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  1. Book ; Online ; E-Book: Therapies for retinal degeneration

    la Rosa, Enrique J de / Cotter, Thomas G.

    targeting common processes

    (Drug discovery series ; 66)

    2019  

    Author's details edited by Enrique J. de la Rosa and Thomas G. Cotter
    Series title Drug discovery series ; 66
    RSC drug discovery series
    Collection RSC drug discovery series
    Keywords Ophthalmic drugs ; Ocular pharmacology ; Retina/Diseases/Chemotherapy
    Subject code 617.7061
    Language English
    Size 1 Online-Ressource (xvi, 260 Seiten), Illustrationen, Diagramme
    Publisher Royal Society of Chemistry
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019960817
    ISBN 978-1-78801-366-6 ; 978-1-78801-536-3 ; 9781782629498 ; 1-78801-366-2 ; 1-78801-536-3 ; 1782629491
    DOI 10.1039/9781788013666
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: La COVID-19 y el valor del conocimiento

    De la Rosa, Enrique J.

    2020  

    Abstract: ... Peer ... ...

    Abstract Peer reviewed
    Keywords covid19
    Language Spanish
    Publisher CSIC - Centro de Investigaciones Biológicas Margarita Salas (CIB)
    Publishing country es
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Exploring the Origin and Physiological Significance of DNA Double Strand Breaks in the Developing Neuroretina.

    Álvarez-Lindo, Noemí / Suárez, Teresa / de la Rosa, Enrique J

    International journal of molecular sciences

    2022  Volume 23, Issue 12

    Abstract: Genetic mosaicism is an intriguing physiological feature of the mammalian brain that generates altered genetic information and provides cellular, and prospectively functional, diversity in a manner similar to that of the immune system. However, both its ... ...

    Abstract Genetic mosaicism is an intriguing physiological feature of the mammalian brain that generates altered genetic information and provides cellular, and prospectively functional, diversity in a manner similar to that of the immune system. However, both its origin and its physiological significance remain poorly characterized. Most, if not all, cases of somatic mosaicism require prior generation and repair of DNA double strand breaks (DSBs). The relationship between DSB generation, neurogenesis, and early neuronal cell death revealed by our studies in the developing retina provides new perspectives on the different mechanisms that contribute to DNA rearrangements in the developing brain. Here, we speculate on the physiological significance of these findings.
    MeSH term(s) Animals ; DNA/metabolism ; DNA Breaks, Double-Stranded ; DNA Repair ; Gene Rearrangement ; Mammals/metabolism ; Neurogenesis/genetics
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2022-06-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23126449
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: TLR2 Is Highly Overexpressed in Retinal Myeloid Cells in the rd10 Mouse Model of Retinitis Pigmentosa.

    Sánchez-Cruz, Alonso / de la Rosa, Enrique J / Hernández-Sánchez, Catalina

    Advances in experimental medicine and biology

    2023  Volume 1415, Page(s) 409–413

    Abstract: Retinitis pigmentosa (RP) is a genetically heterogeneous disease and the predominant cause of hereditary blindness. Irrespective of the causative mutation, traits common to all forms of RP include photoreceptor dysfunction and death, activation of the ... ...

    Abstract Retinitis pigmentosa (RP) is a genetically heterogeneous disease and the predominant cause of hereditary blindness. Irrespective of the causative mutation, traits common to all forms of RP include photoreceptor dysfunction and death, activation of the retinal glial component, and retinal inflammation. Activation of Toll-like receptors (TLRs) in response to tissue damage is associated with inflammatory processes that contribute to neurodegeneration. We show that retinal expression of the genes Tlr1 to Tlr9 is increased in the rd10 mouse model of RP, with Tlr2 showing the greatest increase (36-fold). Flow cytometry analysis of the retinal myeloid population revealed significant increases in numbers of microglia and infiltrating monocytes and macrophages in rd10 retinas. Furthermore, TLR2 expression, which was restricted to myeloid cells, was increased in rd10 retinal microglia. These observations, together with our previous finding of delayed RP progression following Tlr2 deletion, point to TLR2 as a potential therapeutic target for RP.
    MeSH term(s) Mice ; Animals ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 2/metabolism ; Retina/metabolism ; Retinitis Pigmentosa/genetics ; Retinitis Pigmentosa/metabolism ; Photoreceptor Cells/metabolism ; Macrophages/metabolism ; Disease Models, Animal ; Mice, Inbred C57BL
    Chemical Substances Toll-Like Receptor 2
    Language English
    Publishing date 2023-07-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410187-X
    ISSN 0065-2598
    ISSN 0065-2598
    DOI 10.1007/978-3-031-27681-1_60
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3192: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Einzelsignatur: Show issues

