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  1. Article: Application of Positron Emission Tomography in Drug Development.

    Bhattacharyya, Sibaprasad

    Biochemistry & pharmacology : open access

    2014  Volume 1

    Language English
    Publishing date 2014-10-03
    Publishing country United States
    Document type Journal Article
    ISSN 2167-0501
    ISSN 2167-0501
    DOI 10.4172/2167-0501.1000e128
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Progress in Making Ras as a Druggable Target.

    Bhattacharyya, Sibaprasad

    Biochemistry & pharmacology : open access

    2014  Volume 3, Issue 2

    Language English
    Publishing date 2014-03-14
    Publishing country United States
    Document type Journal Article
    ISSN 2167-0501
    ISSN 2167-0501
    DOI 10.4172/2167-0501.1000e157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Dual-mode chemosensor for the fluorescence detection of zinc and hypochlorite on a fluorescein backbone and its cell-imaging applications.

    Maity, Sibaprasad / Maity, Annada C / Das, Avijit Kumar / Bhattacharyya, Nandan

    Analytical methods : advancing methods and applications

    2022  Volume 14, Issue 28, Page(s) 2739–2744

    Abstract: Fluorescein coupled with 3-(aminomethyl)-4,6-dimethylpyridin-2( ... ...

    Abstract Fluorescein coupled with 3-(aminomethyl)-4,6-dimethylpyridin-2(1
    MeSH term(s) Flavin-Adenine Dinucleotide ; Fluorescein ; HeLa Cells ; Humans ; Hypochlorous Acid ; Spectrometry, Fluorescence ; Zinc/chemistry
    Chemical Substances Flavin-Adenine Dinucleotide (146-14-5) ; Hypochlorous Acid (712K4CDC10) ; Zinc (J41CSQ7QDS) ; Fluorescein (TPY09G7XIR)
    Language English
    Publishing date 2022-07-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d2ay00855f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Dual-mode chemosensor for the fluorescence detection of zinc and hypochlorite on a fluorescein backbone and its cell-imaging applications

    Maity, Sibaprasad / Maity, Annada C. / Das, Avijit kumar / Bhattacharyya, Nandan

    Analytical methods. 2022 July 21, v. 14, no. 28

    2022  

    Abstract: Fluorescein coupled with 3-(aminomethyl)-4,6-dimethylpyridin-2(1H)-one (FAD) was synthesized for the selective recognition of Zn²⁺ over other interfering metal ions in acetonitrile/aqueous buffer (1 : 1). Interestingly, there was a significant ... ...

    Abstract Fluorescein coupled with 3-(aminomethyl)-4,6-dimethylpyridin-2(1H)-one (FAD) was synthesized for the selective recognition of Zn²⁺ over other interfering metal ions in acetonitrile/aqueous buffer (1 : 1). Interestingly, there was a significant fluorescence enhancement of FAD in association with Zn²⁺ at 426 nm by strong chelation-induced fluorescence enhancement (CHEF) without interrupting the cyclic spirolactam ring. A binding stoichiometric ratio of 1 : 2 for the ligand FAD with metal Zn²⁺ was proven by a Jobs plot. However, the cyclic spirolactam ring was opened by hypochlorite (OCl⁻) as well as oxidative cleavage of the imine bond, which resulted in the emission enhancement of the wavelength at 520 nm. The binding constant and detection limit of FAD towards Zn²⁺ were determined to be 1 × 10⁴ M⁻¹ and 1.79 μM, respectively, and the detection limit for OCl⁻ was determined as 2.24 μM. We introduced here a dual-mode chemosensor FAD having both the reactive functionalities for the simultaneous detection of Zn²⁺ and OCl⁻ by employing a metal coordination (Zn²⁺) and analytes (OCl⁻) induced chemodosimetric approach, respectively. Furthermore, for the practical application, we studied the fluorescence imaging inside HeLa cells by using FAD, which demonstrated it can be very useful as a selective and sensitive fluorescent probe for zinc.
    Keywords acetonitrile ; chemical species ; detection limit ; fluorescein ; fluorescence ; hypochlorites ; imines ; ligands ; stoichiometry ; wavelengths ; zinc
    Language English
    Dates of publication 2022-0721
    Size p. 2739-2744.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d2ay00855f
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Metallic radionuclides in the development of diagnostic and therapeutic radiopharmaceuticals.

    Bhattacharyya, Sibaprasad / Dixit, Manish

    Dalton transactions (Cambridge, England : 2003)

    2011  Volume 40, Issue 23, Page(s) 6112–6128

    Abstract: Metallic radionuclides are the mainstay of both diagnostic and therapeutic radiopharmaceuticals. Therapeutic nuclear medicine is less advanced but has tremendous potential if the radionuclide is accurately targeted. Great interest exists in the field of ... ...

