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  1. Article ; Online: Pseudo Koebner'S Phenomenon in Tinea.

    Karthick, Kannan / Anupama, Bains

    Journal of cutaneous medicine and surgery

    2023  Volume 27, Issue 1, Page(s) 80

    MeSH term(s) Humans ; Psoriasis ; Tinea/diagnosis
    Language English
    Publishing date 2023-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1361720-5
    ISSN 1615-7109 ; 1203-4754
    ISSN (online) 1615-7109
    ISSN 1203-4754
    DOI 10.1177/12034754221147296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Nitrofurantoin-Associated Acute Granulomatous Interstitial Nephritis.

    Anupama, B K / Sampat, Parth / Gambhir, Harvir S

    Journal of investigative medicine high impact case reports

    2021  Volume 9, Page(s) 23247096211001659

    Abstract: We report the case of a 71-year-old female who was incidentally found to have nonoliguric acute kidney injury on a routine workup for new-onset visual hallucination. Further history revealed inadvertent usage of nitrofurantoin for 3 months for an ... ...

    Abstract We report the case of a 71-year-old female who was incidentally found to have nonoliguric acute kidney injury on a routine workup for new-onset visual hallucination. Further history revealed inadvertent usage of nitrofurantoin for 3 months for an anticipated urological procedure. Renal biopsy demonstrated acute granulomatous interstitial nephritis. The renal function significantly improved following discontinuation of nitrofurantoin and corticosteroid administration. We highlight a rare association of nitrofurantoin with acute granulomatous interstitial nephritis through this case report.
    MeSH term(s) Acute Kidney Injury ; Aged ; Female ; Granuloma/chemically induced ; Humans ; Nephritis, Interstitial/chemically induced ; Nitrofurantoin/adverse effects
    Chemical Substances Nitrofurantoin (927AH8112L)
    Language English
    Publishing date 2021-04-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2710326-2
    ISSN 2324-7096 ; 2324-7096
    ISSN (online) 2324-7096
    ISSN 2324-7096
    DOI 10.1177/23247096211001659
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evaluation of Ocular Perfusion Pressure in Migraine Patients

    S Rashmi / KS Divyalakshmi / K Soujanya / B Anupama / H Pavithra

    Journal of Clinical and Diagnostic Research, Vol 17, Iss 10, Pp 05-

    A Case-control Study

    2023  Volume 08

    Abstract: Introduction: Vascular dysregulation is a common underlying factor between migraine and glaucoma. Fluctuations in Ocular Perfusion Pressure (OPP) can lead to ischaemia and damage to the optic nerve head. It is unclear if the risk of glaucoma in migraine ... ...

    Abstract Introduction: Vascular dysregulation is a common underlying factor between migraine and glaucoma. Fluctuations in Ocular Perfusion Pressure (OPP) can lead to ischaemia and damage to the optic nerve head. It is unclear if the risk of glaucoma in migraine patients is due to low OPP. Aim: To compare the OPP of migraine patients with healthy controls and assess the role of OPP as a risk factor for glaucoma in migraine patients. Materials and Methods: This case-control study was conducted from June 2019 to May 2020 at Yenepoya Medical College Hospital, Mangaluru, Karnataka, India. Adult patients of either gender, aged between 18 and 40 years, diagnosed with migraine, were included in the study. Intraocular Pressure (IOP), blood pressure, and OPP were measured in 94 migraine patients and compared with 94 age-matched controls. Data were analysed using Statistical Package for the Social Sciences (SPSS) version 23.0. Independent t-tests were used for comparison. Adjusted odds ratios were calculated using binary logistic regression, and a p-value <0.05 was considered statistically significant. Results: The mean IOP was 13.27±2.02 mmHg among cases and 13.38±1.87 mmHg among controls. The mean Systolic Blood Pressure (SBP) was 118.91±4.67 mmHg among cases and 116.09±5.18 mmHg among controls. The mean Diastolic Blood Pressure (DBP) was 77.72±4.48 mmHg among cases and 75.77±4.89 mmHg among controls. The mean OPP was 47.69±2.43 mmHg among cases and 46.08±2.46 mmHg among controls. The t-test values showed a statistically significant difference in SBP, DBP, and OPP between the two groups (p-value<0.05). Conclusion: The OPP in migraine patients differed significantly from that of the controls. However, further studies are needed to evaluate the relationship between perfusion pressure abnormalities and the risk of glaucoma in migraine patients.
    Keywords blood pressure ; intraocular pressure ; ischaemia ; glaucoma ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher JCDR Research and Publications Private Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: A Review of Acute Myocardial Injury in Coronavirus Disease 2019.

