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  1. Article ; Online: Unmasking early heart failure with preserved ejection fraction: the role of exercise stress testing.

    Bursi, Francesca

    European journal of preventive cardiology

    2023  Volume 30, Issue 9, Page(s) 900–901

    MeSH term(s) Humans ; Prognosis ; Stroke Volume ; Heart Failure/diagnosis ; Early Diagnosis
    Language English
    Publishing date 2023-05-05
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1093/eurjpc/zwad138
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    Zs.A 4686: Show issues Location:
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  2. Article ; Online: The Left Atrium: Passive Receptacle or Active Contributor to Mitral Regurgitation Severity and Outcome.

    Bursi, Francesca / Enriquez-Sarano, Maurice

    JACC. Case reports

    2024  Volume 29, Issue 3, Page(s) 102195

    Language English
    Publishing date 2024-01-06
    Publishing country Netherlands
    Document type Editorial
    ISSN 2666-0849
    ISSN (online) 2666-0849
    DOI 10.1016/j.jaccas.2023.102195
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  3. Article ; Online: Strain and mitral regurgitation: is atrial functional mitral regurgitation a ventricular disease?

    Bursi, Francesca / Lee, Alex Pui-Wai

    Heart (British Cardiac Society)

    2023  Volume 109, Issue 6, Page(s) 425–426

    MeSH term(s) Humans ; Mitral Valve Insufficiency ; Atrial Fibrillation ; Heart Atria ; Mitral Valve
    Language English
    Publishing date 2023-02-23
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2022-321945
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  4. Article ; Online: Arrhythmogenic Mitral Valve Prolapse and Sudden Cardiac Death: An Update and Current Perspectives.

    Battaglia, Valeria / Santangelo, Gloria / Bursi, Francesca / Simeoli, Pasquale / Guazzi, Marco

    Current problems in cardiology

    2023  Volume 48, Issue 7, Page(s) 101724

    Abstract: Mitral valve prolapse (MVP) affects about 2% to 3% of the general population, mostly women, and is the most common cause of primary chronic mitral regurgitation (MR) in western countries. The natural history is heterogeneous and widely determined by the ... ...

    Abstract Mitral valve prolapse (MVP) affects about 2% to 3% of the general population, mostly women, and is the most common cause of primary chronic mitral regurgitation (MR) in western countries. The natural history is heterogeneous and widely determined by the severity of MR. Although most patients remain asymptomatic with a near-normal life expectancy, approximately 5% to 10 % progress to severe MR. As largely recognized, left ventricular (LV) dysfunction due to chronic volume overload per se identifies a subgroup at risk of cardiac death. However, there is rising evidence of a link between MVP and life threating ventricular arrhythmias (VAs)/sudden cardiac death (SCD) in a small subset of middle-aged patients without significant MR, heart failure and remodeled hearts. The present review focuses on the underlying mechanism of electric instability and unexpected cardiac death in this subset of young patients, from the myocardial scarring of the LV infero-lateral wall due to mechanical stretch exerted by the prolapsing leaflets and mitral annular disjunction, to the inflammation's impact on fibrosis pathways along with a constitutional hyperadrenergic state. The heterogeneity of clinical course reveals a necessity of risk stratification, preferably through noninvasive multimodality imaging, that will help to identify and prevent adverse scenarios in young MVP patients.
    MeSH term(s) Middle Aged ; Humans ; Female ; Male ; Mitral Valve Prolapse/complications ; Mitral Valve Prolapse/epidemiology ; Death, Sudden, Cardiac/epidemiology ; Death, Sudden, Cardiac/etiology ; Death, Sudden, Cardiac/prevention & control ; Arrhythmias, Cardiac/etiology ; Arrhythmias, Cardiac/therapy ; Mitral Valve Insufficiency/complications ; Mitral Valve ; Heart Failure ; Ventricular Dysfunction, Left
    Language English
    Publishing date 2023-03-25
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 441230-8
    ISSN 1535-6280 ; 0146-2806
    ISSN (online) 1535-6280
    ISSN 0146-2806
    DOI 10.1016/j.cpcardiol.2023.101724
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  5. Article ; Online: The Role of Stress Echocardiography in Valvular Heart Disease.

