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  1. Article ; Online: Health inequity assessment in Brazil: is EQ-5D-3L sensible enough to detect differences among distinct socioeconomic groups?

    Tura, Bernardo Rangel / da Costa, Milene Rangel / Lordello, Sylvia / Barros, Danillo / Souza, Yuri / da Silva Santos, Marisa

    Health and quality of life outcomes

    2024  Volume 22, Issue 1, Page(s) 22

    Abstract: ... and "lower" (D and E). EQ-5D-3L index was calculated considering the Brazilian value set. A mixed ... significantly higher for classes A and B (0.874 ± 0.14) compared to class C (0.842 ± 0.15) and classes D and E ...

    Abstract Background: Multidimensional health-related quality of life (HRQOL) instruments, such as the EQ-5D, are increasingly used to assess inequalities in health. However, it is necessary to explore the ability of these instruments to capture differences between population groups, especially in low/middle-income countries. This study aimed to investigate whether the EQ-5D-3L instrument can detect differences in HRQOL between groups of different socioeconomic status (SES) in Brazil.
    Methods: Data collection occurred during the Brazilian EQ-5D-3L valuation study and included respondents aged 18 to 64 years enrolled in urban areas. SES was aggregated into three categories: "higher" (A and B), "intermediate" (C) and "lower" (D and E). EQ-5D-3L index was calculated considering the Brazilian value set. A mixed-effects regression model was estimated with random effects on individuals and marginal effects on SES, sex, and educational attainment. Odds ratios for the chance of reporting problems for each EQ-5D dimension were estimated by logistic regression.
    Results: A total of 9,148 respondents were included in the study. Mean age was 37.80 ± 13.13 years, 47.4% were men and the majority was ranked as classes B or C (38.4% and 50.7%, respectively). Participants in lower SES classes reported increasingly poorer health compared to individuals in higher classes. The mean EQ-5D-3L index decreased as SES deteriorates being significantly higher for classes A and B (0.874 ± 0.14) compared to class C (0.842 ± 0.15) and classes D and E (0.804 ± 0.17) (p < 0.001). The same was observed for the mean EQ-VAS scores (84.0 ± 13.8 in classes A and B, 81.0 ± 17 in class C and 78.3 ± 18.7 in class C [p < 0.001]). The multivariate analysis confirmed that SES is an independent factor that effects EQ-5D-3L index measures. Participants in intermediate and lower SES classes have a statistically significant lower EQ-5D-3L index compared to participants in classes A and B, regardless of age, sex, and educational attainment.
    Conclusion: In a Brazilian population sample, the EQ-5D-3L instrument was able to detect important differences between groups with distinct socioeconomic statuses (SES). The EQ-5D-3L is useful for exploring inequities in health.
    MeSH term(s) Male ; Humans ; Female ; Young Adult ; Adult ; Middle Aged ; Quality of Life ; Health Status ; Brazil ; Surveys and Questionnaires ; Social Class ; Health Inequities
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2098765-1
    ISSN 1477-7525 ; 1477-7525
    ISSN (online) 1477-7525
    ISSN 1477-7525
    DOI 10.1186/s12955-024-02235-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multi-Criteria Model for Evaluating Drugs to Prevent Deep Venous Thrombosis Associated With Orthopedic Surgery: A Hospital-Based Case Study.

    Morais, Quenia Cristina D / Santos, Marisa S

    Value in health regional issues

    2020  Volume 23, Page(s) 105–111

    Abstract: Background: It's estimated that 40% to 60% of patients undergoing major orthopedic surgery of the hip or knee who do not receive thromboprophylaxis will develop deep venous thrombosis Instituto Nacional de Traumatologia e Ortopedia has established a ... ...

