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  1. Article ; Online: DISTORTION RESOLUTION AFTER VITRECTOMY FOR MACULA-INVOLVING RETINAL DETACHMENT REPAIR: Post Hoc Analysis of the PostRD Trial.

    Casswell, Edward J / Yorston, David / Lee, Edward / Charteris, David G

    Retina (Philadelphia, Pa.)

    2022  Volume 42, Issue 12, Page(s) 2315–2320

    Abstract: ... a distortion questionnaire and objective distortion assessment (D chart) 2 and 6 months postoperatively ... months. The median overall and weighted D chart distortion scores fell between 2 and 6 months but 29 ... of patients had a worsening of D chart distortion score. D chart distortion scores were more closely ...

    Abstract Purpose: To investigate changes in subjective and objective distortion in the first 6 months after macula-involving retinal detachment repair.
    Methods: Post hoc analysis of the PostRD trial: a prospective, multicentered randomized controlled trial. Two hundred and sixty-two patients with macula-involving retinal detachments undergoing repair with vitrectomy and gas tamponade were asked to complete a distortion questionnaire and objective distortion assessment (D chart) 2 and 6 months postoperatively. Visual acuity, retinal displacement (measured with fundus autofluorescence imaging), and quality of life were also recorded.
    Results: Two months postoperatively 75.5% of patients reported subjective distortion, and this fell to 61.1% at 6 months. Over that period, distortion persisted in 56.5% of patients, resolved in 19.2%, and developed in 5.6%. Approximately one in four had resolution of their distortion by 6 months. The median overall and weighted D chart distortion scores fell between 2 and 6 months but 29% of patients had a worsening of D chart distortion score. D chart distortion scores were more closely correlated with amplitude of postoperative retinal displacement and quality-of-life scores in comparison with subjective distortion.
    Conclusion: Subjective distortion and objective distortion are common after macula-involving retinal detachment, but can improve over time. Objective measures of distortion were more closely correlated with quality of life and retinal displacement in comparison with subjective distortion.
    MeSH term(s) Humans ; Vitrectomy ; Retinal Detachment/diagnosis ; Retinal Detachment/surgery ; Prospective Studies ; Quality of Life ; Macula Lutea ; Retrospective Studies
    Language English
    Publishing date 2022-08-25
    Publishing country United States
    Document type Randomized Controlled Trial ; Multicenter Study ; Journal Article
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000003605
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  2. Article ; Online: Scleral-fixated intraocular lens implants-evolution of surgical techniques and future developments.

    Shahid, S M / Flores-Sánchez, B C / Chan, E W / Anguita, R / Ahmed, S N / Wickham, L / Charteris, D G

    Eye (London, England)

    2021  Volume 35, Issue 11, Page(s) 2930–2961

    Abstract: Varied options are available for the implantation of secondary intraocular lens implants in the absence of zonular or capsular support. Loss of the capsule can occur in the context of complicated cataract surgery, trauma or inherited conditions such as ... ...

    Abstract Varied options are available for the implantation of secondary intraocular lens implants in the absence of zonular or capsular support. Loss of the capsule can occur in the context of complicated cataract surgery, trauma or inherited conditions such as Marfan syndrome or pseudoexfoliation. Approaches to overcome this include optical measures such as the use of spectacles or contact lenses, and surgical therapy incorporating the use of anterior chamber, iris-fixated or scleral-fixated lenses. Surgical techniques to implant scleral-fixated lenses have undergone various modifications, since the first publication of sutured intrascleral fixation described in the 1980s. However, despite the advances in surgical techniques, studies are limited either by their retrospective nature, small sample size and most importantly small duration of follow-up. This comprehensive review aims to amalgamate the evolution of various surgical techniques with regards to intrascleral lens fixation and suggests areas for future development.
    MeSH term(s) Humans ; Lens Implantation, Intraocular ; Lenses, Intraocular ; Postoperative Complications ; Retrospective Studies ; Sclera/surgery
    Language English
    Publishing date 2021-06-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-021-01571-5
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  3. Article ; Online: Silicone oil versus gas tamponade for giant retinal tear-associated fovea-sparing retinal detachment: a comparison of outcome.

