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Book ; Thesis: Die Etablierung eines neuen Testsystems für die virologische Diagnostik basierend auf dem Prinzip der Split-Luciferase-Komplementierung

Decker, Annegrit Monika Maria

2018

Author's details	vorgelegt von Annegrit Monika Maria Decker
Language	German
Size	VII, 88 Blätter, Illustrationen, Diagramme, 30 cm
Publishing place	Freiburg im Breisgau
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Albert-Ludwigs-Universität Freiburg im Breisgau, 2018
HBZ-ID	HT019812089
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Virushepatitis A–E.

Decker, Annegrit / Neumann-Haefelin, Christoph / Thimme, Robert

Der Internist

2021 Volume 62, Issue 2, Page(s) 163–174

Abstract: Hepatitis viruses A-E cause acute and chronic liver inflammation and thus lead to significant morbidity and mortality worldwide. They differ significantly in their biology, course of disease and therapy options. While hepatitis A virus only causes acute ... ...

Title translation	Viral hepatitis A-E.
Abstract	Hepatitis viruses A-E cause acute and chronic liver inflammation and thus lead to significant morbidity and mortality worldwide. They differ significantly in their biology, course of disease and therapy options. While hepatitis A virus only causes acute infection, hepatitis B can become chronic, even reactivate or occur as coinfection with hepatitis D virus. Whereas these infections are preventable through vaccination, a vaccine does not exist against HCV. However, new direct antiviral agents reliably lead to cure of chronic hepatitis C. Hepatitis E virus frequently causes acute or-in case of immunosuppression-even chronic hepatitis. Continual screening of patients with elevated liver enzymes or risk groups using simple serological markers can enable virus-specific therapy of mostly asymptomatic chronic virus hepatitis, preventing the development of liver cirrhosis and hepatocellular carcinoma.
MeSH term(s)	Antiviral Agents/therapeutic use ; Hepatitis Viruses ; Hepatitis, Viral, Human/diagnosis ; Hepatitis, Viral, Human/drug therapy ; Hepatitis, Viral, Human/prevention & control ; Humans
Chemical Substances	Antiviral Agents
Language	German
Publishing date	2021-01-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2913-0
ISSN	1432-1289 ; 0020-9554
ISSN (online)	1432-1289
ISSN	0020-9554
DOI	10.1007/s00108-020-00923-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Ua VI Zs.380: Show issues

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Article: CME-Fortbildung. Erhöhte Leberwerte. Praktisches Vorgehen anhand von Fällen / CME-Fortbildungsfragen

Decker, Annegrit / Thimme, Robert

Hausarzt-Praxis

2019 Volume 14, Issue 6, Page(s) 9

Language	German
Document type	Article
ZDB-ID	2229849-6
ISSN	1661-6197
Database	Current Contents Medicine

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Zs.A 6266: Show issues

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Article ; Online: Der Lichen planus des Ösophagus – Eine unterschätzte Erkrankung.

Monasterio, Carmen / Decker, Annegrit / Schauer, Franziska / Büttner, Nico / Schmidt, Arthur / Schmitt-Gräff, Annette / Kreisel, Wolfgang

Laryngo- rhino- otologie

2023 Volume 102, Issue 4, Page(s) 272–281

Abstract: An involvement of the esophagus in patients with lichen planus was described for the first time in 1982. Ever since, it has been seen as a rarity. However, studies over the last 10 years have shown a higher prevalence than expected. It may even be ... ...

Title translation	Esophageal Lichen Planus - An Underdiagnosed Disease.
Abstract	An involvement of the esophagus in patients with lichen planus was described for the first time in 1982. Ever since, it has been seen as a rarity. However, studies over the last 10 years have shown a higher prevalence than expected. It may even be supposed that esophageal lichen planus (ELP) is more common than eosinophilic esophagitis. ELP mostly affects middleaged women. The principal symptom is dysphagia. Endoscopically, ELP is characterized by denudation and tearing of the mucosa, trachealization and hyperkeratosis and esophageal stenosis may occur in patients with long courses of the disease. Histologic findings including mucosal detachment, T-lymphocytic infiltrate, intraepithelial apoptosis (civatte bodies) and dyskeratosis are crucial. Direct immunofluorescence shows fibrinogen deposits along the basement membrane zone. So far, there is no well-established therapy but a treatment with topic steroids is effective in 2/3 of the patients. Common therapy of lichen planus of the skin seems to be ineffective for treatment of ELP. Symptomatic esophageal stenosis should be endoscopically dilated. ELP joins the group of "new" immunologic diseases of the esophagus.
MeSH term(s)	Humans ; Female ; Esophageal Stenosis ; Lichen Planus/diagnosis ; Lichen Planus/pathology ; Deglutition Disorders ; Skin/pathology
Language	German
Publishing date	2023-04-11
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	96005-6
ISSN	1438-8685 ; 0340-1588 ; 0935-8943
ISSN (online)	1438-8685
ISSN	0340-1588 ; 0935-8943
DOI	10.1055/a-1861-7187
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Ul II Zs.95: Show issues

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Article ; Online: Esophageal lichen planus: Current knowledge, challenges and future perspectives.

