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Article ; Online: Fast Microwave-Assisted Synthesis of Wells-Dawson-Type 18-Tungsto-2-Phosphate [P 2 W 18 O 62 ] 6−

Vamangi M. Pandya / Ali Haider / Hafiz M. Qasim / Ali S. Mougharbel / Ulrich Kortz / Sachin A. Joshi

Inorganics, Vol 7, Iss 2, p

2019 Volume 23

Abstract: ... phosphate [P 2 W 18 O 62 ] 6− with a 35% yield in 24 h, rather than a week using conventional heating. ...

Abstract	We report on a fast microwave-assisted synthetic procedure of the Wells-Dawson-type 18-tungsto-2-phosphate [P 2 W 18 O 62 ] 6− with a 35% yield in 24 h, rather than a week using conventional heating.
Keywords	microwave ; NMR ; polyoxometalates ; synthesis ; Wells-Dawson ion ; Inorganic chemistry ; QD146-197
Language	English
Publishing date	2019-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Genome-edited allogeneic donor "universal" chimeric antigen receptor T cells.

Qasim, Waseem

Blood

2022 Volume 141, Issue 8, Page(s) 835–845

Abstract: αβ T cell receptor (TCRαβ) T cells modified to express chimeric antigen receptors (CAR), are now available as authorized therapies for certain B-cell malignancies. However the process of autologous harvest and generation of patient-specific products is ... ...

Abstract	αβ T cell receptor (TCRαβ) T cells modified to express chimeric antigen receptors (CAR), are now available as authorized therapies for certain B-cell malignancies. However the process of autologous harvest and generation of patient-specific products is costly, with complex logistics and infrastructure requirements. Premanufactured banks of allogeneic donor-derived CAR T cells could help widen applicability if the challenges of HLA-mismatched T-cell therapy can be addressed. Genome editing is being applied to overcome allogeneic barriers, most notably, by disrupting TCRαβ to prevent graft-versus-host disease, and multiple competing editing technologies, including CRISPR/Cas9 and base editing, have reached clinical phase testing. Improvements in accuracy and efficiency have unlocked applications for a wider range of blood malignancies, with multiplexed editing incorporated to target HLA molecules, shared antigens and checkpoint pathways. Clinical trials will help establish safety profiles and determine the durability of responses as well as the role of consolidation with allogeneic transplantation.
MeSH term(s)	Humans ; Receptors, Chimeric Antigen ; Immunotherapy, Adoptive ; Receptors, Antigen, T-Cell/genetics ; T-Lymphocytes ; Neoplasms/therapy ; Gene Editing ; Receptors, Antigen, T-Cell, alpha-beta/genetics ; Hematopoietic Stem Cell Transplantation
Chemical Substances	Receptors, Chimeric Antigen ; Receptors, Antigen, T-Cell ; Receptors, Antigen, T-Cell, alpha-beta
Language	English
Publishing date	2022-10-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2022016204
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Article ; Online: Genome editing of therapeutic T cells.

Qasim, Waseem

Gene and genome editing

2021 Volume 2, Page(s) None

Abstract: The potential of engineered TCRαβ T cells as potent mediators of leukemic clearance has been demonstrated in clinical trials, and authorised therapies are being deployed against B cell malignancies in particular. While most applications have relied on ... ...

Abstract	The potential of engineered TCRαβ T cells as potent mediators of leukemic clearance has been demonstrated in clinical trials, and authorised therapies are being deployed against B cell malignancies in particular. While most applications have relied on harvest and manipulation of autologous lymphocytes, the emerging application of genome editing technology has demonstrated that allogeneic TCRαβ cells can be engineered to overcome Human Leukocyte Antigen (HLA) barriers and provides a route to more cost effective and widely accessible 'off-the-shelf' therapies. Genome editing also offers the prospect of addressing other hurdles such as shared-antigen expression and has been applied to direct site-specific transgene integration, for improved transcriptional regulation and function.
Language	English
Publishing date	2021-11-25
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2666-3880
ISSN (online)	2666-3880
DOI	10.1016/j.ggedit.2021.100010
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Article: Emerging therapeutic applications of CRISPR genome editing.

Qasim, Waseem

Emerging topics in life sciences

2021 Volume 3, Issue 3, Page(s) 257–260

Abstract: The rapid evolution of tools for genome editing has created a dizzying array of possibilities for novel therapeutic strategies, even though to date only a handful of clinical applications have been realised. Proof-of-concept demonstrations of targeted ... ...

Abstract	The rapid evolution of tools for genome editing has created a dizzying array of possibilities for novel therapeutic strategies, even though to date only a handful of clinical applications have been realised. Proof-of-concept demonstrations of targeted genome modification in vitro and in small animal models of inherited single gene disorders have to be translated into effective therapies. Interest has naturally gravitated towards opportunities for collection, ex vivo modification and return of blood, immune and stem cells. Initial applications designed to modify T cells to protect against HIV or to confer potent anti-leukaemic effects have reached clinical phase, and further applications to modify blood stem cells are close to being applied. There are generic considerations of safety, on- and off-target effects and possible genotoxicity as well as issues relating to more sophisticated systemic approaches where niche occupation and host immunity become relevant. Such issues will be likely addressed over time, with carefully designed clinical trials required to determine therapeutic risks and benefits.
Language	English
Publishing date	2021-03-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2882721-1
ISSN	2397-8554 ; 2397-8554 ; 2397-8562
ISSN (online)	2397-8554
ISSN	2397-8554 ; 2397-8562
DOI	10.1042/ETLS20190010
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Article ; Online: Allogeneic CAR T cell therapies for leukemia.

