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Article ; Online: Hypertension is a possible risk factor for cervical artery dissection.

Abdelnour, Loay H

Journal of clinical hypertension (Greenwich, Conn.)

2022 Volume 24, Issue 12, Page(s) 1618–1619

MeSH term(s)	Humans ; Hypertension/complications ; Hypertension/epidemiology ; Cerebrovascular Disorders ; Risk Factors ; Aortic Dissection/epidemiology ; Aortic Dissection/etiology ; Arteries
Language	English
Publishing date	2022-11-26
Publishing country	United States
Document type	Letter
ZDB-ID	2077222-1
ISSN	1751-7176 ; 1524-6175
ISSN (online)	1751-7176
ISSN	1524-6175
DOI	10.1111/jch.14603
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Article ; Online: Association of styloid process length with cervical carotid artery dissection

Loay H Abdelnour / Mohammed Kurdy / Abubakr Idris

Health Sciences Review, Vol 9, Iss , Pp 100134- (2023)

Meta-analysis

2023

Abstract: This meta-analysis was conducted to investigate the association of elongated styloid process (Eagle syndrome) and cervical artery dissection (CeAD), particularly carotid. Medline, PubMed Central, CINAHL and ProQuest were searched for case-control studies ...

Abstract	This meta-analysis was conducted to investigate the association of elongated styloid process (Eagle syndrome) and cervical artery dissection (CeAD), particularly carotid. Medline, PubMed Central, CINAHL and ProQuest were searched for case-control studies investigating the association of styloid process length (SPL) and CeAD, particularly carotid. SPL was treated as a continuous variable and mean difference was calculated from means and standard deviations with 95 % confidence interval (CI). SPL >30 mm was compared between cases and controls as a dichotomous variable and odds ratio (OR) was calculated with 95 % CI. Heterogeneity was quantified with χ2-based Cochran's Q-test and I2-statistic. Four studies were included comparing 185 dissection cases with 278 controls. Heterogeneity was 50 %, but was reduced to 0 % with sensitivity analysis. Styloid process was significantly longer in dissection group with a mean difference of 2.50 [-0.35, 5.35], P = 0.09. Elimination of one study with high risk of bias resulted in a mean difference of 3.61 [1.47, 5.75], P = 0.0009, and a heterogeneity of 0 %. Two studies showed SPL >30 mm to be more significant in dissection group (OR = 1.53 [0.84,2.80], P = 0.17). With sensitivity analysis the pooled OR was 2.09 [1.04, 4.19], P = 0.04. Three studies showed that mean SPL was significantly longer ipsilateral compared to contralateral side of dissection (mean difference 2.63 [0.46, 4.79], P = 0.02. This meta-analysis suggests that CeAD is significantly associated with styloid process mean length and SPL >30 mm. Case-control studies with bigger numbers are required to substantiate this association.
Keywords	Dissection ; Carotid ; Vertebral ; Styloid process ; Medicine ; R
Subject code	150
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Systematic review of postpartum and pregnancy-related cervical artery dissection.

Abdelnour, Loay H / Kurdy, Mohammed / Idris, Abubakr

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2022 Volume 35, Issue 26, Page(s) 10287–10295

Abstract: Background: Cervical artery dissection (CeAD) is responsible of one fifth of cases of ischemic stroke, but is uncommon during pregnancy or the early postpartum period and evidence is derived from published case reports and case series.: Objectives: ... ...

Abstract	Background: Cervical artery dissection (CeAD) is responsible of one fifth of cases of ischemic stroke, but is uncommon during pregnancy or the early postpartum period and evidence is derived from published case reports and case series. Objectives: This systematic review with a prospectively registered protocol was conducted to study the clinical presentation, management and prognosis of this condition. Methods: Ovid-Medline, PubMed Central, and CINAHL were searched without language restriction. Results: Fifty-seven articles (50 case reports and seven case series) reporting on 77 patients were included. The mean age was 33.7 years. The main possible risk factors identified were migraine, hyperlipidemia, connective tissue disorders, preeclampsia and eclampsia, HELLP syndrome and prolonged second stage of labor. Headache was the most frequent symptom, followed by neck pain. Acute medical treatments included anticoagulation, antiplatelets, and endovascular therapy. No patients received thrombolysis. The overall prognosis was good with 77.8% of patients making full clinical recovery. Conclusions: Cervical artery dissection is a rare, but an important complication of pregnancy and puerperium. Diagnosis requires a high index of suspicion. The strong association with hypertensive and connective tissue disorders requires further research.
MeSH term(s)	Adult ; Female ; Humans ; Pregnancy ; HELLP Syndrome/epidemiology ; Postpartum Period ; Pre-Eclampsia/epidemiology ; Vertebral Artery Dissection/epidemiology ; Pregnancy Complications, Cardiovascular/epidemiology ; Risk Factors
Language	English
Publishing date	2022-09-29
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2022.2122799
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Article: Progression of CXR features on a COVID-19 survivor.

