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Article: Programming a serial killer: CAR T cells form non-classical immune synapses.

Davenport, Alexander J / Jenkins, Misty R

Oncoscience

2018 Volume 5, Issue 3-4, Page(s) 69–70

Language	English
Publishing date	2018-04-29
Publishing country	United States
Document type	Editorial
ISSN	2331-4737
ISSN	2331-4737
DOI	10.18632/oncoscience.406
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Article ; Online: Publisher Correction: A Dataset of Amphibian Species in U.S. National Parks.

LaFrance, Benjamin J / Ray, Andrew M / Fisher, Robert N / Grant, Evan H Campbell / Shafer, Charles / Beamer, David A / Spear, Stephen F / Pierson, Todd W / Davenport, Jon M / Niemiller, Matthew L / Pyron, R Alexander / Glorioso, Brad M / Barichivich, William J / Halstead, Brian J / Roberts, Kory G / Hossack, Blake R

Scientific data

2024 Volume 11, Issue 1, Page(s) 409

Language	English
Publishing date	2024-04-22
Publishing country	England
Document type	Published Erratum
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-024-03257-5
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Article ; Online: Navigating through the haemostatic paradox in kidney failure: A practical overview.

Caruana, Jessica / Riva, Nicoletta / Vella, Kevin / Davenport, Andrew / Gatt, Alexander

British journal of haematology

2023 Volume 202, Issue 2, Page(s) 230–247

Abstract: Chronic kidney disease (CKD) affects around 9.1% of humankind globally resulting in a significant health burden. Some of these individuals will also require renal replacement therapy with dialysis due to complete kidney failure. Patients with CKD are ... ...

Abstract	Chronic kidney disease (CKD) affects around 9.1% of humankind globally resulting in a significant health burden. Some of these individuals will also require renal replacement therapy with dialysis due to complete kidney failure. Patients with CKD are known to be at increased risk of both bleeding and thrombosis. Often it is very difficult to manage these yin and yang since both risks tend to co-exist. Clinically, very few studies have looked at the effects of antiplatelet agents and anticoagulants in this highly vulnerable subgroup of medical patients and evidence is very limited. This review attempts to explain the current state-of-the-art regarding the basic science of haemostasis in patients with end-stage kidney disease. We also try to transfer this knowledge into the clinics by looking at some common haemostasis challenges that are encountered in this cohort of patients and what evidence and guidance there is for their optimal management.
MeSH term(s)	Humans ; Hemostatics/therapeutic use ; Anticoagulants/therapeutic use ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Renal Insufficiency, Chronic/complications ; Hemostasis
Chemical Substances	Hemostatics ; Anticoagulants
Language	English
Publishing date	2023-06-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.18903
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Article ; Online: A Dataset of Amphibian Species in U.S. National Parks.

Scientific data

2024 Volume 11, Issue 1, Page(s) 32

Abstract: National parks and other protected areas are important for preserving landscapes and biodiversity worldwide. An essential component of the mission of the United States (U.S.) National Park Service (NPS) requires understanding and maintaining accurate ... ...

Abstract	National parks and other protected areas are important for preserving landscapes and biodiversity worldwide. An essential component of the mission of the United States (U.S.) National Park Service (NPS) requires understanding and maintaining accurate inventories of species on protected lands. We describe a new, national-scale synthesis of amphibian species occurrence in the NPS system. Many park units have a list of amphibian species observed within their borders compiled from various sources and available publicly through the NPSpecies platform. However, many of the observations in NPSpecies remain unverified and the lists are often outdated. We updated the amphibian dataset for each park unit by collating old and new park-level records and had them verified by regional experts. The new dataset contains occurrence records for 292 of the 424 NPS units and includes updated taxonomy, international and state conservation rankings, hyperlinks to a supporting reference for each record, specific notes, and related fields which can be used to better understand and manage amphibian biodiversity within a single park or group of parks.
MeSH term(s)	Animals ; Amphibians ; Biodiversity ; Conservation of Natural Resources ; Parks, Recreational ; United States
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Dataset ; Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-023-02836-2
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Article ; Online: Super-killer CTLs are generated by single gene deletion of Bach2.

