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Article: Measurement of cos2beta in B;{0}-->D;{(*)}h;{0} decays with a time-dependent Dalitz plot analysis of D-->K_{s};{0}pi;{+}pi;{-}.

Aubert, B / Bona, M / Boutigny, D / Karyotakis, Y / Lees, J P / Poireau, V / Prudent, X / Tisserand, V / Zghiche, A / Tico, J Garra / Grauges, E / Lopez, L / Palano, A / Pappagallo, M / Eigen, G / Stugu, B / Sun, L / Abrams, G S / Battaglia, M /

Brown, D N / Button-Shafer, J / Cahn, R N / Groysman, Y / Jacobsen, R G / Kadyk, J A / Kerth, L T / Kolomensky, Yu G / Kukartsev, G / Pegna, D Lopes / Lynch, G / Mir, L M / Orimoto, T J / Osipenkov, I L / Ronan, M T / Tackmann, K / Tanabe, T / Wenzel, W A / Del Amo Sanchez, P / Hawkes, C M / Watson, A T / Koch, H / Schroeder, T / Walker, D / Asgeirsson, D J / Cuhadar-Donszelmann, T / Fulsom, B G / Hearty, C / Mattison, T S / McKenna, J A / Khan, A / Saleem, M / Teodorescu, L / Blinov, V E / Bukin, A D / Druzhinin, V P / Golubev, V B / Onuchin, A P / Serednyakov, S I / Skovpen, Yu I / Solodov, E P / Todyshev, K Yu / Bondioli, M / Curry, S / Eschrich, I / Kirkby, D / Lankford, A J / Lund, P / Mandelkern, M / Martin, E C / Stoker, D P / Abachi, S / Buchanan, C / Foulkes, S D / Gary, J W / Liu, F / Long, O / Shen, B C / Vitug, G M / Zhang, L / Paar, H P / Rahatlou, S / Sharma, V / Berryhill, J W / Campagnari, C / Cunha, A / Dahmes, B / Hong, T M / Kovalskyi, D / Richman, J D / Beck, T W / Eisner, A M / Flacco, C J / Heusch, C A / Kroseberg, J / Lockman, W S / Schalk, T / Schumm, B A / Seiden, A / Wilson, M G / Winstrom, L O / Chen, E / Cheng, C H / Fang, F / Hitlin, D G / Narsky, I / Piatenko, T / Porter, F C / Andreassen, R / Mancinelli, G / Meadows, B T / Mishra, K / Sokoloff, M D / Blanc, F / Bloom, P C / Chen, S / Ford, W T / Hirschauer, J F / Kreisel, A / Nagel, M / Nauenberg, U / Olivas, A / Smith, J G / Ulmer, K A / Wagner, S R / Zhang, J / Gabareen, A M / Soffer, A / Toki, W H / Wilson, R J / Winklmeier, F / Altenburg, D D / Feltresi, E / Hauke, A / Jasper, H / Merkel, J / Petzold, A / Spaan, B / Wacker, K / Klose, V / Kobel, M J / Lacker, H M / Mader, W F / Nogowski, R / Schubert, J / Schubert, K R / Schwierz, R / Sundermann, J E / Volk, A / Bernard, D / Bonneaud, G R / Latour, E / Lombardo, V / Thiebaux, Ch / Verderi, M / Clark, P J / Gradl, W / Muheim, F / Playfer, S / Robertson, A I / Watson, J E / Xie, Y / Andreotti, M / Bettoni, D / Bozzi, C / Calabrese, R / Cecchi, A / Cibinetto, G / Franchini, P / Luppi, E / Negrini, M / Petrella, A / Piemontese, L / Prencipe, E / Santoro, V / Anulli, F / Baldini-Ferroli, R / Calcaterra, A / de Sangro, R / Finocchiaro, G / Pacetti, S / Patteri, P / Peruzzi, I M / Piccolo, M / Rama, M / Zallo, A / Buzzo, A / Contri, R / Lo Vetere, M / Macri, M M / Monge, M R / Passaggio, S / Patrignani, C / Robutti, E / Santroni, A / Tosi, S / Chaisanguanthum, K S / Morii, M / Wu, J / Dubitzky, R S / Marks, J / Schenk, S / Uwer, U / Bard, D J / Dauncey, P D / Flack, R L / Nash, J A / Vazquez, W Panduro / Tibbetts, M / Behera, P K / Chai, X / Charles, M J / Mallik, U / Cochran, J / Crawley, H B / Dong, L / Eyges, V / Meyer, W T / Prell, S / Rosenberg, E I / Rubin, A E / Gao, Y Y / Gritsan, A V / Guo, Z J / Lae, C K / Denig, A G / Fritsch, M / Schott, G / Arnaud, N / Béquilleux, J / D'Orazio, A / Davier, M / Grosdidier, G / Höcker, A / Lepeltier, V / Le Diberder, F / Lutz, A M / Pruvot, S / Rodier, S / Roudeau, P / Schune, M H / Serrano, J / Sordini, V / Stocchi, A / Wang, W F / Wormser, G / Lange, D J / Wright, D M / Bingham, I / Chavez, C A / Fry, J R / Gabathuler, E / Gamet, R / Hutchcroft, D E / Payne, D J / Schofield, K C / Touramanis, C / Bevan, A J / George, K A / Di Lodovico, F / Sacco, R / Cowan, G / Flaecher, H U / Hopkins, D A / Paramesvaran, S / Salvatore, F / Wren, A C / Davis, C L / Allison, J / Bailey, D / Barlow, N R / Barlow, R J / Chia, Y M / Edgar, C L / Lafferty, G D / West, T J / Yi, J I / Anderson, J / Chen, C / Jawahery, A / Roberts, D A / Simi, G / Tuggle, J M / Blaylock, G / Dallapiccola, C / Hertzbach, S S / Li, X / Moore, T B / Salvati, E / Saremi, S / Cowan, R / Dujmic, D / Fisher, P H / Koeneke, K / Sciolla, G / Spitznagel, M / Taylor, F / Yamamoto, R K / Zhao, M / Zheng, Y / McLachlin, S E / Patel, P M / Robertson, S H / Lazzaro, A / Palombo, F / Bauer, J M / Cremaldi, L / Eschenburg, V / Godang, R / Kroeger, R / Sanders, D A / Summers, D J / Zhao, H W / Brunet, S / Côté, D / Simard, M / Taras, P / Viaud, F B / Nicholson, H / De Nardo, G / Fabozzi, F / Lista, L / Monorchio, D / Sciacca, C / Baak, M A / Raven, G / Snoek, H L / Jessop, C P / Knoepfel, K J / Losecco, J M / Benelli, G / Corwin, L A / Honscheid, K / Kagan, H / Kass, R / Morris, J P / Rahimi, A M / Regensburger, J J / Sekula, S J / Wong, Q K / Blount, N L / Brau, J / Frey, R / Igonkina, O / Kolb, J A / Lu, M / Rahmat, R / Sinev, N B / Strom, D / Strube, J / Torrence, E / Gagliardi, N / Gaz, A / Margoni, M / Morandin, M / Pompili, A / Posocco, M / Rotondo, M / Simonetto, F / Stroili, R / Voci, C / Ben-Haim, E / Briand, H / Calderini, G / Chauveau, J / David, P / Del Buono, L / de la Vaissière, Ch / Hamon, O / Leruste, Ph / Malclès, J / Ocariz, J / Perez, A / Prendki, J / Gladney, L / Biasini, M / Covarelli, R / Manoni, E / Angelini, C / Batignani, G / Bettarini, S / Carpinelli, M / Cenci, R / Cervelli, A / Forti, F / Giorgi, M A / Lusiani, A / Marchiori, G / Mazur, M A / Morganti, M / Neri, N / Paoloni, E / Rizzo, G / Walsh, J J / Biesiada, J / Elmer, P / Lau, Y P / Lu, C / Olsen, J / Smith, A J S / Telnov, A V / Baracchini, E / Bellini, F / Cavoto, G / Del Re, D / Di Marco, E / Faccini, R / Ferrarotto, F / Ferroni, F / Gaspero, M / Jackson, P D / Gioi, L Li / Mazzoni, M A / Morganti, S / Piredda, G / Polci, F / Renga, F / Voena, C / Ebert, M / Hartmann, T / Schröder, H / Waldi, R / Adye, T / Castelli, G / Franek, B / Olaiya, E O / Roethel, W / Wilson, F F / Emery, S / Escalier, M / Gaidot, A / Ganzhur, S F / de Monchenault, G Hamel / Kozanecki, W / Vasseur, G / Yèche, Ch / Zito, M / Chen, X R / Liu, H / Park, W / Purohit, M V / White, R M / Wilson, J R / Allen, M T / Aston, D / Bartoldus, R / Bechtle, P / Claus, R / Coleman, J P / Convery, M R / Dingfelder, J C / Dorfan, J / Dubois-Felsmann, G P / Dunwoodie, W / Field, R C / Glanzman, T / Gowdy, S J / Graham, M T / Grenier, P / Hast, C / Innes, W R / Kaminski, J / Kelsey, M H / Kim, H / Kim, P / Kocian, M L / Leith, D W G S / Li, S / Luitz, S / Luth, V / Lynch, H L / Macfarlane, D B / Marsiske, H / Messner, R / Muller, D R / O'Grady, C P / Ofte, I / Perazzo, A / Perl, M / Pulliam, T / Ratcliff, B N / Roodman, A / Salnikov, A A / Schindler, R H / Schwiening, J / Snyder, A / Su, D / Sullivan, M K / Suzuki, K / Swain, S K / Thompson, J M / Va'vra, J / Wagner, A P / Weaver, M / Wisniewski, W J / Wittgen, M / Wright, D H / Yarritu, A K / Yi, K / Young, C C / Ziegler, V / Burchat, P R / Edwards, A J / Majewski, S A / Miyashita, T S / Petersen, B A / Wilden, L / Ahmed, S / Alam, M S / Bula, R / Ernst, J A / Jain, V / Pan, B / Saeed, M A / Wappler, F R / Zain, S B / Krishnamurthy, M / Spanier, S M / Eckmann, R / Ritchie, J L / Ruland, A M / Schilling, C J / Schwitters, R F / Izen, J M / Lou, X C / Ye, S / Bianchi, F / Gallo, F / Gamba, D / Pelliccioni, M / Bomben, M / Bosisio, L / Cartaro, C / Cossutti, F / Della Ricca, G / Lanceri, L / Vitale, L / Azzolini, V / Lopez-March, N / Martinez-Vidal, F / Milanes, D A / Oyanguren, A / Albert, J / Banerjee, Sw / Bhuyan, B / Hamano, K / Kowalewski, R / Nugent, I M / Roney, J M / Sobie, R J / Harrison, P F / Ilic, J / Latham, T E / Mohanty, G B / Band, H R / Chen, X / Dasu, S / Flood, K T / Hollar, J J / Kutter, P E / Pan, Y / Pierini, M / Prepost, R / Wu, S L / Neal, H

