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  1. Article ; Online: Stigma Kills Psychiatric Patients and Is Now Killing Clinical Research Too.

    Post, Robert M

    The Journal of clinical psychiatry

    2022  Volume 84, Issue 1

    MeSH term(s) Humans ; Social Stigma
    Language English
    Publishing date 2022-11-28
    Publishing country United States
    Document type Letter
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.22l14716
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 108: Show issues Location:
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    Zs.MO 247: Show issues

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  2. Article ; Online: The Epigenetic Connection to Black Disparity.

    Post, Robert M

    The Journal of clinical psychiatry

    2021  Volume 82, Issue 3

    MeSH term(s) Adverse Childhood Experiences/ethnology ; African Americans/ethnology ; African Americans/genetics ; Epigenesis, Genetic/genetics ; Health Status Disparities ; Humans ; Psychological Trauma/ethnology ; Psychological Trauma/genetics ; Social Discrimination/ethnology ; Stress, Psychological/ethnology ; Stress, Psychological/genetics ; Telomere Shortening/genetics ; United States/ethnology
    Language English
    Publishing date 2021-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 716287-x
    ISSN 1555-2101 ; 0160-6689
    ISSN (online) 1555-2101
    ISSN 0160-6689
    DOI 10.4088/JCP.20com13858
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 247: Show issues

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  3. Article: The Kindling/Sensitization Model and Early Life Stress.

    Post, Robert M

    Current topics in behavioral neurosciences

    2021  Volume 48, Page(s) 255–275

    Abstract: Introduction: Few animal models address the characteristics of the longitudinal course of bipolar disorder. However, behavioral sensitization (to recurrent stressors and psychomotor stimulants) and kindling of seizures both provide clues to mechanisms ... ...

    Abstract Introduction: Few animal models address the characteristics of the longitudinal course of bipolar disorder. However, behavioral sensitization (to recurrent stressors and psychomotor stimulants) and kindling of seizures both provide clues to mechanisms in the progressive course of bipolar disorder.
    Methods: We describe aspects of bipolar illness that show sensitization and kindling-like increases reactivity to the recurrence of stressors, mood episodes, and bouts of substance abuse. Mechanisms of these events and clinical implications for treatment are discussed.
    Results: Early life stress is a risk factor for the development of episodes of unipolar depression and bipolar disorder and the acquisition of substance abuse. Initial affective episodes are often triggered by the recurrence of psychosocial stressors in adulthood, but after many episodes have occurred, episodes may also begin to emerge spontaneously in a kindling-like progression. More prior episodes are associated with faster recurrences, dysfunction, disability, frontal cortical abnormalities, cognitive impairment, shorter telomeres, treatment refractoriness, and an increased risk of a diagnosis of dementia in old age. Sensitization to stressors, episodes, and substances of abuse each appear driven by epigenetic mechanisms and their accumulation on DNA, histones, and microRNA. Patients with bipolar illness in the USA are more ill than those from Europe and experience more sensitization to stressors, episodes, substance abuse, as well as more genetic vulnerability across four generations.
    Discussion: The sensitization and kindling models highlight the importance of early intervention and prevention in order to limit or halt the downhill progression of bipolar disorder and its multiple comorbidities toward treatment refractoriness. Clinical data support this conclusion as well but have not been sufficient to change practice in the direction of early intervention. It is hoped that a better understanding of sensitization and kindling-like mechanisms will add neurobiological rationales for the importance of prevention and sustained prophylactic intervention in rendering bipolar disorder a more benign illness.
    MeSH term(s) Adult ; Adverse Childhood Experiences ; Animals ; Bipolar Disorder ; Comorbidity ; Humans ; Recurrence ; Substance-Related Disorders
    Language English
    Publishing date 2021-01-11
    Publishing country Germany
    Document type Journal Article
    ISSN 1866-3370
    ISSN 1866-3370
    DOI 10.1007/7854_2020_172
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A shocking deficit in bipolar disorder treatment research funding.

    Post, Robert M

    Bipolar disorders

    2020  Volume 22, Issue 8, Page(s) 864–865

    Language English
    Publishing date 2020-10-11
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 1472242-2
    ISSN 1399-5618 ; 1398-5647
    ISSN (online) 1399-5618
    ISSN 1398-5647
    DOI 10.1111/bdi.13010
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    Zs.A 5604: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Early Detection and Preventive Treatment in Bipolar Disorder.