    Abstract Background: It's estimated that 40% to 60% of patients undergoing major orthopedic surgery of the hip or knee who do not receive thromboprophylaxis will develop deep venous thrombosis Instituto Nacional de Traumatologia e Ortopedia has established a guideline to prevent DVT with the administration of the Enoxaparin. Recently, institute stakeholders have been questioning this guideline as new oral anticoagulants that offer more comfort and efficacy, but present higher risk of bleeding, have been appearing in the market for treating deep venous thrombosis.
    Objective: This study aims to validate the application of a multicriteria decision analysis in a real-world problem, the use of rivaroxaban and enoxaparin to prevent deep venous thrombosis.
    Methods: The multicriteria method MACBETH (Measuring Attractiveness by a Categorical Based Evaluation Technique) was used in a decision conferencing process to develop an evaluation model for measuring the relative value of the drugs on each evaluation criterion, separately and globally. The model-building process was informed by a literature review and meta-analysis of randomized clinical trials with a critical appraisal of the evidence.
    Results: We report a model-structure with eight criteria, each one associated with a weighting coefficient and value function. Following a simple additive aggregation process, the model-outputs showed that Rivaroxaban was considered a robust option for DVT. Sensitivity analysis and robustness analysis were performed and testify the consistency of the results.
    Conclusion: This article contributes to literature by showing how MACBETH method can be combined with scientific evidence and participatory group processes, for health technology assessment in hospitals.
    MeSH term(s) Anticoagulants/adverse effects ; Anticoagulants/economics ; Anticoagulants/therapeutic use ; Brazil/epidemiology ; Enoxaparin/adverse effects ; Enoxaparin/economics ; Enoxaparin/therapeutic use ; Hemorrhage/economics ; Hemorrhage/epidemiology ; Hemorrhage/etiology ; Humans ; Orthopedic Procedures/adverse effects ; Orthopedic Procedures/economics ; Orthopedic Procedures/methods ; Pharmaceutical Preparations/economics ; Pharmaceutical Preparations/standards ; Postoperative Complications/economics ; Postoperative Complications/epidemiology ; Postoperative Complications/prevention & control ; Rivaroxaban/adverse effects ; Rivaroxaban/economics ; Rivaroxaban/therapeutic use ; Venous Thrombosis/drug therapy ; Venous Thrombosis/epidemiology ; Venous Thrombosis/prevention & control
    Chemical Substances Anticoagulants ; Enoxaparin ; Pharmaceutical Preparations ; Rivaroxaban (9NDF7JZ4M3)
    Language English
    Publishing date 2020-11-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2679127-4
    ISSN 2212-1102 ; 2212-1099
    ISSN (online) 2212-1102
    ISSN 2212-1099
    DOI 10.1016/j.vhri.2020.08.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cost-Utility Model of Nirmatrelvir/Ritonavir in Brazil: Analysis of a Vaccinated Population.

    Fernandes, Ricardo R A / Barros, Bruno M / da Costa, Milene R / Magliano, Carlos A S / Tura, Bernardo R / Morais, Quenia Cristina D / Santos, Marisa

    Value in health regional issues

    2023  Volume 40, Page(s) 74–80

    Abstract: Objectives: The aim of this study is to conduct a cost-utility analysis of the use of the antiviral nirmatrelvir/ritonavir, applied to a vaccinated Brazilian population against COVID-19, from the perspective of the Brazilian Public Health System (SUS).!# ...

    Abstract Objectives: The aim of this study is to conduct a cost-utility analysis of the use of the antiviral nirmatrelvir/ritonavir, applied to a vaccinated Brazilian population against COVID-19, from the perspective of the Brazilian Public Health System (SUS).
    Methods: A microsimulation model was created with individual-level data and daily cycles, with a 1-year time horizon, to compare the current scenario of standard care with a scenario in which nirmatrelvir/ritonavir is offered to the population. Adults of any age group that received ≥2 doses of the COVID-19 vaccine formed the investigated population. Direct medical costs of the outpatients and inpatients admitted to the ward or intensive care unit were included. The effectiveness of the model was measured in quality-adjusted life-years (QALYs).
    Results: In all simulations, the use of nirmatrelvir/ritonavir resulted in incremental costs per patient of US dollar (USD)245.86 and incremental effectiveness of 0.009 QALY, over a year. The incremental cost-utility ratio was USD27 220.70/QALY. The relative risk of the vaccinated population was the factor that affected the outcome most, according to the univariate sensitivity analysis. The probabilistic sensitivity analysis resulted in 100% of the simulations being more costly and effective, but that only 4% of them were below the established cost-effectiveness threshold of USD24 000.00/QALY. In the scenario considering only the population over 60 years old and immunosuppressed (of any age), the incremental cost-utility ratio was USD7589.37/QALY.
    Conclusions: The use of nirmatrelvir/ritonavir in the treatment of COVID-19 in a vaccinated population was cost-effective only for immunosuppressed individuals and people over 60 years of age.
    MeSH term(s) Adult ; Humans ; Middle Aged ; Aged ; Ritonavir/therapeutic use ; Brazil ; COVID-19 Vaccines/therapeutic use ; COVID-19/prevention & control ; Lactams ; Leucine ; Nitriles ; Proline
    Chemical Substances Ritonavir (O3J8G9O825) ; nirmatrelvir (7R9A5P7H32) ; COVID-19 Vaccines ; Lactams ; Leucine (GMW67QNF9C) ; Nitriles ; Proline (9DLQ4CIU6V)
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2679127-4
    ISSN 2212-1102 ; 2212-1099
    ISSN (online) 2212-1102
    ISSN 2212-1099
    DOI 10.1016/j.vhri.2023.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bacillus velezensis iturins inhibit the hemolytic activity of Staphylococcus aureus.