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  5. Article ; Online: Exploring the Origin and Physiological Significance of DNA Double Strand Breaks in the Developing Neuroretina

    Noemí Álvarez-Lindo / Teresa Suárez / Enrique J. de la Rosa

    International Journal of Molecular Sciences, Vol 23, Iss 6449, p

    2022  Volume 6449

    Abstract: Genetic mosaicism is an intriguing physiological feature of the mammalian brain that generates altered genetic information and provides cellular, and prospectively functional, diversity in a manner similar to that of the immune system. However, both its ... ...

    Abstract Genetic mosaicism is an intriguing physiological feature of the mammalian brain that generates altered genetic information and provides cellular, and prospectively functional, diversity in a manner similar to that of the immune system. However, both its origin and its physiological significance remain poorly characterized. Most, if not all, cases of somatic mosaicism require prior generation and repair of DNA double strand breaks (DSBs). The relationship between DSB generation, neurogenesis, and early neuronal cell death revealed by our studies in the developing retina provides new perspectives on the different mechanisms that contribute to DNA rearrangements in the developing brain. Here, we speculate on the physiological significance of these findings.
    Keywords DSBs ; neuron somatic mosaicism ; Rag2 ; recombination ; NHEJ ; neurogenesis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The Absence of FAIM Leads to a Delay in Dark Adaptation and Hampers Arrestin-1 Translocation upon Light Reception in the Retina.

    Sirés, Anna / Pazo-González, Mateo / López-Soriano, Joaquín / Méndez, Ana / de la Rosa, Enrique J / de la Villa, Pedro / Comella, Joan X / Hernández-Sánchez, Catalina / Solé, Montse

    Cells

    2023  Volume 12, Issue 3

    Abstract: The short and long isoforms of FAIM (FAIM-S and FAIM-L) hold important functions in the central nervous system, and their expression levels are specifically enriched in the retina. We previously described ... ...

    Abstract The short and long isoforms of FAIM (FAIM-S and FAIM-L) hold important functions in the central nervous system, and their expression levels are specifically enriched in the retina. We previously described that
    MeSH term(s) Animals ; Mice ; Arrestin/metabolism ; Dark Adaptation ; Mice, Knockout ; Retina/metabolism ; Retinal Rod Photoreceptor Cells/metabolism ; Translocation, Genetic ; Vision, Ocular
    Chemical Substances Arrestin ; Faim protein, mouse
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12030487
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Possible Role of Insulin-Degrading Enzyme in the Physiopathology of Retinitis Pigmentosa.

    Sánchez-Cruz, Alonso / Hernández-Fuentes, María D / Murillo-Gómez, Cayetana / de la Rosa, Enrique J / Hernández-Sánchez, Catalina

    Cells

    2022  Volume 11, Issue 10

    Abstract: Insulin-degrading enzyme (IDE) was named after its role as a proteolytic enzyme of insulin. However, recent findings suggest that IDE is a widely expressed, multitask protein, with both proteolytic and non-proteolytic functions. Here, we characterize the ...

    Abstract Insulin-degrading enzyme (IDE) was named after its role as a proteolytic enzyme of insulin. However, recent findings suggest that IDE is a widely expressed, multitask protein, with both proteolytic and non-proteolytic functions. Here, we characterize the expression of IDE in the mammalian retina in both physiological and pathological conditions. We found that IDE was enriched in cone inner segments. IDE levels were downregulated in the dystrophic retina of several mouse models of retinitis pigmentosa carrying distinct mutations. In
    MeSH term(s) Animals ; Disease Models, Animal ; Insulysin/genetics ; Insulysin/metabolism ; Mammals ; Mice ; Retina/metabolism ; Retinitis Pigmentosa/genetics
    Chemical Substances Insulysin (EC 3.4.24.56)
    Language English
    Publishing date 2022-05-12
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells11101621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Tlr2

    Sánchez-Cruz, Alonso / Méndez, Andrea C / Lizasoain, Ignacio / de la Villa, Pedro / de la Rosa, Enrique J / Hernández-Sánchez, Catalina

    International journal of molecular sciences

    2021  Volume 22, Issue 15

    Abstract: Although considered a rare retinal dystrophy, retinitis pigmentosa (RP) is the primary cause of hereditary blindness. Given its diverse genetic etiology (>3000 mutations in >60 genes), there is an urgent need for novel treatments that target common ... ...

