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Article: Combined balance and brisk walking training to improve motor and non-motor symptoms in people with Parkinson disease: abridged secondary publication.

Mak, K Y M / Cheung, T H R / Ho, S L

Hong Kong medical journal = Xianggang yi xue za zhi

2024 Volume 30 Suppl 1, Issue 1, Page(s) 16–17

MeSH term(s)	Humans ; Parkinson Disease/complications ; Walking ; Exercise Therapy ; Postural Balance
Language	English
Publishing date	2024-02-28
Publishing country	China
Document type	Journal Article
ZDB-ID	1239255-8
ISSN	1024-2708
ISSN	1024-2708
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Article: Detection of significant liver fibrosis in Chinese psoriasis patients receiving methotrexate: a comparison between transient elastography and liver histology.

Wong, C S M / Mak, L L Y / Lee, V K H / Lo, R C L / Chung, M M H / Chu, F / Yeung, C K / Yuen, M F / Chan, H H L

Hong Kong medical journal = Xianggang yi xue za zhi

2024 Volume 30, Issue 2, Page(s) 110–119

Abstract: Introduction: Methotrexate (MTX) is effective for treating psoriasis and psoriatic arthritis, but its potential hepatoxicity remains a concern. Liver biopsy, the gold standard for detecting MTX-induced liver injury, is invasive and carries considerable ... ...

Abstract	Introduction: Methotrexate (MTX) is effective for treating psoriasis and psoriatic arthritis, but its potential hepatoxicity remains a concern. Liver biopsy, the gold standard for detecting MTX-induced liver injury, is invasive and carries considerable risk. Transient elastography (TE) offers a non-invasive alternative for detecting advanced liver fibrosis. This study investigated the performance of TE in detecting MTX-induced liver fibrosis among Chinese psoriasis patients, compared with liver biopsy. Methods: This study included adult patients with clinical psoriasis. Liver stiffness measurement using TE was performed in patients receiving MTX. Exclusion criteria were known liver cirrhosis, positive viral hepatitis carrier status, or conditions influencing TE performance. Liver biopsy was performed when liver stiffness was ≥7.1 kilopascals (kPa) or when the total cumulative dose (TCD) of MTX was ≥3.5 g. Results: A total of 228 patients were screened; among 34 patients who met the inclusion criteria, nine (26.5%) had significant liver fibrosis (Roenigk grade ≥3a). The area under the receiver operating characteristic curve was 0.76 (95% confidence interval=0.59-0.93; P=0.021), indicating that TE had satisfactory performance in detecting liver fibrosis. A cut-off value of 7.1 kPa of liver stiffness yielded 100% sensitivity and 68% specificity. Liver fibrosis was not correlated with the TCD of MTX or the duration of MTX use; it was significantly correlated with obesity and diabetes status (body mass index ≥30 kg/m Conclusion: Transient elastography is reliable and superior to the TCD for detecting liver fibrosis in Chinese psoriasis patients receiving MTX. Liver biopsy should be reserved for high-risk patients or patients with liver stiffness ≥11.7 kPa on TE.
MeSH term(s)	Humans ; Elasticity Imaging Techniques/methods ; Methotrexate/adverse effects ; Methotrexate/therapeutic use ; Methotrexate/administration & dosage ; Liver Cirrhosis/diagnostic imaging ; Liver Cirrhosis/pathology ; Male ; Psoriasis/drug therapy ; Psoriasis/complications ; Psoriasis/pathology ; Female ; Middle Aged ; Adult ; Liver/pathology ; Liver/diagnostic imaging ; Biopsy ; ROC Curve ; Dermatologic Agents/therapeutic use ; Dermatologic Agents/adverse effects ; Dermatologic Agents/administration & dosage ; Aged ; East Asian People
Chemical Substances	Methotrexate (YL5FZ2Y5U1) ; Dermatologic Agents
Language	English
Publishing date	2024-04-22
Publishing country	China
Document type	Journal Article ; Comparative Study
ZDB-ID	1239255-8
ISSN	1024-2708
ISSN	1024-2708
DOI	10.12809/hkmj2210364
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Article ; Online: Changes in Aqueous Cytokine Levels Following Intravitreal Aflibercept in Treatment-Naive Patients with Diabetic Macular Edema.

