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  1. Book ; Online ; E-Book: Handbook of intervention and Alzheimer's disease

    Raji, Cyrus A. / Leng, Yue / Ashford, John Wesson / Khalsa, Dharma Singh

    (Advances in Alzheimer's disease series ; 11)

    2024  

    Author's details edited by Cyrus A. Raji, Yue Leng, J. Wesson Ashford and Dharma Singh Khalsa
    Series title Advances in Alzheimer's disease series ; 11
    Collection
    Language English
    Size 1 Online-Ressource (xiii, 752 Seiten), Illustrationen, Diagramme
    Publisher IOS Press
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030694943
    ISBN 978-1-64368-501-4 ; 9781643685007 ; 1-64368-501-5 ; 1643685007
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Handbook of prevention and Alzheimer's disease

    Raji, Cyrus A. / Leng, Yue / Ashford, John Wesson / Khalsa, Dharma Singh

    (Advances in Alzheimer's disease series ; 10)

    2024  

    Author's details edited by Cyrus A. Raji, Yue Leng, J. Wesson Ashford and Dharma Singh Khalsa
    Series title Advances in Alzheimer's disease series ; 10
    Collection
    Language English
    Size 1 Online-Ressource (xiii, 658 Seiten), Illustrationen, Diagramme
    Publisher IOS Press
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT030694964
    ISBN 978-1-64368-493-2 ; 9781643684925 ; 1-64368-493-0 ; 1643684922
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Routine Hearing Assessments in Midlife to Detect Future Dementia.

    Raji, Cyrus A

    JAMA otolaryngology-- head & neck surgery

    2023  Volume 149, Issue 7, Page(s) 578–579

    MeSH term(s) Humans ; Dementia/diagnosis ; Risk Factors ; Hearing
    Language English
    Publishing date 2023-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2023.0829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Benefits of a 12-Week Non-Drug "Brain Fitness Program" for Patients with Attention-Deficit/Hyperactive Disorder, Post-Concussion Syndrome, or Memory Loss.

    Fotuhi, Majid / Khorrami, Noah D / Raji, Cyrus A

    Journal of Alzheimer's disease reports

    2023  Volume 7, Issue 1, Page(s) 675–697

    Abstract: Background: Non-pharmacologic interventions can potentially improve cognitive function, sleep, and/or mood in patients with attention-deficit/hyperactive disorder (ADHD), post-concussion syndrome (PCS), or memory loss.: Objective: We evaluated the ... ...

    Abstract Background: Non-pharmacologic interventions can potentially improve cognitive function, sleep, and/or mood in patients with attention-deficit/hyperactive disorder (ADHD), post-concussion syndrome (PCS), or memory loss.
    Objective: We evaluated the benefits of a brain rehabilitation program in an outpatient neurology practice that consists of targeted cognitive training, lifestyle coaching, and electroencephalography (EEG)-based neurofeedback, twice weekly (90 minutes each), for 12 weeks.
    Methods: 223 child and adult patients were included: 71 patients with ADHD, 88 with PCS, and 64 with memory loss (mild cognitive impairment or subjective cognitive decline). Patients underwent a complete neurocognitive evaluation, including tests for Verbal Memory, Complex Attention, Processing Speed, Executive Functioning, and Neurocognition Index. They completed questionnaires about sleep, mood, diet, exercise, anxiety levels, and depression-as well as underwent quantitative EEG-at the beginning and the end of the program.
    Results: Pre-post test score comparison demonstrated that all patient subgroups experienced statistically significant improvements on most measures, especially the PCS subgroup, which experienced significant score improvement on all measures tested (
    Conclusion: This study demonstrates that a multimodal brain rehabilitation program can have benefits for patients with ADHD, PCS, or memory loss and supports further clinical trials in this field.
    Language English
    Publishing date 2023-06-29
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2542-4823
    ISSN (online) 2542-4823
    DOI 10.3233/ADR-220091
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Conceptualizing cognitive health to optimize dementia prevention and care.

    Raji, Cyrus A

    Journal of the neurological sciences

    2017  Volume 372, Page(s) 126–127

    MeSH term(s) Cognition ; Cognition Disorders ; Cognitive Dysfunction ; Dementia/prevention & control ; Humans
    Language English
    Publishing date 2017-01-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80160-4
    ISSN 1878-5883 ; 0022-510X ; 0374-8642
    ISSN (online) 1878-5883
    ISSN 0022-510X ; 0374-8642
    DOI 10.1016/j.jns.2016.11.039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 308: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Brain PET Imaging: Frontotemporal Dementia.

