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Article ; Online: Real-time cerebral blood flow velocity during limb-shaking transient ischemic attacks.

Kitano, Takaya / Sakaguchi, Manabu / Okazaki, Shuhei / Todo, Kenichi / Mochizuki, Hideki

2022 Volume 123, Issue 2, Page(s) 635–636

MeSH term(s)	Humans ; Ischemic Attack, Transient/diagnostic imaging ; Extremities ; Tremor ; Cerebrovascular Circulation ; Blood Flow Velocity
Language	English
Publishing date	2022-03-14
Publishing country	Italy
Document type	Letter
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-022-01914-3
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Article: Single-Stage Surgical Treatment of Acute Type A Aortic Dissection and Blunt Abdominal Trauma: A Case Report.

Taniguchi, Tomoaki / Furukawa, Koji / Ishii, Hirohito / Kawagoe, Katsuya / Sakaguchi, Shuhei / Meiri, Risa

Annals of vascular diseases

2023 Volume 16, Issue 3, Page(s) 238–241

Abstract: A 53-year-old man suddenly developed chest and back pain while driving, resulting in an accident. Computed tomography revealed acute type A aortic dissection with malperfusion of the left lower extremity, retroperitoneal extravasation, hematoma in the ... ...

Abstract	A 53-year-old man suddenly developed chest and back pain while driving, resulting in an accident. Computed tomography revealed acute type A aortic dissection with malperfusion of the left lower extremity, retroperitoneal extravasation, hematoma in the anterior mediastinum, and ascites in the rectovesical pouch. Exploratory laparotomy before aortic repair revealed intestinal perforation and retroperitoneal bleeding, which were repaired, and an ascending aortic replacement was performed. Visceral trauma with active bleeding should be treated with priority, even if the need for systemic heparinization accompanies acute type A aortic dissection during surgery for aortic dissection.
Language	English
Publishing date	2023-09-15
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2394256-3
ISSN	1881-6428 ; 1881-641X
ISSN (online)	1881-6428
ISSN	1881-641X
DOI	10.3400/avd.cr.23-00017
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Article ; Online: Attenuation correction using deep learning for brain perfusion SPECT images.

Sakaguchi, Kenta / Kaida, Hayato / Yoshida, Shuhei / Ishii, Kazunari

Annals of nuclear medicine

2021 Volume 35, Issue 5, Page(s) 589–599

Abstract: Objective: Non-uniform attenuation correction using computed tomography (CT) improves the image quality and quantification of single-photon emission computed tomography (SPECT). However, it is not widely used because it requires a SPECT/CT scanner. This ...

Abstract	Objective: Non-uniform attenuation correction using computed tomography (CT) improves the image quality and quantification of single-photon emission computed tomography (SPECT). However, it is not widely used because it requires a SPECT/CT scanner. This study constructs a convolutional neural network (CNN) to generate attenuation-corrected SPECT images directly from non-attenuation-corrected SPECT images. Methods: We constructed an auto-encoder (AE) using a CNN to correct the attenuation in brain perfusion SPECT images. SPECT image datasets of 270 (44,528 slices including augmentation), 60 (5002 slices), and 30 (2558 slices) cases were used for training, validation, and testing, respectively. The acquired projection data were reconstructed in three patterns: uniform attenuation correction using Chang's method (Chang-AC), non-uniform attenuation correction using CT (CT-AC), and no attenuation correction (No-AC). The AE learned an end-to-end mapping between the No-AC and CT-AC images. The No-AC images in the test dataset were loaded into the trained AE, which generated images simulating the CT-AC images as output. The generated SPECT images were employed as attenuation-corrected images using the AE (AE-AC). The accuracy of the AE-AC images was evaluated in terms of the peak signal-to-noise ratio (PSNR) and the structural similarity metric (SSIM). The intensities of the AE-AC and CT-AC images were compared by voxel-by-voxel and region-by-region analysis. Results: The PSNRs of the AE-AC and Chang-AC images, compared using CT-AC images, were 62.2, and 57.9, and their SSIM values were 0.9995 and 0.9985, respectively. The AE-AC and CT-AC images were visually and statistically in good agreement. Conclusions: The proposed AE-AC method yields highly accurate attenuation-corrected brain perfusion SPECT images.
MeSH term(s)	Artifacts ; Brain/blood supply ; Brain/diagnostic imaging ; Deep Learning ; Humans ; Image Processing, Computer-Assisted ; Male ; Signal-To-Noise Ratio ; Tomography, Emission-Computed, Single-Photon
Language	English
Publishing date	2021-03-09
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1146984-5
ISSN	1864-6433 ; 0914-7187
ISSN (online)	1864-6433
ISSN	0914-7187
DOI	10.1007/s12149-021-01600-z
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Article ; Online: BMPR-2 gates activity-dependent stabilization of primary dendrites during mitral cell remodeling.