Barton, Philippa R / Davenport, Alexander J / Hukelmann, Jens / Cantrell, Doreen A / Stinchcombe, Jane C / Richard, Arianne C / Griffiths, Gillian M

European journal of immunology

2022 Volume 52, Issue 11, Page(s) 1776–1788

Abstract: Bach2 codes for a transcriptional regulator exerting major influences on T cell-mediated immune regulation. Effector CTLs derived from in vitro activation of murine ... ...

Abstract	Bach2 codes for a transcriptional regulator exerting major influences on T cell-mediated immune regulation. Effector CTLs derived from in vitro activation of murine CD8
MeSH term(s)	Mice ; Animals ; CD8-Positive T-Lymphocytes ; Cytotoxicity, Immunologic ; Gene Deletion ; Proteomics ; T-Lymphocytes, Cytotoxic ; Perforin ; Granzymes/genetics ; Basic-Leucine Zipper Transcription Factors/genetics
Chemical Substances	Perforin (126465-35-8) ; Granzymes (EC 3.4.21.-) ; Basic-Leucine Zipper Transcription Factors ; Bach2 protein, mouse
Language	English
Publishing date	2022-09-26
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.202249797
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Article ; Online: Web-Based Health Information Seeking by People Living With Multiple Sclerosis: Qualitative Investigation of the Multiple Sclerosis Online Course.

Bevens, William / Davenport, Rebekah / Neate, Sandra / Yu, Maggie / Jelinek, Pia / Jelinek, George Alexander / Reece, Jeanette

Journal of medical Internet research

2024 Volume 26, Page(s) e53372

Abstract: Background: Digital technologies have afforded people living with multiple sclerosis (MS) access to telehealth consultations, diagnostic tools, and monitoring. Although health care professionals remain the most trusted source of information, the ... ...

Abstract	Background: Digital technologies have afforded people living with multiple sclerosis (MS) access to telehealth consultations, diagnostic tools, and monitoring. Although health care professionals remain the most trusted source of information, the internet has emerged as a valuable resource for providing MS-related information, particularly during the COVID-19 pandemic. Notably, people living with MS are increasingly seeking educational content for a range of topics related to the self-management of MS; however, web-based information seeking remains largely underevaluated. To address this gap and ensure that web-based health-related information is accessible and engaging, this study used qualitative methods to analyze the reflections from participants of web-based educational programs for people living with MS. Objective: This study aimed to explore the motivations, behaviors, and expectations of web-based health information seeking for people living with MS. Methods: We conducted semistructured interviews for 38 people living with MS 1 month after they completed the novel MS Online Course, which provided information on modifiable lifestyle-related risk factors for people living with MS. Of the 38 participants, 22 (58%) completed the intervention course and 16 (42%) completed the standard care course. Inductive thematic analysis was used within a qualitative paradigm, and 2 authors coded each interview separately and arrived at themes with consensus. Results: We identified 2 themes: motivation to learn and MS information on the web. The diagnosis of MS was described as a pivotal moment for precipitating web-based information seeking. People living with MS sought lifestyle-related information to facilitate self-management and increase control of their MS. Although social media sites and MS websites were considered useful for providing both support and information, discretion was needed to critically appraise information. Recognizable institutions were frequently accessed because of their trustworthiness. Conclusions: This study provided novel insights into the motivations of people living with MS for seeking web-based health information. Furthermore, their preferences for the content and format of the web-based information accessed and their experiences and reactions to this information were explored. These findings may guide educators, researchers, and clinicians involved in MS care to optimize the engagement and processing of web-based health information seeking by people living with MS.
MeSH term(s)	Humans ; Information Seeking Behavior ; Multiple Sclerosis/therapy ; Pandemics ; Health Personnel ; Internet
Language	English
Publishing date	2024-02-09
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2028830-X
ISSN	1438-8871 ; 1438-8871
ISSN (online)	1438-8871
ISSN	1438-8871
DOI	10.2196/53372
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Article: A combined immunopeptidomics, proteomics, and cell surface proteomics approach to identify immunotherapy targets for diffuse intrinsic pontine glioma.