    Sabino, Yasmin Neves Vieira / de Araújo Domingues, Katialaine Corrêa / O'Connor, Paula Mary / Marques, Pedro Henrique / Santos, Eduardo Horta / Tótola, Marcos Rogério / Abreu, Lucas Magalhães / de Queiroz, Marisa Vieira / Cotter, Paul D / Mantovani, Hilario Cuquetto

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 9469

    Abstract: Bovine mastitis caused by S. aureus has a major economic impact on the dairy sector. With the crucial need for new therapies, anti-virulence strategies have gained attention as alternatives to antibiotics. Here we aimed to identify novel compounds that ... ...

    Abstract Bovine mastitis caused by S. aureus has a major economic impact on the dairy sector. With the crucial need for new therapies, anti-virulence strategies have gained attention as alternatives to antibiotics. Here we aimed to identify novel compounds that inhibit the production/activity of hemolysins, a virulence factor of S. aureus associated with mastitis severity. We screened Bacillus strains obtained from diverse sources for compounds showing anti-hemolytic activity. Our results demonstrate that lipopeptides produced by Bacillus spp. completely prevented the hemolytic activity of S. aureus at certain concentrations. Following purification, both iturins, fengycins, and surfactins were able to reduce hemolysis caused by S. aureus, with iturins showing the highest anti-hemolytic activity (up to 76% reduction). The lipopeptides showed an effect at the post-translational level. Molecular docking simulations demonstrated that these compounds can bind to hemolysin, possibly interfering with enzyme action. Lastly, molecular dynamics analysis indicated general stability of important residues for hemolysin activity as well as the presence of hydrogen bonds between iturins and these residues, with longevous interactions. Our data reveals, for the first time, an anti-hemolytic activity of lipopeptides and highlights the potential application of iturins as an anti-virulence therapy to control bovine mastitis caused by S. aureus.
    MeSH term(s) Bacillus/metabolism ; Bacillus/chemistry ; Staphylococcus aureus/drug effects ; Hemolysis/drug effects ; Animals ; Molecular Docking Simulation ; Cattle ; Lipopeptides/pharmacology ; Lipopeptides/chemistry ; Hemolysin Proteins/antagonists & inhibitors ; Hemolysin Proteins/metabolism ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Mastitis, Bovine/microbiology ; Mastitis, Bovine/drug therapy ; Female ; Peptides, Cyclic/pharmacology ; Peptides, Cyclic/chemistry ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology ; Molecular Dynamics Simulation
    Chemical Substances Lipopeptides ; Hemolysin Proteins ; Anti-Bacterial Agents ; Peptides, Cyclic
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-58973-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Membranolytic Activity Profile of Nonyl 3,4-Dihydroxybenzoate: A New Anti-Biofilm Compound for the Treatment of Dermatophytosis.

