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  1. Book ; Conference proceedings: 16th Symposium on the Treatment of Parkinson's Disease

    Mizuno, Yoshikuni

    September 15, 2007, Tokyo

    (Journal of neurology ; 255, Suppl. 4)

    2008  

    Event/congress Symposium on the Treatment of Parkinson's Disease (16, 2007, Tokio)
    Author's details guest-ed.-in-chief: Yoshikuni Mizuno
    Series title Journal of neurology ; 255, Suppl. 4
    Collection
    Language English
    Size 45 S. : Ill., graph. Darst.
    Publisher Springer/Steinkopff
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT015688068
    Database Catalogue ZB MED Medicine, Health

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  2. Book ; Conference proceedings: 9th International Symposium on the Treatment of Parkinson's Disease

    Mizuno, Yoshikuni

    [held in Kobe, Japan, in September 2004]

    (Parkinsonism & related disorders ; 11, Suppl. 1)

    2005  

    Event/congress International Symposium on the Treatment of Parkinson's Disease (9, 2004, Kōbe)
    Author's details guest ed. Yoshikuni Mizuno
    Series title Parkinsonism & related disorders ; 11, Suppl. 1
    Collection
    Language English
    Size S51 S. : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT014407821
    Database Catalogue ZB MED Medicine, Health

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  3. Book ; Conference proceedings: 8th International Symposium on the Treatment of Parkinson's Disease

    Mizuno, Yoshikuni

    [held in Kobe, Japan, from September 27th to 28th of 2003]

    (Parkinsonism & related disorders ; 10, Suppl. 1)

    2004  

    Institution International Symposium on the Treatment of Parkinson's Disease
    Author's details guest ed. Yoshikuni Mizuno
    Series title Parkinsonism & related disorders ; 10, Suppl. 1
    Collection
    Language English
    Size S57 S. : graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT014051623
    Database Catalogue ZB MED Medicine, Health

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  4. Book ; Conference proceedings: 7th International Symposium on the Treatment of Parkinsonism and Related Disorders

    Mizuno, Yoshikuni

    [held in Kobe, Japan, from 28th to 29th September 2002 ; proceedings]

    (Parkinsonism & related disorders ; 9, Suppl. 2)

    2003  

    Institution International Symposium on the Treatment of Parkinsonism and Related Disorders
    Author's details guest ed. Yoshikuni Mizuno
    Series title Parkinsonism & related disorders ; 9, Suppl. 2
    Collection
    Language English
    Size S. S53 - S115 : graph. Darst.
    Publisher Elsevier
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT013770256
    Database Catalogue ZB MED Medicine, Health

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  5. Article ; Online: More than 20 years of the discovery of Park2.

    Mizuno, Yoshikuni

    Neuroscience research

    2020  Volume 159, Page(s) 3–8

    Abstract: Discovery of Park2 is our finding of a family of young onset parkinsonism, in which this family was thought to be associated with a polymorphism of the manganese superoxide gene. The gene locus of the manganese superoxide dismutase has been known. We ... ...

    Abstract Discovery of Park2 is our finding of a family of young onset parkinsonism, in which this family was thought to be associated with a polymorphism of the manganese superoxide gene. The gene locus of the manganese superoxide dismutase has been known. We were able to pick up a gene for this family and related families in the close approximate position at the long arm of chromosome 6. The gene for this disease has a ubiquitin-like motif in the N-terminus and two RING finger structures. It was shown that this gene had a ubiquitin-protein ligase activity. But it is not elucidated the substrate of this enzyme. Meanwhile, it has become clear that PINK1 and Parkin work together to remove the mitochondria of the lowered membrane potential in the autophagosomes (mitophagy). Now that the molecular mechanisms of mitophagy is under investigation. In addition, many hot topics are going on such as Lewy body in Park2, single heterozygotes, rare clinical manifestations, and so on.
    MeSH term(s) Amino Acid Motifs ; Humans ; Mitochondria/genetics ; Mitophagy/genetics ; Parkinsonian Disorders/genetics ; Parkinsonian Disorders/physiopathology ; Protein Kinases/metabolism ; Ubiquitin-Protein Ligases/genetics
    Chemical Substances Ubiquitin-Protein Ligases (EC 2.3.2.27) ; parkin protein (EC 2.3.2.27) ; Protein Kinases (EC 2.7.-) ; PTEN-induced putative kinase (EC 2.7.11.1)
    Language English
    Publishing date 2020-05-23
    Publishing country Ireland
    Document type Journal Article ; Review
    ZDB-ID 605842-5
    ISSN 1872-8111 ; 0168-0102 ; 0921-8696
    ISSN (online) 1872-8111
    ISSN 0168-0102 ; 0921-8696
    DOI 10.1016/j.neures.2020.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Conference proceedings: 6th International Symposium on the Treatment of Parkinsonism and Related Disorders

