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  1. Article: Matthew Walker, Sr, MD: his surgical legacy.

    Brown, C E

    Journal of the National Medical Association

    1979  Volume 71, Issue 5, Page(s) 508–510

    MeSH term(s) General Surgery/history ; History, 20th Century ; Tennessee
    Language English
    Publishing date 1979-05
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 419737-9
    ISSN 0027-9684
    ISSN 0027-9684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 150: Show issues Location:
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  2. Article: Between nations: delivering services on an island native reserve. Interview by Matthew D. Pavelich.

    Brown, B

    Leadership in health services = Leadership dans les services de sante

    1994  Volume 3, Issue 3, Page(s) 37–9, 44

    MeSH term(s) British Columbia ; Community-Institutional Relations ; Equipment and Supplies, Hospital/supply & distribution ; Health Services, Indigenous/organization & administration ; Hospital Bed Capacity, under 100 ; Hospital Costs ; Hospitals, Rural/organization & administration ; Humans ; Indians, North American
    Language English
    Publishing date 1994-05
    Publishing country Canada
    Document type Interview
    ZDB-ID 1168333-8
    ISSN 1188-3669
    ISSN 1188-3669
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Polygenic risk scores.

    Brown, Matthew A

    Seminars in arthritis and rheumatism

    2023  Volume 64S, Page(s) 152330

    Abstract: Polygenic risk scores (PRS) estimate an individual's genetic risk for a disease or trait compared to a matched population. For many rheumatic diseases PRS have been developed that have discriminatory capacity better than some widely used biomarkers, and ... ...

    Abstract Polygenic risk scores (PRS) estimate an individual's genetic risk for a disease or trait compared to a matched population. For many rheumatic diseases PRS have been developed that have discriminatory capacity better than some widely used biomarkers, and in some cases are the most discriminatory tests available. These PRS assessments do not rely on the disease being present or its activity level, making them highly valuable for predicting disease development or enabling early diagnosis. However, most PRS to date have been developed in research settings, and in populations of European-ancestry. Further studies are required to assess their utility in clinical settings, in relation to existing tests, and in non-European populations. Such studies are underway, and it is likely in the near future these tests will become widely available, with significant benefits for the practice of medicine.
    MeSH term(s) Humans ; Genetic Risk Score ; Phenotype ; Rheumatic Diseases/diagnosis ; Rheumatic Diseases/genetics ; Risk Factors ; Genetic Predisposition to Disease
    Language English
    Publishing date 2023-11-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120247-9
    ISSN 1532-866X ; 0049-0172
    ISSN (online) 1532-866X
    ISSN 0049-0172
    DOI 10.1016/j.semarthrit.2023.152330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 790: Show issues Location:
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  4. Book: Homilies on the Gospel of Saint Matthew

    Johannes / Prevost, George / Riddle, Matthew Brown / Schaff, Philip

    (A select library of Nicene and post-Nicene Fathers of the Christian Church ; / ed. by Philip Schaff ; Ser. 1, Vol. 10)

    1956  

    Title translation Homiliae in Matthaeum <engl.>
    Author's details Saint Chrysostom. [Transl. by George Prevost. Rev., with notes by M. B. Riddle]
    Series title A select library of Nicene and post-Nicene Fathers of the Christian Church
    / ed. by Philip Schaff ; Ser. 1, Vol. 10
    Language English
    Size XXII, 551 S
    Publisher Eerdmans
    Publishing place Grand Rapids, Mich
    Document type Book
    Database Former special subject collection: coastal and deep sea fishing

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  5. Book ; Online: Fast Facts : Perioperative Pain

    Brown, Matthew

    Effective management has numerous benefits

    2021  

    Abstract: The importance of effective and safe pain management in the perioperative period has never been greater. The populations clinicians serve are rapidly changing and, when considered in combination with socioeconomic issues, it is clear that the challenges ... ...