Physical review letters

2007 Volume 99, Issue 23, Page(s) 231802

Abstract: We study the time-dependent Dalitz plot of D-->K_{S};{0}pi;{+}pi;{-} in B;{0}-->D;{(*)}h;{0} decays ... where h;{0} is a pi;{0}, eta, eta;{'}, or omega meson and D;{*}-->Dpi;{0}, using a data sample of 383x10 ...

Abstract	We study the time-dependent Dalitz plot of D-->K_{S};{0}pi;{+}pi;{-} in B;{0}-->D;{()}h;{0} decays, where h;{0} is a pi;{0}, eta, eta;{'}, or omega meson and D;{}-->Dpi;{0}, using a data sample of 383x10;{6} Upsilon(4S)-->BB[over ] decays collected with the BABAR detector. We determine cos2beta=0.42+/-0.49+/-0.09+/-0.13, sin2beta=0.29+/-0.34+/-0.03+/-0.05, and \|lambda\|=1.01+/-0.08+/-0.02, where the first error is statistical, the second is the experimental systematic uncertainty, and the third, where given, is the Dalitz model uncertainty. Assuming the world average value for sin2beta and \|lambda\|=1, cos2beta>0 is preferred over cos2beta<0 at 86% confidence level.
Language	English
Publishing date	2007-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.99.231802
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Article: Hyperendemic H. pylori and tapeworm infections in a U.S.-Mexico border population.

Cardenas, Victor M / Mena, Kristina D / Ortiz, Melchor / Karri, Sitrulasi / Variyam, Easwaran / Behravesh, Casey Barton / Snowden, Karen F / Flisser, Ana / Bristol, John R / Mayberry, Lillian F / Ortega, Ynes R / Fukuda, Yoshihiro / Campos, Armando / Graham, David Y

Public health reports (Washington, D.C. : 1974)

2010 Volume 125, Issue 3, Page(s) 441–447

Abstract: Objective: A higher incidence of infectious disease has been documented in U.S. regions bordering ... infections in Ciudad Juarez, Mexico, and El Paso, Texas, the largest binational community along the U.S ... all ages were tested for Helicobacter pylori (H. pylori), Cryptosporidium spp., Giardia spp., and ...

