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Article: Dynamic chest radiography: moving from basic research to clinical application.

Yamasaki, Yuzo / Hino, Takuya

2023 Volume 15, Issue 12, Page(s) 7155–7158

Language	English
Publishing date	2023-12-11
Publishing country	China
Document type	Editorial ; Comment
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-23-1403
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Article ; Online: Vascular endothelial cell-specific overexpression of CNP did not improve liver fibrosis in HFFCD-induced NASH, but did improve renal lesions.

Ensho, Takuya / Hino, Jun / Ueda, Yoko / Miyazato, Mikiya / Iwakura, Hiroshi

Peptides

2023 Volume 172, Page(s) 171146

Abstract: Mice with endothelial-cell-specific overexpression of C-type natriuretic peptide (E-CNP Tg mice) were shown to be protected against hepatic fibrosis and inflammation induced by high fat diet (HFD) feeding, with improved insulin sensitivity and attenuated ...

Abstract	Mice with endothelial-cell-specific overexpression of C-type natriuretic peptide (E-CNP Tg mice) were shown to be protected against hepatic fibrosis and inflammation induced by high fat diet (HFD) feeding, with improved insulin sensitivity and attenuated weight gain. A recently developed high-fat, high-fructose, high-cholesterol diet (HFFCD) is considered to be a superior model to HFD, owing to the resemblance to human non-alcoholic steatohepatitis (NASH). In this study, we therefore aimed to reveal whether these previous findings with E-CNP Tg mice on HFD can be observed in a newly developed NASH model.　Patients with NASH have been suggested to be at higher risk of developing chronic kidney disease, so we also assessed the kidney histology of these mice. After 8 months of HFFCD feeding, the livers of E-CNP Tg mice and controls showed progressive fibrosis, which resembled the features of human NASH. However, no significant differences were observed in NAFLD activity scores between E-CNP Tg mice and controls, although there was a tendency for improvement in E-CNP Tg mice. The reduced levels of GCB, a receptor for CNP, may have weakened the action of CNP in the current model. In the kidneys, HFFCD showed glomerular hypertrophy and tubular atrophy in the cortical region, which were suppressed in E-CNP Tg mice. The present study did not prove the therapeutic effect of CNP on NASH in the HFFCD model, but provided evidence of its potential beneficial effects on NASH-associated renal damage.
MeSH term(s)	Humans ; Mice ; Animals ; Non-alcoholic Fatty Liver Disease/pathology ; Liver ; Liver Cirrhosis/pathology ; Kidney/pathology ; Endothelial Cells ; Diet, High-Fat ; Mice, Inbred C57BL ; Disease Models, Animal
Language	English
Publishing date	2023-12-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	769028-9
ISSN	1873-5169 ; 0196-9781
ISSN (online)	1873-5169
ISSN	0196-9781
DOI	10.1016/j.peptides.2023.171146
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Zs.A 1649: Show issues

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Article ; Online: Development of Neutron Interferometer Using Multilayer Mirrors and Measurements of Neutron-Nuclear Scattering Length with Pulsed Neutron Source.

Fujiie, Takuhiro / Hino, Masahiro / Hosobata, Takuya / Ichikawa, Go / Kitaguchi, Masaaki / Mishima, Kenji / Seki, Yoshichika / Shimizu, Hirohiko M / Yamagata, Yutaka

Physical review letters

2024 Volume 132, Issue 2, Page(s) 23402

Abstract: This study entailed the successful deployment of a novel neutron interferometer that utilizes multilayer mirrors. The apparatus facilitates a precise evaluation of the wavelength dependence of interference fringes utilizing a pulsed neutron source. Our ... ...

Abstract	This study entailed the successful deployment of a novel neutron interferometer that utilizes multilayer mirrors. The apparatus facilitates a precise evaluation of the wavelength dependence of interference fringes utilizing a pulsed neutron source. Our interferometer achieved an impressive precision of 0.02 rad within a 20-min recording time. Compared to systems using silicon crystals, the measurement sensitivity was maintained even when using a simplified disturbance suppressor. By segregating beam paths entirely, we achieved successful measurements of neutron-nuclear scattering lengths across various samples. The values measured for Si, Al, and Ti were in agreement with those found in the literature, while V showed a disparity of 45%. This discrepancy may be attributable to impurities encountered in previous investigations. The accuracy of measurements can be enhanced further by mitigating systematic uncertainties that are associated with neutron wavelength, sample impurity, and thickness. This novel neutron interferometer enables us to measure fundamental parameters, such as the neutron-nuclear scattering length of materials, with a precision that surpasses that of conventional interferometers.
Language	English
Publishing date	2024-01-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.132.023402
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Article: Use of Eltrombopag for the First Trimester Pregnancy Complicated with Refractory Idiopathic Thrombocytopenic Purpura: A Case Report and Literature Review.