Qasim, Waseem

American journal of hematology

2019 Volume 94, Issue S1, Page(s) S50–S54

Abstract: Allogeneic chimeric antigen receptor T (CAR T) cells can offer advantages over autologous T cell therapies, including the availability of "fit" cells for production, and elimination of risks associated with inadvertent transduction of leukemic blasts. ... ...

Abstract	Allogeneic chimeric antigen receptor T (CAR T) cells can offer advantages over autologous T cell therapies, including the availability of "fit" cells for production, and elimination of risks associated with inadvertent transduction of leukemic blasts. However, allogeneic T cell therapies must address HLA barriers and conventionally rely on the availability of a suitable HLA-matched donor if graft-vs-host-disease and rejection effects are to be avoided. More recently, the incorporation of additional genome editing manipulations, to disrupt T cell receptor expression and address other critical pathways have been explored. Clinical trials are underway investigating non-HLA matched T cells expressing anti-CD19 CARs for the treatment of B cell acute lymphoblastic leukemia (B-ALL) and anti-CD123 CAR for acute myeloid leukemia (AML). Such approaches continue to be refined and improved to widen accessibility and reduce the cost of T cell therapies for a wider range of conditions.
MeSH term(s)	Humans ; Immunotherapy, Adoptive/methods ; Leukemia/therapy ; Leukemia, Myeloid, Acute/therapy ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Receptors, Chimeric Antigen/immunology ; Receptors, Chimeric Antigen/therapeutic use ; Transplantation, Homologous
Chemical Substances	Receptors, Chimeric Antigen
Language	English
Publishing date	2019-02-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	196767-8
ISSN	1096-8652 ; 0361-8609
ISSN (online)	1096-8652
ISSN	0361-8609
DOI	10.1002/ajh.25399
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Article ; Online: Genome-Edited T Cell Therapies.

Ottaviano, Giorgio / Qasim, Waseem

Hematology/oncology clinics of North America

2022 Volume 36, Issue 4, Page(s) 729–744

Abstract: Chimeric antigen receptor (CAR) T-cells are widely being investigated against malignancies, and allogeneic 'universal donor' CAR-T cells offer the possibility of widened access to pre-manufactured, off-the-shelf therapies. Different genome-editing ... ...

Abstract	Chimeric antigen receptor (CAR) T-cells are widely being investigated against malignancies, and allogeneic 'universal donor' CAR-T cells offer the possibility of widened access to pre-manufactured, off-the-shelf therapies. Different genome-editing platforms have been used to address human leukocyte antigen (HLA) barriers to generate universal CAR-T cell therapy and early applications have been reported in children and adults against B cell malignancies. Recently developed Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based systems and related technologies offer the prospect of enhanced cellular immunotherapies for a wider range of hematological malignancies.
MeSH term(s)	CRISPR-Cas Systems ; Child ; Gene Editing/methods ; Humans ; Immunotherapy, Adoptive/methods ; Neoplasms/therapy ; T-Lymphocytes
Language	English
Publishing date	2022-06-27
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	93115-9
ISSN	1558-1977 ; 0889-8588
ISSN (online)	1558-1977
ISSN	0889-8588
DOI	10.1016/j.hoc.2022.03.006
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Article ; Online: Letter to the editor: Hemodynamic effects of trauma rapid sequence intubation induction agents are not only related to the medication used.

Qasim, Zaffer / Cannon, Jeremy W

The journal of trauma and acute care surgery

2021 Volume 91, Issue 3, Page(s) e79

MeSH term(s)	Hemodynamics ; Hypnotics and Sedatives ; Intubation, Intratracheal ; Rapid Sequence Induction and Intubation
Chemical Substances	Hypnotics and Sedatives
Language	English
Publishing date	2021-05-26
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2651070-4
ISSN	2163-0763 ; 2163-0755
ISSN (online)	2163-0763
ISSN	2163-0755
DOI	10.1097/TA.0000000000003283
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Article ; Online: Measuring Sexual Intelligence for Evaluating Sexual Health.

Husain, Waqar / Kiran, Abeera / Qasim, Umara / Gul, Saleha / Iftikhar, Javairia

Psychological reports

2023 , Page(s) 332941231152388

Abstract: The current paper reports four consecutive studies that were conducted to link sexual health with a new construct of sexual intelligence by developing and validating a new scale to measure sexual intelligence. Sexual intelligence was defined as "the ... ...