Juncal, Verena R / Mak, Michael Y K / Bamakrid, Motaz / Muni, Rajeev H

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics

2020 Volume 36, Issue 9, Page(s) 697–702

Abstract: Purpose: ...

Abstract	Purpose:
MeSH term(s)	Aged ; Angiogenesis Inhibitors/administration & dosage ; Aqueous Humor/drug effects ; Aqueous Humor/metabolism ; Cohort Studies ; Cytokines/antagonists & inhibitors ; Cytokines/metabolism ; Diabetic Retinopathy/diagnostic imaging ; Diabetic Retinopathy/drug therapy ; Diabetic Retinopathy/metabolism ; Female ; Humans ; Inflammation Mediators/antagonists & inhibitors ; Inflammation Mediators/metabolism ; Intravitreal Injections/methods ; Macular Edema/diagnostic imaging ; Macular Edema/drug therapy ; Macular Edema/metabolism ; Male ; Middle Aged ; Prospective Studies ; Receptors, Vascular Endothelial Growth Factor/administration & dosage ; Recombinant Fusion Proteins/administration & dosage ; Tomography, Optical Coherence/methods
Chemical Substances	Angiogenesis Inhibitors ; Cytokines ; Inflammation Mediators ; Recombinant Fusion Proteins ; aflibercept (15C2VL427D) ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1)
Language	English
Publishing date	2020-06-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	1237021-6
ISSN	1557-7732 ; 1080-7683
ISSN (online)	1557-7732
ISSN	1080-7683
DOI	10.1089/jop.2020.0038
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Zs.A 2099: Show issues

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Article ; Online: An Automated, Dynamic Radiation Oncology Prescription Checking System.

Pashtan, I M / Kosak, T / Shin, K-Y / Molodowitch, C / Killoran, J H / Hancox, C / Czerminska, M / Bredfeldt, J S / Cail, D W / Kearney, M / Tishler, R B / Mak, R H

Practical radiation oncology

2023

Abstract: Purpose: Despite serving as a critical communication tool, radiation oncology prescriptions are entered manually and prone to error. An automated prescription checking system was developed and implemented to help address this problem.: Methods and ... ...

Abstract	Purpose: Despite serving as a critical communication tool, radiation oncology prescriptions are entered manually and prone to error. An automated prescription checking system was developed and implemented to help address this problem. Methods and materials: Rules defining clinically appropriate prescriptions were generated, examining specific types of errors: (1) unapproved dose per fraction for a given disease site; (2) dose per fraction too large for nonstereotactic treatment technique; and (3) dose per fraction too low. With a goal of catching errors as upstream as possible to minimize their propagation, a report was created and ran every 30 minutes to check all newly written or approved prescriptions against the 3 rules. When a prescription violated these rules, an automated email was immediately sent to the prescriber alerting them of the potential error. System performance was continuously monitored and the criteria triggering an alert adjusted to balance error detection against false positives. Alerts leading to prescription amendment were considered true errors. Results: From June 2021 to November 2022, the system checked 24,047 prescriptions. A total of 241 email alerts were triggered, for an average alert rate of 1%. Of the 241 alerts, 198 (82.2%) were unapproved doses per fraction for the disease site, 14 (5.8%) were doses per fraction that were too low, and 29 (12%) were doses too large for nonstereotactic treatment technique. Thirty-one percent of alerts led to a change of prescription, suggesting they were true errors. The baseline rate of erroneous prescription entry was 0.3%. A regression model showed that trainee prescription entry and dose per fraction <150 cGy were significantly associated with true errors. Conclusions: Given the significant consequences of erroneous prescription entry, which ranged from wasted resources and treatment delays to potentially serious misadministration, there is significant value in implementing automated prescription checking systems in radiation oncology clinics.
Language	English
Publishing date	2023-12-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2655748-4
ISSN	1879-8519 ; 1879-8500
ISSN (online)	1879-8519
ISSN	1879-8500
DOI	10.1016/j.prro.2023.12.002
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Article ; Online: Left ventrolateral prefrontal cortical activity during reward expectancy predicts mania risk up to one year post scan.