Abdelnour, Loay H / Abdalla, Mohammed E

IDCases

2020 Volume 21, Page(s) e00834

Abstract: COVID-19 causes consolidations or ground glass opacities that are predominantly peripheral, basal, and bilateral on chest x-ray (CXR). There are no published case reports that present over ten serial CXRs on the same patient. We present a case report of ... ...

Abstract	COVID-19 causes consolidations or ground glass opacities that are predominantly peripheral, basal, and bilateral on chest x-ray (CXR). There are no published case reports that present over ten serial CXRs on the same patient. We present a case report of a 68-year-old patient with confirmed COVID-19 and a prolonged course of admission, receiving nasal and humidified oxygen, non-invasive and then mechanical ventilation. She self-extubated, but remained stable on nasal oxygen only and was transferred for rehabilitation. We present 12 of her serial CXRs over six weeks, showing progression from subtle changes to overt widespread pneumonitis to slow resolution. She is also an example of a rare case of COVID-19 pneumonitis causing persistent hypoxia for over six weeks.
Keywords	covid19
Language	English
Publishing date	2020-05-22
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2745454-X
ISSN	2214-2509
ISSN	2214-2509
DOI	10.1016/j.idcr.2020.e00834
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Article: Septic sacroiliitis in the post-partum period with haematogenous spread.

Walsh, Ryan / Thornton, Aoife / Abdelnour, Loay H

IDCases

2021 Volume 24, Page(s) e01118

Abstract: Pelvic pain is a very common gynaecological complaint especially during the puerperium. It is rarely associated with development of septic sacroiliitis or haematogenous spread to other sites within the body. The case below demonstrates a 30 year old ... ...

Abstract	Pelvic pain is a very common gynaecological complaint especially during the puerperium. It is rarely associated with development of septic sacroiliitis or haematogenous spread to other sites within the body. The case below demonstrates a 30 year old female 10 days post-partum presenting with left hand cellulitis secondary to development of septic sacroiliitis. Her case supplements a small cohort of reports among literature identifying septic arthritis in the postpartum period, recognises the delay to diagnosis and increased morbidity of this condition.
Language	English
Publishing date	2021-04-09
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2745454-X
ISSN	2214-2509
ISSN	2214-2509
DOI	10.1016/j.idcr.2021.e01118
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Article ; Online: Progression of CXR features on a COVID-19 survivor

Abdelnour, Loay H / Abdalla, Mohammed E

IDCases

2020 Volume 21, Page(s) e00834

Keywords	covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	2745454-X
ISSN	2214-2509
ISSN	2214-2509
DOI	10.1016/j.idcr.2020.e00834
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Article: Progression of CXR features on a COVID-19 survivor

Abdelnour, Loay H / Abdalla, Mohammed E

IDCases

Abstract	COVID-19 causes consolidations or ground glass opacities that are predominantly peripheral, basal, and bilateral on chest x-ray (CXR). There are no published case reports that present over ten serial CXRs on the same patient. We present a case report of a 68-year-old patient with confirmed COVID-19 and a prolonged course of admission, receiving nasal and humidified oxygen, non-invasive and then mechanical ventilation. She self-extubated, but remained stable on nasal oxygen only and was transferred for rehabilitation. We present 12 of her serial CXRs over six weeks, showing progression from subtle changes to overt widespread pneumonitis to slow resolution. She is also an example of a rare case of COVID-19 pneumonitis causing persistent hypoxia for over six weeks.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #327383
Database	COVID19

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Article ; Online: Progression of CXR features on a COVID-19 survivor

Loay H Abdelnour / Mohammed E Abdalla

IDCases, Vol 21, Iss , Pp e00834- (2020)

2020

Abstract	COVID-19 causes consolidations or ground glass opacities that are predominantly peripheral, basal, and bilateral on chest x-ray (CXR). There are no published case reports that present over ten serial CXRs on the same patient. We present a case report of a 68-year-old patient with confirmed COVID-19 and a prolonged course of admission, receiving nasal and humidified oxygen, non-invasive and then mechanical ventilation. She self-extubated, but remained stable on nasal oxygen only and was transferred for rehabilitation. We present 12 of her serial CXRs over six weeks, showing progression from subtle changes to overt widespread pneumonitis to slow resolution. She is also an example of a rare case of COVID-19 pneumonitis causing persistent hypoxia for over six weeks.
Keywords	COVID-19 ; CXR ; Consolidation ; Hypoxia ; Radiological ; Infectious and parasitic diseases ; RC109-216 ; covid19
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis.