    Abstract Metallic radionuclides are the mainstay of both diagnostic and therapeutic radiopharmaceuticals. Therapeutic nuclear medicine is less advanced but has tremendous potential if the radionuclide is accurately targeted. Great interest exists in the field of inorganic chemistry for developing target specific radiopharmaceuticals based on radiometals for non-invasive disease detection and cancer radiotherapy. This perspective will focus on the nuclear properties of a few important radiometals and their recent applications to developing radiopharmaceuticals for imaging and therapy. Other topics for discussion will include imaging techniques, radiotherapy, analytical techniques, and radiation safety. The ultimate goal of this perspective is to introduce inorganic chemists to the field of nuclear medicine and radiopharmaceutical development, where many applications of fundamental inorganic chemistry can be found.
    MeSH term(s) Coordination Complexes/chemistry ; Coordination Complexes/therapeutic use ; Drug Design ; Humans ; Metals/chemistry ; Neoplasms/diagnosis ; Neoplasms/therapy ; Positron-Emission Tomography ; Radiopharmaceuticals/chemistry ; Radiopharmaceuticals/therapeutic use ; Tomography, Emission-Computed, Single-Photon
    Chemical Substances Coordination Complexes ; Metals ; Radiopharmaceuticals
    Language English
    Publishing date 2011-05-03
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/c1dt10379b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Rapid synthesis of [18F]fluoroestradiol: remarkable advantage of microwaving over conventional heating.

    Shi, Jianfeng / Afari, George / Bhattacharyya, Sibaprasad

    Journal of labelled compounds & radiopharmaceuticals

    2014  Volume 57, Issue 14, Page(s) 730–736

    Abstract: 16α-[(18)F]fluoroestradiol ([(18)F]FES) is known as a clinically important tracer in nuclear medicine as an estrogen receptor ligand for investigating primary and metastatic breast cancers. Synthesizing [(18)F]FES is a two-step process associated with [( ... ...

    Abstract 16α-[(18)F]fluoroestradiol ([(18)F]FES) is known as a clinically important tracer in nuclear medicine as an estrogen receptor ligand for investigating primary and metastatic breast cancers. Synthesizing [(18)F]FES is a two-step process associated with [(18)F]fluoride incorporation to the precursor (3-methoxymethyl 16β,17β-epiestriol-O-cyclic sulfone) and subsequent hydrolysis of the [(18)F]fluorinated intermediate with 2 N HCl. The impact of microwave (MW) heating on both fluorination and hydrolysis reactions was investigated. The duration and temperatures of the fluorination reaction were varied for both MW heating and conventional heating (CH) methods. Chemical and radiochemical purity and radiochemical yields were investigated for CH and compared with MW-assisted radiosyntheses. Quality control tests of MW-assisted [(18)F]FES were performed following US Pharmacopeia procedures for clinical-grade positron emission tomography pharmaceuticals. The results demonstrate that microwaving not only improves the (18)F-fluoride incorporation (~55% improvement at 110°C for 4 min) but also significantly reduces hydrolysis time (approximately sevenfold reduction at 120°C) in comparison with CH under similar conditions. The overall isolated radiochemical yield of purified [(18)F]FES was significantly higher (~90% improvement) with MW, and side products were notably fewer. Quality control test results demonstrated that [(18)F]FES produced by microwaving was suitable for human injection.
    MeSH term(s) Breast Neoplasms/diagnostic imaging ; Chemistry Techniques, Synthetic/methods ; Estradiol/analogs & derivatives ; Estradiol/chemical synthesis ; Estradiol/chemistry ; Fluorine Radioisotopes ; Hot Temperature ; Humans ; Isotope Labeling ; Kinetics ; Microwaves ; Positron-Emission Tomography ; Quality Control ; Radiochemistry ; Radiopharmaceuticals/chemical synthesis ; Radiopharmaceuticals/chemistry
    Chemical Substances Fluorine Radioisotopes ; Radiopharmaceuticals ; Estradiol (4TI98Z838E) ; 16-fluoroestradiol (84693-92-5)
    Language English
    Publishing date 2014-12-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 196095-7
    ISSN 1099-1344 ; 0362-4803 ; 0022-2135
    ISSN (online) 1099-1344
    ISSN 0362-4803 ; 0022-2135
    DOI 10.1002/jlcr.3248
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1332: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article: Dosimetry and first human experience with

    Lindenberg, Liza / Adler, Stephen / Turkbey, Ismail B / Mertan, Francesca / Ton, Anita / Do, Khanh / Kummar, Shivaani / Gonzalez, Esther Mena / Bhattacharyya, Sibaprasad / Jacobs, Paula M / Choyke, Peter

    American journal of nuclear medicine and molecular imaging

    2017  Volume 7, Issue 4, Page(s) 195–203

    Abstract: ... ...

    Abstract 89
    Language English
    Publishing date 2017-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2623515-8
    ISSN 2160-8407
    ISSN 2160-8407
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  8. Article ; Online: Preparation of clinical-grade (89) Zr-panitumumab as a positron emission tomography biomarker for evaluating epidermal growth factor receptor-targeted therapy.