    B K, Anupama / Chaudhuri, Debanik

    Cureus

    2020  Volume 12, Issue 6, Page(s) e8426

    Abstract: In December 2019, an outbreak of pneumonia caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), occurred in Wuhan, Hubei province, China, and it has spread rapidly across the world, causing the coronavirus disease ... ...

    Abstract In December 2019, an outbreak of pneumonia caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), occurred in Wuhan, Hubei province, China, and it has spread rapidly across the world, causing the coronavirus disease 2019 (COVID-19) pandemic. Although SARS-CoV-2 infection predominantly results in pulmonary issues, accumulating evidence suggests the increased frequency of a variety of cardiovascular complications in patients with COVID-19. Acute cardiac injury, defined as elevated cardiac troponin levels, is the most reported cardiac abnormality in COVID-19 and strongly associated with mortality. In this article, we summarize the currently available data on the association of SARS-CoV-2 and COVID-19 with acute myocardial injury.
    Keywords covid19
    Language English
    Publishing date 2020-06-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.8426
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Transient Cardiomyopathy in a Patient With Coronavirus Disease-2019.

    Anupama, B K / Thapa, Simant S / Amzuta, Ioana

    Journal of investigative medicine high impact case reports

    2020  Volume 8, Page(s) 2324709620947577

    Abstract: A 66-year-old male patient with coronavirus disease-19 (COVID-19) developed cardiogenic shock with echocardiographic evidence of decreased left ventricular ejection fraction and global hypokinesia concomitant with a robust systemic inflammatory response. ...

    Abstract A 66-year-old male patient with coronavirus disease-19 (COVID-19) developed cardiogenic shock with echocardiographic evidence of decreased left ventricular ejection fraction and global hypokinesia concomitant with a robust systemic inflammatory response. Following the administration of convalescent plasma therapy and inotropic support, left ventricular function recovered fully in accordance with the decrease in the concentration of the inflammatory markers. Thus, we demonstrate the presence of transient reversible cardiomyopathy in a patient with severe COVID-19 and illustrate the association of acute cardiac dysfunction with profound systemic inflammation among COVID-19 patients.
    MeSH term(s) Aged ; Betacoronavirus ; Cardiomyopathies/complications ; Cardiomyopathies/immunology ; Cardiomyopathies/therapy ; Coronavirus Infections/complications ; Coronavirus Infections/immunology ; Coronavirus Infections/metabolism ; Coronavirus Infections/therapy ; Humans ; Immunization, Passive/methods ; Male ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/immunology ; Pneumonia, Viral/therapy ; Stroke Volume ; Treatment Outcome ; Ventricular Function, Left
    Keywords covid19
    Language English
    Publishing date 2020-08-18
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2710326-2
    ISSN 2324-7096 ; 2324-7096
    ISSN (online) 2324-7096
    ISSN 2324-7096
    DOI 10.1177/2324709620947577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Non-pruritic blisters over extensors in a young male.

    Kannan, Karthick / Bains, Anupama / Alam, Afroz / Bano, Nazneen / Thirunavukkarasu, Balamurugan

    Indian journal of dermatology, venereology and leprology

    2024  , Page(s) 1–4

    Language English
    Publishing date 2024-03-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 416068-x
    ISSN 0973-3922 ; 0019-5162 ; 0378-6323
    ISSN (online) 0973-3922
    ISSN 0019-5162 ; 0378-6323
    DOI 10.25259/IJDVL_22_2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Prevalence of Depression and Anxiety Among Medical Students and House Staff During the COVID-19 Health-Care Crisis.

    Gupta, Pratishtha / B K, Anupama / Ramakrishna, Kartik

    Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry

    2021  Volume 45, Issue 5, Page(s) 575–580

    Abstract: Objective: The objective of the study was to evaluate the prevalence of anxiety and depression among medical trainees during the initial wave of the COVID-19 pandemic.: Methods: This was a cross-sectional study of the prevalence of depression and ... ...