    Banerjee, P J / Chandra, A / Petrou, P / Charteris, D G

    Eye (London, England)

    2017  Volume 31, Issue 9, Page(s) 1302–1307

    Abstract: PurposeSilicone oil is the most common choice of tamponade agent used when managing a giant retinal tear (GRT). Concern exists regarding its potential detrimental effect on vision. We herein report on visual and surgical outcomes of all patients treated ... ...

    Abstract PurposeSilicone oil is the most common choice of tamponade agent used when managing a giant retinal tear (GRT). Concern exists regarding its potential detrimental effect on vision. We herein report on visual and surgical outcomes of all patients treated at Moorfields Eye Hospital for a GRT over a five year period. We further analysed a subgroup of fovea-sparing retinal detachments (RD) treated by pars plana vitrectomy (PPV) with either silicone oil or gas tamponade.MethodsRetrospective comparative, non-randomised, cross-sectional review of patients with a new diagnosis of GRT from 1 September 2005 to 31 August 2010ResultsOne hundred twenty four eyes of 118 patients were identified with mean age of 45.5 years and median follow-up of 24 months. Subgroup analysis of fovea-sparing RDs (Silicone Oil n=49, Gas n=15) revealed visual loss (≥2 Snellen Lines of vision) in 49.0% (n=24) of patients managed with oil compared to 13.3% (n=2) of gas patients (P=0.019). In all, 73.3% (n=11) in the gas group achieved a final vision of 6/12 or better, compared to 36.7% (n=18) in the oil group (P=0.031). No difference was observed in eventual or primary anatomical success rate (100 vs 93.9%, and 66.7 vs 79.6%, gas vs oil, respectively, (P>0.1)). Postoperative complications were absent in 66.7% (n=10) of gas patients compared with 14.3% (n=7) of oil patients (P=0.002). Multiple variable linear regression determined tamponade choice as the only variable predictive of final visual acuity (P=0.046).ConclusionEyes with fovea-sparing GRT-related RDs managed with gas achieved a better visual outcome with fewer postoperative complications and no significant difference in anatomical success. A multicentre approach to investigate this further is advised.
    MeSH term(s) Cross-Sectional Studies ; Endotamponade/methods ; Female ; Fluorocarbons/administration & dosage ; Humans ; Male ; Middle Aged ; Postoperative Complications ; Retinal Perforations/physiopathology ; Retinal Perforations/surgery ; Retrospective Studies ; Silicone Oils/administration & dosage ; Sulfur Hexafluoride/administration & dosage ; Treatment Outcome ; Visual Acuity/physiology ; Vitrectomy/methods
    Chemical Substances Fluorocarbons ; Silicone Oils ; perflutren (CK0N3WH0SR) ; Sulfur Hexafluoride (WS7LR3I1D6)
    Language English
    Publishing date 2017-08-11
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/eye.2017.167
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  4. Article ; Online: A randomised controlled trial of adjunctive triamcinolone acetonide in eyes undergoing vitreoretinal surgery for open globe trauma - the ASCOT study.

    Charteris, David G / Cro, Suzie / Casswell, Edward / Edwards, Rhiannon Tudor / Ezeofor, Victory / Anthony, Bethany / Bunce, Catey / Robertson, Elizabeth / Kelly, Joanna / Murphy, Caroline / Banerjee, Philip / Cornelius, Victoria R

    Health technology assessment (Winchester, England)

    2023  Volume 27, Issue 12, Page(s) 1–50

    Abstract: ... LNO/1428, IRAS 156358, Local R&D registration CHAD 1031.: Funding: This project was funded ...