    Ward, Joshua / Ly, Maria / Raji, Cyrus A

    PET clinics

    2022  Volume 18, Issue 1, Page(s) 123–133

    Abstract: Brain PET adds value in diagnosing neurodegenerative disorders, especially frontotemporal dementia (FTD) due to its syndromic presentation that overlaps with a variety of other neurodegenerative and psychiatric disorders. 18F-FDG-PET has improved ... ...

    Abstract Brain PET adds value in diagnosing neurodegenerative disorders, especially frontotemporal dementia (FTD) due to its syndromic presentation that overlaps with a variety of other neurodegenerative and psychiatric disorders. 18F-FDG-PET has improved sensitivity and specificity compared with structural MR imaging, with optimal diagnostic results achieved when both techniques are utilized. PET demonstrates superior sensitivity compared with SPECT for FTD diagnosis that is primarily a supplement to other imaging and clinical evaluations. Tau-PET and amyloid-PET primary use in FTD diagnosis is differentiation from Alzheimer disease, although these methods are limited mainly to research settings.
    MeSH term(s) Humans ; Frontotemporal Dementia/diagnostic imaging ; Brain/diagnostic imaging ; Alzheimer Disease/diagnostic imaging ; Tomography, Emission-Computed, Single-Photon ; Positron-Emission Tomography
    Language English
    Publishing date 2022-11-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2764575-7
    ISSN 1879-9809 ; 1556-8598
    ISSN (online) 1879-9809
    ISSN 1556-8598
    DOI 10.1016/j.cpet.2022.09.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Einzelsignatur: Show issues

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  7. Article ; Online: Paving the Way for Alzheimer's Disease Prevention: A Systematic Review of Global Open-Access Neuroimaging Datasets in Healthy Individuals.

    Ly, Maria / Yu, Gary Z / Chwa, Won Jong / Raji, Cyrus A

    Journal of Alzheimer's disease : JAD

    2023  Volume 96, Issue 4, Page(s) 1441–1451

    Abstract: Background: Given the advent of large-scale neuroimaging data-driven endeavors for Alzheimer's disease, there is a burgeoning need for well-characterized neuroimaging databases of healthy individuals. With the rise of initiatives around the globe for ... ...

    Abstract Background: Given the advent of large-scale neuroimaging data-driven endeavors for Alzheimer's disease, there is a burgeoning need for well-characterized neuroimaging databases of healthy individuals. With the rise of initiatives around the globe for the rapid and unrestricted sharing of data resources, there is now an abundance of open-source neuroimaging datasets available to the research community. However, there is not yet a systematic review that fully details the demographic information and modalities actually available in all open access neuroimaging databases around the globe.
    Objective: This systematic review aims to provide compile a list of MR structural imaging databases encompassing healthy individuals across the lifespan.
    Methods: In this systematic review, we searched EMBASE and PubMed until May 2022 for open-access neuroimaging databases containing healthy control participants of any age, race, with normal development and cognition having at least one structural T1-weighted neuroimaging scan.
    Results: A total of 403 databases were included, for up to total of 48,268 participants with all available demographic information and imaging modalities detailed in Supplementary Table 1. There were significant trends noted when compiling normative databases for this systematic review, notably that 11.7% of databases included reported ethnicity in their participants, with underrepresentation of many socioeconomic groups globally.
    Conclusions: As efforts to improve primary prevention of AD may require a broader perspective including increased relevance of earlier stages in life, and strategies in addressing modifiable risk factors may be individualized to specific demographics, improving data characterization to be richer and more rigorous will greatly enhance these efforts.
    MeSH term(s) Humans ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/prevention & control ; Neuroimaging/methods ; Magnetic Resonance Imaging ; Cognition ; Risk Factors ; Brain/diagnostic imaging
    Language English
    Publishing date 2023-11-12
    Publishing country Netherlands
    Document type Systematic Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-230738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6084: Show issues Location:
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  8. Article ; Online: Quantified Brain Magnetic Resonance Imaging Volumes Differentiate Behavioral Variant Frontotemporal Dementia from Early-Onset Alzheimer's Disease.

    Meysami, Somayeh / Raji, Cyrus A / Mendez, Mario F

    Journal of Alzheimer's disease : JAD

    2022  Volume 87, Issue 1, Page(s) 453–461

    Abstract: Background: The differentiation of behavioral variant frontotemporal dementia (bvFTD) from early-onset Alzheimer's disease (EOAD) by clinical criteria can be inaccurate. The volumetric quantification of clinically available magnetic resonance (MR) brain ...