Singh, Bhagteshwar / Lant, Suzannah / Cividini, Sofia / Cattrall, Jonathan W S / Goodwin, Lynsey C / Benjamin, Laura / Michael, Benedict D / Khawaja, Ayaz / Matos, Aline de Moura Brasil / Alkeridy, Walid / Pilotto, Andrea / Lahiri, Durjoy / Rawlinson, Rebecca / Mhlanga, Sithembinkosi / Lopez, Evelyn C / Sargent, Brendan F / Somasundaran, Anushri / Tamborska, Arina / Webb, Glynn /

Younas, Komal / Al Sami, Yaqub / Babu, Heavenna / Banks, Tristan / Cavallieri, Francesco / Cohen, Matthew / Davies, Emma / Dhar, Shalley / Fajardo Modol, Anna / Farooq, Hamzah / Harte, Jeffrey / Hey, Samuel / Joseph, Albert / Karthikappallil, Dileep / Kassahun, Daniel / Lipunga, Gareth / Mason, Rachel / Minton, Thomas / Mond, Gabrielle / Poxon, Joseph / Rabas, Sophie / Soothill, Germander / Zedde, Marialuisa / Yenkoyan, Konstantin / Brew, Bruce / Contini, Erika / Cysique, Lucette / Zhang, Xin / Maggi, Pietro / van Pesch, Vincent / Lechien, Jérome / Saussez, Sven / Heyse, Alex / Brito Ferreira, Maria Lúcia / Soares, Cristiane N / Elicer, Isabel / Eugenín-von Bernhardi, Laura / Ñancupil Reyes, Waleng / Yin, Rong / Azab, Mohammed A / Abd-Allah, Foad / Elkady, Ahmed / Escalard, Simon / Corvol, Jean-Christophe / Delorme, Cécile / Tattevin, Pierre / Bigaut, Kévin / Lorenz, Norbert / Hornuss, Daniel / Hosp, Jonas / Rieg, Siegbert / Wagner, Dirk / Knier, Benjamin / Lingor, Paul / Winkler, Andrea Sylvia / Sharifi-Razavi, Athena / Moein, Shima T / SeyedAlinaghi, SeyedAhmad / JamaliMoghadamSiahkali, Saeidreza / Morassi, Mauro / Padovani, Alessandro / Giunta, Marcello / Libri, Ilenia / Beretta, Simone / Ravaglia, Sabrina / Foschi, Matteo / Calabresi, Paolo / Primiano, Guido / Servidei, Serenella / Biagio Mercuri, Nicola / Liguori, Claudio / Pierantozzi, Mariangela / Sarmati, Loredana / Boso, Federica / Garazzino, Silvia / Mariotto, Sara / Patrick, Kimani N / Costache, Oana / Pincherle, Alexander / Klok, Frederikus A / Meza, Roger / Cabreira, Verónica / Valdoleiros, Sofia R / Oliveira, Vanessa / Kaimovsky, Igor / Guekht, Alla / Koh, Jasmine / Fernández Díaz, Eva / Barrios-López, José María / Guijarro-Castro, Cristina / Beltrán-Corbellini, Álvaro / Martínez-Poles, Javier / Diezma-Martín, Alba María / Morales-Casado, Maria Isabel / García García, Sergio / Breville, Gautier / Coen, Matteo / Uginet, Marjolaine / Bernard-Valnet, Raphaël / Du Pasquier, Renaud / Kaya, Yildiz / Abdelnour, Loay H / Rice, Claire / Morrison, Hamish / Defres, Sylviane / Huda, Saif / Enright, Noelle / Hassell, Jane / D'Anna, Lucio / Benger, Matthew / Sztriha, Laszlo / Raith, Eamon / Chinthapalli, Krishna / Nortley, Ross / Paterson, Ross / Chandratheva, Arvind / Werring, David J / Dervisevic, Samir / Harkness, Kirsty / Pinto, Ashwin / Jillella, Dinesh / Beach, Scott / Gunasekaran, Kulothungan / Rocha Ferreira Da Silva, Ivan / Nalleballe, Krishna / Santoro, Jonathan / Scullen, Tyler / Kahn, Lora / Kim, Carla Y / Thakur, Kiran T / Jain, Rajan / Umapathi, Thirugnanam / Nicholson, Timothy R / Sejvar, James J / Hodel, Eva Maria / Tudur Smith, Catrin / Solomon, Tom

