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  1. Article ; Online: Characteristics of the 6th Japanese wave of COVID-19 in hemodialysis patients.

    Haruta, Munenori / Otsubo, Shigeru / Otsubo, Yuriko

    Renal replacement therapy

    2022  Volume 8, Issue 1, Page(s) 61

    Abstract: Background: We examined the clinical characteristics of hemodialysis patients with COVID-19 during the 6th wave of infection (mainly Omicron variant) in Japan.: Methods: Hemodialysis patients admitted in January 2022 and thereafter were grouped as ... ...

    Abstract Background: We examined the clinical characteristics of hemodialysis patients with COVID-19 during the 6th wave of infection (mainly Omicron variant) in Japan.
    Methods: Hemodialysis patients admitted in January 2022 and thereafter were grouped as the 6th wave group (
    Results: The proportion of vaccinations was significantly higher in the 6th wave group than in the 1st-5th wave group (96.2% vs 10.6%,
    Conclusion: The prognosis of hemodialysis patients in the 6th wave group was good. The vaccination and advances in the treatment may have contributed to the outcomes.
    Language English
    Publishing date 2022-12-02
    Publishing country England
    Document type Journal Article
    ISSN 2059-1381
    ISSN (online) 2059-1381
    DOI 10.1186/s41100-022-00451-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Globalization and development

    Otsubo, Shigeru

    2016  

    Author's details ed. by Shigeru Thomas Otsubo
    Keywords Globalization/Economic aspects
    Language English
    Dates of publication 2016-9999
    Size 3 volumes cm
    Publisher Routledge
    Publishing place London u.a.
    Document type Book
    Database ECONomics Information System

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  3. Book: Country experiences

    Otsubo, Shigeru

    (Globalization and development ; / edited by Shigeru Thomas Otsubo ; volume 2)

    2016  

    Author's details edited by Shigeru Thomas Otsubo
    Series title Globalization and development
    / edited by Shigeru Thomas Otsubo ; volume 2
    Keywords Entwicklung ; Globalisierung ; Asien ; Afrika
    Language English
    Size xxxii, 288 Seiten, 1 Illustration, Diagramme
    Publisher Routledge
    Publishing place London ; New York
    Document type Book
    Note Enth. 8 Beitr.
    ISBN 9781138781566 ; 9781138781597 ; 9781315681641 ; 1138781568 ; 1138781592 ; 1315681641
    Database ECONomics Information System

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  4. Book: In search of a new development paradigm

    Otsubo, Shigeru

    (Globalization and development ; / edited by Shigeru Thomas Otsubo ; volume 3)

    2016  

    Author's details edited by Shigeru Thomas Otsubo
    Series title Globalization and development
    / edited by Shigeru Thomas Otsubo ; volume 3
    Keywords Entwicklung ; Wirtschaftswachstum ; Nachhaltige Entwicklung ; Globalisierung
    Language English
    Size xxx, 295 Seiten, 1 Illustration, Diagramme
    Publisher Routledge
    Publishing place London ; New York
    Document type Book
    Note Enth. 10 Beitr.
    ISBN 9781138932265 ; 9781138932272 ; 9781315678344 ; 1138932264 ; 1138932272 ; 1315678349
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  5. Book: Leading issues in development with globalization

    Otsubo, Shigeru

    (Globalization and development ; / edited by Shigeru Thomas Otsubo ; volume 1)

    2016  

    Author's details edited by Shigeru Thomas Otsubo
    Series title Globalization and development
    / edited by Shigeru Thomas Otsubo ; volume 1
    Keywords Economic development ; Millenium Development Goals ; Globalisierung
    Language English
    Size xxxi, 380 Seiten, Illustrationen, Diagramme
    Publisher Routledge
    Publishing place London ; New York
    Document type Book
    Note Enth. 12 Beitr.
    ISBN 9781138781511 ; 9781138781542 ; 9781315687102 ; 1138781517 ; 1138781541 ; 1315687100
    Database ECONomics Information System

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  6. Article ; Online: Adding High-Dose Spironolactone to Tolvaptan Improves Acute Decompensated Heart Failure Due to Obstructive Hypertrophic Cardiomyopathy and Aortic Stenosis: A Case Report.