Abstract	Objective: A higher incidence of infectious disease has been documented in U.S. regions bordering Mexico compared with non-border areas. We assessed the prevalence of important gastrointestinal infections in Ciudad Juarez, Mexico, and El Paso, Texas, the largest binational community along the U.S.-Mexico border. Methods: Fecal specimens from a sample of the asymptomatic population representing all ages were tested for Helicobacter pylori (H. pylori), Cryptosporidium spp., Giardia spp., and other intestinal parasitic pathogens using flotation, immunoassays, and/or polymerase chain reaction. We also measured indicators of microbiological contamination of drinking water, hands of food preparers, and kitchen surfaces. Results: Overall, of the 386 participants, H. pylori was present in 38.2%, Taenia spp. in 3.3%, Giardia spp. in 2.7%, Cryptosporidium spp. in 1.9%, Entamoeba dispar in 1.3%, and Ascaris lumbricoides and Necator americanus in 0.3% of the study subjects; Cyclospora spp. and Entamoeba histolytica were not found. H. pylori infection was associated with handwashing (prevalence ratio [PR] = 1.3, 95% confidence interval [CI] 1.0, 1.8). Taenia spp. was found more often on the U.S. side (PR=8.6, 95% CI 2.3, 30.8). We did not find an association between these infections and the occurrence of total coliforms or fecal coliforms on kitchen surfaces. In addition, Escherichia coli was not found in any drinking water sample. Conclusion: The study results indicated that H. pylori and Taenia spp. infections may be highly prevalent along the U.S.-Mexico border. Additional research is necessary to adequately characterize the prevalence, as well as determine whether interventions that reduce these infections are warranted.
MeSH term(s)	Adolescent ; Adult ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Helicobacter Infections/epidemiology ; Helicobacter Infections/prevention & control ; Helicobacter pylori ; Humans ; Infant ; Infant, Newborn ; Intestinal Diseases, Parasitic/epidemiology ; Intestinal Diseases, Parasitic/prevention & control ; Male ; Mexico/epidemiology ; Middle Aged ; Prevalence ; Risk Factors ; Taeniasis/epidemiology ; Taeniasis/prevention & control ; United States/epidemiology
Language	English
Publishing date	2010-04-29
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	120953-x
ISSN	1468-2877 ; 0033-3549
ISSN (online)	1468-2877
ISSN	0033-3549
DOI	10.1177/003335491012500313
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Article ; Online: Succinyl-CoA Synthetase Dysfunction as a Mechanism of Mitochondrial Encephalomyopathy: More than Just an Oxidative Energy Deficit.

Lancaster, Makayla S / Graham, Brett H

International journal of molecular sciences

2023 Volume 24, Issue 13

Abstract: Biallelic pathogenic variants in subunits of succinyl-CoA synthetase (SCS), a tricarboxylic acid (TCA) cycle enzyme, are associated with mitochondrial encephalomyopathy in humans. SCS catalyzes the interconversion of succinyl-CoA to succinate, coupled to ...

Abstract	Biallelic pathogenic variants in subunits of succinyl-CoA synthetase (SCS), a tricarboxylic acid (TCA) cycle enzyme, are associated with mitochondrial encephalomyopathy in humans. SCS catalyzes the interconversion of succinyl-CoA to succinate, coupled to substrate-level phosphorylation of either ADP or GDP, within the TCA cycle. SCS-deficient encephalomyopathy typically presents in infancy and early childhood, with many patients succumbing to the disease during childhood. Common symptoms include abnormal brain MRI, basal ganglia lesions and cerebral atrophy, severe hypotonia, dystonia, progressive psychomotor regression, and growth deficits. Although subunits of SCS were first identified as causal genes for progressive metabolic encephalomyopathy in the early 2000s, recent investigations are now beginning to unravel the pathomechanisms underlying this metabolic disorder. This article reviews the current understanding of SCS function within and outside the TCA cycle as it relates to the complex and multifactorial mechanisms underlying SCS-related mitochondrial encephalomyopathy.
MeSH term(s)	Child, Preschool ; Humans ; Mitochondrial Encephalomyopathies/genetics ; Mitochondrial Encephalomyopathies/metabolism ; Mitochondria/metabolism ; Succinate-CoA Ligases/genetics ; Succinate-CoA Ligases/metabolism ; Oxidative Stress
Chemical Substances	succinyl-coenzyme A (BSI27HW5EQ) ; Succinate-CoA Ligases (EC 6.2.1.-)
Language	English
Publishing date	2023-06-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241310725
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Article ; Online: Why the Vonoprazan Helicobacter pylori Therapies in the US-European Trial Produced Unacceptable Cure Rates.