    Citro, Rodolfo / Bursi, Francesca / Bellino, Michele / Picano, Eugenio

    Current cardiology reports

    2022  Volume 24, Issue 10, Page(s) 1477–1485

    Abstract: Purpose of review: Stress echocardiography is recommended in valvular heart disease when there is a mismatch between resting transthoracic echocardiography findings and symptoms during activities of daily living. We describe the current methodology and ... ...

    Abstract Purpose of review: Stress echocardiography is recommended in valvular heart disease when there is a mismatch between resting transthoracic echocardiography findings and symptoms during activities of daily living. We describe the current methodology and the evidence supporting these applications.
    Recent findings: The comprehensive stress echo assessment includes valve function (gradients and regurgitation), left ventricular global systolic and diastolic function, left atrial volume, pulmonary congestion, pulmonary arterial pressure, and right ventricular function, integrated with blood pressure response with cuff sphygmomanometer, chronotropic reserve with heart rate, and symptoms. Recent guidelines recommend the evaluation of asymptomatic severe or symptomatic non-severe mitral regurgitation or stenosis with exercise stress and suspected low-flow, low-gradient severe aortic stenosis with reduced ejection fraction with low dose (up to 20 mcg, without atropine) dobutamine stress. Prospective, large-scale studies based on a comprehensive protocol (ABCDE +) capturing the multiplicity of clinical phenotypes are needed to support stress echo-driven treatment strategies.
    MeSH term(s) Activities of Daily Living ; Aortic Valve Stenosis ; Atropine Derivatives ; Dobutamine ; Echocardiography, Stress ; Heart Valve Diseases ; Humans ; Mitral Valve Insufficiency/diagnostic imaging ; Prospective Studies ; Ventricular Function, Left
    Chemical Substances Atropine Derivatives ; Dobutamine (3S12J47372)
    Language English
    Publishing date 2022-08-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055373-0
    ISSN 1534-3170 ; 1523-3782
    ISSN (online) 1534-3170
    ISSN 1523-3782
    DOI 10.1007/s11886-022-01765-7
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    Zs.A 5524: Show issues Location:
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  6. Article ; Online: Aortic pseudoaneurysm with fistula to pulmonary trunk causing recurrent pulmonary oedema: a rare late complication of ascending aorta replacement.

    Gentile, Domitilla / Bursi, Francesca / Mangini, Andrea / Carugo, Stefano

    European heart journal

    2020  Volume 42, Issue 25, Page(s) 2509

    MeSH term(s) Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Aorta ; Fistula ; Humans ; Pulmonary Artery/diagnostic imaging ; Pulmonary Edema/diagnostic imaging ; Pulmonary Edema/etiology
    Language English
    Publishing date 2020-10-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehaa712
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    Zs.A 1563: Show issues Location:
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    Zs.MO 640: Show issues

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  7. Article ; Online: Prevalence of left atrial thrombus by real time three-dimensional echocardiography in patients undergoing electrical cardioversion of atrial fibrillation: A contemporary cohort study.

    Bursi, Francesca / Santangelo, Gloria / Ferrante, Giulia / Massironi, Laura / Carugo, Stefano

    Echocardiography (Mount Kisco, N.Y.)

    2021  Volume 38, Issue 4, Page(s) 518–524

    Abstract: Background: The prevalence of left atrial thrombi in patients scheduled for electrical cardioversion (ECV) of atrial fibrillation (AF) remains unknown in contemporary real-life practice.: Methods and results: Patients scheduled for ECV underwent ... ...

    Abstract Background: The prevalence of left atrial thrombi in patients scheduled for electrical cardioversion (ECV) of atrial fibrillation (AF) remains unknown in contemporary real-life practice.
    Methods and results: Patients scheduled for ECV underwent transesophageal echocardiography (TEE) regardless of AF duration and type of anticoagulant. Of 277 consecutive patients (65% men, mean age 71 ± 10 years, CHA
    Conclusion: Patients with AF, on effective anticoagulation, had a prevalence of thrombus not negligible regardless of type of anticoagulant. TEE is prudent before ECV and mandatory if unsuccessful anticoagulation is proved or suspected.
    Language English
    Publishing date 2021-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 843645-9
    ISSN 1540-8175 ; 0742-2822
    ISSN (online) 1540-8175
    ISSN 0742-2822
    DOI 10.1111/echo.15015
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    Zs.MO 359: Show issues

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  8. Article ; Online: Spontaneous coronary dissection in a patient with Beals syndrome.