    Mizuno, Yoshikuni

    [held in Kobe, Japan, from 29 to 30 September 2001 ; proceedings]

    (Parkinsonism & related disorders ; 9,1)

    2002  

    Institution International Symposium on the Treatment of Parkinsonism and Related Disorders
    Author's details Y. Mizuno (guest ed.)
    Series title Parkinsonism & related disorders ; 9,1
    Collection
    Language English
    Size S. 1 - 67 : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT013495379
    Database Catalogue ZB MED Medicine, Health

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  7. Book ; Conference proceedings: 5th International Symposium on the Treatment of Parkinson's Disease

    Mizuno, Yoshikuni

    [held on 30 September and 1 October in 2000 in Kobe, Japan ; proceedings]

    (Parkinsonism & related disorders ; 8,2)

    2001  

    Event/congress International Symposium on the Treatment of Parkinson's Disease (5, 2000, Kōbe)
    Author's details Y. Mizuno (guest ed.)
    Series title Parkinsonism & related disorders ; 8,2
    Collection
    Language English
    Size S. 77 - 153 : Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT013156673
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  8. Book ; Conference proceedings: Mapping the progress of Alzheimer's and Parkinson's disease

    Mizuno, Yoshikuni

    [proceedings of the 5th International Conference on the Progress in Alzheimer's and Parkinson's Disease, held from march 31st to april 5th, 2001, in Kyoto, Japan]

    (Advances in behavioral biology ; 51)

    2002  

    Event/congress International Conference on Progress in Alzheimer's and Parkinson's Diseases (5, 2001, Kyōto)
    Author's details ed. by Yoshikuni Mizuno
    Series title Advances in behavioral biology ; 51
    Collection
    Keywords Alzheimer Disease ; Parkinson Disease ; Parkinson-Krankheit ; Alzheimerkrankheit
    Subject Alzheimer-Krankheit ; Alzheimersche Krankheit ; Alzheimer-Demenz ; Morbus Alzheimer ; Greisenblödsinn ; Alzheimer's Disease ; Schüttellähmung ; Paralysis agitans ; Idiopathischer Parkinsonismus ; Morbus Parkinson
    Language English
    Size XXII, 565 S. : Ill., graph. Darst.
    Publisher Kluwer u.a.
    Publishing place New York u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT013331387
    ISBN 0-306-46763-1 ; 978-0-306-46763-9
    Database Catalogue ZB MED Medicine, Health

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  9. Book ; Conference proceedings: 4th International Symposium on the Treatment of Parkinson's Disease

    Mizuno, Yoshikuni

    [held on September 25th and 26th in 1999 in Kobe, Japan ; proceedings]

    (Parkinsonism & related disorders ; 7,1)

    2000  

    Event/congress International Symposium on the Treatment of Parkinson's Disease (4, 1999, Kob̄e)
    Author's details Y. Mizuno (guest ed.)
    Series title Parkinsonism & related disorders ; 7,1
    Collection
    Language English
    Size S. 1 - 80 : graph. Darst.
    Publisher Elsevier
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT012853375
    Database Catalogue ZB MED Medicine, Health

    Kategorien

  10. Book ; Conference proceedings: Second International Symposium on the Treatment of Parkinson's Disease

    Mizuno, Yoshikuni

    (Neurology ; 51, Suppl. 2)

    1998  

    Event/congress International Symposium on the Treatment of Parkinson's Disease (2, 1997, Kōbe)
    Author's details Yoshikuni Mizuno, suppl. ed
    Series title Neurology ; 51, Suppl. 2
    Collection
    Language English
    Size S40 S. : graph. Darst.
    Publisher Lippincott-Raven
    Publishing place Hagerstown, Md
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT009051966
    Database Catalogue ZB MED Medicine, Health

    Kategorien

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