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  1. Article ; Online: Targeted immunomodulation: a primer for intensivists.

    Janssen, Malou / Endeman, Henrik / Bos, Lieuwe D J

    Intensive care medicine

    2023  Volume 49, Issue 4, Page(s) 462–464

    MeSH term(s) Humans ; Critical Care ; Intensive Care Units
    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07009-8
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    Zs.A 1089: Show issues Location:
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  2. Article ; Online: Beta-lactam Therapeutic Drug Monitoring in Critically ill Patients: Learnings for Future Research.

    Rietdijk, Wim J R / Dräger, Sarah / Endeman, Henrik / Koch, Birgit C P

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue 4, Page(s) 663–664

    MeSH term(s) Humans ; beta-Lactams/therapeutic use ; Critical Illness/therapy ; Drug Monitoring ; Anti-Bacterial Agents/therapeutic use ; Infusions, Intravenous
    Chemical Substances beta-Lactams ; Anti-Bacterial Agents
    Language English
    Publishing date 2023-10-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad215
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    Zs.MO 480: Show issues

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  3. Article ; Online: Which trial do we need? One or two antimicrobials with anti-pseudomonal activity for the empirical treatment of Ventilator-associated pneumonia due to Gram-negative bacteria.

    Yusuf, Erlangga / Zavascki, Alexandre P / Endeman, Henrik / Kalil, Andre C

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  

    Language English
    Publishing date 2023-08-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.08.004
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    Zs.A 4541: Show issues Location:
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    Zs.MO 284: Show issues

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  4. Article ; Online: Reply to: Higher PEEP in intubated COVID-19-associated ARDS patients? We are not sure.

    Somhorst, Peter / van der Zee, Philip / Endeman, Henrik / Gommers, Diederik

    Critical care (London, England)

    2022  Volume 26, Issue 1, Page(s) 388

    MeSH term(s) Humans ; COVID-19 ; Respiration, Artificial ; Positive-Pressure Respiration ; Respiratory Distress Syndrome/therapy
    Language English
    Publishing date 2022-12-14
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-022-04262-z
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  5. Article ; Online: Individualised dosing of antibiotics in ICU patients: timing, target and model selection matter. Author's reply.

    Ewoldt, Tim M J / Abdulla, Alan / Muller, Anouk E / Endeman, Henrik / Koch, Birgit C P

    Intensive care medicine

    2023  Volume 49, Issue 4, Page(s) 477–478

    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Intensive Care Units
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-02-17
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07002-1
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    Zs.A 1089: Show issues Location:
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  6. Article: Diaphragm excursions as proxy for tidal volume during spontaneous breathing in invasively ventilated ICU patients.

    Janssen, Matthijs L / Jonkman, Annemijn H / Wennen, Myrte / Wils, Evert-Jan / Endeman, Henrik / Heunks, Leo

    Intensive care medicine experimental

    2023  Volume 11, Issue 1, Page(s) 73

    Abstract: There is a need to monitor tidal volume in critically ill patients with acute respiratory failure, given its relation with adverse clinical outcome. However, quantification of tidal volume in non-intubated patients is challenging. In this proof-of- ... ...

    Abstract There is a need to monitor tidal volume in critically ill patients with acute respiratory failure, given its relation with adverse clinical outcome. However, quantification of tidal volume in non-intubated patients is challenging. In this proof-of-concept study, we evaluated whether ultrasound measurements of diaphragm excursion could be a valid surrogate for tidal volume in patients with respiratory failure. Diaphragm excursions and tidal volumes were simultaneously measured in invasively ventilated patients (N = 21) and healthy volunteers (N = 20). Linear mixed models were used to estimate the ratio between tidal volume and diaphragm excursion. The tidal volume-diaphragm excursion ratio was 201 mL/cm in ICU patients [95% confidence interval (CI) 161-240 mL/cm], and 361 (294-428) mL/cm in healthy volunteers. An excellent association was shown within participants (R
    Language English
    Publishing date 2023-10-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2740385-3
    ISSN 2197-425X
    ISSN 2197-425X
    DOI 10.1186/s40635-023-00553-z
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  7. Article ; Online: Electrical Impedance Tomography as a monitoring tool during weaning from mechanical ventilation: an observational study during the spontaneous breathing trial.

