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  1. Article: Fabrication of mesoporous silica nanoparticles for targeted delivery of sunitinib to ovarian cancer cells.

    Torabi, Mitra / Aghanejad, Ayuob / Savadi, Pouria / Barzegari, Abolfazl / Omidi, Yadollah / Barar, Jaleh

    BioImpacts : BI

    2023  Volume 13, Issue 3, Page(s) 255–267

    Language English
    Publishing date 2023-01-23
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2604624-6
    ISSN 2228-5660 ; 2228-5652
    ISSN (online) 2228-5660
    ISSN 2228-5652
    DOI 10.34172/bi.2023.25298
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fabrication of mesoporous silica nanoparticles for targeted delivery of sunitinib to ovarian cancer cells

    Mitra Torabi / Ayuob Aghanejad / Pouria Savadi / Abolfazl Barzegari / Yadollah Omidi / Jaleh Barar

    BioImpacts, Vol 13, Iss 3, Pp 255-

    2023  Volume 267

    Abstract: Introduction: Mesoporous silica nanoparticles (MSNPs) are considered innovative multifunctional structures for targeted drug delivery owing to their outstanding physicochemical characteristics. Methods: MSNPs were fabricated using the sol-gel method, and ...

    Abstract Introduction: Mesoporous silica nanoparticles (MSNPs) are considered innovative multifunctional structures for targeted drug delivery owing to their outstanding physicochemical characteristics. Methods: MSNPs were fabricated using the sol-gel method, and polyethylene glycol-600 (PEG600) was used for MSNPs modification. Subsequently, sunitinib (SUN) was loaded into the MSNPs, MSNP-PEG and MSNP-PEG/SUN were grafted with mucin 16 (MUC16) aptamers. The nanosystems (NSs) were characterized using FT-IR, TEM, SEM, DLS, XRD, BJH, and BET. Furthermore, the biological impacts of MSNPs were evaluated on the ovarian cancer cells by MTT assay and flow cytometry analysis. Results: The results revealed that the MSNPs have a spherical shape with an average dimension, pore size, and surface area of 56.10 nm, 2.488 nm, and 148.08 m2g-1, respectively. The cell viability results showed higher toxicity of targeted MSNPs in MUC16 overexpressing OVCAR-3 cells as compared to the SK-OV-3 cells; that was further confirmed by the cellular uptake results. The cell cycle analysis exhibited that the induction of sub-G1 phase arrest mostly occurred in MSNP-PEG/SUN-MUC16 treated OVCAR-3 cells and MSNP-PEG/SUN treated SK-OV-3 cells. DAPI staining showed apoptosis induction upon exposure to targeted MSNP in MUC16 positive OVCAR-3 cells. Conclusion: According to our results, the engineered NSs could be considered an effective multifunctional targeted drug delivery platform for the mucin 16 overexpressing cells.
    Keywords ovarian cancer ; mucin 16 aptamer ; mesoporous silica nanoparticles ; targeted drug delivery ; sunitinib ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Subject code 500
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Tabriz University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Cardiac Calcified Amorphous Tumor in the Neonatal Period.

    Hematian, Mohammad Nasir / Hessami, Kamran / Saleh, Maasoumeh / Shirdel Abdolmaleki, Abolfazl / Torabi, Shirin / Hantoushzadeh, Sedigheh

    Case reports in pediatrics

    2022  Volume 2022, Page(s) 9087597

    Abstract: Calcified amorphous tumor (CAT) of the heart is a rare nonneoplastic cardiac mass that may exhibit symptoms resembling malignancy. In this report, we presented a 4-month-old male baby with repeated attacks of cyanosis and a cardiac murmur. ... ...

    Abstract Calcified amorphous tumor (CAT) of the heart is a rare nonneoplastic cardiac mass that may exhibit symptoms resembling malignancy. In this report, we presented a 4-month-old male baby with repeated attacks of cyanosis and a cardiac murmur. Echocardiography revealed a tumoral noncircumscribed mass in the right atrium adhering to the interatrial septum which extends to the inferior vena cava. Cardiac exploration was carried out to excise the tumor. A histopathological study demonstrated the presence of thrombus-like tissue with extensive calcification and foreign body type giant cell reactions. After operation, the patient had an uneventful hospitalization. Although CAT is mainly diagnosed in adult patients, it should be considered in the causes of cardiac mass in the neonatal period.
    Language English
    Publishing date 2022-01-10
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2659094-3
    ISSN 2090-6811 ; 2090-6803
    ISSN (online) 2090-6811
    ISSN 2090-6803
    DOI 10.1155/2022/9087597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Dopamine D1 Receptor-Mediated Regulation of Per1, Per2, CLOCK, and BMAL1 Expression in the Suprachiasmatic Nucleus in Adult Male Rats.