    Abstract Background: Eyes sustaining open globe trauma are at high risk of severe visual impairment. Proliferative vitreoretinopathy is the most common cause of retinal detachment and visual loss in eyes with open globe trauma. There is evidence from experimental studies and pilot clinical trials that the use of adjunctive steroid medication triamcinolone acetonide can reduce the incidence of proliferative vitreoretinopathy and improve outcomes of surgery for open globe trauma.
    Objective: The Adjunctive Steroid Combination in Ocular Trauma or ASCOT study aimed to investigate the clinical effectiveness of adjunctive triamcinolone acetonide given at the time of vitreoretinal surgery for open globe trauma.
    Design: A phase 3 multicentre double-masked randomised controlled trial randomising patients undergoing vitrectomy following open globe trauma to either adjunctive triamcinolone acetonide or standard care.
    Setting: Hospital vitreoretinal surgical services dealing with open globe trauma.
    Participants: Patients undergoing vitrectomy surgery who had sustained open globe trauma.
    Interventions: Triamcinolone acetonide 4 mg/0.1 ml into the vitreous cavity and 40 mg/1 ml sub-Tenon's or standard vitreoretinal surgery and postoperative care.
    Main outcome measures: The primary outcome was the proportion of patients with at least 10 letters of improvement in corrected visual acuity at six months. Secondary outcomes included retinal detachment secondary to proliferative vitreoretinopathy, retinal reattachment, macula reattachment, tractional retinal detachment, number of operations, hypotony, elevated intraocular pressure and quality of life. Health-related quality of life was assessed using the EuroQol Five Domain and Visual Function Questionnaire 25 questionnaires.
    Results: A total of 280 patients were randomised; 129 were analysed from the control group and 130 from the treatment group. The treatment group appeared, by chance, to have more severe pathology on presentation. The primary outcome (improvement in visual acuity) and principal secondary outcome (change in visual acuity) did not demonstrate any treatment benefit for triamcinolone acetonide. The proportion of patients with improvement in visual acuity was 47% for triamcinolone acetonide and 43% for standard care (odds ratio 1.03, 95% confidence interval 0.61 to 1.75,
    Conclusions: The use of combined intraocular and sub-Tenon's capsule triamcinolone acetonide is not recommended as an adjunct to vitrectomy surgery for intraocular trauma. Secondary outcome measures are suggestive of a negative effect of the adjunct, although the treatment group appeared to have more severe pathology on presentation.
    Future work: The use of alternative adjunctive medications in cases undergoing surgery for open globe trauma should be investigated. Refinement of clinical grading and case selection will enable better trail design for future studies.
    Trial registration: This trial is registered as ISRCTN 30012492, EudraCT number 2014-002193-37, REC 14/LNO/1428, IRAS 156358, Local R&D registration CHAD 1031.
    Funding: This project was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme (12/35/64) and will be published in full in
    MeSH term(s) Humans ; Triamcinolone Acetonide/therapeutic use ; Glucocorticoids/therapeutic use ; Retinal Detachment/surgery ; Retinal Detachment/complications ; Vitreoretinopathy, Proliferative/drug therapy ; Vitreoretinopathy, Proliferative/surgery ; Vitreoretinopathy, Proliferative/etiology ; Vitreoretinal Surgery/adverse effects ; Quality of Life
    Chemical Substances Triamcinolone Acetonide (F446C597KA) ; Glucocorticoids
    Language English
    Publishing date 2023-10-25
    Publishing country England
    Document type Randomized Controlled Trial ; Multicenter Study ; Clinical Trial, Phase III ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2006765-3
    ISSN 2046-4924 ; 1366-5278
    ISSN (online) 2046-4924
    ISSN 1366-5278
    DOI 10.3310/GNBJ1387
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  5. Article ; Online: Postretinal Detachment Retinal Displacement: How Best to Detect It?

    Casswell, Edward J / Heeren, Tjebo F C / Lee, Edward / Khabra, Komel / Yorston, David / Charteris, David G

    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde

    2019  Volume 243, Issue 4, Page(s) 280–287

    Abstract: Purpose: The reported incidence of postretinal detachment (RD) macular displacement varies markedly (14-72%). This may in part be due to the imaging modalities used. We compared the ability of 2 types of fundus autofluorescence (FAF) imaging modalities ... ...