    Wisse, Jantine J / Goos, Tom G / Jonkman, Annemijn H / Somhorst, Peter / Reiss, Irwin K M / Endeman, Henrik / Gommers, Diederik

    Respiratory research

    2024  Volume 25, Issue 1, Page(s) 179

    Abstract: Background: Prolonged weaning from mechanical ventilation is associated with poor clinical outcome. Therefore, choosing the right moment for weaning and extubation is essential. Electrical Impedance Tomography (EIT) is a promising innovative lung ... ...

    Abstract Background: Prolonged weaning from mechanical ventilation is associated with poor clinical outcome. Therefore, choosing the right moment for weaning and extubation is essential. Electrical Impedance Tomography (EIT) is a promising innovative lung monitoring technique, but its role in supporting weaning decisions is yet uncertain. We aimed to evaluate physiological trends during a T-piece spontaneous breathing trail (SBT) as measured with EIT and the relation between EIT parameters and SBT success or failure.
    Methods: This is an observational study in which twenty-four adult patients receiving mechanical ventilation performed an SBT. EIT monitoring was performed around the SBT. Multiple EIT parameters including the end-expiratory lung impedance (EELI), delta Tidal Impedance (ΔZ), Global Inhomogeneity index (GI), Rapid Shallow Breathing Index (RSBI
    Results: EELI values dropped after the start of the SBT (p < 0.001) and did not recover to baseline after restarting mechanical ventilation. The ΔZ dropped (p < 0.001) but restored to baseline within seconds after restarting mechanical ventilation. Five patients failed the SBT, the GI (p = 0.01) and transcutaneous CO
    Conclusion: EIT has the potential to assess changes in ventilation distribution and quantify the inhomogeneity of the lungs during the SBT. High lung inhomogeneity was found during SBT failure. Insight into physiological trends for the individual patient can be obtained with EIT during weaning from mechanical ventilation, but its role in predicting weaning failure requires further study.
    MeSH term(s) Humans ; Ventilator Weaning/methods ; Electric Impedance ; Male ; Female ; Middle Aged ; Aged ; Tomography/methods ; Monitoring, Physiologic/methods ; Adult ; Respiration, Artificial/methods ; Respiration ; Aged, 80 and over ; Lung/physiopathology ; Lung/diagnostic imaging ; Lung/physiology
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Observational Study ; Journal Article
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-024-02801-6
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  8. Article ; Online: PEEP-FiO

    Somhorst, Peter / van der Zee, Philip / Endeman, Henrik / Gommers, Diederik

    Critical care (London, England)

    2022  Volume 26, Issue 1, Page(s) 272

    Abstract: Rationale: It is unknown how to titrate positive end-expiratory pressure (PEEP) in patients with COVID-19-related acute respiratory distress syndrome (ARDS). Guidelines recommend the one-size-fits-all PEEP-FiO: Objectives: To compare baseline PEEP ... ...

    Abstract Rationale: It is unknown how to titrate positive end-expiratory pressure (PEEP) in patients with COVID-19-related acute respiratory distress syndrome (ARDS). Guidelines recommend the one-size-fits-all PEEP-FiO
    Objectives: To compare baseline PEEP according to the high PEEP-FiO
    Methods: We performed an EIT-guided decremental PEEP trial in patients with moderate-to-severe COVID-19-related ARDS upon intensive care unit admission. PEEP was set at the lowest PEEP above the intersection of curves representing relative alveolar overdistention and collapse. Baseline PEEP was compared with PEEP set according to EIT. We identified patients in whom the EIT-guided PEEP trial resulted in a decrease or increase in PEEP of ≥ 2 cmH
    Measurements and main results: We performed a PEEP trial in 75 patients. In 23 (31%) patients, PEEP was decreased ≥ 2 cmH
    Conclusions: An EIT-guided PEEP trial resulted in a relevant change in PEEP in 63% of patients. These results support the hypothesis that PEEP should be personalized in patients with ARDS.
    MeSH term(s) COVID-19/complications ; COVID-19/therapy ; Electric Impedance ; Humans ; Respiration, Artificial ; Respiratory Distress Syndrome/therapy ; Retrospective Studies
    Language English
    Publishing date 2022-09-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-022-04135-5
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    Zs.A 5517: Show issues Location:
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  9. Article ; Online: Prognostic models for outcome prediction following in-hospital cardiac arrest using pre-arrest factors: a systematic review, meta-analysis and critical appraisal.