    Abstract Objective: The objective of the study was to evaluate the prevalence of anxiety and depression among medical trainees during the initial wave of the COVID-19 pandemic.
    Methods: This was a cross-sectional study of the prevalence of depression and anxiety among medical students, residents, and fellows at a medical university hospital in New York using self-reported PHQ-9 and GAD-7 screening tools administered via an anonymized survey. The study was conducted in April 2020.
    Results: The authors received 438 responses (33.4% response rate). Nearly half (44.5%) were medical students and female (56.6%). The prevalence of positive screen for depression (45.3%) and anxiety (48.1%) was high. Many reported moderate to severe depression (17.2%) and anxiety (20.3%). Over half (57.3%) experienced significant mood changes and inability to concentrate, and 14.6% had reconsidered their choice of profession since the start of the pandemic. Those who had reconsidered their profession had higher PHQ-9 [8.1 (6.4) vs 4.4 (4.3), p < 0.0001] and GAD-7 scores [8.3 (6.1) vs 4.7 (4.6), p < 0.0001], indicating adverse mental health partly contributed to their reconsideration of choice of profession. Women were more likely to screen positive for anxiety (OR: 1.68) and medical students more likely to screen positive for anxiety (OR: 2.55) and depression (OR: 2.74).
    Conclusion: The COVID-19 pandemic has placed great strain on health-care resources, including the mental health of medical trainees.
    MeSH term(s) Anxiety/epidemiology ; COVID-19 ; Cross-Sectional Studies ; Depression/epidemiology ; Female ; Humans ; Internship and Residency ; Pandemics ; Prevalence ; SARS-CoV-2 ; Students, Medical
    Language English
    Publishing date 2021-05-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1045331-3
    ISSN 1545-7230 ; 1042-9670
    ISSN (online) 1545-7230
    ISSN 1042-9670
    DOI 10.1007/s40596-021-01454-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Prolonged QT Interval in a Patient With Coronavirus Disease-2019: Beyond Hydroxychloroquine and Azithromycin.

    Anupama, B K / Adhikari, Soumya / Chaudhuri, Debanik

    Journal of investigative medicine high impact case reports

    2020  Volume 8, Page(s) 2324709620948407

    Abstract: Recent reports have suggested an increased risk of QT prolongation and subsequent life-threatening ventricular arrhythmias, particularly torsade de pointes, in patients with coronavirus disease-2019 (COVID-19) treated with hydroxychloroquine and ... ...

    Abstract Recent reports have suggested an increased risk of QT prolongation and subsequent life-threatening ventricular arrhythmias, particularly torsade de pointes, in patients with coronavirus disease-2019 (COVID-19) treated with hydroxychloroquine and azithromycin. In this article, we report the case of a 75-year-old female with a baseline prolonged QT interval in whom the COVID-19 illness resulted in further remarkable QT prolongation (>700 ms), precipitating recurrent self-terminating episodes of torsade de pointes that necessitated temporary cardiac pacing. Despite the correction of hypoxemia and the absence of reversible factors, such as adverse medication effects, electrolyte derangements, and usage of hydroxychloroquine/azithromycin, the QT interval remained persistently prolonged compared with the baseline with subsequent degeneration into ventricular tachycardia and death. Thus, we highlight that COVID-19 illness itself can potentially lead to further prolongation of QT interval and unmask fatal ventricular arrhythmias in patients who have a prolonged QT and low repolarization reserve at baseline.
    MeSH term(s) Aged ; Azithromycin/therapeutic use ; Betacoronavirus ; Coronavirus Infections/complications ; Coronavirus Infections/diet therapy ; Coronavirus Infections/drug therapy ; Coronavirus Infections/metabolism ; Coronavirus Infections/physiopathology ; Fatal Outcome ; Female ; Humans ; Hydroxychloroquine/therapeutic use ; Long QT Syndrome/drug therapy ; Long QT Syndrome/physiopathology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diet therapy ; Pneumonia, Viral/physiopathology ; Tachycardia, Ventricular/etiology ; Tachycardia, Ventricular/physiopathology
    Chemical Substances Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5)
    Keywords covid19
    Language English
    Publishing date 2020-06-18
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2710326-2
    ISSN 2324-7096 ; 2324-7096
    ISSN (online) 2324-7096
    ISSN 2324-7096
    DOI 10.1177/2324709620948407
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: A Review of Acute Myocardial Injury in Coronavirus Disease 2019

    Anupama, B. K. / Chaudhuri, Debanik

    Cureus

    Abstract: In December 2019, an outbreak of pneumonia caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), occurred in Wuhan, Hubei province, China, and it has spread rapidly across the world, causing the coronavirus disease ... ...