    Abstract Background: The differentiation of behavioral variant frontotemporal dementia (bvFTD) from early-onset Alzheimer's disease (EOAD) by clinical criteria can be inaccurate. The volumetric quantification of clinically available magnetic resonance (MR) brain scans may facilitate early diagnosis of these neurodegenerative dementias.
    Objective: To determine if volumetric quantification of brain MR imaging can identify persons with bvFTD from EOAD.
    Methods: 3D T1 MR brain scans of 20 persons with bvFTD and 45 with EOAD were compared using Neuroreader to measure subcortical, and lobar volumes, and Volbrain for hippocampal subfields. Analyses included: 1) discriminant analysis with leave one out cross-validation; 2) input of predicted probabilities from this process into a receiver operator characteristic (ROC) analysis; and 3) Automated linear regression to identify predictive regions.
    Results: Both groups were comparable in age and sex with no statistically significant differences in symptom duration. bvFTD had lower volume percentiles in frontal lobes, thalamus, and putamen. EOAD had lower parietal lobe volumes. ROC analyses showed 99.3% accuracy with Neuroreader percentiles and 80.2% with subfields. The parietal lobe was the most predictive percentile. Although there were differences in hippocampal (particularly left CA2-CA3) subfields, it did not add to the discriminant analysis.
    Conclusion: Percentiles from an MR based volumetric quantification can help differentiate between bvFTD from EOAD in routine clinical care. Use of hippocampal subfield volumes does not enhance the diagnostic separation of these two early-onset dementias.
    MeSH term(s) Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/pathology ; Brain/diagnostic imaging ; Brain/pathology ; Frontotemporal Dementia/diagnostic imaging ; Frontotemporal Dementia/pathology ; Humans ; Magnetic Resonance Imaging/methods ; Neuroimaging
    Language English
    Publishing date 2022-03-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-215667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6084: Show issues Location:
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  9. Article ; Online: The Value of Neuroimaging in Dementia Diagnosis.

    Raji, Cyrus A / Benzinger, Tammie L S

    Continuum (Minneapolis, Minn.)

    2022  Volume 28, Issue 3, Page(s) 800–821

    Abstract: Purpose of review: This article discusses neuroimaging in dementia diagnosis, with a focus on new applications of MRI and positron emission tomography (PET).: Recent findings: Although the historical use of MRI in dementia diagnosis has been ... ...

    Abstract Purpose of review: This article discusses neuroimaging in dementia diagnosis, with a focus on new applications of MRI and positron emission tomography (PET).
    Recent findings: Although the historical use of MRI in dementia diagnosis has been supportive to exclude structural etiologies, recent innovations allow for quantification of atrophy patterns that improve sensitivity for supporting the diagnosis of dementia causes. Neuronuclear approaches allow for localization of specific amyloid and tau neuropathology on PET and are available for clinical use, in addition to dopamine transporter scans in dementia with Lewy bodies and metabolic studies with fludeoxyglucose PET (FDG-PET).
    Summary: Using computerized software programs for MRI analysis and cross-sectional and longitudinal evaluations of hippocampal, ventricular, and lobar volumes improves sensitivity in support of the diagnosis of Alzheimer disease and frontotemporal dementia. MRI protocol requirements for such quantification are three-dimensional T1-weighted volumetric imaging protocols, which may need to be specifically requested. Fluid-attenuated inversion recovery (FLAIR) and 3.0T susceptibility-weighted imaging (SWI) sequences are useful for the detection of white matter hyperintensities as well as microhemorrhages in vascular dementia and cerebral amyloid angiopathy. PET studies for amyloid and/or tau pathology can add additional specificity to the diagnosis but currently remain largely inaccessible outside of research settings because of prohibitive cost constraints in most of the world. Dopamine transporter PET scans can help identify Lewy body dementia and are thus of potential clinical value.
    MeSH term(s) Alzheimer Disease/diagnostic imaging ; Cross-Sectional Studies ; Dopamine Plasma Membrane Transport Proteins ; Humans ; Lewy Body Disease/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Neuroimaging ; Positron-Emission Tomography
    Chemical Substances Dopamine Plasma Membrane Transport Proteins
    Language English
    Publishing date 2022-06-08
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1538-6899
    ISSN (online) 1538-6899
    DOI 10.1212/CON.0000000000001133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Beyond the

    Raji, Cyrus A / Benzinger, Tammie L S

    AJR. American journal of roentgenology

    2020  Volume 216, Issue 5, Page(s) 1170

    MeSH term(s) Brain/diagnostic imaging ; Humans ; Longevity ; Magnetic Resonance Imaging
    Language English
    Publishing date 2020-10-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 82076-3
    ISSN 1546-3141 ; 0361-803X ; 0092-5381
    ISSN (online) 1546-3141
    ISSN 0361-803X ; 0092-5381
    DOI 10.2214/AJR.20.24985
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