Graham, David Y

Digestive diseases and sciences

2023 Volume 68, Issue 5, Page(s) 1691–1697

Abstract: ... etiologically related to gastric cancer. The U.S. Food and Drug Administration recently approved two 14-day ... vonoprazan-containing regimens (vonoprazan-amoxicillin with or without clarithromycin) for H. pylori ... that vonoprazan-clarithromycin triple therapies should not be prescribed for H. pylori infection. Dual vonoprazan ...

Abstract	Introduction: Helicobacter pylori infects a large percentage of the world's population and is etiologically related to gastric cancer. The U.S. Food and Drug Administration recently approved two 14-day vonoprazan-containing regimens (vonoprazan-amoxicillin with or without clarithromycin) for H. pylori infections in the United States/Europe. Methods: We critically reviewed the trial methods to discover why the results were unacceptable low [i.e., no regimen achieved clinically acceptable (≥ 90%) or even conditionally acceptable cure rates (≥ 85%)]. Cure rates with antibiotic susceptible strains were 84.7 for vonoprazan triple therapy, 78.5 for vonoprazan-amoxicillin, and 78.7 for lansoprazole triple therapy, respectively. As was previously shown in Japan, the benefit from adding clarithromycin to vonoprazan-amoxicillin was minimal and the majority of the clarithromycin administered was unnecessary. Results: The possible reasons for failure to achieve high cure rates discussed include (a) reduced intragastric antibiotic concentrations, (b) an increase in heteroresistance, and (c) failure to achieve an intragastric pH conducive for amoxicillin to eradicate the infection. In addition, there was no pilot study or other attempt to optimize any regimen. Conclusion: The most likely reason for failure was failure to achieve high intragastric concentrations of antibiotics or to achieve an intragastric pH conducive for amoxicillin to be active. Importantly, vonoprazan triple therapy resulted in > 10 tons of unneeded clarithromycin/million courses of vonoprazan triple therapy. Antibiotic misuse combined with low cure rates suggest that vonoprazan-clarithromycin triple therapies should not be prescribed for H. pylori infection. Dual vonoprazan-amoxicillin therapy has proven effective elsewhere and after optimization may eventually prove useful in the U.S./Europe.
MeSH term(s)	Humans ; Clarithromycin/therapeutic use ; Helicobacter pylori ; Proton Pump Inhibitors ; Drug Therapy, Combination ; Anti-Bacterial Agents ; Amoxicillin ; Helicobacter Infections/drug therapy ; Treatment Outcome
Chemical Substances	Clarithromycin (H1250JIK0A) ; 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine ; Proton Pump Inhibitors ; Anti-Bacterial Agents ; Amoxicillin (804826J2HU)
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-023-07886-5
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Article ; Online: ASO Author Reflections: The Impact of Oncocytic Histology on Survival in Adrenocortical Carcinoma.

Shirali, Aditya S / Graham, Paul H

Annals of surgical oncology

2022 Volume 29, Issue 9, Page(s) 5564–5565

MeSH term(s)	Adrenal Cortex Neoplasms/pathology ; Adrenal Cortex Neoplasms/surgery ; Adrenocortical Carcinoma/pathology ; Adrenocortical Carcinoma/surgery ; Humans ; Oxyphil Cells/pathology
Language	English
Publishing date	2022-05-10
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-022-11635-9
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Article ; Online: Literature Highlights.

Felker, I / Tiberi, S / Graham, S / Blackbourn, H D

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

2023 Volume 27, Issue 2, Page(s) 98–100

Abstract: Literature Highlights is a digest of notable papers recently published in the leading respiratory journals. Coverage includes clinical trials of a new vaccine for COVID-19; phase 3 trials of two shorter regimen for drug-resistant TB; evaluation of early ... ...