    Mesgar, Somaye / Jameie, Seyed Behnamedin / Aliaghaei, Abbas / Parvardeh, Siavash / Torabi, Abolfazl / Haghparast, Abbas

    Journal of molecular neuroscience : MN

    2021  Volume 72, Issue 3, Page(s) 618–625

    Abstract: Photic and non-photic inputs are reported to affect clock gene expressions and behavioral activities in the SCN. However, it is not known whether dopaminergic input mediates these regulatory effects on clock genes. The present study examined the ... ...

    Abstract Photic and non-photic inputs are reported to affect clock gene expressions and behavioral activities in the SCN. However, it is not known whether dopaminergic input mediates these regulatory effects on clock genes. The present study examined the molecular effects of dopamine D1 agonist on Per1, Per2, CLOCK, and Bmal1 expressions in the SCN and its effect on behavioral activities to determine the role of dopamine D1 receptor in regulation of these gene expressions and behavioral activities in adult male Wistar rats. To examine the molecular effects of dopamine D1 agonist day and night, we injected 20 mg/kg SKF38393 to the first group of rats at 6 a.m. and the second group at 6 p.m. We also injected saline to the third and fourth groups of rats at 6 a.m. and 6 p.m. as control groups. All rats were sacrificed 2 h following the injections. The real-time PCR technique was used to evaluate the clock gene expression. In addition, to examine the effects of dopamine D1 agonists on behavioral activities, we injected 20 mg/kg SKF38393 to SKF receiving group and saline to control group. The behavioral activities of the rats were monitored on the running wheel for 21 days, 1 week following the injections. SKF injections increased the Per2 and CLOCK expressions in the daytime and significantly decreased the Per1 and Bmal1 expressions. However, at night, SKF injections increased only Per2 expressions significantly and decreased the Per1, CLOCK, and Bmal1 genes expressions. Both saline receiving groups showed that all gene expressions were significantly higher except Per2 during nighttime. SKF injection increased the running wheel activity during nighttime significantly. Based on the obtained result, clock gene expression and behavioral activities in adult male Wistar rats may be altered or monitored by administration of exogenous dopamine.
    MeSH term(s) ARNTL Transcription Factors/genetics ; ARNTL Transcription Factors/metabolism ; Animals ; Circadian Rhythm/genetics ; Gene Expression Regulation ; Male ; Period Circadian Proteins/genetics ; Period Circadian Proteins/metabolism ; Rats ; Rats, Wistar ; Receptors, Dopamine D1/genetics ; Receptors, Dopamine D1/metabolism ; Suprachiasmatic Nucleus/metabolism
    Chemical Substances ARNTL Transcription Factors ; Drd1 protein, rat ; Per1 protein, rat ; Per2 protein, rat ; Period Circadian Proteins ; Receptors, Dopamine D1
    Language English
    Publishing date 2021-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1043392-2
    ISSN 1559-1166 ; 0895-8696
    ISSN (online) 1559-1166
    ISSN 0895-8696
    DOI 10.1007/s12031-021-01923-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Determination of critical time points in non-collision incidents of elderly passengers in standing position on urban bus.

    Arabian, Ali / Masjoodi, Sadegh / Makkiabadi, Bahador / Ghafari, Ehsan / Torabi Nassaj, Ebrahim / Zakerian, Seyed Abolfazl

    Traffic injury prevention

    2020  Volume 21, Issue 2, Page(s) 151–155

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Acceleration/adverse effects ; Accidents, Traffic/statistics & numerical data ; Aged ; Deceleration/adverse effects ; Electromyography ; Humans ; Iran/epidemiology ; Leg/physiology ; Male ; Motor Vehicles ; Muscle, Skeletal/physiology ; Standing Position ; Time Factors ; Urban Population/statistics & numerical data ; Wounds and Injuries/epidemiology
    Language English
    Publishing date 2020-03-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2089818-6
    ISSN 1538-957X ; 1538-9588
    ISSN (online) 1538-957X
    ISSN 1538-9588
    DOI 10.1080/15389588.2020.1723793
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A hybridized model based on neural network and swarm intelligence-grey wolf algorithm for spatial prediction of urban flood-inundation

    Darabi, Hamid / Torabi Haghighi, Ali / Rahmati, Omid / Jalali Shahrood, Abolfazl / Rouzbeh, Sajad / Pradhan, Biswajeet / Tien Bui, Dieu

    Journal of hydrology. 2021 Dec., v. 603

    2021  

    Abstract: In regions with lack of hydrological and hydraulic data, a spatial flood modeling and mapping is an opportunity for the urban authorities to predict the spatial distribution and the intensity of the flooding. It helps decision-makers to develop effective ...

