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  1. Article ; Online: Autophagy in disease: hunger for translation.

    Pentimalli, Francesca

    Cell death & disease

    2019  Volume 10, Issue 3, Page(s) 247

    MeSH term(s) Adenosine Triphosphate/metabolism ; Apoptosis/physiology ; Autophagy/genetics ; Autophagy/immunology ; Autophagy/physiology ; Cell Death/genetics ; Cell Death/physiology ; Immunity, Innate/physiology ; Mitophagy/physiology ; Neoplasms ; Neoplastic Stem Cells/metabolism ; Neovascularization, Pathologic/metabolism ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
    Chemical Substances Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2019-02-17
    Publishing country England
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-019-1419-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Empowering Persons with Autism Through Cross-Reality and Conversational Agents.

    Garzotto, Franca / Gianotti, Mattia / Patti, Alberto / Pentimalli, Francesca / Vona, Francesco

    IEEE transactions on visualization and computer graphics

    2024  Volume 30, Issue 5, Page(s) 2591–2601

    Abstract: Autism Spectrum Disorder is a neurodevelopmental condition that can affect autonomy and independence. Our research explores the integration of Cross-Reality and Conversational Agents for Autistic persons to improve ability and confidence in everyday life ...

    Abstract Autism Spectrum Disorder is a neurodevelopmental condition that can affect autonomy and independence. Our research explores the integration of Cross-Reality and Conversational Agents for Autistic persons to improve ability and confidence in everyday life situations. We combine two technologies of the Virtual-Real continuum. User experiences unfold from the simulation of tasks in VR to the execution of similar tasks supported by AR in the real world. A speech-based Conversational Agent is integrated with both VR and AR. It provides contextualized help, promotes generalization, and stimulates users to apply what they learned in the virtual space. The paper presents the approach and describes an empirical study involving 17 young Autistic persons.
    MeSH term(s) Humans ; Autistic Disorder ; Autism Spectrum Disorder ; Computer Graphics ; Learning ; Power, Psychological
    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Journal Article
    ISSN 1941-0506
    ISSN (online) 1941-0506
    DOI 10.1109/TVCG.2024.3372110
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Updates from the TP53 universe.

    Pentimalli, Francesca

    Cell death and differentiation

    2017  Volume 25, Issue 1, Page(s) 10–12

    MeSH term(s) Animals ; Humans ; Neoplasms/genetics ; Neoplasms/metabolism ; Tumor Suppressor Protein p53/deficiency ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
    Chemical Substances Tumor Suppressor Protein p53
    Language English
    Publishing date 2017-11-10
    Publishing country England
    Document type Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1225672-9
    ISSN 1476-5403 ; 1350-9047
    ISSN (online) 1476-5403
    ISSN 1350-9047
    DOI 10.1038/cdd.2017.190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4230: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 80: Show issues

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  4. Article ; Online: BCL2: a 30-year tale of life, death and much more to come.

    Pentimalli, Francesca

    Cell death and differentiation

    2017  Volume 25, Issue 1, Page(s) 7–9

    MeSH term(s) Apoptosis ; Humans ; Proto-Oncogene Proteins c-bcl-2/metabolism
    Chemical Substances Proto-Oncogene Proteins c-bcl-2
    Language English
    Publishing date 2017-11-10
    Publishing country England
    Document type Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1225672-9
    ISSN 1476-5403 ; 1350-9047
    ISSN (online) 1476-5403
    ISSN 1350-9047
    DOI 10.1038/cdd.2017.189
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4230: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 80: Show issues

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  5. Article ; Online: Cancer, immunity and inflammation. Report from the CDD Cambridge Conferences 2018 and 2019.

    Liccardi, Gianmaria / Pentimalli, Francesca

    Cell death & disease

    2019  Volume 10, Issue 11, Page(s) 798

    MeSH term(s) History, 21st Century ; Humans ; Inflammation/immunology ; Neoplasms/immunology
    Language English
    Publishing date 2019-10-22
    Publishing country England
    Document type Clinical Conference ; Historical Article ; Journal Article
    ZDB-ID 2541626-1
    ISSN 2041-4889 ; 2041-4889
    ISSN (online) 2041-4889
    ISSN 2041-4889
    DOI 10.1038/s41419-019-2032-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Intratumor microbiota as a novel potential prognostic indicator in mesothelioma.

    Pentimalli, Francesca / Krstic-Demonacos, Marija / Costa, Caterina / Mutti, Luciano / Bakker, Emyr Yosef

    Frontiers in immunology

    2023  Volume 14, Page(s) 1129513

    Abstract: Introduction: Despite increased attention on immunotherapy, primarily immune checkpoint blockade, as a therapeutic approach for mesothelioma (MMe), its efficacy and tolerability remain questioned. One potential explanation for different responses to ... ...