Decker, Annegrit / Schauer, Franziska / Lazaro, Adhara / Monasterio, Carmen / Schmidt, Arthur Robert / Schmitt-Graeff, Annette / Kreisel, Wolfgang

World journal of gastroenterology

2022 Volume 28, Issue 41, Page(s) 5893–5909

Abstract: Lichen planus (LP) is a frequent, chronic inflammatory disease involving the skin, mucous membranes and/or skin appendages. Esophageal involvement in lichen planus (ELP) is a clinically important albeit underdiagnosed inflammatory condition. This ... ...

Abstract	Lichen planus (LP) is a frequent, chronic inflammatory disease involving the skin, mucous membranes and/or skin appendages. Esophageal involvement in lichen planus (ELP) is a clinically important albeit underdiagnosed inflammatory condition. This narrative review aims to give an overview of the current knowledge on ELP, its prevalence, pathogenesis, clinical manifestation, diagnostic criteria, and therapeutic options in order to provide support in clinical management. Studies on ELP were collected using PubMed/Medline. Relevant clinical and therapeutical characteristics from published patient cohorts including our own cohort were extracted and summarized. ELP mainly affects middle-aged women. The principal symptom is dysphagia. However, asymptomatic cases despite progressed macroscopic esophageal lesions may occur. The pathogenesis is unknown, however an immune-mediated mechanism is probable. Endoscopically, ELP is characterized by mucosal denudation and tearing, trachealization, and hyperkeratosis. Scarring esophageal stenosis may occur in chronic courses. Histologic findings include mucosal detachment, T-lymphocytic infiltrations, epithelial apoptosis (Civatte bodies), dyskeratosis, and hyperkeratosis. Direct immuno-fluorescence shows fibrinogen deposits along the basement membrane zone. To date, there is no established therapy. However, treatment with topical steroids induces symptomatic and histologic improvement in two thirds of ELP patients in general. More severe cases may require therapy with immunosuppressors. In symptomatic esophageal stenosis, endoscopic dilation may be necessary. ELP may be regarded as a precancerous condition as transition to squamous cell carcinoma has been documented in literature. ELP is an underdiagnosed yet clinically important differential diagnosis for patients with unclear dysphagia or esophagitis. Timely diagnosis and therapy might prevent potential sequelae such as esophageal stenosis or development of invasive squamous cell carcinoma. Further studies are needed to gain more knowledge about the pathogenesis and treatment options.
MeSH term(s)	Humans ; Middle Aged ; Female ; Esophageal Diseases/diagnosis ; Esophageal Diseases/therapy ; Esophageal Diseases/pathology ; Esophageal Stenosis ; Deglutition Disorders/etiology ; Lichen Planus/diagnosis ; Lichen Planus/drug therapy ; Carcinoma, Squamous Cell/complications
Language	English
Publishing date	2022-11-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v28.i41.5893
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Article: Der Lichen planus des Ösophagus – Eine unterschätzte Erkrankung

Monasterio, Carmen / Decker, Annegrit / Schauer, Franziska / Büttner, Nico / Schmidt, Arthur / Schmitt-Gräff, Annette / Kreisel, Wolfgang

Aktuelle Dermatologie

2023 Volume 49, Issue 04, Page(s) 164–173

Abstract: Eine Beteiligung des Ösophagus bei der Hauterkrankung Lichen planus wurde erstmals 1982 beschrieben und fast 30 Jahre lang als eine Rarität angesehen. Untersuchungen der letzten 10 Jahre aber zeigen, dass diese Erkrankung weniger selten ist als ... ...