Shibata, Satoshi / Misugi, Takuya / Nakane, Takahiko / Hino, Masayuki / Tachibana, Daisuke

Cureus

2022 Volume 14, Issue 2, Page(s) e22505

Abstract: Severe idiopathic thrombocytopenic purpura (ITP) is thought to occur in approximately one in 10,000 pregnancies and refractoriness for conventional treatment is life-threatening. We herein describe a pregnant case of refractory ITP successfully treated ... ...

Abstract	Severe idiopathic thrombocytopenic purpura (ITP) is thought to occur in approximately one in 10,000 pregnancies and refractoriness for conventional treatment is life-threatening. We herein describe a pregnant case of refractory ITP successfully treated with eltrombopag, orally medicated thrombopoietin receptor agonist (TPO-RA). The patient was diagnosed with ITP at the age of 22 and corticosteroid, immune globulin treatments, or splenectomy was invalid. Eltrombopag was administered at 25 mg/day and the platelet count was maintained at 50-80 × 10
Language	English
Publishing date	2022-02-22
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.22505
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Article ; Online: Tumor Volume Nadir in Patients With

Nishino, Mizuki / Wei, Zihan / Mazzola, Emanuele / Hino, Takuya / Tseng, Shu-Chi / Sanchez, Michelle E / Hatabu, Hiroto / Johnson, Bruce E / Awad, Mark M

JCO precision oncology

2023 Volume 7, Page(s) e2200603

Abstract: Purpose: Patients with oncogene-driven advanced non-small-cell lung cancer (NSCLC) treated with effective targeted therapy demonstrate characteristic tumor volume dynamics with initial response, nadir, and subsequent regrowth. This study investigated ... ...

Abstract	Purpose: Patients with oncogene-driven advanced non-small-cell lung cancer (NSCLC) treated with effective targeted therapy demonstrate characteristic tumor volume dynamics with initial response, nadir, and subsequent regrowth. This study investigated tumor volume nadir and time to nadir in patients with Materials and methods: In patients with advanced Results: Among 45 patients who experienced initial volume decrease, 37 patients (25 with tumor regrowth and 12 without regrowth but >6 months follow-up) were studied for nadir volume (V Conclusion: The tumor nadir volume in patients with
MeSH term(s)	Humans ; Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Tumor Burden ; Anaplastic Lymphoma Kinase/genetics
Chemical Substances	alectinib (LIJ4CT1Z3Y) ; Anaplastic Lymphoma Kinase (EC 2.7.10.1)
Language	English
Publishing date	2023-03-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2473-4284
ISSN (online)	2473-4284
DOI	10.1200/PO.22.00603
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Article ; Online: Salvage Human Leukocyte Antigen-Haploidentical Hematopoietic Cell Transplant With Posttransplant Cyclophosphamide for Graft Failure in a Patient With Chronic Active Epstein-Barr Virus Infection.

Nakaya, Yosuke / Koh, Hideo / Harada, Naonori / Okamura, Hiroshi / Misugi, Takuya / Suekane, Tomoki / Tachibana, Daisuke / Kimura, Hiroshi / Hino, Masayuki / Nakamae, Hirohisa

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

2023 Volume 21, Issue 2, Page(s) 184–188

Abstract: Salvage human leukocyte antigen-haploidentical hematopoietic cell transplant using posttransplant cyclophosphamide has shown promising results for graft failure in various hematological disorders. However, to our knowledge, no such findings have been ... ...