    Abstract Introduction: Despite increased attention on immunotherapy, primarily immune checkpoint blockade, as a therapeutic approach for mesothelioma (MMe), its efficacy and tolerability remain questioned. One potential explanation for different responses to immunotherapy is the gut and intratumor microbiota; however, these remain an underexplored facet of MMe. This article highlights the cancer intratumor microbiota as a novel potential prognostic indicator in MMe.
    Methods: TCGA data on 86 MMe patients from cBioPortal underwent bespoke analysis. Median overall survival was used to divide patients into "Low Survivors" and "High Survivors". Comparison of these groups generated Kaplan-Meier survival analysis, differentially expressed genes (DEGs), and identification of differentially abundant microbiome signatures. Decontamination analysis refined the list of signatures, which were validated as an independent prognostic indicator through multiple linear regression modelling and Cox proportional hazards modelling. Finally, functional annotation analysis on the list of DEGs was performed to link the data together.
    Results: 107 genera signatures were significantly associated with patient survival (positively or negatively), whilst clinical characteristic comparison between the two groups demonstrated that epithelioid histology was more common in "High Survivors" versus biphasic in "Low Survivors". Of the 107 genera, 27 had published articles related to cancer, whilst only one (Klebsiella) had MMe-related published articles. Functional annotation analysis of the DEGs between the two groups highlighted fatty acid metabolism as the most enriched term in "High Survivors", whilst for "Low Survivors" the enriched terms primarily related to cell cycle/division. Linking these ideas and findings together is that the microbiome influences, and is influenced by, lipid metabolism. Finally, to validate the independent prognostic value of the microbiome, multiple linear regression modelling as well as Cox proportional hazards modelling were employed, with both approaches demonstrating that the microbiome was a better prognostic indicator than patient age or stage of the cancer.
    Discussion: The findings presented herein, alongside the very limited literature from scoping searches to validate the genera, highlight the microbiome and microbiota as a potentially rich source of fundamental analysis and prognostic value. Further in vitro studies are needed to elucidate the molecular mechanisms and functional links that may lead to altered survival.
    MeSH term(s) Humans ; Prognosis ; Mesothelioma, Malignant ; Mesothelioma/pathology ; Microbiota
    Chemical Substances MME (78185-58-7)
    Language English
    Publishing date 2023-03-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1129513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: CONFIRM trial: what is the real efficacy of second-line immunotherapy in mesothelioma?

    Correale, Pierpaolo / Pentimalli, Francesca / Nardone, Valerio / Giordano, Antonio / Mutti, Luciano

    The Lancet. Oncology

    2021  Volume 23, Issue 1, Page(s) e13

    Language English
    Publishing date 2021-12-30
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(21)00702-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5696: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 460: Show issues

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  8. Article: The Emerging Role of Cyclin-Dependent Kinase Inhibitors in Treating Diet-Induced Obesity: New Opportunities for Breast and Ovarian Cancers?

    Benot-Dominguez, Reyes / Cimini, Annamaria / Barone, Daniela / Giordano, Antonio / Pentimalli, Francesca

    Cancers

    2022  Volume 14, Issue 11

    Abstract: Overweight and obesity constitute the most impactful lifestyle-dependent risk factors for cancer and have been tightly linked to a higher number of tumor-related deaths nowadays. The excessive accumulation of energy can lead to an imbalance in the level ... ...

    Abstract Overweight and obesity constitute the most impactful lifestyle-dependent risk factors for cancer and have been tightly linked to a higher number of tumor-related deaths nowadays. The excessive accumulation of energy can lead to an imbalance in the level of essential cellular biomolecules that may result in inflammation and cell-cycle dysregulation. Nutritional strategies and phytochemicals are gaining interest in the management of obesity-related cancers, with several ongoing and completed clinical studies that support their effectiveness. At the same time, cyclin-dependent kinases (CDKs) are becoming an important target in breast and ovarian cancer treatment, with various FDA-approved CDK4/6 inhibitors that have recently received more attention for their potential role in diet-induced obesity (DIO). Here we provide an overview of the most recent studies involving nutraceuticals and other dietary strategies affecting cell-cycle pathways, which might impact the management of breast and ovarian cancers, as well as the repurposing of already commercialized chemotherapeutic options to treat DIO.
    Language English
    Publishing date 2022-05-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14112709
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  9. Article: Targeting SRC Family Kinases in Mesothelioma: Time to Upgrade.

    Indovina, Paola / Forte, Iris Maria / Pentimalli, Francesca / Giordano, Antonio

    Cancers

    2020  Volume 12, Issue 7

    Abstract: ... ...

    Abstract A
    Language English
    Publishing date 2020-07-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12071866
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: RBL2/p130: a direct AKT substrate and mediator of AKT inhibition-induced apoptosis.

    Ventura, Elisa / Pentimalli, Francesca / Giordano, Antonio

    Oncoscience

    2018  Volume 5, Issue 11-12, Page(s) 278–280

    Language English
    Publishing date 2018-08-28
    Publishing country United States
    Document type Journal Article
    ISSN 2331-4737
    ISSN 2331-4737
    DOI 10.18632/oncoscience.467
    Database MEDical Literature Analysis and Retrieval System OnLINE

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