Abstract	Eine Beteiligung des Ösophagus bei der Hauterkrankung Lichen planus wurde erstmals 1982 beschrieben und fast 30 Jahre lang als eine Rarität angesehen. Untersuchungen der letzten 10 Jahre aber zeigen, dass diese Erkrankung weniger selten ist als angenommen. Es ist sogar anzunehmen, dass der ösophageale Lichen planus (Esophageal Lichen planus, ELP) häufiger ist als die Eosinophile Ösophagitis (EoE). Die Ösophagusbeteiligung betrifft meist Frauen im mittleren Alter. Das Hauptsymptom ist eine Dysphagie. Endoskopisch erkennt man in der Speiseröhre eine charakteristische Schleimhautablösung, eine Trachealisierung, und gelegentlich Hyperkeratosen und bei langem Bestehen auch Stenosen. Wegweisend ist die Histologie mit einer subepithelialen Ablösung sowie einem bandförmigen Infiltrat aus T-Lymphozyten, dem Nachweis von apoptotischen Keratinozyten (Civatte Bodies) und Dyskeratosen. Die direkte Immunfluoreszenz zeigt Fibrinogen-Ablagerungen entlang der Basalmembran. Eine etablierte Therapie gibt es bisher nicht. Die Behandlung mit topischen Steroiden ist in ⅔ der Fälle wirksam. Eine Therapie wie beim klassischen Lichen planus scheint unwirksam zu sein. Bei symptomatischen Stenosen kann eine Dilatation indiziert sein. Der ELP reiht sich in die Gruppe der „neuen“ immunologisch vermittelten Erkrankungen des Ösophagus ein.
Language	German
Publishing date	2023-04-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2072318-0
ISSN	1438-938X ; 0340-2541
ISSN (online)	1438-938X
ISSN	0340-2541
DOI	10.1055/a-1753-7120
Database	Thieme publisher's database

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Article ; Online: Comparison between traumatic and atraumatic over-the-scope clips in patients with duodenal ulcer bleeding: a retrospective analysis with propensity score-based matching.

Hollenbach, Marcus / Decker, Annegrit / Schmidt, Arthur / Möschler, Oliver / Jung, Carlo / Blasberg, Tobias / Seif, Ali Amir Hosseini / Vu Trung, Kien / Hoffmeister, Albrecht / Hochberger, Jürgen / Ellenrieder, Volker / Wedi, Edris

Gastrointestinal endoscopy

2023 Volume 98, Issue 1, Page(s) 51–58.e2

Abstract: Background and aims: Over-the-scope clips (OTSCs) substantially improved the endoscopic armamentarium for the treatment of severe GI bleeding and can potentially overcome limitations of standard clips. Data indicate a superiority of OTSCs in hemostasis ... ...

Abstract	Background and aims: Over-the-scope clips (OTSCs) substantially improved the endoscopic armamentarium for the treatment of severe GI bleeding and can potentially overcome limitations of standard clips. Data indicate a superiority of OTSCs in hemostasis as first- and second-line therapy. However, the impact of the OTSC designs, in particular the traumatic (-t) or atraumatic (-a) type, in duodenal ulcer bleeding has not been analyzed so far. Methods: This was a retrospective analysis of a prospective collected database from 2009 to 2020 of 6 German endoscopic centers. All patients who underwent emergency endoscopy and were treated using an OTSC for duodenal ulcer bleeding were included. OTSC-t and OTSC-a patients were compared by the Fisher exact test, χ Results: The entire cohort comprised 173 patients (93 OTSC-a, 80 OTSC-t). Age, gender, anticoagulant therapy, Rockall score, and treatment regimen had similar distributions in the 2 groups. However, the OTSC-t group showed significantly more active bleeding ulcers (Forrest Ia/b). Matching identified 132 patients (66 in both groups) with comparable baseline characteristics. Initial bleeding hemostasis (OTSC-a, 90.9%; OTSC-t, 87.9%; P = .82) and 72-hour mortality (OTSC-a, 4.5%; OTSC-t, 6.0%; P > .99) were not significantly different, but the OTSC-t group revealed a clearly higher rate of recurrent bleeding (34.9% vs 7.6%, P < .001) and necessity of red blood cell transfusions (5.1 ± 3.4 vs 2.5 ± 2.4 concentrates, P < .001). Conclusions: For OTSC use, the OTSC-a should be the preferred option for duodenal ulcer bleeding.
MeSH term(s)	Humans ; Hemostasis, Endoscopic/adverse effects ; Duodenal Ulcer/complications ; Duodenal Ulcer/surgery ; Retrospective Studies ; Prospective Studies ; Propensity Score ; Peptic Ulcer Hemorrhage/surgery ; Peptic Ulcer Hemorrhage/etiology ; Endoscopy, Gastrointestinal ; Treatment Outcome
Language	English
Publishing date	2023-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2023.01.051
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Zs.B 283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Der Lichen planus des Ösophagus – Eine unterschätzte Erkrankung.