    Abstract Purpose: The reported incidence of postretinal detachment (RD) macular displacement varies markedly (14-72%). This may in part be due to the imaging modalities used. We compared the ability of 2 types of fundus autofluorescence (FAF) imaging modalities to detect this phenomenon.
    Methods: Prospective study of 70 eyes with macula-involving RDs. 8 weeks postoperatively, patients underwent FAF imaging with 2 machines: a confocal scanning laser ophthalmoscope (cSLO) and a digital fundus camera (FC). Images were graded for the presence of hyperautofluorescent RPE (retinal pigment epithelium) ghost vessels, indicative of retinal displacement, by 2 masked, independent graders.
    Results: In total, 87.1% of FC images were gradable versus 88.6% of cSLO images. Retinal displacement was detectable in 61.4% of FC images versus 52.8% of cSLO images. Vessel shift often appeared more autofluorescent on FC imaging, but choroidal vessels were more visible. Cohen's agreement between the imaging modalities was 0.50, rated as moderate agreement. For both imaging modalities, the inter- and intragrader agreement was substantial, representing good test-retest reliability.
    Conclusions: Detection of post-RD retinal displacement was similar between FC and cSLO FAF imaging, with only moderate agreement between both modalities.
    MeSH term(s) Female ; Fluorescein Angiography/methods ; Follow-Up Studies ; Fundus Oculi ; Humans ; Male ; Middle Aged ; Ophthalmologic Surgical Procedures/methods ; Ophthalmoscopy/methods ; Postoperative Period ; Prospective Studies ; Retinal Diseases/diagnosis ; Retinal Diseases/surgery ; Retinal Pigment Epithelium/pathology
    Language English
    Publishing date 2019-12-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 209735-7
    ISSN 1423-0267 ; 0030-3755
    ISSN (online) 1423-0267
    ISSN 0030-3755
    DOI 10.1159/000504713
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  6. Article ; Online: Anterior chamber lens implantation in vitrectomised eyes.

    Negretti, G S / Lai, M / Petrou, P / Walker, R / Charteris, D

    Eye (London, England)

    2017  Volume 32, Issue 3, Page(s) 597–601

    Abstract: PurposeTo investigate long-term visual acuity (VA) outcomes and complication rates in vitrectomised eyes undergoing anterior chamber intraocular lens (ACIOL) insertion.Patients and methodsA single-centre, retrospective case series including all patients ... ...

    Abstract PurposeTo investigate long-term visual acuity (VA) outcomes and complication rates in vitrectomised eyes undergoing anterior chamber intraocular lens (ACIOL) insertion.Patients and methodsA single-centre, retrospective case series including all patients who had undergone ACIOL placement at the time of vitrectomy surgery or having had previous vitrectomy, between January 2007 and January 2013. Patients were identified using an electronic database and paper casefile notes were analysed for all patients. Patients were excluded if they had <3 months follow-up.ResultsTwo hundred and seventy-one patients were included in the analysis. Mean follow-up was 27 months. One hundred and forty-eight patients were vitrectomised before ACIOL placement. One hundred and twenty-three patients underwent vitrectomy at the time of ACIOL placement. Mean best-corrected visual acuity (BCVA) before ACIOL placement was 1.27 LogMar (SD 0.95). Mean BCVA at final follow-up was 0.51 LogMar (SD 0.66) (paired-sample T-test P<0.001). Forty (15%) patients developed postoperative cystoid macular oedema (CMO). Eighty-seven (32%) patients had an intraocular pressure (IOP) rise acutely post ACIOL insertion. Fifteen (6%) patients developed corneal decompensation. Five subsequently required corneal grafting. Sixteen patients had ACIOL displacement or instability requiring further surgery.ConclusionsACIOL insertion after vitrectomy is effective. Ninety-two per cent of patients maintained or gained VA, comparable to previous studies of ACIOL insertion post complicated cataract surgery. Raised IOP was the most frequent complication: 61 patients were on topical therapy at most recent follow-up. CMO tended to be acute. Corneal decompensation was infrequent.
    MeSH term(s) Adult ; Aged ; Anterior Chamber/surgery ; Aphakia/physiopathology ; Aphakia/surgery ; Female ; Humans ; Intraocular Pressure/physiology ; Lens Implantation, Intraocular/methods ; Lenses, Intraocular ; Male ; Middle Aged ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/diet therapy ; Postoperative Complications/etiology ; Retrospective Studies ; Visual Acuity/physiology ; Vitrectomy
    Language English
    Publishing date 2017-12-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/eye.2017.261
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  7. Article ; Online: Routine use of topical cyclopentolate as a predisposing factor to recurrent urinary tract infections in a susceptible adult.