Edmiston, E K / Fournier, J C / Chase, H W / Aslam, H A / Lockovich, J / Graur, S / Bebko, G / Bertocci, M / Rozovsky, R / Mak, K / Forbes, E E / Stiffler, R / Phillips, M L

Journal of affective disorders

2022 Volume 319, Page(s) 325–328

Abstract: Introduction: Identification of neural markers associated with risk for manic symptoms is an important challenge for neuropsychiatric research. Previous work has highlighted the association between predisposition for mania/hypomania and elevated reward ... ...

Abstract	Introduction: Identification of neural markers associated with risk for manic symptoms is an important challenge for neuropsychiatric research. Previous work has highlighted the association between predisposition for mania/hypomania and elevated reward sensitivity. Elevated activity in the left ventrolateral prefrontal cortex (L vlPFC) during reward expectancy (RE) is associated with measures predictive of risk for manic/hypomanic symptoms. However, no studies have examined this relationship longitudinally. The goal of this study was to identify a neural marker associated with longitudinal risk for manic/hypomanic symptoms. Methods: We used a card guessing functional magnetic resonance imaging (fMRI) paradigm to examine RE-related L vlPFC activity. One hundred and three young adults who were either healthy or experiencing psychological distress completed a single baseline fMRI scan and self-report measures of manic/hypomanic symptoms. Self-report measures were repeated up to two follow up visits over one year. Results: We identified a significant positive relationship between baseline RE-related L vlPFC activity and MOODS Manic Domain scores up to one-year post scan. This relationship was specific to manic symptoms and was not present for MOODS depression-related domains. Limitations: This study was not designed to predict conversion to bipolar disorder, but rather the more proximal construct of lifetime risk for mania/hypomania. Conclusions: RE-related L vlPFC activity may serve as an important marker of risk for future manic/hypomanic symptoms and may also be a potential target for intervention.
MeSH term(s)	Young Adult ; Humans ; Mania ; Reward ; Bipolar Disorder/diagnosis ; Cerebral Cortex ; Magnetic Resonance Imaging
Language	English
Publishing date	2022-09-08
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2022.08.081
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Zs.A 1485: Show issues

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Article ; Online: Proteomic Profiling of Extracellular Matrix Components from Patient Metastases Identifies Consistently Elevated Proteins for Developing Nanobodies That Target Primary Tumors and Metastases.

Jailkhani, Noor / Clauser, Karl R / Mak, Howard H / Rickelt, Steffen / Tian, Chenxi / Whittaker, Charles A / Tanabe, Kenneth K / Purdy, Stephen R / Carr, Steven A / Hynes, Richard O

Cancer research

2023 Volume 83, Issue 12, Page(s) 2052–2065

Abstract: Metastases are hard to detect and treat, and they cause most cancer-related deaths. The relative lack of therapies targeting metastases represents a major unmet clinical need. The extracellular matrix (ECM) forms a major component of the tumor ... ...

Abstract	Metastases are hard to detect and treat, and they cause most cancer-related deaths. The relative lack of therapies targeting metastases represents a major unmet clinical need. The extracellular matrix (ECM) forms a major component of the tumor microenvironment in both primary and metastatic tumors, and certain ECM proteins can be selectively and abundantly expressed in tumors. Nanobodies against ECM proteins that show selective abundance in metastases have the potential to be used as vehicles for delivery of imaging and therapeutic cargoes. Here, we describe a strategy to develop phage-display libraries of nanobodies against ECM proteins expressed in human metastases, using entire ECM-enriched preparations from triple-negative breast cancer (TNBC) and colorectal cancer metastases to different organs as immunogens. In parallel, LC-MS/MS-based proteomics were used to define a metastasis-associated ECM signature shared by metastases from TNBC and colorectal cancer, and this conserved set of ECM proteins was selectively elevated in other tumors. As proof of concept, selective and high-affinity nanobodies were isolated against an example protein from this signature, tenascin-C (TNC), known to be abundant in many tumor types and to play a role in metastasis. TNC was abundantly expressed in patient metastases and widely expressed across diverse metastatic sites originating from several primary tumor types. Immuno-PET/CT showed that anti-TNC nanobodies bind TNBC tumors and metastases with excellent specificity. We propose that such generic nanobodies against tumors and metastases are promising cancer-agnostic tools for delivery of therapeutics to tumor and metastatic ECM. Significance: Nanobodies specific for extracellular matrix markers commonly expressed in primary tumors and metastases are promising agents for noninvasive detection of tumors and metastases and potential tools for targeted therapy.
MeSH term(s)	Humans ; Single-Domain Antibodies ; Proteomics/methods ; Triple Negative Breast Neoplasms/pathology ; Chromatography, Liquid ; Tandem Mass Spectrometry ; Extracellular Matrix/metabolism ; Tenascin/metabolism ; Colorectal Neoplasms/pathology ; Tumor Microenvironment
Chemical Substances	Single-Domain Antibodies ; Tenascin
Language	English
Publishing date	2023-04-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1432-1
ISSN	1538-7445 ; 0008-5472
ISSN (online)	1538-7445
ISSN	0008-5472
DOI	10.1158/0008-5472.CAN-22-1532
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Article ; Online: Effects of cadmium acetate contaminated drinking water on vital organs: A histopathological and biochemical study.