Abstract	Salvage human leukocyte antigen-haploidentical hematopoietic cell transplant using posttransplant cyclophosphamide has shown promising results for graft failure in various hematological disorders. However, to our knowledge, no such findings have been reported for a case of chronic active Epstein-Barr virus infection, although graft failure is relatively common in patients with chronic active Epstein-Barr virus infection. We report a case of a 32-year-old woman with natural killer-cell type chronic active Epstein-Barr virus infection who experienced graft failure after a first allogeneic hematopoietic cell transplant from an unrelated human leukocyte antigen-matched donor.The patientreceived a second allogeneic hematopoietic cell transplant with human leukocyte antigen-haploidentical hematopoietic cell transplant using posttransplant cyclophosphamide (cyclophosphamide, 50 mg/kg, on day 3 and day 4) following reduced-intensity conditioning as rescue therapy. Neutrophils successfully engrafted on day 19, and the patient sustained remission without severe transplant-related complication 10 months after salvage human leukocyte antigen- haploidentical hematopoietic cell transplant using posttransplant cyclophosphamide. This report suggests that salvage human leukocyte antigen- haploidentical hematopoietic cell transplant using posttransplant cyclophosphamide may be a feasible therapeutic option for graft failure in patients with chronic active Epstein-Barr virus infection.
MeSH term(s)	Female ; Humans ; Adult ; Hematopoietic Stem Cell Transplantation/adverse effects ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/diagnosis ; Epstein-Barr Virus Infections/therapy ; Graft vs Host Disease/etiology ; Herpesvirus 4, Human ; Cyclophosphamide ; HLA Antigens ; Transplantation Conditioning/methods
Chemical Substances	Cyclophosphamide (8N3DW7272P) ; HLA Antigens
Language	English
Publishing date	2023-03-15
Publishing country	Turkey
Document type	Case Reports ; Journal Article
ZDB-ID	2396778-X
ISSN	2146-8427 ; 1304-0855
ISSN (online)	2146-8427
ISSN	1304-0855
DOI	10.6002/ect.2022.0322
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Zs.A 6632: Show issues

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Article ; Online: Amide proton transfer (APT) imaging of breast cancers and its correlation with biological status.

Kamitani, Takeshi / Sagiyama, Koji / Yamasaki, Yuzo / Hino, Takuya / Wada, Tatsuhiro / Kubo, Makoto / Akiyoshi, Sayuri / Yamamoto, Hidetaka / Yabuuchi, Hidetake / Ishigami, Kousei

Clinical imaging

2023 Volume 96, Page(s) 38–43

Abstract: Purpose: To assess the usefulness of amide proton transfer (APT) imaging to predict the biological status of breast cancers.: Method: Sixty-six patients (age range 31-85 years, mean 58.9 years) with histopathologically proven invasive ductal ... ...

Abstract	Purpose: To assess the usefulness of amide proton transfer (APT) imaging to predict the biological status of breast cancers. Method: Sixty-six patients (age range 31-85 years, mean 58.9 years) with histopathologically proven invasive ductal carcinomas of 2 cm or larger in diameter were included in this study. 3D APT weighted imaging was conducted on a 3 T scanner. Mean APT signal intensity (SI) was analyzed in relation to biological subtypes, Ki-67 labeling index, and nuclear grades (NGs). Results: The triple-negative (TN) cancers (n = 10; 2.75 ± 0.42%) showed significantly higher APT SI than the luminal type cancers (n = 48; 1.74 ± 0.83) and HER2 cancers (n = 8; 1.83 ± 0.21) (P = 0.0007, 0.03). APT SI had weakly positive correlation with the Ki-67 labeling index (r = 0.38, P = 0.002). The mean APT SIs were significantly higher for high-Ki-67 (>30%) (n = 31; 2.25 ± 0.70) than low-Ki-67 (≤30%) cancers (n = 35; 1.60 ± 0.79) (P = 0.0007). There was no significant difference in the APT SIs between NG 1-2 (n = 31; 1.71 ± 0.84) and NG 3 (n = 35; 2.08 ± 0.76%) cancers (P = 0.06). Conclusions: TN and high-Ki-67 breast cancers showed high APT SIs. APT imaging can help to predict the biological status of breast cancers.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Female ; Magnetic Resonance Imaging/methods ; Protons ; Breast Neoplasms ; Ki-67 Antigen ; Amides ; Brain Neoplasms/pathology
Chemical Substances	Protons ; Ki-67 Antigen ; Amides
Language	English
Publishing date	2023-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1028123-x
ISSN	1873-4499 ; 0899-7071
ISSN (online)	1873-4499
ISSN	0899-7071
DOI	10.1016/j.clinimag.2023.02.002
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Zs.A 1469: Show issues

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Article ; Online: Virtual monochromatic spectral CT imaging in preoperative evaluations for intraductal spread of breast cancer: comparison with conventional CT and MRI.