PloS one

2022 Volume 17, Issue 6, Page(s) e0263595

Abstract: Background: Neurological COVID-19 disease has been reported widely, but published studies often lack information on neurological outcomes and prognostic risk factors. We aimed to describe the spectrum of neurological disease in hospitalised COVID-19 ... ...

Abstract	Background: Neurological COVID-19 disease has been reported widely, but published studies often lack information on neurological outcomes and prognostic risk factors. We aimed to describe the spectrum of neurological disease in hospitalised COVID-19 patients; characterise clinical outcomes; and investigate factors associated with a poor outcome. Methods: We conducted an individual patient data (IPD) meta-analysis of hospitalised patients with neurological COVID-19 disease, using standard case definitions. We invited authors of studies from the first pandemic wave, plus clinicians in the Global COVID-Neuro Network with unpublished data, to contribute. We analysed features associated with poor outcome (moderate to severe disability or death, 3 to 6 on the modified Rankin Scale) using multivariable models. Results: We included 83 studies (31 unpublished) providing IPD for 1979 patients with COVID-19 and acute new-onset neurological disease. Encephalopathy (978 [49%] patients) and cerebrovascular events (506 [26%]) were the most common diagnoses. Respiratory and systemic symptoms preceded neurological features in 93% of patients; one third developed neurological disease after hospital admission. A poor outcome was more common in patients with cerebrovascular events (76% [95% CI 67-82]), than encephalopathy (54% [42-65]). Intensive care use was high (38% [35-41]) overall, and also greater in the cerebrovascular patients. In the cerebrovascular, but not encephalopathic patients, risk factors for poor outcome included breathlessness on admission and elevated D-dimer. Overall, 30-day mortality was 30% [27-32]. The hazard of death was comparatively lower for patients in the WHO European region. Interpretation: Neurological COVID-19 disease poses a considerable burden in terms of disease outcomes and use of hospital resources from prolonged intensive care and inpatient admission; preliminary data suggest these may differ according to WHO regions and country income levels. The different risk factors for encephalopathy and stroke suggest different disease mechanisms which may be amenable to intervention, especially in those who develop neurological symptoms after hospital admission.
MeSH term(s)	COVID-19/complications ; COVID-19/therapy ; Hospitalization ; Humans ; Prognosis ; Risk Factors ; Stroke
Language	English
Publishing date	2022-06-02
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0263595
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease

Bhagteshwar Singh / Suzannah Lant / Sofia Cividini / Jonathan W S Cattrall / Lynsey C Goodwin / Laura Benjamin / Benedict D Michael / Ayaz Khawaja / Aline de Moura Brasil Matos / Walid Alkeridy / Andrea Pilotto / Durjoy Lahiri / Rebecca Rawlinson / Sithembinkosi Mhlanga / Evelyn C Lopez / Brendan F Sargent / Anushri Somasundaran / Arina Tamborska / Glynn Webb /