    Kajimoto, Katsuya / Otsubo, Shigeru

    The American journal of case reports

    2019  Volume 20, Page(s) 1006–1010

    Abstract: BACKGROUND In the setting of acute decompensated heart failure (ADHF), tolvaptan, a selective V₂ receptor antagonist, did not alter plasma renin activity or angiotensin II level, but significantly increased plasma aldosterone by the activation of V₁ₐ ... ...

    Abstract BACKGROUND In the setting of acute decompensated heart failure (ADHF), tolvaptan, a selective V₂ receptor antagonist, did not alter plasma renin activity or angiotensin II level, but significantly increased plasma aldosterone by the activation of V₁ₐ receptor, suggesting that a high-dose mineralocorticoid receptor antagonist (MRA) combined with a V₂ receptor antagonist might be of interest, especially in ADHF patients. However, in the setting of ADHF, the short-term and long-term efficacy of a high-dose MRA combined with tolvaptan remains unclear. CASE REPORT An 86-year-old woman with a history of chronic HF with a preserved ejection fraction due to obstructive hypertrophic cardiomyopathy and severe aortic stenosis was transferred to our hospital complaining of persistent dyspnea (New York Heart Association class IV). She did not respond to standard therapy with tolvaptan (15.0 mg/day). However, the present case demonstrated that adding high-dose spironolactone (100 mg/day) to low-dose tolvaptan (15.0 mg/day) is safe and well tolerated, resulting in an increase in urine output and improvement of the symptoms or signs of ADHF in a patient who was refractory to loop diuretics and tolvaptan. CONCLUSIONS The short- and long-term efficacy of high-dose spironolactone combined with low-dose tolvaptan may be associated with an attenuation of the aldosterone level, which is increased through V₁ₐ activation by vasopressin during tolvaptan administration.
    MeSH term(s) Acute Disease ; Aged, 80 and over ; Antidiuretic Hormone Receptor Antagonists/administration & dosage ; Aortic Valve Stenosis/complications ; Aortic Valve Stenosis/drug therapy ; Cardiomyopathy, Hypertrophic/complications ; Cardiomyopathy, Hypertrophic/drug therapy ; Drug Therapy, Combination ; Dyspnea ; Female ; Heart Failure/drug therapy ; Heart Failure/etiology ; Humans ; Mineralocorticoid Receptor Antagonists/administration & dosage ; Spironolactone/administration & dosage ; Tolvaptan/administration & dosage
    Chemical Substances Antidiuretic Hormone Receptor Antagonists ; Mineralocorticoid Receptor Antagonists ; Tolvaptan (21G72T1950) ; Spironolactone (27O7W4T232)
    Language English
    Publishing date 2019-07-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.917060
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: Globalization and Development Volume III

    Otsubo, Shigeru Thomas

    In search of a new development paradigm

    2015  

    Language English
    Size Online-Ressource (291 p)
    Publisher Taylor and Francis
    Publishing place s.l
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9781138932265 ; 1138932264
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Book ; Online: Globalization and Development Volume II

    Otsubo, Shigeru Thomas

    Country experiences

    2015  

    Language English
    Size Online-Ressource (281 p)
    Publisher Taylor and Francis
    Publishing place s.l
    Document type Book ; Online
    Note Description based upon print version of record
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  9. Book ; Online: Globalization and Development Volume III

    Otsubo, Shigeru Thomas

    In search of a new development paradigm

    2015  

    Language English
    Size Online-Ressource (326 p)
    Document type Book ; Online
    Note Description based upon print version of record
    Database ECONomics Information System

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  10. Book ; Online: Globalization and Development Volume II

    Otsubo, Shigeru Thomas

    Country experiences

    2015  

    Language English
    Size Online-Ressource (321 p)
    Document type Book ; Online
    Note Description based upon print version of record
    ISBN 9781138781566 ; 1138781568
    Database ECONomics Information System

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