Pandey, Kirti / Wang, Stacie S / Mifsud, Nicole A / Faridi, Pouya / Davenport, Alexander J / Webb, Andrew I / Sandow, Jarrod J / Ayala, Rochelle / Monje, Michelle / Cross, Ryan S / Ramarathinam, Sri H / Jenkins, Misty R / Purcell, Anthony W

Frontiers in oncology

2023 Volume 13, Page(s) 1192448

Abstract: Introduction: Diffuse intrinsic pontine glioma (DIPG), recently reclassified as a subtype of diffuse midline glioma, is a highly aggressive brainstem tumor affecting children and young adults, with no cure and a median survival of only 9 months. ... ...

Abstract	Introduction: Diffuse intrinsic pontine glioma (DIPG), recently reclassified as a subtype of diffuse midline glioma, is a highly aggressive brainstem tumor affecting children and young adults, with no cure and a median survival of only 9 months. Conventional treatments are ineffective, highlighting the need for alternative therapeutic strategies such as cellular immunotherapy. However, identifying unique and tumor-specific cell surface antigens to target with chimeric antigen receptor (CAR) or T-cell receptor (TCR) therapies is challenging. Methods: In this study, a multi-omics approach was used to interrogate patient-derived DIPG cell lines and to identify potential targets for immunotherapy. Results: Through immunopeptidomics, a range of targetable peptide antigens from cancer testis and tumor-associated antigens as well as peptides derived from human endogenous retroviral elements were identified. Proteomics analysis also revealed upregulation of potential drug targets and cell surface proteins such as Cluster of differentiation 27 (CD276) B7 homolog 3 protein (B7H3), Interleukin 13 alpha receptor 2 (IL-13Rα2), Human Epidermal Growth Factor Receptor 3 (HER2), Ephrin Type-A Receptor 2 (EphA2), and Ephrin Type-A Receptor 3 (EphA3). Discussion: The results of this study provide a valuable resource for the scientific community to accelerate immunotherapeutic approaches for DIPG. Identifying potential targets for CAR and TCR therapies could open up new avenues for treating this devastating disease.
Language	English
Publishing date	2023-08-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1192448
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Article ; Online: HER2 chimeric antigen receptor T cell immunotherapy is an effective treatment for diffuse intrinsic pontine glioma.

Wang, Stacie S / Davenport, Alexander J / Iliopoulos, Melinda / Hughes-Parry, Hannah E / Watson, Katherine A / Arcucci, Valeria / Mulazzani, Matthias / Eisenstat, David D / Hansford, Jordan R / Cross, Ryan S / Jenkins, Misty R

Neuro-oncology advances

2023 Volume 5, Issue 1, Page(s) vdad024

Abstract: Background: Diffuse intrinsic pontine glioma (DIPG) and other diffuse midline gliomas (DMG) of the thalamus and spinal cord are rare but devastating high-grade glial tumors of childhood with no curative treatment. Despite aggressive treatment attempts ... ...

Abstract	Background: Diffuse intrinsic pontine glioma (DIPG) and other diffuse midline gliomas (DMG) of the thalamus and spinal cord are rare but devastating high-grade glial tumors of childhood with no curative treatment. Despite aggressive treatment attempts the prognosis has remained poor. Chimeric antigen receptor (CAR) T cell therapy has been identified as a promising new approach in the treatment of DMG tumors; however, additional targets are urgently required given known tumor heterogeneity and the prospect of antigen escape of this cancer. Methods: Using cell surface mass spectrometry, we detected high HER2 cell surface protein across a panel of patient-derived DIPG cells, thereby identifying an existing CAR T cell therapy for use in DIPG. Primary human T cells were transduced to express a second-generation HER2 CAR and interrogated for efficacy against patient-derived DIPG cells. Results: HER2 CAR T cells demonstrated potent and antigen-specific cytotoxicity and cytokine secretion when co-cultured with patient-derived DIPG cells. Furthermore, HER2 CAR T cells provided a significant regression in intracranial DIPG xenograft tumors. Conclusions: HER2 CAR T cells are already in clinic development and are well tolerated in pediatric patients. Here we provide strong preclinical evidence for the inclusion of DIPG patients in future pediatric CNS tumor HER2 CAR T cell clinical trials.
Language	English
Publishing date	2023-05-04
Publishing country	England
Document type	Journal Article
ZDB-ID	3009682-0
ISSN	2632-2498 ; 2632-2498
ISSN (online)	2632-2498
ISSN	2632-2498
DOI	10.1093/noajnl/vdad024
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Article ; Online: Evaluation of Physician Knowledge of Safety and Safe Use Information for Intravitreal Aflibercept Injection in Europe: A Second Survey of Physicians Following Dissemination of Updated Risk-Minimization Materials.