Aihara, Shuhei / Fujimoto, Satoshi / Sakaguchi, Richi / Imai, Takeshi

Cell reports

2021 Volume 35, Issue 12, Page(s) 109276

Abstract: Developing neurons initially form excessive neurites and then remodel them based on molecular cues and neuronal activity. Developing mitral cells in the olfactory bulb initially extend multiple primary dendrites. They then stabilize single primary ... ...

Abstract	Developing neurons initially form excessive neurites and then remodel them based on molecular cues and neuronal activity. Developing mitral cells in the olfactory bulb initially extend multiple primary dendrites. They then stabilize single primary dendrites while eliminating others. However, the mechanisms underlying selective dendrite remodeling remain elusive. Using CRISPR-Cas9-based knockout screening combined with in utero electroporation, we identify BMPR-2 as a key regulator for selective dendrite stabilization. Bmpr2 knockout and its rescue experiments show that BMPR-2 inhibits LIMK without ligands and thereby permits dendrite destabilization. In contrast, the overexpression of antagonists and agonists indicates that ligand-bound BMPR-2 stabilizes dendrites, most likely by releasing LIMK. Using genetic and FRET imaging experiments, we demonstrate that free LIMK is activated by NMDARs via Rac1, facilitating dendrite stabilization through F-actin formation. Thus, the selective stabilization of primary dendrites is ensured by concomitant inputs of BMP ligands and neuronal activity.
MeSH term(s)	Actin Cytoskeleton/metabolism ; Actin Depolymerizing Factors/metabolism ; Actins/metabolism ; Animals ; Bone Morphogenetic Protein Receptors, Type II/chemistry ; Bone Morphogenetic Protein Receptors, Type II/metabolism ; Bone Morphogenetic Proteins/metabolism ; Dendrites/metabolism ; Glutamic Acid/metabolism ; Ligands ; Lim Kinases/metabolism ; Mice, Inbred C57BL ; Olfactory Bulb/cytology ; Protein Domains ; Receptors, N-Methyl-D-Aspartate/metabolism ; Structure-Activity Relationship ; p21-Activated Kinases/metabolism ; rac1 GTP-Binding Protein/metabolism ; Mice
Chemical Substances	Actin Depolymerizing Factors ; Actins ; Bone Morphogenetic Proteins ; Ligands ; Receptors, N-Methyl-D-Aspartate ; Glutamic Acid (3KX376GY7L) ; Lim Kinases (EC 2.7.11.1) ; Limk1 protein, mouse (EC 2.7.11.1) ; p21-Activated Kinases (EC 2.7.11.1) ; Bone Morphogenetic Protein Receptors, Type II (EC 2.7.11.30) ; rac1 GTP-Binding Protein (EC 3.6.5.2)
Language	English
Publishing date	2021-06-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2021.109276
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Article ; Online: Photoactive carbon monoxide-releasing coordination polymer particles.

Carné-Sánchez, Arnau / Ikemura, Shuya / Sakaguchi, Reiko / Craig, Gavin A / Furukawa, Shuhei

Chemical communications (Cambridge, England)

2022 Volume 58, Issue 71, Page(s) 9894–9897

Abstract: We report the synthesis of photoactive carbon monoxide-releasing coordination polymer particles through the assembly of Mn(I) carbonyl complexes with bis(imidazole) ligands. The use of Mn(I) carbonyl complexes as metallic nodes in the coordination ... ...

Abstract	We report the synthesis of photoactive carbon monoxide-releasing coordination polymer particles through the assembly of Mn(I) carbonyl complexes with bis(imidazole) ligands. The use of Mn(I) carbonyl complexes as metallic nodes in the coordination network avoids the potential for aggregation-induced self-quenching, favouring their use in the solid state.
MeSH term(s)	Carbon Monoxide ; Coordination Complexes ; Ligands ; Polymers
Chemical Substances	Coordination Complexes ; Ligands ; Polymers ; Carbon Monoxide (7U1EE4V452)
Language	English
Publishing date	2022-09-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d2cc03907a
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Article: Successful Surgical Repair of Type A Acute Aortic Dissection in a Patient with Vascular Ehlers-Danlos Syndrome.