    Gentile, Domitilla / Toriello, Filippo / Santangelo, Gloria / Bursi, Francesca / Carugo, Stefano

    Journal of cardiovascular medicine (Hagerstown, Md.)

    2021  Volume 22, Issue 12, Page(s) e18–e20

    MeSH term(s) Arachnodactyly/diagnosis ; Arachnodactyly/genetics ; Arachnodactyly/physiopathology ; Arachnodactyly/therapy ; Contracture/diagnosis ; Contracture/genetics ; Contracture/physiopathology ; Contracture/therapy ; Coronary Angiography/methods ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/physiopathology ; Coronary Stenosis/surgery ; Coronary Vessel Anomalies/diagnostic imaging ; Coronary Vessel Anomalies/physiopathology ; Coronary Vessel Anomalies/surgery ; Diagnosis, Differential ; Drug-Eluting Stents ; Female ; Fibrillin-2/genetics ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/etiology ; Humans ; Loeys-Dietz Syndrome/diagnosis ; Loeys-Dietz Syndrome/physiopathology ; Marfan Syndrome/diagnosis ; Marfan Syndrome/physiopathology ; Middle Aged ; Mutation ; Percutaneous Coronary Intervention/instrumentation ; Percutaneous Coronary Intervention/methods ; Treatment Outcome ; Vascular Diseases/congenital ; Vascular Diseases/diagnostic imaging ; Vascular Diseases/physiopathology ; Vascular Diseases/surgery
    Chemical Substances FBN2 protein, human ; Fibrillin-2
    Language English
    Publishing date 2021-04-20
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2223461-5
    ISSN 1558-2035 ; 1558-2027
    ISSN (online) 1558-2035
    ISSN 1558-2027
    DOI 10.2459/JCM.0000000000001200
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    Zs.A 5210: Show issues Location:
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    Zs.MO 559: Show issues

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  9. Article: Case Report: A rare homozygous patient affected by

    Micaglio, Emanuele / Santangelo, Gloria / Moscardelli, Silvia / Rusconi, Daniela / Musca, Francesco / Verde, Alessandro / Campiglio, Laura / Bursi, Francesca / Guazzi, Marco

    Frontiers in cardiovascular medicine

    2023  Volume 10, Page(s) 1164916

    Abstract: Hereditary transthyretin amyloidosis is a severe, adult-onset autosomal dominant inherited systemic disease predominantly affecting the peripheral and autonomic nervous system, heart, kidney, and the eyes. We present a case of a Caucasian 65-year-old man ...

    Abstract Hereditary transthyretin amyloidosis is a severe, adult-onset autosomal dominant inherited systemic disease predominantly affecting the peripheral and autonomic nervous system, heart, kidney, and the eyes. We present a case of a Caucasian 65-year-old man with cardiac amyloidosis and the homozygous mutation Val142Ile (classically, Val122Ile) in the transthyretin gene. We provide a genotype-phenotype correlation regarding the genetic status of both heterozygous and homozygous individuals and their clinical conditions at the time of genetic testing.
    Language English
    Publishing date 2023-08-29
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2023.1164916
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  10. Article: The Global Burden of Valvular Heart Disease: From Clinical Epidemiology to Management.

    Santangelo, Gloria / Bursi, Francesca / Faggiano, Andrea / Moscardelli, Silvia / Simeoli, Pasquale Simone / Guazzi, Marco / Lorusso, Roberto / Carugo, Stefano / Faggiano, Pompilio

    Journal of clinical medicine

    2023  Volume 12, Issue 6

    Abstract: Valvular heart disease is a leading cause of cardiovascular morbidity and mortality and a major contributor of symptoms and functional disability. Knowledge of valvular heart disease epidemiology and a deep comprehension of the geographical and temporal ... ...

    Abstract Valvular heart disease is a leading cause of cardiovascular morbidity and mortality and a major contributor of symptoms and functional disability. Knowledge of valvular heart disease epidemiology and a deep comprehension of the geographical and temporal trends are crucial for clinical advances and the formulation of effective health policy for primary and secondary prevention. This review mainly focuses on the epidemiology of primary (organic, related to the valve itself) valvular disease and its management, especially emphasizing the importance of heart valve centers in ensuring the best care of patients through a multidisciplinary team.
    Language English
    Publishing date 2023-03-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12062178
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