Matsuura, Yuko / Kamitani, Takeshi / Sagiyama, Koji / Yamasaki, Yuzo / Hino, Takuya / Kubo, Makoto / Ijichi, Hideki / Yamamoto, Hidetaka / Yabuuchi, Hidetake / Ishigami, Kousei

Japanese journal of radiology

2023 Volume 41, Issue 7, Page(s) 733–740

Abstract: Purpose: To investigate the efficacy of virtual monochromatic spectral computed tomography imaging (VMI) in the preoperative evaluation for intraductal spread of breast cancer.: Materials and methods: Twenty-four women who underwent spectral CT and ... ...

Abstract	Purpose: To investigate the efficacy of virtual monochromatic spectral computed tomography imaging (VMI) in the preoperative evaluation for intraductal spread of breast cancer. Materials and methods: Twenty-four women who underwent spectral CT and were pathologically diagnosed with ductal carcinoma with a ≥ 2-cm noninvasive component were retrospectively enrolled in Group 1. Twenty-two women with 22 lesions pathologically diagnosed with ductal carcinoma in situ or microinvasive carcinoma were enrolled in Group 2. We compared the contrast-to-noise ratios (CNRs) of the lesions on conventional 120-kVp CT images and 40-keV VMIs in Group 1. Two board-certified radiologists measured the maximum diameters of enhancing areas on 120-kVp CT, 40-keV VMI, and MRI in Group 2 and compared with histopathological sizes. Results: The quantitative assessment of Group 1 revealed that the mean ± SD of the CNRs in the 40-keV images were significantly greater than those in the 120-kVp images (5.5 ± 1.9 vs. 3.6 ± 1.5, p < 0.0001). The quantitative assessment of Group 2 demonstrated that the lesion size observed in the conventional 120-kVp CT images by both readers was significantly underestimated as compared to the histopathological size (p = 0.017, 0.048), whereas both readers identified no significant differences between the lesion size measured on 40-keV VMI and the histopathological data. In a comparison with MRI, 40-keV VMI provided measurement within a 10-mm error range in more lesions as compared to the conventional 120-kVp CT. Conclusion: VMI improves the evaluation of intraductal spread and is useful for the preoperative evaluations of breast cancer.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/surgery ; Retrospective Studies ; Tomography, X-Ray Computed/methods ; Magnetic Resonance Imaging ; Radiographic Image Interpretation, Computer-Assisted/methods
Language	English
Publishing date	2023-02-02
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2488907-6
ISSN	1867-108X ; 1867-1071
ISSN (online)	1867-108X
ISSN	1867-1071
DOI	10.1007/s11604-023-01392-4
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Article ; Online: Interstitial Lung Abnormalities at CT: Subtypes, Clinical Significance, and Associations with Lung Cancer.

Hata, Akinori / Hino, Takuya / Yanagawa, Masahiro / Nishino, Mizuki / Hida, Tomoyuki / Hunninghake, Gary M / Tomiyama, Noriyuki / Christiani, David C / Hatabu, Hiroto

Radiographics : a review publication of the Radiological Society of North America, Inc

2022 Volume 42, Issue 7, Page(s) 1925–1939

Abstract: Interstitial lung ... ...

Abstract	Interstitial lung abnormality
MeSH term(s)	Humans ; Tomography, X-Ray Computed/methods ; Disease Progression ; Lung Diseases, Interstitial ; Lung Neoplasms/surgery ; Lung
Language	English
Publishing date	2022-09-09
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	603172-9
ISSN	1527-1323 ; 0271-5333
ISSN (online)	1527-1323
ISSN	0271-5333
DOI	10.1148/rg.220073
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Article ; Online: Traction Bronchiectasis/Bronchiolectasis in Interstitial Lung Abnormality: Follow-up in the COPDGene Study.

Hata, Akinori / Hino, Takuya / Li, Yi / Johkoh, Takeshi / Christiani, David C / Lynch, David A / Cho, Michael H / Silverman, Edwin K / Hunninghake, Gary M / Hatabu, Hiroto

American journal of respiratory and critical care medicine

2023 Volume 207, Issue 10, Page(s) 1395–1398

MeSH term(s)	Humans ; Follow-Up Studies ; Traction ; Lung Diseases ; Bronchiectasis/genetics ; Lung
Language	English
Publishing date	2023-03-07
Publishing country	United States
Document type	Letter ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202211-2061LE
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