Mori, Kousuke / Ishii, Hirohito / Sakaguchi, Shuhei / Sakurahara, Daichi / Iwasaki, Ayaka / Furukawa, Koji

Annals of vascular diseases

2022 Volume 15, Issue 1, Page(s) 58–61

Abstract: Surgery for vascular complications of a patient with vascular Ehlers-Danlos syndrome (vEDS) is challenging due to the fragility of the associated tissues. In this study, we present a type A acute aortic dissection case in a patient with vEDS successfully ...

Abstract	Surgery for vascular complications of a patient with vascular Ehlers-Danlos syndrome (vEDS) is challenging due to the fragility of the associated tissues. In this study, we present a type A acute aortic dissection case in a patient with vEDS successfully treated via total arch replacement. A 42-year-old woman was transferred to our hospital 10 days after the onset of symptoms and underwent emergency surgery. Intraoperative findings revealed severe inflammatory changes without tissue fragility that is distinctive of vEDS. The postoperative course was uneventful except for left recurrent laryngeal nerve palsy, and 24 months after the operation, the patient has remained free from any arterial event.
Language	English
Publishing date	2022-04-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2394256-3
ISSN	1881-6428 ; 1881-641X
ISSN (online)	1881-6428
ISSN	1881-641X
DOI	10.3400/avd.cr.21-00122
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Article ; Online: Activity-dependent local protection and lateral inhibition control synaptic competition in developing mitral cells in mice.

Fujimoto, Satoshi / Leiwe, Marcus N / Aihara, Shuhei / Sakaguchi, Richi / Muroyama, Yuko / Kobayakawa, Reiko / Kobayakawa, Ko / Saito, Tetsuichiro / Imai, Takeshi

Developmental cell

2023 Volume 58, Issue 14, Page(s) 1221–1236.e7

Abstract: In developing brains, activity-dependent remodeling facilitates the formation of precise neuronal connectivity. Synaptic competition is known to facilitate synapse elimination; however, it has remained unknown how different synapses compete with one ... ...

Abstract	In developing brains, activity-dependent remodeling facilitates the formation of precise neuronal connectivity. Synaptic competition is known to facilitate synapse elimination; however, it has remained unknown how different synapses compete with one another within a post-synaptic cell. Here, we investigate how a mitral cell in the mouse olfactory bulb prunes all but one primary dendrite during the developmental remodeling process. We find that spontaneous activity generated within the olfactory bulb is essential. We show that strong glutamatergic inputs to one dendrite trigger branch-specific changes in RhoA activity to facilitate the pruning of the remaining dendrites: NMDAR-dependent local signals suppress RhoA to protect it from pruning; however, the subsequent neuronal depolarization induces neuron-wide activation of RhoA to prune non-protected dendrites. NMDAR-RhoA signals are also essential for the synaptic competition in the mouse barrel cortex. Our results demonstrate a general principle whereby activity-dependent lateral inhibition across synapses establishes a discrete receptive field of a neuron.
MeSH term(s)	Dendrites/physiology ; Olfactory Bulb/physiology ; Synapses/physiology ; Neurons ; Cell Differentiation
Language	English
Publishing date	2023-06-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2054967-2
ISSN	1878-1551 ; 1534-5807
ISSN (online)	1878-1551
ISSN	1534-5807
DOI	10.1016/j.devcel.2023.05.004
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Zs.A 5742: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Electrical muscle stimulation in young adults: effect of muscle volume on brain-derived neurotrophic factor levels.

Nishikawa, Yuichi / Sakaguchi, Hiroyuki / Kawade, Shuhei / Maeda, Noriaki / Tanaka, Shinobu / Hyngstrom, Allison

European journal of applied physiology

2022 Volume 123, Issue 2, Page(s) 361–366

Abstract: Purpose: Electrical muscle stimulation (EMS) is known to be effective at stimulating brain-derived neurotrophic factor (BDNF) levels, but the relationship between the volume of muscle stimulated and BDNF levels is not clear. The purpose of this study ... ...