    Costa-Orlandi, Caroline B / Bila, Níura M / Bonatti, Jean Lucas C / Vaso, Carolina O / Santos, Mariana B / Polaquini, Carlos R / Santoni Biasioli, Mariana M / Herculano, Rondinelli D / Regasini, Luis O / Fusco-Almeida, Ana Marisa / Mendes-Giannini, Maria José S

    Pharmaceutics

    2023  Volume 15, Issue 5

    Abstract: The ability of dermatophytes to live in communities and resist antifungal drugs may explain treatment recurrence, especially in onychomycosis. Therefore, new molecules with reduced toxicity that target dermatophyte biofilms should be investigated. This ... ...

    Abstract The ability of dermatophytes to live in communities and resist antifungal drugs may explain treatment recurrence, especially in onychomycosis. Therefore, new molecules with reduced toxicity that target dermatophyte biofilms should be investigated. This study evaluated nonyl 3,4-dihydroxybenzoate (nonyl) susceptibility and mechanism of action on planktonic cells and biofilms of
    Language English
    Publishing date 2023-05-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics15051402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Perianal Paget Disease: Different Entities With the Same Name.

    Santos, Marisa D / Soares, Filomena / Presa-Fernandes, José M / Silva, Donzília S

    Cureus

    2021  Volume 13, Issue 5, Page(s) e15161

    Abstract: Extramammary Paget disease (EMPD) is a rare form of cancer that involves skin areas rich in apocrine glands. The common sites of occurrence include the vulva, perianal region, perineum, and axilla. Perianal Paget disease (PPD) is a subset of EMPD, which ... ...

    Abstract Extramammary Paget disease (EMPD) is a rare form of cancer that involves skin areas rich in apocrine glands. The common sites of occurrence include the vulva, perianal region, perineum, and axilla. Perianal Paget disease (PPD) is a subset of EMPD, which arises in the perianal skin. The disease commonly presents with a thickened plaque-like lesion with erythema or white scaly appearance. It is generally classified into two categories based on the origin of the tumor cells: (1) primary PPD if the tumor arises from intraepidermal cells and (2) secondary PPD if cancer originates from the underlying colorectal or urinary tract neoplasm. Due to its rarity, only a few sporadic case reports have been published in the literature, and treatment methods are yet to be standardized. In light of this, we report two PPD cases with different etiopathogenesis and staging: one involved only the perianal skin without regional or metastatic disease, and was not accompanied by visceral adenocarcinomas although there was a previous history of sigmoid adenocarcinoma; the other was probably secondary to an anal canal tumor spreading with disseminated disease involving the perianal and perineum area with bilateral inguinal, pelvic lymph node, and liver metastasis. The treatment plans and the outcomes of both cases were necessarily different from each other.
    Language English
    Publishing date 2021-05-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.15161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Immunomodulatory Effect of Polysaccharides from the Mushroom-Forming Basidiomycete

    Caldas, Lhaís A / Santos, Patricia D / Carbonero, Elaine R / Ionta, Marisa / Miyazawa, Marta / Caixeta, Ester S / Fregnan, Antonio M / Nóbrega, Bianca Barros / Di Medeiros, Maria Carolina B / Menolli, Nelson / Soares, Douglas M M / Stevani, Cassius V / Sartorelli, Patricia

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 10

    Abstract: ... ...

    Abstract Gymnopilus
    Language English
    Publishing date 2022-09-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15101179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Bone formation after surgically assisted rapid maxillary expansion: comparison of 2 distraction osteogenesis protocols.

    Holzinger, Daniel / Carvalho, Pedro Henrique de Azambuja / Dos Santos, José Cleveilton / Wagner, Florian / Gabrielli, Marisa Aparecida Cabrini / Gabrielli, Mario Francisco Real / Filho, Valfrido Antonio Pereira

    Oral surgery, oral medicine, oral pathology and oral radiology

    2021  Volume 133, Issue 3, Page(s) 271–276

    Abstract: ... 3 × 0.25 mm/d; group 2 [G2], 1 mm start followed by 2 × 0.25 mm/d) was analyzed using CBCT scans ...