    Abstract In December 2019, an outbreak of pneumonia caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), occurred in Wuhan, Hubei province, China, and it has spread rapidly across the world, causing the coronavirus disease 2019 (COVID-19) pandemic Although SARS-CoV-2 infection predominantly results in pulmonary issues, accumulating evidence suggests the increased frequency of a variety of cardiovascular complications in patients with COVID-19 Acute cardiac injury, defined as elevated cardiac troponin levels, is the most reported cardiac abnormality in COVID-19 and strongly associated with mortality In this article, we summarize the currently available data on the association of SARS-CoV-2 and COVID-19 with acute myocardial injury
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #600043
    Database COVID19

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  10. Article ; Online: Design, in silico study, synthesis and in vitro evaluation of some N5-(1H-pyrazol-3-yl)-3H-benzo[d]imidazole-2,5-diamine derivatives as potential pancreatic lipase inhibitors for anti-obesity activity.

    Unnisa, A / Huwaimel, B / Almahmoud, S / Abouzied, A S / Younes, K M / Anupama, B / Kola, P K / Lakshmi, N V K C

    European review for medical and pharmacological sciences

    2022  Volume 26, Issue 19, Page(s) 7245–7255

    Abstract: Objective: The aim of the study is to design N5-(1H-pyrazol-3-yl)-3H-benzo[d]imidazole-2,5-diamine derivatives and evaluate its anti-obesity activity.: Materials and methods: A few pyrazole-fused benzimidazole derivatives were designed as potential ... ...

    Abstract Objective: The aim of the study is to design N5-(1H-pyrazol-3-yl)-3H-benzo[d]imidazole-2,5-diamine derivatives and evaluate its anti-obesity activity.
    Materials and methods: A few pyrazole-fused benzimidazole derivatives were designed as potential Pancreatic Lipase (PL) inhibitors. The designed N5-(1H-pyrazol-3-yl)-3H-benzo[d]imidazole-2,5-diamine derivatives have been screened using the Lipinski rule of five, ADMET analysis, acute toxicity prediction, and molecular docking. Later on, the derivatives which possess the most drug-likeness properties and displayed the most potent inhibition of the enzyme in molecular docking were synthesized. Then, in vitro enzyme assay was performed.
    Results: Orlistat used as the standard exhibited 91±1.68% inhibition of the enzyme, displayed binding affinity (BA) of only -4.5 kcal/mol with Pancreatic Lipase (PL), and made only one salt bridge attractive charge and carbon-hydrogen bond with ASP79 and TRP252, respectively. Compound 9 displayed the most potent activity (93±1.12% inhibition of P.L. and -9.5 kcal/mol BA). It has formed five conventional H- bonds with GLU253, ILE78, ASP79, PHE258, and one Pi-donor H- bond with ILE78. From the present investigation, we hereby reported (E)-N2-((naphthalene-1-yl)methylene)-N5-(1H-pyrazol-3-yl)-3H-benzo[d]imidazole-2,5-diamine as most potent PL inhibitor for the treatment of obesity, which can be further optimized by undergoing more studies using in vivo and in vitro models.
    Conclusions: (E)-N2-((naphthalene-1-yl)methylene)-N5-(1H-pyrazol-3-yl)-3H-benzo[d]imidazole-2,5-diamine as most potent PL inhibitor for the treatment of obesity which can be further optimized better using more in vivo and in vitro models. PL plays a critical role in digesting dietary fat. Therefore, PL inhibitors are verified as a potential therapy for treating obesity.
    MeSH term(s) Molecular Docking Simulation ; Lipase ; Diamines ; Orlistat/pharmacology ; Pyrazoles/pharmacology ; Imidazoles ; Benzimidazoles/pharmacology ; Naphthalenes ; Dietary Fats ; Carbon ; Structure-Activity Relationship
    Chemical Substances Lipase (EC 3.1.1.3) ; Diamines ; Orlistat (95M8R751W8) ; Pyrazoles ; Imidazoles ; Benzimidazoles ; Naphthalenes ; Dietary Fats ; Carbon (7440-44-0)
    Language English
    Publishing date 2022-10-20
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202210_29917
    Database MEDical Literature Analysis and Retrieval System OnLINE

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