    Abstract In regions with lack of hydrological and hydraulic data, a spatial flood modeling and mapping is an opportunity for the urban authorities to predict the spatial distribution and the intensity of the flooding. It helps decision-makers to develop effective flood prevention and management plans. In this study, flood inventory data were prepared based on the historical and field surveys data by Sari municipality and regional water company of Mazandaran, Iran. The collected flood data accompanied with different variables (digital elevation model and slope have been considered as topographic variables, land use/land cover, precipitation, curve number, distance to river, distance to channel and depth to groundwater as environmental variables) were applied to novel hybridized model based on neural network and swarm intelligence-grey wolf algorithm (NN-SGW) to map flood-inundation. Several confusion matrix criteria were used for accuracy evaluation by cutoff-dependent and independent metrics (e.g., efficiency (E), positive predictive value (PPV), negative predictive value (NPV), area under the receiver operating characteristic curve (AUC)). The accuracy of the flood inundation map produced by the NN-SGW model was compared with that of maps produced by four state-of-the-art benchmark models: random forest (RF), logistic model tree (LMT), classification and regression trees (CART), and J48 decision tree (J48DT). The NN-SGW model outperformed all benchmark models in both training (E = 90.5%, PPV = 93.7%, NPV = 87.3%, AUC = 96.3%) and validation (E = 79.4%, PPV = 85.3%, NPV = 73.5%, AUC = 88.2%). As the NN-SGW model produced the most accurate flood-inundation map, it can be employed for robust flood contingency planning. Based on the obtained results from NN-SGW model, distance from channel, distance from river, and depth to groundwater were identified as the most important variables for spatial prediction of urban flood inundation. This work can serve as a basis for future studies seeking to predict flood susceptibility in urban areas using hybridized machine learning (ML) models and can also be applied in other urban areas where flood inundation presents a pressing challenge, and there are some problems regarding required model and availability of input data.
    Keywords algorithms ; decision making ; decision support systems ; digital elevation models ; flood control ; groundwater ; inventories ; land cover ; land use ; logit analysis ; prediction ; rivers ; topography ; wolves ; Iran
    Language English
    Dates of publication 2021-12
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1473173-3
    ISSN 1879-2707 ; 0022-1694
    ISSN (online) 1879-2707
    ISSN 0022-1694
    DOI 10.1016/j.jhydrol.2021.126854
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Evaluation of motor proficiency and adiponectin in adolescent students with attention deficit hyperactivity disorder after high-intensity intermittent training.

    Torabi, Farnaz / Farahani, Abolfazl / Safakish, Sepide / Ramezankhani, Azam / Dehghan, Firouzeh

    Psychiatry research

    2017  Volume 261, Page(s) 40–44

    Abstract: Attention deficit hyperactivity disorder (ADHD) is a chronic condition with frequent comorbidities such as obesity, troubled relationships, low self-esteem, and difficulty in motor proficiency. This study aims to elucidate the effect of high-intensity ... ...

    Abstract Attention deficit hyperactivity disorder (ADHD) is a chronic condition with frequent comorbidities such as obesity, troubled relationships, low self-esteem, and difficulty in motor proficiency. This study aims to elucidate the effect of high-intensity intermittent training on motor proficiency, adiponectin, and insulin resistance in adolescent students with ADHD disorder. Fifty adolescent students of both genders with ADHD diagnosis participated and assigned into four experimental groups (each group with 15 girls and 10 boys students; two experimental and two control groups). High-intensity intermittent training was performed continuously 3 times a week for 6 weeks in experimental groups. Serum adiponectin level significantly increased in the experimental groups of both genders after 6 weeks intermittent training while insulin resistance levels were markedly decreased. Furthermore, motor proficiency score were significantly improved in the experimental groups of both genders. In addition gender had no significant impact on adiponectin, insulin resistance and motor proficiency rating. The findings of this study suggest that high intensity intermittent training improved physiological systems in ADHD population that leads to reduce risk factors for future development of comorbidities.
    MeSH term(s) Adiponectin/blood ; Adolescent ; Adolescent Behavior ; Attention Deficit Disorder with Hyperactivity/blood ; Attention Deficit Disorder with Hyperactivity/psychology ; Attention Deficit Disorder with Hyperactivity/therapy ; Biomarkers/blood ; Child ; Comorbidity ; Female ; High-Intensity Interval Training/methods ; High-Intensity Interval Training/psychology ; High-Intensity Interval Training/trends ; Humans ; Insulin Resistance/physiology ; Male ; Motor Skills/physiology ; Students/psychology
    Chemical Substances ADIPOQ protein, human ; Adiponectin ; Biomarkers
    Language English
    Publishing date 2017-12-19
    Publishing country Ireland
    Document type Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2017.12.053
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Assessing the effect of Mentha longifolia essential oils on COX-2 expression in animal model of sepsis induced by caecal ligation and puncture.