Monasterio, Carmen / Decker, Annegrit / Schauer, Franziska / Büttner, Nico / Schmidt, Arthur / Schmitt-Gräff, Annette / Kreisel, Wolfgang

Zeitschrift fur Gastroenterologie

2021 Volume 59, Issue 5, Page(s) 460–469

Title translation	Esophageal Lichen Planus - an Underdiagnosed Disease.
Abstract	An involvement of the esophagus in patients with lichen planus was described for the first time in 1982. Ever since, it has been seen as a rarity. However, studies over the last 10 years have shown a higher prevalence than expected. It may even be supposed that esophageal lichen planus (ELP) is more common than eosinophilic esophagitis. ELP mostly affects middle-aged women. The principal symptom is dysphagia. Endoscopically, ELP is characterized by denudation and tearing of the mucosa, trachealization and hyperkeratosis and esophageal stenosis may occur in patients with long courses of the disease. Histologic findings including mucosal detachment, T-lymphocytic infiltrate, intraepithelial apoptosis (civatte bodies) and dyskeratosis are crucial. Direct immunofluorescence shows fibrinogen deposits along the basement membrane zone. So far, there is no well-established therapy but a treatment with topic steroids is effective in 2/3 of the patients. Common therapy of lichen planus of the skin seems to be ineffective for treatment of ELP. Symptomatic esophageal stenosis should be endoscopically dilated. ELP joins the group of "new" immunologic diseases of the esophagus.
MeSH term(s)	Deglutition Disorders ; Esophageal Diseases/diagnosis ; Esophageal Diseases/epidemiology ; Esophageal Stenosis/diagnosis ; Esophageal Stenosis/epidemiology ; Female ; Humans ; Lichen Planus/diagnosis ; Lichen Planus/epidemiology ; Middle Aged ; Mucous Membrane
Language	German
Publishing date	2021-04-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	201387-3
ISSN	1439-7803 ; 0172-8504 ; 0044-2771
ISSN (online)	1439-7803
ISSN	0172-8504 ; 0044-2771
DOI	10.1055/a-1378-9380
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Zs.A 111: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Prolonged SARS-CoV-2 shedding and mild course of COVID-19 in a patient after recent heart transplantation.

Decker, Annegrit / Welzel, Markus / Laubner, Katharina / Grundmann, Sebastian / Kochs, Georg / Panning, Marcus / Thimme, Robert / Bode, Christoph / Wagner, Dirk / Lother, Achim

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2020 Volume 20, Issue 11, Page(s) 3239–3245

Abstract: In the coronavirus disease 2019 (COVID-19) pandemic, organ transplant recipients are considered to be at high risk for an unfavorable outcome. However, in particular the role of immunosuppression in patients infected with severe acute respiratory ... ...

Abstract	In the coronavirus disease 2019 (COVID-19) pandemic, organ transplant recipients are considered to be at high risk for an unfavorable outcome. However, in particular the role of immunosuppression in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains undetermined. Here, we present a 62-year-old male COVID-19 patient with recent heart transplantation who developed only mild symptoms, but had prolonged virus shedding, and summarize the available data on COVID-19 in cardiac allograft recipients. Initially the patient presented with a transient episode of fever and sore throat but no other symptoms, in particular no cough or dyspnea at rest. After diagnosis, immunosuppression was continued unchanged. On day 7, his temperature increased again with concurrent mild rise of C-reactive protein, IL-6, and pro-B-type natriuretic peptide levels. Hydroxychloroquine was started and continued for 7 days. While the patient no longer had clinical symptoms 20 days after initial presentation, virus culture of throat swabs on days 18 and 21 confirmed active virus replication and SARS-CoV-2 PCR remained positive on day 35 with copy numbers similar to the onset of infection. In conclusion, the immunosuppression regimen in transplant recipients with mild COVID-19-associated symptoms may be continued unchanged. However, it may contribute to delayed virus polymerase chain reaction conversion and thus possible prolonged infectivity.
MeSH term(s)	Aged ; Antiviral Agents/therapeutic use ; COVID-19/epidemiology ; COVID-19/virology ; Comorbidity ; Heart Failure/epidemiology ; Heart Failure/surgery ; Heart Transplantation/methods ; Humans ; Male ; Middle Aged ; Pandemics ; RNA, Viral/analysis ; SARS-CoV-2/genetics ; Transplant Recipients ; Virus Shedding ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents ; RNA, Viral
Keywords	covid19
Language	English
Publishing date	2020-07-04
Publishing country	United States
Document type	Case Reports
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.16133
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Article ; Online: Prolonged SARS‐CoV‐2 shedding and mild course of COVID‐19 in a patient after recent heart transplantation

Decker, Annegrit / Welzel, Markus / Laubner, Katharina / Grundmann, Sebastian / Kochs, Georg / Panning, Marcus / Thimme, Robert / Bode, Christoph / Wagner, Dirk / Lother, Achim

American Journal of Transplantation ; ISSN 1600-6135 1600-6143

2020

Keywords	Immunology and Allergy ; Pharmacology (medical) ; Transplantation ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
DOI	10.1111/ajt.16133
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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