    Grandbois van Ravenhorst, Casey / Schluep, Marc / Endeman, Henrik / Stolker, Robert-Jan / Hoeks, Sanne Elisabeth

    Critical care (London, England)

    2023  Volume 27, Issue 1, Page(s) 32

    Abstract: Background: Several prediction models of survival after in-hospital cardiac arrest (IHCA) have been published, but no overview of model performance and external validation exists. We performed a systematic review of the available prognostic models for ... ...

    Abstract Background: Several prediction models of survival after in-hospital cardiac arrest (IHCA) have been published, but no overview of model performance and external validation exists. We performed a systematic review of the available prognostic models for outcome prediction of attempted resuscitation for IHCA using pre-arrest factors to enhance clinical decision-making through improved outcome prediction.
    Methods: This systematic review followed the CHARMS and PRISMA guidelines. Medline, Embase, Web of Science were searched up to October 2021. Studies developing, updating or validating a prediction model with pre-arrest factors for any potential clinical outcome of attempted resuscitation for IHCA were included. Studies were appraised critically according to the PROBAST checklist. A random-effects meta-analysis was performed to pool AUROC values of externally validated models.
    Results: Out of 2678 initial articles screened, 33 studies were included in this systematic review: 16 model development studies, 5 model updating studies and 12 model validation studies. The most frequently included pre-arrest factors included age, functional status, (metastatic) malignancy, heart disease, cerebrovascular events, respiratory, renal or hepatic insufficiency, hypotension and sepsis. Only six of the developed models have been independently validated in external populations. The GO-FAR score showed the best performance with a pooled AUROC of 0.78 (95% CI 0.69-0.85), versus 0.59 (95%CI 0.50-0.68) for the PAM and 0.62 (95% CI 0.49-0.74) for the PAR.
    Conclusions: Several prognostic models for clinical outcome after attempted resuscitation for IHCA have been published. Most have a moderate risk of bias and have not been validated externally. The GO-FAR score showed the most acceptable performance. Future research should focus on updating existing models for use in clinical settings, specifically pre-arrest counselling. Systematic review registration PROSPERO CRD42021269235. Registered 21 July 2021.
    MeSH term(s) Humans ; Prognosis ; Heart Arrest/therapy ; Cardiopulmonary Resuscitation ; Forecasting ; Hospitals
    Language English
    Publishing date 2023-01-20
    Publishing country England
    Document type Systematic Review ; Meta-Analysis ; Journal Article
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-023-04306-y
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  10. Article ; Online: Advanced respiratory monitoring in mechanically ventilated patients with coronavirus disease 2019-associated acute respiratory distress syndrome.

    Somhorst, Peter / Gommers, Diederik / Endeman, Henrik

    Current opinion in critical care

    2021  Volume 28, Issue 1, Page(s) 66–73

    Abstract: Purpose of review: To summarize the current knowledge about the application of advanced monitoring techniques in coronavirus disease 2019 (COVID-19).: Recent findings: Due to the heterogeneity between patients, management of COVID-19 requires daily ... ...

    Abstract Purpose of review: To summarize the current knowledge about the application of advanced monitoring techniques in coronavirus disease 2019 (COVID-19).
    Recent findings: Due to the heterogeneity between patients, management of COVID-19 requires daily monitoring of and/or aeration and inspiratory effort. Electrical impedance tomography can be used to optimize positive end-expiratory pressure, monitor the response to changes in treatment or body position and assess pulmonary perfusion and ventilation/perfusion matching. Lung ultrasound is more readily available and can be used to measure and monitor recruitment, provide an indication of diaphragm function and pulmonary perfusion disturbances. Esophageal pressure measurements enable the calculation of the transpulmonary pressure and inspiratory effort in order to prevent excessive stress on the lung. While esophageal pressure measurements are the golden standard in determining inspiratory effort, alternatives like P0.1, negative pressure swing during a single airway occlusion and change in central venous pressure are more readily available and capable of diagnosing extreme inspiratory efforts.
    Summary: Although there is little data on the effectiveness of advanced monitoring techniques in COVID-19, regular monitoring should be a central part of the management of COVID-19-related acute respiratory distress syndrome (C-ARDS).
    MeSH term(s) COVID-19 ; Humans ; Positive-Pressure Respiration ; Respiration, Artificial/adverse effects ; Respiratory Distress Syndrome/therapy ; SARS-CoV-2
    Language English
    Publishing date 2021-10-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000000905
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