    Dadkhah, Abolfazl / Fatemi, Faezeh / Rasooli, Azadeh / Mohammadi Malayeri, Mohammad Reza / Torabi, Fatemeh

    Pharmaceutical biology

    2018  Volume 56, Issue 1, Page(s) 495–504

    Abstract: Context: Mentha longifolia L. (Lamiaceae), a traditional Iranian plant, possesses antimicrobial and antioxidant activities.: Objective: We investigated the potential protective effects of M. longifolia essential oils (E.Os) on caecal ligation and ... ...

    Abstract Context: Mentha longifolia L. (Lamiaceae), a traditional Iranian plant, possesses antimicrobial and antioxidant activities.
    Objective: We investigated the potential protective effects of M. longifolia essential oils (E.Os) on caecal ligation and puncture (CLP) induced liver injury.
    Materials and methods: Wistar Albino rats (n = 50) were grouped as follows: (1) a laparotomy group (LAP); (2) a CLP group (CLP); (3) the treatment groups received orally the E.Os (50 and 100 mg/kg b.w) and indomethacin (2 mg/kg b.w) for 2 weeks. The oxidative stress parameters, liver enzymes and prostaglandin E2 (PGE2) level were measured in liver and plasma tissues. The liver was also harvested for the real time PCR of cyclooxygenase (COX-2) expression following histopathological examinations.
    Results: The results indicated that the CLP operation significantly increased lipid peroxidation (LP) [1.79-fold], myeloperoxidase (MPO) [2.76-fold], PGE2 [1.56-fold] besides plasma aspartate aminotransferase (AST) [2.4-fold] and alanine aminotransferase (ALT) activities [2.22-fold], while, markedly reduced glutathione (GSH) [0.63-fold] and ferric reducing ability of plasma (FRAP) levels [0.63-fold]. Even COX2 expression significantly increased in the CLP group as compared to the LAP group. Treatments of rats with the E.Os could return all the hepatic and plasma biomarkers to the normal levels. These results were further confirmed by pathological examination on liver indicating that E.Os could successfully improve the CLP-induced liver injuries.
    Discussion and conclusions: Our findings suggest that E.Os is able to protect liver injuries against sepsis via modulating the oxidative stress parameters concomitant with the suppression of inflammatory reactions such as PGE2 and COX-2.
    MeSH term(s) Animals ; Antioxidants/isolation & purification ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Cecum ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/isolation & purification ; Cyclooxygenase 2 Inhibitors/pharmacology ; Cyclooxygenase 2 Inhibitors/therapeutic use ; Disease Models, Animal ; Gene Expression Regulation, Enzymologic ; Ligation ; Male ; Mentha ; Oils, Volatile/isolation & purification ; Oils, Volatile/pharmacology ; Oils, Volatile/therapeutic use ; Oxidative Stress/drug effects ; Oxidative Stress/physiology ; Rats ; Rats, Wistar ; Sepsis/drug therapy ; Sepsis/enzymology
    Chemical Substances Antioxidants ; Cyclooxygenase 2 Inhibitors ; Oils, Volatile ; Cyclooxygenase 2 (EC 1.14.99.1)
    Language English
    Publishing date 2018-09-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 1440131-9
    ISSN 1744-5116 ; 1388-0209
    ISSN (online) 1744-5116
    ISSN 1388-0209
    DOI 10.1080/13880209.2018.1510972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The effect of 3-nitropropionic acid on behavioral dysfunction, neuron loss and gliosis in the brain of adult male rats: The case of prefrontal cortex, hippocampus and the cerebellum

    Torabi, Abolfazl / Joneidi, Mohammadjavad / Mohammadzadeh, Ibrahim / Abdollahifar, Mohammad-amin / Khatmi, Aysan / Ezi, Samira / Moghaddam, Meysam Hassani / Rafiei, Romina / Kahrizirad, Farshad / Norozian, Mohsen / Aliaghaei, Abbas

    Toxicon. 2020 Aug., v. 183

    2020  

    Abstract: 3-nitropropionic acid (3-NP) is a mycotoxin widely used to produce a rat model of Huntington's disease. While there are numerous studies on the effect of this neurotoxin, still further investigation is required to understand the influence of this toxin ... ...