    Title variant Perioperative Pain
    Author's details Matthew Brown, Katherin Peperzak
    Abstract The importance of effective and safe pain management in the perioperative period has never been greater. The populations clinicians serve are rapidly changing and, when considered in combination with socioeconomic issues, it is clear that the challenges of providing a high-quality perioperative experience are extensive. Fast Facts: Perioperative Pain provides a succinct and accessible guide to the practice of perioperative pain management, covering the complete surgical journey from the preoperative assessment phase through to postoperative management, including persistent postsurgical pain. Packed with detailed figures and illustrations, this valuable resource is suitable for all multidisciplinary team members who encounter surgical patients in pain during the course of their work. Table of Contents: • Pain mechanisms • Preoperative phase • Diagnosis and assessment • Multimodal strategies • Systemic therapies • Non-systemic therapies • Non-pharmacological management • Specific management strategies • Persistent postsurgical pain • Substance use disorder
    MeSH term(s) Pain, Postoperative/therapy. ; Analgesics/therapeutic use.
    Keywords Pain/Treatment
    Language English
    Size 1 online resource (100 pages) :, 14 figures, 14 in color, 12 tables
    Publisher S. Karger
    Publishing place Basel
    Document type Book ; Online
    ISBN 3-318-06879-9 ; 3-318-06877-2 ; 978-3-318-06879-5 ; 978-3-318-06877-1
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Book ; Online: Science and Moral Imagination

    Brown, Matthew J.

    A New Ideal for Values in Science

    2020  

    Keywords Philosophy of science
    Language 0|e
    Size 1 electronic resource (288 pages)
    Publisher University of Pittsburgh Press
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021612154
    ISBN 9780822987673 ; 0822987678
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Article: Single-cell RNA sequencing reveals microenvironment context-specific routes for epithelial-mesenchymal transition in pancreas cancer cells.

    Brown, Brooke A / Lazzara, Matthew J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: In the PDAC tumor microenvironment, multiple factors initiate the epithelial-mesenchymal transition (EMT) that occurs heterogeneously among transformed ductal cells, but it is unclear if different drivers promote EMT through common or distinct signaling ... ...

    Abstract In the PDAC tumor microenvironment, multiple factors initiate the epithelial-mesenchymal transition (EMT) that occurs heterogeneously among transformed ductal cells, but it is unclear if different drivers promote EMT through common or distinct signaling pathways. Here, we use single-cell RNA sequencing (scRNA-seq) to identify the transcriptional basis for EMT in pancreas cancer cells in response to hypoxia or EMT-inducing growth factors. Using clustering and gene set enrichment analysis, we find EMT gene expression patterns that are unique to the hypoxia or growth factor conditions or that are common between them. Among the inferences from the analysis, we find that the FAT1 cell adhesion protein is enriched in epithelial cells and suppresses EMT. Further, the receptor tyrosine kinase AXL is preferentially expressed in hypoxic mesenchymal cells in a manner correlating with YAP nuclear localization, which is suppressed by FAT1 expression. AXL inhibition prevents EMT in response to hypoxia but not growth factors. Relationships between FAT1 or AXL expression with EMT were confirmed through analysis of patient tumor scRNA-seq data. Further exploration of inferences from this unique dataset will reveal additional microenvironment context-specific signaling pathways for EMT that may represent novel drug targets for PDAC combination therapies.
    Language English
    Publishing date 2023-05-31
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.05.30.542969
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Structural determination and modeling of ciliary microtubules.

    Walton, Travis / Doran, Matthew H / Brown, Alan

    Acta crystallographica. Section D, Structural biology

    2024  Volume 80, Issue Pt 4, Page(s) 220–231

    Abstract: The axoneme, a microtubule-based array at the center of every cilium, has been the subject of structural investigations for decades, but only recent advances in cryo-EM and cryo-ET have allowed a molecular-level interpretation of the entire complex to be ...