Abstract	Literature Highlights is a digest of notable papers recently published in the leading respiratory journals. Coverage includes clinical trials of a new vaccine for COVID-19; phase 3 trials of two shorter regimen for drug-resistant TB; evaluation of early diagnosis and treatment of TB in children; understanding the costs of TB services; use of digital eHealth for TB care; a review of the diagnostic accuracy of different molecular assays for TB in children.
Language	English
Publishing date	2023-02-28
Publishing country	France
Document type	Review ; Journal Article
ZDB-ID	1385624-8
ISSN	1815-7920 ; 1027-3719
ISSN (online)	1815-7920
ISSN	1027-3719
DOI	10.5588/ijtld.23.9902
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Article ; Online: Literature Highlights.

Trauer, J M / Tiberi, S / Graham, S M / Blackbourn, H D

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

2023 Volume 27, Issue 10, Page(s) 721–723

Abstract: Literature Highlights is a digest of notable papers recently published in the leading respiratory journals, allowing our readers to stay up-to-date with research advances. Coverage in this issue includes time to smear and culture conversion during TB ... ...

Abstract	Literature Highlights is a digest of notable papers recently published in the leading respiratory journals, allowing our readers to stay up-to-date with research advances. Coverage in this issue includes time to smear and culture conversion during TB treatment; probability of diagnosing ventilator-associated pneumonia in intensive care and use of antimicrobials; optimising computer-aided chest X-ray to diagnose intra-thoracic TB in children; and clinical standards for asthma in low- and middle-income countries.
MeSH term(s)	Child ; Humans ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/epidemiology ; Asthma/diagnosis ; Asthma/drug therapy ; Probability
Language	English
Publishing date	2023-09-26
Publishing country	France
Document type	Editorial
ZDB-ID	1385624-8
ISSN	1815-7920 ; 1027-3719
ISSN (online)	1815-7920
ISSN	1027-3719
DOI	10.5588/ijtld.23.9910
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Article ; Online: Témoignage

Jessica Graham

Brésil(s), Vol

2022 Volume 5

Keywords	Anthropology ; GN1-890 ; Social Sciences ; H
Language	French
Publishing date	2022-11-01T00:00:00Z
Publisher	Maison des Science de l'Homme
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Response to Letter to the Editor on "The Paradox of Patient-Reported Outcome Measures: Should We Prioritize "Feeling Better" or "Feeling Good" After Total Knee Arthroplasty?"

Goh, Graham S / Lonner, Jess H

The Journal of arthroplasty

2022 Volume 37, Issue 10, Page(s) e10–e11

MeSH term(s)	Arthroplasty, Replacement, Knee ; Humans ; Knee Prosthesis ; Patient Reported Outcome Measures
Language	English
Publishing date	2022-09-06
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	632770-9
ISSN	1532-8406 ; 0883-5403
ISSN (online)	1532-8406
ISSN	0883-5403
DOI	10.1016/j.arth.2022.05.030
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Succinyl-CoA Synthetase Dysfunction as a Mechanism of Mitochondrial Encephalomyopathy

Makayla S. Lancaster / Brett H. Graham

International Journal of Molecular Sciences, Vol 24, Iss 10725, p

More than Just an Oxidative Energy Deficit

2023 Volume 10725

Abstract	Biallelic pathogenic variants in subunits of succinyl-CoA synthetase (SCS), a tricarboxylic acid (TCA) cycle enzyme, are associated with mitochondrial encephalomyopathy in humans. SCS catalyzes the interconversion of succinyl-CoA to succinate, coupled to substrate-level phosphorylation of either ADP or GDP, within the TCA cycle. SCS-deficient encephalomyopathy typically presents in infancy and early childhood, with many patients succumbing to the disease during childhood. Common symptoms include abnormal brain MRI, basal ganglia lesions and cerebral atrophy, severe hypotonia, dystonia, progressive psychomotor regression, and growth deficits. Although subunits of SCS were first identified as causal genes for progressive metabolic encephalomyopathy in the early 2000s, recent investigations are now beginning to unravel the pathomechanisms underlying this metabolic disorder. This article reviews the current understanding of SCS function within and outside the TCA cycle as it relates to the complex and multifactorial mechanisms underlying SCS-related mitochondrial encephalomyopathy.
Keywords	succinyl-CoA synthetase ; tricarboxylic acid cycle ; mitochondria ; encephalomyopathy ; mitochondrial DNA ; protein succinylation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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