    Abstract Objective: The aim of this study was to compare bone formation between 2 distraction osteogenesis protocols by analyzing cone beam computed tomography (CBCT) scan data.
    Study design: In this retrospective study, the efficacy of 2 different surgically assisted rapid maxillary expansion protocols (group 1 [G1], 3 × 0.25 mm/d; group 2 [G2], 1 mm start followed by 2 × 0.25 mm/d) was analyzed using CBCT scans obtained at 3 time points: preoperatively (T0), immediately after surgery (T1), and 6 months after surgery (T2). Bone formation at T0, T1, and T2 was analyzed using the Dolphin Imaging 11 program.
    Results: At T1, both groups had significantly higher bone volume than at T0 (G1, 135.6 vs 124.65 mm
    Conclusions: Bone density between the incisors decreased with progressive distraction (i.e., increasing volume), regardless of the distraction protocol used; thus, both protocols can be used safely in clinical practice. Nevertheless, our results indicate that stress should not be applied to the incisors within 6 months of surgery, regardless of the protocol used. Surgeons and orthodontists should therefore consider immature bone formation and avoid using excessive force to close a diastema.
    MeSH term(s) Cephalometry/methods ; Cone-Beam Computed Tomography/methods ; Humans ; Maxilla/diagnostic imaging ; Maxilla/surgery ; Osteogenesis ; Osteogenesis, Distraction/methods ; Palatal Expansion Technique ; Retrospective Studies
    Language English
    Publishing date 2021-06-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2021.06.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Bagaza Virus in Wild Birds, Portugal, 2021.

    Queirós, João / Barros, Sílvia C / Sánchez-Cano, Alberto / Henriques, Ana Margarida / Fagulha, Teresa / Dos Santos, Fábio Abade / Duarte, Margarida D / Fontoura-Gonçalves, Catarina / Gonçalves, David / Rodrigues, Marisa / Cabrera, Teresa Cardona / de Mera, Isabel G Fernández / Gortazar, Christian / Höfle, Ursula / Alves, Paulo Célio

    Emerging infectious diseases

    2022  Volume 28, Issue 7, Page(s) 1504–1506

    Abstract: Bagaza virus emerged in Spain in 2010 and was not reported in other countries in Europe until 2021, when the virus was detected by molecular methods in a corn bunting and several red-legged partridges in Portugal. Sequencing revealed high similarity ... ...

    Abstract Bagaza virus emerged in Spain in 2010 and was not reported in other countries in Europe until 2021, when the virus was detected by molecular methods in a corn bunting and several red-legged partridges in Portugal. Sequencing revealed high similarity between the 2021 strains from Portugal and the 2010 strains from Spain.
    MeSH term(s) Animals ; Animals, Wild/virology ; Bird Diseases/epidemiology ; Bird Diseases/virology ; Flavivirus/classification ; Flavivirus/isolation & purification ; Flavivirus Infections/epidemiology ; Flavivirus Infections/veterinary ; Galliformes/virology ; Portugal/epidemiology ; Spain
    Language English
    Publishing date 2022-06-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2807.212408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Miniprobe endoscopic ultrasonography for the diagnosis of colon hemangiolymphangioma.

    Castro-Poças, Fernando M / Bernardo, Sónia / Lima, Olinda M G / Santos, Marisa D

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2019  Volume 111, Issue 6, Page(s) 488–490

    Abstract: Hemangiolymphangioma is a very rare benign vascular tumor that affects the gastrointestinal tract in less than 1% of cases. We present the case of an asymptomatic 52-year-old female referred for endoscopic colorectal cancer screening. A sub-epithelial ... ...

    Abstract Hemangiolymphangioma is a very rare benign vascular tumor that affects the gastrointestinal tract in less than 1% of cases. We present the case of an asymptomatic 52-year-old female referred for endoscopic colorectal cancer screening. A sub-epithelial pediculated polypoid lesion in the splenic angle of the colon was identified. An endoscopic ultrasonography with a miniprobe was performed, which identified an anechoic lesion in the submucosal layer. Surgery was performed and the histologic findings were compatible with two hemangiolymphangioma lesions. This is one of the few cases reported in the literature of hemangiolymphangioma diagnosed by miniprobe endoscopic ultrasonography and the first to describe two lesions in the same patient.
    MeSH term(s) Colonic Neoplasms/diagnostic imaging ; Endosonography ; Female ; Hemangioma/diagnostic imaging ; Humans ; Lymphangioma/diagnostic imaging ; Middle Aged
    Language English
    Publishing date 2019-05-29
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2019.6144/2018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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