    Wei, Ling / Shi, Jianfeng / Afari, George / Bhattacharyya, Sibaprasad

    Journal of labelled compounds & radiopharmaceuticals

    2013  Volume 57, Issue 1, Page(s) 25–35

    Abstract: Panitumumab is a fully human monoclonal antibody approved for the treatment of epidermal growth factor receptor (EGFR) positive colorectal cancer. Recently, panitumumab has been radiolabeled with (89) Zr and evaluated for its potential to be used as ... ...

    Abstract Panitumumab is a fully human monoclonal antibody approved for the treatment of epidermal growth factor receptor (EGFR) positive colorectal cancer. Recently, panitumumab has been radiolabeled with (89) Zr and evaluated for its potential to be used as immuno-positron emission tomography (PET) probe for EGFR positive cancers. Interesting preclinical results published by several groups of researchers have prompted us to develop a robust procedure for producing clinical-grade (89) Zr-panitumumab as an immuno-PET probe to evaluate EGFR-targeted therapy. In this process, clinical-grade panitumumab is bio-conjugated with desferrioxamine chelate and subsequently radiolabeled with (89) Zr resulting in high radiochemical yield (>70%, n = 3) and purity (>98%, n = 3). All quality control (QC) tests were performed according to United States Pharmacopeia specifications. QC tests showed that (89) Zr-panitumumab met all specifications for human injection. Herein, we describe a step-by-step method for the facile synthesis and QC tests of (89) Zr-panitumumab for medical use. The entire process of bioconjugation, radiolabeling, and all QC tests will take about 5 h. Because the synthesis is fully manual, two rapid, in-process QC tests have been introduced to make the procedure robust and error free.
    MeSH term(s) Antibodies, Monoclonal ; Endotoxins/analysis ; ErbB Receptors/metabolism ; Humans ; Hydrogen-Ion Concentration ; Molecular Targeted Therapy ; Panitumumab ; Positron-Emission Tomography/methods ; Quality Control ; Radiochemistry/methods ; Radioisotopes ; Radiopharmaceuticals/chemical synthesis ; Radiopharmaceuticals/chemistry ; Zirconium
    Chemical Substances Antibodies, Monoclonal ; Endotoxins ; Radioisotopes ; Radiopharmaceuticals ; Panitumumab (6A901E312A) ; Zirconium (C6V6S92N3C) ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2013-11-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 196095-7
    ISSN 1099-1344 ; 0362-4803 ; 0022-2135
    ISSN (online) 1099-1344
    ISSN 0362-4803 ; 0022-2135
    DOI 10.1002/jlcr.3134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1332: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Synthesis of Clinical-Grade [18F]-Fluoroestradiol as a Surrogate PET Biomarker for the Evaluation of Estrogen Receptor-Targeting Therapeutic Drug

    Manish Dixit / Jianfeng Shi / Ling Wei / George Afari / Sibaprasad Bhattacharyya

    International Journal of Molecular Imaging, Vol

    2013  Volume 2013

    Keywords Medical technology ; R855-855.5 ; Medicine (General) ; R5-920 ; Medicine ; R ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Rapid detection of hydrazine in a naphthol-fused chromenyl loop and its effectiveness in human lung cancer cells: tuning remarkable selectivity via the reaction altered pathway supported by theoretical studies.

    Goswami, Shyamaprosad / Das, Avijit Kumar / Saha, Urmila / Maity, Sibaprasad / Khanra, Kalyani / Bhattacharyya, Nandan

    Organic & biomolecular chemistry

    2015  Volume 13, Issue 7, Page(s) 2134–2139

    Abstract: Our designed and synthesized chemosensor naphthalene based chromenyl derivative (NAC) [1-(3-hydroxy-3 methyl-3H-benzo[f]chromen-2-yl) ethanone] has been used for fast (<30 s, DL = 0.22 ppb) and selective detection of N2H4 by a new way via the chromenyl ... ...

    Abstract Our designed and synthesized chemosensor naphthalene based chromenyl derivative (NAC) [1-(3-hydroxy-3 methyl-3H-benzo[f]chromen-2-yl) ethanone] has been used for fast (<30 s, DL = 0.22 ppb) and selective detection of N2H4 by a new way via the chromenyl ring opening followed by the pyrazole ring formation giving a strong blue fluorescence. The DFT study and the real application in different water samples along with the dipstick method in low cost devices have also been performed here. Human lung cancer cells (NCI-H460) have been used for hydrazinolysis of the NAC in vivo system for detection by the appearance of blue fluorescence and also for the MTT assay showing its remarkable cancer sensitivity.
    MeSH term(s) Chromones/chemical synthesis ; Chromones/chemistry ; Humans ; Hydrazines/analysis ; Lung Neoplasms/chemistry ; Lung Neoplasms/pathology ; Molecular Structure ; Naphthols/chemistry ; Quantum Theory ; Spectrometry, Fluorescence
    Chemical Substances Chromones ; Hydrazines ; Naphthols ; hydrazine (27RFH0GB4R)
    Language English
    Publishing date 2015-02-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/c4ob01842g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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