    Abstract Although considered a rare retinal dystrophy, retinitis pigmentosa (RP) is the primary cause of hereditary blindness. Given its diverse genetic etiology (>3000 mutations in >60 genes), there is an urgent need for novel treatments that target common features of the disease. TLR2 is a key activator of innate immune response. To examine its role in RP progression we characterized the expression profile of
    MeSH term(s) Animals ; Disease Models, Animal ; Gene Deletion ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microglia/cytology ; Microglia/metabolism ; Neuroprotective Agents ; Retinal Degeneration/etiology ; Retinal Degeneration/metabolism ; Retinal Degeneration/pathology ; Retinal Degeneration/prevention & control ; Retinitis Pigmentosa/complications ; Toll-Like Receptor 2/physiology
    Chemical Substances Neuroprotective Agents ; Tlr2 protein, mouse ; Toll-Like Receptor 2
    Language English
    Publishing date 2021-07-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22157815
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Ag

    Coro, Amalia / Herrero Ruiz, Ada / Pazo-González, Mateo / Sánchez-Cruz, Alonso / Busch, Tobias / Hernández Medel, Alejandro / Ximendes, Erving C / Ortgies, Dirk H / López-Méndez, Rosalía / Espinosa, Ana / Jimenez de Aberasturi, Dorleta / Jaque, Daniel / Fernández Monsalve, Nuria / de la Rosa, Enrique J / Hernández-Sánchez, Catalina / Martín Rodríguez, Emma / H Juárez, Beatriz

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 19, Issue 49, Page(s) e2305026

    Abstract: ... ...

    Abstract Ag
    MeSH term(s) Tomography, Optical Coherence ; Contrast Media ; Nanoparticles ; Polymers ; Optical Imaging
    Chemical Substances Contrast Media ; Polymers
    Language English
    Publishing date 2023-08-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202305026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The Absence of FAIM Leads to a Delay in Dark Adaptation and Hampers Arrestin-1 Translocation upon Light Reception in the Retina

    Anna Sirés / Mateo Pazo-González / Joaquín López-Soriano / Ana Méndez / Enrique J. de la Rosa / Pedro de la Villa / Joan X. Comella / Catalina Hernández-Sánchez / Montse Solé

    Cells, Vol 12, Iss 487, p

    2023  Volume 487

    Abstract: The short and long isoforms of FAIM (FAIM-S and FAIM-L) hold important functions in the central nervous system, and their expression levels are specifically enriched in the retina. We previously described that Faim knockout (KO) mice present structural ... ...

    Abstract The short and long isoforms of FAIM (FAIM-S and FAIM-L) hold important functions in the central nervous system, and their expression levels are specifically enriched in the retina. We previously described that Faim knockout (KO) mice present structural and molecular alterations in the retina compatible with a neurodegenerative phenotype. Here, we aimed to study Faim KO retinal functions and molecular mechanisms leading to its alterations. Electroretinographic recordings showed that aged Faim KO mice present functional loss of rod photoreceptor and ganglion cells. Additionally, we found a significant delay in dark adaptation from early adult ages. This functional deficit is exacerbated by luminic stress, which also caused histopathological alterations. Interestingly, Faim KO mice present abnormal Arrestin-1 redistribution upon light reception, and we show that Arrestin-1 is ubiquitinated, a process that is abrogated by either FAIM-S or FAIM-L in vitro. Our results suggest that FAIM assists Arrestin-1 light-dependent translocation by a process that likely involves ubiquitination. In the absence of FAIM, this impairment could be the cause of dark adaptation delay and increased light sensitivity. Multiple retinal diseases are linked to deficits in photoresponse termination, and hence, investigating the role of FAIM could shed light onto the underlying mechanisms of their pathophysiology.
    Keywords retina ; rod photoreceptors ; Arrestin-1 ; FAIM ; dark adaptation ; ubiquitin ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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