    Abstract 3-nitropropionic acid (3-NP) is a mycotoxin widely used to produce a rat model of Huntington's disease. While there are numerous studies on the effect of this neurotoxin, still further investigation is required to understand the influence of this toxin on different regions of the brain. In the present study, there are two groups of rats of which one is treated with 3-NP. Behavioral, stereological and immunohistochemical analyses were conducted. The results show that locomotor activity is largely affected and anxiety is induced up to a certain level, but there is no gross manifestation of deficit in memory. Microscopic observations illustrate damages in the hippocampus and other parts of the brain. Astrogliosis and glial scars were another finding of this study. In conclusion, although 3-NP can be used as a model of Huntington's disease, it exerts a disseminated effect on different regions of the brain.
    Keywords 3-nitropropionic acid ; adults ; animal models ; anxiety ; cerebellum ; hippocampus ; immunohistochemistry ; locomotion ; males ; memory ; mycotoxins ; neurons ; neurotoxins ; prefrontal cortex
    Language English
    Dates of publication 2020-08
    Size p. 44-50.
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 204479-1
    ISSN 1879-3150 ; 0041-0101
    ISSN (online) 1879-3150
    ISSN 0041-0101
    DOI 10.1016/j.toxicon.2020.05.012
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: RiMARS: An automated river morphodynamics analysis method based on remote sensing multispectral datasets

    Shahrood, Abolfazl Jalali / Darabi, Hamid / Haghighi, Ali Torabi / Kløve, Bjørn / Menberu, Meseret Walle / Rahmati, Omid / Rossi, Pekka M

    Science of the total environment. 2020 June 01, v. 719

    2020  

    Abstract: Assessment and monitoring of river morphology own an important role in river engineering; since, changes in river morphology including erosion and sedimentation affect river cross-sections and flow processes. An approach for River Morphodynamics Analysis ...

    Abstract Assessment and monitoring of river morphology own an important role in river engineering; since, changes in river morphology including erosion and sedimentation affect river cross-sections and flow processes. An approach for River Morphodynamics Analysis based on Remote Sensing (RiMARS) was developed and tested on the case of Mollasadra dam construction on the Kor River, Iran. Landsat multispectral images obtained from the open USGS dataset are used to extract river morphology dynamics by the Modified Normalized Difference Water Index (MNDWI). RiMARS comes with a river extraction module which is independent of threshold segmentation methods to produce binary-level images. In addition, RiMARS is equipped with developed indices for assessing the morphological alterations. Five characteristics of river morphology (spatiotemporal Sinuosity Index (SI), Absolute Centerline Migration (ACM), Rate of Centerline Migration (RCM), River Linear Pattern (RLP), and Meander Migration Index (MMI)), are applied to quantify river morphology changes. The results indicated that the Kor River centerline underwent average annual migration of 40 cm to the southwest during 1993–2003 (pre-construction impact), 20 cm to the northeast during 2003–2011, and 40 cm to the south-west during 2011–2017 (post-construction impact). Spatially, as the Kor River runs towards the Doroudzan dam, changes in river morphology have increased from upstream to downstream; particularly evident where the river flows in a plain instead of the valley. Based on SI values, there was a 5% change in the straight sinuosity class in the pre-construction period, but an 18% decrease in the straight class during the post-construction period. Here we demonstrate the application of RiMARS in assessing the impact of dam construction on morphometric processes in Kor River, but it can be used to assess other riverine changes, including tracking the unauthorized water consumption using diverted canals. RiMARS can be applied on multispectral images.
    Keywords automation ; dams (hydrology) ; data collection ; Landsat ; migratory behavior ; monitoring ; morphometry ; multispectral imagery ; remote sensing ; river engineering ; rivers ; United States Geological Survey ; Iran
    Language English
    Dates of publication 2020-0601
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2020.137336
    Database NAL-Catalogue (AGRICOLA)

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