Zografos, Laurie J / Andrews, Elizabeth / Wolin, Dan L / Calingaert, Brian / Davenport, Eric K / Michel, Alexander / Latocha, Margarete / Schmidt-Ott, Ursula Maria / Lovic, Nejra / Brunck, Lynne R / Johnson, Kristian T / Suzart-Woischnik, Kiliana

Pharmaceutical medicine

2023 Volume 38, Issue 1, Page(s) 63–73

Abstract: Background: Materials have been distributed in the European Union to inform physicians on the safe use of intravitreal aflibercept (IVT-AFL) as part of the risk-minimization plan for IVT-AFL.: Objective: We aimed to measure physician knowledge and ... ...

Abstract	Background: Materials have been distributed in the European Union to inform physicians on the safe use of intravitreal aflibercept (IVT-AFL) as part of the risk-minimization plan for IVT-AFL. Objective: We aimed to measure physician knowledge and understanding of key safety information for IVT-AFL. Methods: The current study was a follow-up cross-sectional survey ('wave 2') to an earlier survey ('wave 1') examining the effectiveness of the IVT-AFL educational materials by assessing physician knowledge of the key safety information. Based on wave 1 results, the educational materials were revised to focus more on items of key concern (e.g., use in women of childbearing potential, procedural information); physicians in France, Germany, Italy, Spain, and the UK completed a questionnaire to evaluate their knowledge of key safety information in the revised educational materials. Results: Among 454 physician respondents (of 4715 invited; response rate 9.6%), most reported having received the IVT-AFL Summary of Product Characteristics (SmPC; 89%) and Prescriber Guide (82%). More than half reported receiving the Injection Procedure Video (54%) and Patient Booklet (65%). The highest percentage of correct answers was observed for questions concerning procedural steps, the most important risks, and safe use as emphasized by the educational materials and the SmPC. Conclusion: Physician knowledge and understanding of safe use of IVT-AFL, including for questions that prompted revisions to the educational materials, suggests the need to reconsider methods for developing educational materials to follow best practices (e.g., focusing on only key messages and pretesting with end users).
MeSH term(s)	Humans ; Female ; Cross-Sectional Studies ; Europe ; Physicians ; Surveys and Questionnaires ; Recombinant Fusion Proteins ; Receptors, Vascular Endothelial Growth Factor
Chemical Substances	aflibercept (15C2VL427D) ; Recombinant Fusion Proteins ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1)
Language	English
Publishing date	2023-12-05
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2415165-8
ISSN	1179-1993 ; 1178-2595
ISSN (online)	1179-1993
ISSN	1178-2595
DOI	10.1007/s40290-023-00506-7
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Article ; Online: Neutrophils and emergency granulopoiesis drive immune suppression and an extreme response endotype during sepsis.

Kwok, Andrew J / Allcock, Alice / Ferreira, Ricardo C / Cano-Gamez, Eddie / Smee, Madeleine / Burnham, Katie L / Zurke, Yasemin-Xiomara / McKechnie, Stuart / Mentzer, Alexander J / Monaco, Claudia / Udalova, Irina A / Hinds, Charles J / Todd, John A / Davenport, Emma E / Knight, Julian C

Nature immunology

2023 Volume 24, Issue 5, Page(s) 767–779

Abstract: Sepsis arises from diverse and incompletely understood dysregulated host response processes following infection that leads to life-threatening organ dysfunction. Here we showed that neutrophils and emergency granulopoiesis drove a maladaptive response ... ...

Abstract	Sepsis arises from diverse and incompletely understood dysregulated host response processes following infection that leads to life-threatening organ dysfunction. Here we showed that neutrophils and emergency granulopoiesis drove a maladaptive response during sepsis. We generated a whole-blood single-cell multiomic atlas (272,993 cells, n = 39 individuals) of the sepsis immune response that identified populations of immunosuppressive mature and immature neutrophils. In co-culture, CD66b
MeSH term(s)	Humans ; Neutrophils ; Hematopoiesis ; Sepsis ; Hematopoietic Stem Cells ; Gene Expression Regulation
Language	English
Publishing date	2023-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-023-01490-5
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