Syed, Murtaza H / Rubab, Syeda A / Abbas, Syed R / Qutaba, Syed / Mohd Zahari, Mior A K / Abdullah, Norhayati

Journal of biochemical and molecular toxicology

2023 Volume 37, Issue 8, Page(s) e23382

Abstract: Cadmium (Cd) is a heavy metal with various human exposure sources. It accumulates in the liver, forming a complex with metallothionein protein and progresses to other organs. As a heavy metal, cadmium can replace calcium and other divalent ions and ... ...

Abstract	Cadmium (Cd) is a heavy metal with various human exposure sources. It accumulates in the liver, forming a complex with metallothionein protein and progresses to other organs. As a heavy metal, cadmium can replace calcium and other divalent ions and disturb their cascades, ultimately affecting the vital organs. Since cadmium acetate (CA) is considered more lethal than other Cd compounds, the current study examines the effect of different concentrations of CA doses in drinking water for different exposure times in murine models (Mus musculus). After the exposure period, the murine models were then examined histopathologically and biochemically. The histopathological examination of the heart, liver, and kidneys of the experimental group showed extensive degenerative effects. Atomic absorption spectroscopy was used to determine the quantity of cadmium in serum, kidney, and hepatic tissues. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of hepatic proteins, especially metallothionein, directly related to Cd administration. The biochemical parameters, including creatine kinase, alanine aminotransferase, aspartate aminotransferase, total proteins, glucose, urea, uric acid, and creatinine, were also analyzed. After thorough histochemical and biochemical analysis, it was concluded that even low dose exposure of CA is hazardous to murine models with damaging effects.
MeSH term(s)	Humans ; Mice ; Animals ; Cadmium/toxicity ; Drinking Water/metabolism ; Liver/metabolism ; Kidney ; Metallothionein/metabolism ; Metallothionein/pharmacology
Chemical Substances	cadmium acetate (95KC50Z1L0) ; Cadmium (00BH33GNGH) ; Drinking Water ; Metallothionein (9038-94-2)
Language	English
Publishing date	2023-05-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1410020-4
ISSN	1099-0461 ; 1095-6670
ISSN (online)	1099-0461
ISSN	1095-6670
DOI	10.1002/jbt.23382
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Article ; Online: A single institutional experience with suction thrombectomy in acute mesenteric ischemia.

Mak, Allison K / Andraska, Elizabeth A / Reitz, Katherine M / Chaer, Rabih / Eslami, Mohammed H / Avgerinos, Efthymios

Annals of vascular surgery. Brief reports and innovations

2022 Volume 2, Issue 2

Abstract: Acute mesenteric ischemia (AMI) is typically treated by open surgery or hybrid techniques. Catheter-based aspiration thrombectomy represents another minimally invasive alternative with a potential additional safety benefit of minimizing the bleeding risk ...