Abstract	The current paper reports four consecutive studies that were conducted to link sexual health with a new construct of sexual intelligence by developing and validating a new scale to measure sexual intelligence. Sexual intelligence was defined as "the ability to perceive, understand and respond to sexual needs and desires in a personal and social context." Sexual Intelligence Scale (SIS), comprising of 8 items in English and 2 factors (sexual knowledge & sexual behavior), was developed and validated by involving 959 respondents in the process of 4 consecutive studies. The validity of SIS was tested step by step for its face, content, factorial, convergent, discriminant, and predictive validities. The reliability was measured through internal consistency and item-total & item-scale correlations. The study found significantly higher levels of sexual intelligence in men as compared to women. Sexual intelligence, moreover, had significant positive correlations with age, education, emotional intelligence, social intelligence, sexual health, and satisfaction with life. Sexual health was linked with sexual intelligence and the SIS was accepted as a reliable and valid tool to measure sexual intelligence.
Language	English
Publishing date	2023-01-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	205658-6
ISSN	1558-691X ; 0033-2941
ISSN (online)	1558-691X
ISSN	0033-2941
DOI	10.1177/00332941231152388
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Article ; Online: Nonclassic Congenital Adrenal Hyperplasia Metabolic Resolution Post Roux-en-Y Gastric Bypass and Associated Weight Loss.

Romo, Karina G / Shu, Sharon W / Iqbal, Qasim Z / Uwaifo, Gabriel I

JCEM case reports

2024 Volume 2, Issue 3, Page(s) luae018

Abstract: Nonclassic congenital adrenal hyperplasia (NCCAH) is characterized by mild cortisol deficiency, excess androgens and adrenocorticotropin (ACTH) production, and often with various features of dysmetabolic syndrome. Elective bariatric surgery is one of the ...

Abstract	Nonclassic congenital adrenal hyperplasia (NCCAH) is characterized by mild cortisol deficiency, excess androgens and adrenocorticotropin (ACTH) production, and often with various features of dysmetabolic syndrome. Elective bariatric surgery is one of the most effective long-term management strategies for severe obesity. Our case presents a 34-year-old woman with symptomatic NCCAH and class III obesity who status post Roux-en-Y gastric bypass (RYGB) had significant weight loss with metabolic resolution of NCCAH, and no longer required glucocorticoid (GC) therapy. At 11 months post operation and off GC therapy, she had a weight deficit of approximately 160 pounds (72.57 kg) with continued metabolic resolution of NCCAH markers including ACTH, 17-hydroxyprogesterone, and androstenedione. Presently, GC therapy remains one of the few available treatments for symptomatic NCCAH; however, long-term GC therapy has the potential for various complications and side effects. Our case presents elective bariatric surgery as a potential and unique treatment option for patients with NCCAH with associated class III obesity. The exact pathophysiologic basis for this effect and its potential role in long-term management of appropriate NCCAH patients requires further study.
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Case Reports
ISSN	2755-1520
ISSN (online)	2755-1520
DOI	10.1210/jcemcr/luae018
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Article ; Online: The Effect of Combined Application of Tricalcium Phosphate Containing Varnish and ER, CR

Aisha Akram Qasim

Journal of Research in Medical and Dental Science, Vol 9, Iss 12, Pp 558-

YSGG Laser on Resistance of Enamel to Caries: An In Vitro Study

2021 Volume 568

Abstract: ... exclusively from Clinpro White Varnish. Group (L2): Er,Cr:YSGG laser (0.75 W, 8.5 J/cm2, 20 Hz, 11% air, 0 ...

Abstract	Background: This study aims to investigate the efficacy of functionalized tri-calcium phosphate containing varnish combined with ER, CR: YSGG laser in preventing of enamel caries. Materials and Methods: Freshly extracted 50 sound upper first premolars teeth were divided into five groups, each group of ten samples. Group (C): only washed with deionized water. Group (V): functionalized tricalcium phosphate (fTCP) exclusively from Clinpro White Varnish. Group (L2): Er,Cr:YSGG laser (0.75 W, 8.5 J/cm2, 20 Hz, 11% air, 0% water) was irradiated. Group (V/L2): First Clinpro White varnish was applied then Er,Cr:YSGG laser. Group (L2/V): Er,Cr:YSGG laser was irradiated followed by Clinpro White varnish. Then, the pH cycling model was used to induce artificial caries. The effect was studied in vitro using Vickers microhardness test and the obtained results were statistically analyzed. The surface morphology was also examined by scanning electron microscopy. Results: there was a decreasing in surface microhardness in all groups due to the demineralization, but the least reduction in surface microhardness belonged to the group of Er,Cr:YSGG laser followed by Clinpro White varnish. Morphological changes of enamel surfaces were in relation with increasing of enamel resistance to demineralization. Conclusions: Er:Cr:YSGG Laser at energy density of 8.5 J/cm2 is indicated on decreasing the loss of enamel hardness with comparable effects to fTCP varnish application. There is an advantage in using laser at 8.5 J in combined with fTCP varnish over using laser alone and fTCP varnish alone with more benefit when laser was applied before application of fTCP varnish than the opposite.
Keywords	er ; cr:ysgg laser ; enamel demineralization ; functionalized tri-calcium phosphate ; microhardness ; Dentistry ; RK1-715 ; Medicine (General) ; R5-920
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Amber Publication
Document type	Article ; Online
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