharyngeal squamous cell carcinoma treated with transoral robotic versus open surgery. Study design: Retrospective cohort study. Setting: Tertiary care referral center, University of Alabama at Birmingham Hospital. Subjects: One hundred thirty total (65 per treatment arm) with primary oropharyngeal squamous cell carcinoma (OPSCC). Methods: Patients treated for primary oropharyngeal squamous cell carcinoma with either transoral robotic (TORS) or open surgery plus standard of care adjuvant therapy between October 2004 and March 2012 were matched based on TNM staging before a retrospective chart review was performed. Carcinoma tissue was stained both prospectively and retrospectively with CINtec p16-INK4a kits for surrogate human papillomavirus typing. Recurrence-free survival was used to evaluate the impact of human papillomavirus tumor status and method of surgical intervention on prognosis. Results: As a whole, patients treated with transoral robotic surgery survived more frequently (94%, 91%, 89% at 1, 2, 3 years, respectively) than those treated with open surgery (85%, 75%, 73% at 1, 2, 3 years, correspondingly) (P = .035). The subgroup of patients with human papillomavirus-negative malignancies treated with open surgery survived without recurrence less frequently at 1, 2, and 3 year rates of 58%, 25%, 25%, respectively (P < .01). Conclusion: These retrospective data suggest that oncologic outcomes are not being sacrificed when patients with OPSCC are treated with TORS instead of open surgery regardless of tumor human papillomavirus immunohistochemical staining.
MeSH term(s)	Aged ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/surgery ; Carcinoma, Squamous Cell/virology ; Disease-Free Survival ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Oropharyngeal Neoplasms/pathology ; Oropharyngeal Neoplasms/surgery ; Oropharyngeal Neoplasms/virology ; Papillomaviridae/isolation & purification ; Retrospective Studies ; Robotic Surgical Procedures ; Treatment Outcome
Language	English
Publishing date	2014-10
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	392085-9
ISSN	1097-6817 ; 0161-6439 ; 0194-5998
ISSN (online)	1097-6817
ISSN	0161-6439 ; 0194-5998
DOI	10.1177/0194599814542939
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