Komal Younas / Yaqub Al Sami / Heavenna Babu / Tristan Banks / Francesco Cavallieri / Matthew Cohen / Emma Davies / Shalley Dhar / Anna Fajardo Modol / Hamzah Farooq / Jeffrey Harte / Samuel Hey / Albert Joseph / Dileep Karthikappallil / Daniel Kassahun / Gareth Lipunga / Rachel Mason / Thomas Minton / Gabrielle Mond / Joseph Poxon / Sophie Rabas / Germander Soothill / Marialuisa Zedde / Konstantin Yenkoyan / Bruce Brew / Erika Contini / Lucette Cysique / Xin Zhang / Pietro Maggi / Vincent van Pesch / Jérome Lechien / Sven Saussez / Alex Heyse / Maria Lúcia Brito Ferreira / Cristiane N Soares / Isabel Elicer / Laura Eugenín-von Bernhardi / Waleng Ñancupil Reyes / Rong Yin / Mohammed A Azab / Foad Abd-Allah / Ahmed Elkady / Simon Escalard / Jean-Christophe Corvol / Cécile Delorme / Pierre Tattevin / Kévin Bigaut / Norbert Lorenz / Daniel Hornuss / Jonas Hosp / Siegbert Rieg / Dirk Wagner / Benjamin Knier / Paul Lingor / Andrea Sylvia Winkler / Athena Sharifi-Razavi / Shima T Moein / SeyedAhmad SeyedAlinaghi / Saeidreza JamaliMoghadamSiahkali / Mauro Morassi / Alessandro Padovani / Marcello Giunta / Ilenia Libri / Simone Beretta / Sabrina Ravaglia / Matteo Foschi / Paolo Calabresi / Guido Primiano / Serenella Servidei / Nicola Biagio Mercuri / Claudio Liguori / Mariangela Pierantozzi / Loredana Sarmati / Federica Boso / Silvia Garazzino / Sara Mariotto / Kimani N Patrick / Oana Costache / Alexander Pincherle / Frederikus A Klok / Roger Meza / Verónica Cabreira / Sofia R Valdoleiros / Vanessa Oliveira / Igor Kaimovsky / Alla Guekht / Jasmine Koh / Eva Fernández Díaz / José María Barrios-López / Cristina Guijarro-Castro / Álvaro Beltrán-Corbellini / Javier Martínez-Poles / Alba María Diezma-Martín / Maria Isabel Morales-Casado / Sergio García García / Gautier Breville / Matteo Coen / Marjolaine Uginet / Raphaël Bernard-Valnet / Renaud Du Pasquier / Yildiz Kaya / Loay H Abdelnour / Claire Rice / Hamish Morrison / Sylviane Defres / Saif Huda / Noelle Enright / Jane Hassell / Lucio D'Anna / Matthew Benger / Laszlo Sztriha / Eamon Raith / Krishna Chinthapalli / Ross Nortley / Ross Paterson / Arvind Chandratheva / David J Werring / Samir Dervisevic / Kirsty Harkness / Ashwin Pinto / Dinesh Jillella / Scott Beach / Kulothungan Gunasekaran / Ivan Rocha Ferreira Da Silva / Krishna Nalleballe / Jonathan Santoro / Tyler Scullen / Lora Kahn / Carla Y Kim / Kiran T Thakur / Rajan Jain / Thirugnanam Umapathi / Timothy R Nicholson / James J Sejvar / Eva Maria Hodel / Catrin Tudur Smith / Tom Solomon

PLoS ONE, Vol 17, Iss 6, p e

An individual patient data meta-analysis.

2022 Volume 0263595

Abstract: Background Neurological COVID-19 disease has been reported widely, but published studies often lack information on neurological outcomes and prognostic risk factors. We aimed to describe the spectrum of neurological disease in hospitalised COVID-19 ... ...

Abstract	Background Neurological COVID-19 disease has been reported widely, but published studies often lack information on neurological outcomes and prognostic risk factors. We aimed to describe the spectrum of neurological disease in hospitalised COVID-19 patients; characterise clinical outcomes; and investigate factors associated with a poor outcome. Methods We conducted an individual patient data (IPD) meta-analysis of hospitalised patients with neurological COVID-19 disease, using standard case definitions. We invited authors of studies from the first pandemic wave, plus clinicians in the Global COVID-Neuro Network with unpublished data, to contribute. We analysed features associated with poor outcome (moderate to severe disability or death, 3 to 6 on the modified Rankin Scale) using multivariable models. Results We included 83 studies (31 unpublished) providing IPD for 1979 patients with COVID-19 and acute new-onset neurological disease. Encephalopathy (978 [49%] patients) and cerebrovascular events (506 [26%]) were the most common diagnoses. Respiratory and systemic symptoms preceded neurological features in 93% of patients; one third developed neurological disease after hospital admission. A poor outcome was more common in patients with cerebrovascular events (76% [95% CI 67-82]), than encephalopathy (54% [42-65]). Intensive care use was high (38% [35-41]) overall, and also greater in the cerebrovascular patients. In the cerebrovascular, but not encephalopathic patients, risk factors for poor outcome included breathlessness on admission and elevated D-dimer. Overall, 30-day mortality was 30% [27-32]. The hazard of death was comparatively lower for patients in the WHO European region. Interpretation Neurological COVID-19 disease poses a considerable burden in terms of disease outcomes and use of hospital resources from prolonged intensive care and inpatient admission; preliminary data suggest these may differ according to WHO regions and country income levels. The different risk factors for encephalopathy and ...
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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