    Abstract The axoneme, a microtubule-based array at the center of every cilium, has been the subject of structural investigations for decades, but only recent advances in cryo-EM and cryo-ET have allowed a molecular-level interpretation of the entire complex to be achieved. The unique properties of the nine doublet microtubules and central pair of singlet microtubules that form the axoneme, including the highly decorated tubulin lattice and the docking of massive axonemal complexes, provide opportunities and challenges for sample preparation, 3D reconstruction and atomic modeling. Here, the approaches used for cryo-EM and cryo-ET of axonemes are reviewed, while highlighting the unique opportunities provided by the latest generation of AI-guided tools that are transforming structural biology.
    MeSH term(s) Microtubules/chemistry ; Axoneme ; Cilia/chemistry ; Molecular Biology
    Language English
    Publishing date 2024-03-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2968623-4
    ISSN 2059-7983 ; 0907-4449
    ISSN (online) 2059-7983
    ISSN 0907-4449
    DOI 10.1107/S2059798324001815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: An 8 mm endoscopic histotripsy array with integrated high-resolution ultrasound imaging.

    Mallay, Matthew G / Landry, Thomas G / Brown, Jeremy A

    Ultrasonics

    2024  Volume 139, Page(s) 107275

    Abstract: An 8 mm diameter, image-guided, annular array histotripsy transducer was fabricated and characterized. The array was laser etched on a 5 MHz, 1-3 dice and fill, PZT-5H/epoxy composite with a 45 % volume fraction. Flexible PCBs were used to electrically ... ...

    Abstract An 8 mm diameter, image-guided, annular array histotripsy transducer was fabricated and characterized. The array was laser etched on a 5 MHz, 1-3 dice and fill, PZT-5H/epoxy composite with a 45 % volume fraction. Flexible PCBs were used to electrically connect to the array elements using wirebonds. The array was backed with a low acoustic impedance epoxy mixture. A 3.6 by 3.8 mm, 64-element, 30 MHz phased array imaging probe was positioned in the center hole, to co-align the imaging plane with the bubble cloud produced by the therapy array. A custom 16-channel high voltage pulse generator was used to test the annular array for focal lengths ranging from 3- to 8-mm. An aluminum lens-focussed transducer with a 7 mm focal length was fabricated using the same piezocomposite and backing material and tested along with the histotripsy array. Simulated results from COMSOL FEM models were compared to measured results for low voltage characterization of the array and lens-focussed transducer. The measured transmit sensitivity of the array ranged from 0.113 to 0.167 MPa/V, while the lens-focussed transducer was 0.192 MPa/V. Simulated values were 0.160 to 0.174 MPa/V and 0.169 MPa/V, respectively. The measured acoustic fields showed a significantly increased depth-of-field compared the lens-focussed transducer, while the beamwidths of the array focus were comparable to the lens. The measured cavitation voltage in water was between 254 V and 498 V depending on the focal length, and 336 V for the lens-focussed transducer. The array had a lower cavitation voltage than the lens-focussed transducer for a comparable operating depth. The histotripsy array was tested in a tissue phantom and an in vivo rat brain. It was used to produce an elongated lesion in the brain by electronically steering the focal length from 3- to 8-mm axially. Real time ultrasound imaging with a Doppler overlay was used to target the tissue and monitor ablation progress, and histology confirmed the targeted tissue was fully homogenized.
    MeSH term(s) High-Intensity Focused Ultrasound Ablation/methods ; Ultrasonography ; Phantoms, Imaging
    Language English
    Publishing date 2024-03-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 200839-7
    ISSN 1874-9968 ; 0041-624X
    ISSN (online) 1874-9968
    ISSN 0041-624X
    DOI 10.1016/j.ultras.2024.107275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Two new species of the hyperdiverse geometrid moth genus

    Doan, Lydia M / Miller, James S / Brown, John W / Forister, Matthew L / Dyer, Lee A

    ZooKeys

    2024  Volume 1192, Page(s) 111–140

    Abstract: The hyperdiverse geometrid ... ...

    Abstract The hyperdiverse geometrid genus
    Language English
    Publishing date 2024-02-21
    Publishing country Bulgaria
    Document type Journal Article
    ZDB-ID 2445640-8
    ISSN 1313-2970 ; 1313-2989
    ISSN (online) 1313-2970
    ISSN 1313-2989
    DOI 10.3897/zookeys.1192.111275
    Database MEDical Literature Analysis and Retrieval System OnLINE

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