Abstract	Acute mesenteric ischemia (AMI) is typically treated by open surgery or hybrid techniques. Catheter-based aspiration thrombectomy represents another minimally invasive alternative with a potential additional safety benefit of minimizing the bleeding risk associated with thrombolytics. In this institutional case series, we present five clinical cases of aspiration thrombectomy for high-risk AMI using the Penumbra aspiration system. All patients underwent technically successful endovascular thrombectomy as demonstrated by intraoperative angiography results. However, bowel necrosis and sepsis adversely affected postoperative outcomes. Lack of intraoperative bowel assessment is a limitation of endovascular methods, highlighting the importance of patient selection.
Language	English
Publishing date	2022-04-04
Publishing country	United States
Document type	Journal Article
ISSN	2772-6878
ISSN (online)	2772-6878
DOI	10.1016/j.avsurg.2022.100070
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Article: Per urethral insertion of foreign body for erotism: case reports.

Mak, C W H / Cho, C L / Chan, W K W / Chu, R W H / Law, I C

Hong Kong medical journal = Xianggang yi xue za zhi

2019 Volume 25, Issue 4, Page(s) 320–322

MeSH term(s)	Adult ; Female ; Foreign Bodies/diagnosis ; Foreign Bodies/therapy ; Humans ; Male ; Middle Aged ; Sexual Behavior ; Urethra
Language	English
Publishing date	2019-08-15
Publishing country	China
Document type	Case Reports ; Journal Article
ZDB-ID	1239255-8
ISSN	1024-2708
ISSN	1024-2708
DOI	10.12809/hkmj177044
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Article ; Online: External validation of

Tjong, M C / Zhang, S C / Gasho, J O / Silos, K D / Gay, C / McKenzie, E M / Steers, J / Bitterman, D S / Nikolova, A P / Nohria, A / Hoffmann, U / Brantley, K D / Mak, R H / Atkins, K M

Clinical and translational radiation oncology

2023 Volume 42, Page(s) 100660

Abstract: Background and purpose: Major adverse cardiac events(MACE) are prevalent in patients with locally advanced-non-small cell lung cancer(LA-NSCLC) following radiotherapy(RT). The : Patients and methods: Patients with LA-NSCLC treated with RT were ... ...

Abstract	Background and purpose: Major adverse cardiac events(MACE) are prevalent in patients with locally advanced-non-small cell lung cancer(LA-NSCLC) following radiotherapy(RT). The Patients and methods: Patients with LA-NSCLC treated with RT were included. CHyLL score was calculated:5.51CHD + 1.28HTN + 1.48ln(LADV15 + 1)-1.36CHDln(LADV15 + 1). CHyLL performance in predicting MACE was assessed and compared to mean heart dose(MHD) using Cox-proportional hazard(PH) analyses and Harrel's concordance(C)-indices. MACE and overall survival(OS) among low-vs high-risk groups(CHyLL < 5 vs ≥ 5) were compared. Results:* In the external validation cohort(N = 102), the median age was 71 years and 55% were females. Most(n = 74,73%), had clinical Stage III disease and 35(34%) underwent surgery. CHyLL demonstrated good MACE prediction with C-index of 0.73(95% Confidence Interval(CI):0.58-0.89), while MHD did not (C-index = 0.46 (95% CI:0.30-0.62)). Per CHyLL, 32(31%) and 70(69%) patients were considered low-and high-risk for MACE, respectively. CHyLL consistently identified lower MACE rates in the low-vs high-risk group(log-rank p = 0.108):0 vs 8%(12 months),5 vs 16%(24 months),5 vs 16%(36 months),and 5 vs 19%(48 months) post-RT. In the pooled internal and external validation cohort(N = 303), MACE rates in low-vs high-risk groups were statistically significantly different(log-rank p = 0.01):1 vs 6%(12 months),3 vs 12%(24 months),6 vs 19%(36 months),and 6 vs 21%(48 months). Conclusions: CHyLL was externally validated and superior to MHD in predicting MACE. CHyLL has the potential to identify high-risk patients who may benefit from cardio-oncology optimization and to estimate personalized LADV15 constraints based on cardiac risk factors and acceptable MACE thresholds.
Language	English
Publishing date	2023-07-24
Publishing country	Ireland
Document type	Journal Article
ISSN	2405-6308
ISSN (online)	2405-6308
DOI	10.1016/j.ctro.2023.100660
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