    Banerjee, P J / Elgohary, M A / Charteris, D G

    Eye (London, England)

    2013  Volume 27, Issue 5, Page(s) 676

    MeSH term(s) Child Behavior Disorders/chemically induced ; Cyclopentolate/adverse effects ; Gait Ataxia/chemically induced ; Hallucinations/chemically induced ; Humans ; Male ; Mydriatics/adverse effects ; Speech Disorders/chemically induced
    Chemical Substances Mydriatics ; Cyclopentolate (I76F4SHP7J)
    Language English
    Publishing date 2013-03-01
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/eye.2013.29
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  8. Article ; Online: Cataract extraction after retinal detachment repair by vitrectomy: visual outcome and complications.

    Cole, C J / Charteris, D G

    Eye (London, England)

    2009  Volume 23, Issue 6, Page(s) 1377–1381

    Abstract: Aims: To determine the intraoperative and postoperative complications and visual outcome of eyes undergoing cataract extraction after previous retinal detachment repair by pars plana vitrectomy (PPV).: Methods: Retrospective analysis of 72 patients ... ...

    Abstract Aims: To determine the intraoperative and postoperative complications and visual outcome of eyes undergoing cataract extraction after previous retinal detachment repair by pars plana vitrectomy (PPV).
    Methods: Retrospective analysis of 72 patients who had cataract extraction by phacoemulsification having had retinal detachment repair by vitrectomy and internal tamponade.
    Results: Best-corrected visual acuity (BCVA) had improved in 53 (74%) of eyes at 3 weeks after cataract surgery and 65 (90%) at final follow-up. Fifty-three eyes (74%) attained 6/12 visual acuity at final follow-up compared with 19 (26%) eyes with a preoperative vision better than 6/12. There was a significant improvement in BCVA after cataract extraction (P<0.001). Poor vision was usually related to retinal comorbidity.Intraoperative events occurred in nine eyes (12.5%) including capsulorrhexis tears, zonular dehiscence and vitreous loss. Postoperative events occurred in 15 eyes (20.8%). Retinal re-detachment occurred in four eyes (5.6%).
    Conclusions: Cataract extraction after retinal detachment surgery by vitrectomy generally results in a significant visual improvement, however, there is an increased intraoperative and postoperative complication rate. The risk of retinal re-detachment may previously have been underestimated.
    MeSH term(s) Cataract/complications ; Female ; Humans ; Intraoperative Complications ; Male ; Phacoemulsification ; Postoperative Complications ; Retinal Detachment/complications ; Retinal Detachment/surgery ; Retrospective Studies ; Visual Acuity ; Vitrectomy
    Language English
    Publishing date 2009-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/eye.2008.255
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  9. Article ; Online: Spontaneous relocation of a trapped retrolenticular slow-release dexamethasone implant (Ozurdex) in a silicone oil-filled eye of a pseudophakic patient.

    Banerjee, P J / Petrou, P / Zvobgo, T M / Charteris, D G

    Eye (London, England)

    2014  Volume 28, Issue 8, Page(s) 1036–1037

    MeSH term(s) Dexamethasone/administration & dosage ; Female ; Glucocorticoids/administration & dosage ; Humans ; Macular Edema/drug therapy ; Prosthesis Failure/etiology ; Vitreous Body
    Chemical Substances Glucocorticoids ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2014-05-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/eye.2014.84
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  10. Article: Retinal detachment associated with excimer laser.

    Charteris, D G

    Current opinion in ophthalmology

    1999  Volume 10, Issue 3, Page(s) 173–176

    Abstract: Recent reports of retinal pathology associated with laser refractive surgery are documented. The overall risk of retinal disease following photorefractive keratectomy or laser-assisted in situ keratomileusis is discussed, and the potential causal ... ...

    Abstract Recent reports of retinal pathology associated with laser refractive surgery are documented. The overall risk of retinal disease following photorefractive keratectomy or laser-assisted in situ keratomileusis is discussed, and the potential causal associations between anterior segment laser and posterior segment pathology are assessed.
    MeSH term(s) Cornea/surgery ; Corneal Transplantation/methods ; Humans ; Incidence ; Laser Therapy/adverse effects ; Lasers, Excimer ; Photorefractive Keratectomy/adverse effects ; Refractive Surgical Procedures ; Retinal Detachment/epidemiology ; Retinal Detachment/etiology
    Language English
    Publishing date 1999-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1049383-9
    ISSN 1531-7021 ; 1040-8738
    ISSN (online) 1531-7021
    ISSN 1040-8738
    DOI 10.1097/00055735-199906000-00004
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