Abstract	Purpose: Electrical muscle stimulation (EMS) is known to be effective at stimulating brain-derived neurotrophic factor (BDNF) levels, but the relationship between the volume of muscle stimulated and BDNF levels is not clear. The purpose of this study was to quantify BDNF as a function of muscle volume stimulated in young adults. Methods: Twelve young adults (male, n = 9, age = 27.3 ± 5.5 years) were enrolled in this study. Participants completed three testing conditions in randomized order: 23 min of maximum tolerated bilateral stimulation of (1) the quadriceps muscle or (2) the musculature of the entire lower limbs and (3) control testing and retesting after 23 min without an intervention. Blood samples were collected before, immediately after, 20 min after, and 40 min after the intervention when EMS was applied to the thighs or the entire lower limb conditions. Serum obtained from blood collection was used for BDNF analysis. Results: The delta value of BDNF for the test and retest in the control condition was - 42.1 ± 73.8 pg/mL, and there was no significant difference between the test and retest BDNF. Compared to stimulation of the quadriceps muscle, stimulation of the entire lower limbs produced significantly higher BDNF at 20 min post-treatment than those at pre-treatment or 40 min post-treatment, and BDNF was also significantly higher immediately post-treatment than those at pre-treatment. Only stimulation of the quadriceps muscle did not induce a significant change between pre- and post-treatment. Conclusion: Our findings suggest that the volume of muscle stimulation is important for increased BDNF.
MeSH term(s)	Humans ; Male ; Young Adult ; Adult ; Brain-Derived Neurotrophic Factor ; Quadriceps Muscle ; Lower Extremity
Chemical Substances	Brain-Derived Neurotrophic Factor
Language	English
Publishing date	2022-10-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124793-1
ISSN	1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
ISSN (online)	1439-6327 ; 1432-1025
ISSN	0301-5548 ; 1439-6319
DOI	10.1007/s00421-022-05078-z
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Article ; Online: Von Willebrand Factor Antigen Levels Predict Poor Outcomes in Patients With Stroke and Cancer: Findings From the Multicenter, Prospective, Observational SCAN Study.

Kawano, Tomohiro / Gon, Yasufumi / Sakaguchi, Manabu / Yamagami, Hiroshi / Abe, Soichiro / Hashimoto, Hiroyuki / Ohara, Nobuyuki / Takahashi, Daisuke / Abe, Yuko / Takahashi, Tsutomu / Okazaki, Shuhei / Todo, Kenichi / Mochizuki, Hideki / Sasaki, Tsutomu

Journal of the American Heart Association

2024 Volume 13, Issue 3, Page(s) e032284

Abstract: Background: Patients with acute ischemic stroke and active cancer have more severe neurological symptoms, elevated risks of stroke recurrence, and death compared with the general population. We examined whether von Willebrand factor (vWF) antigen levels ...

Abstract	Background: Patients with acute ischemic stroke and active cancer have more severe neurological symptoms, elevated risks of stroke recurrence, and death compared with the general population. We examined whether von Willebrand factor (vWF) antigen levels at stroke onset were associated with the poor outcomes of patients with stroke and cancer. Methods and results: Using data from 90 patients with acute ischemic stroke and active cancer who were registered in the SCAN (Ischemic Stroke in Patients With Cancer and Neoplasia) study, a prospective multicenter, observational study in Japan, we divided patients into 2 groups according to their median vWF antigen levels (high, n=46; or low, n=44). The high-vWF group had a significantly higher initial National Institutes of Health Stroke Scale score (median, 7 [interquartile range, 3-11.25] versus 3 [interquartile range, 1-8.5]; Conclusions: Elevated vWF antigen levels were associated with adverse outcomes in patients with cancer-associated stroke and may represent a useful biomarker to guide future therapeutic interventions.
MeSH term(s)	Humans ; Ischemic Stroke/complications ; Neoplasms/complications ; Neoplasms/epidemiology ; Prospective Studies ; Risk Factors ; Stroke/diagnosis ; von Willebrand Factor ; Multicenter Studies as Topic ; Observational Studies as Topic
Chemical Substances	von Willebrand Factor
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.123.032284
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Article: Photoactive carbon monoxide-releasing coordination polymer particles

Carné-Sánchez, Arnau / Ikemura, Shuya / Sakaguchi, Reiko / Craig, Gavin A. / Furukawa, Shuhei

Chemical communications. 2022 Sept. 1, v. 58, no. 71

2022

Abstract: We report the synthesis of photoactive carbon monoxide-releasing coordination polymer particles through the assembly of Mn(i) carbonyl complexes with bis(imidazole) ligands. The use of Mn(i) carbonyl complexes as metallic nodes in the coordination ... ...

Abstract	We report the synthesis of photoactive carbon monoxide-releasing coordination polymer particles through the assembly of Mn(i) carbonyl complexes with bis(imidazole) ligands. The use of Mn(i) carbonyl complexes as metallic nodes in the coordination network avoids the potential for aggregation-induced self-quenching, favouring their use in the solid state.
Keywords	carbon ; coordination polymers ; imidazole ; ligands
Language	English
Dates of publication	2022-0901
Size	p. 9894-9897.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d2cc03907a
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