    Post, Robert M

    The American journal of psychiatry

    2020  Volume 177, Issue 9, Page(s) 867

    MeSH term(s) Bipolar Disorder ; Early Diagnosis ; Fantasy ; Humans ; Schizophrenia
    Language English
    Publishing date 2020-09-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 280045-7
    ISSN 1535-7228 ; 0002-953X
    ISSN (online) 1535-7228
    ISSN 0002-953X
    DOI 10.1176/appi.ajp.2020.19111148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: How to prevent the malignant progression of bipolar disorder.

    Post, Robert M

    Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

    2020  Volume 42, Issue 5, Page(s) 552–557

    Abstract: There is increasing recognition that, in a high percentage of cases, bipolar disorder is a progressive illness. Multiple types of sensitization (or increased reactivity to repetition of the same stimulus) drive illness progression. One of the clearest is ...

    Abstract There is increasing recognition that, in a high percentage of cases, bipolar disorder is a progressive illness. Multiple types of sensitization (or increased reactivity to repetition of the same stimulus) drive illness progression. One of the clearest is that of episode sensitization, where increased numbers of prior episodes are associated with: faster recurrences; more dysfunction; disability; social, educational, and employment deficits; suicide; medical comorbidities; cognitive dysfunction; and an increased incidence of dementia in old age. Repetition of stressors and bouts of substance abuse can also result in sensitization. Each type of sensitization appears to have an epigenetic basis, such that preventing sensitization should minimize the accumulation of adverse epigenetic chemical marks on DNA, histones, and microRNA. New data emphasize the importance of early, consistent intervention after an initial manic episode. The cognitive dysfunction associated with a first episode improves only if there are no further episode recurrences during the next year. A randomized study has also shown that comprehensive multimodal prophylactic intervention for 2 years leads to improvements in illness course extending over a total of 6 years. Intensive treatment of the earliest stages of bipolar disorder can thus exert lasting positive effects on the course of illness.
    MeSH term(s) Bipolar Disorder/epidemiology ; Bipolar Disorder/prevention & control ; Comorbidity ; Disease Progression ; Humans ; Recurrence ; Substance-Related Disorders
    Language English
    Publishing date 2020-06-24
    Publishing country Brazil
    Document type Journal Article
    ISSN 1809-452X
    ISSN (online) 1809-452X
    DOI 10.1590/1516-4446-2020-0874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Bipolar II Disorder: Not So Sure It Is Time for Something New.

    Post, Robert M

    Canadian journal of psychiatry. Revue canadienne de psychiatrie

    2019  Volume 64, Issue 8, Page(s) 544–547

    MeSH term(s) Bipolar Disorder ; Diagnostic and Statistical Manual of Mental Disorders ; Humans
    Language English
    Publishing date 2019-05-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 304227-3
    ISSN 1497-0015 ; 0008-4824 ; 0706-7437
    ISSN (online) 1497-0015
    ISSN 0008-4824 ; 0706-7437
    DOI 10.1177/0706743719852097
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 110: Show issues Location:
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  8. Article ; Online: Bipolar II: Comments on its validity and utility.

    Post, Robert M

    Bipolar disorders

    2018  Volume 20, Issue 3, Page(s) 280–281

    Language English
    Publishing date 2018-01-12
    Publishing country Denmark
    Document type Journal Article ; Comment
    ZDB-ID 1472242-2
    ISSN 1399-5618 ; 1398-5647
    ISSN (online) 1399-5618
    ISSN 1398-5647
    DOI 10.1111/bdi.12607
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  9. Article ; Online: Disturbing Lack of Early Intervention Studies in Bipolar Disorder.

    Post, Robert M

    JAMA psychiatry

    2018  Volume 75, Issue 11, Page(s) 1201–1202

    MeSH term(s) Bipolar Disorder ; Early Intervention (Education) ; Humans ; Psychotic Disorders ; Research
    Language English
    Publishing date 2018-11-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2018.2396
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    Ui I Zs.235: Show issues Location:
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  10. Book: Treatment of bipolar mania

    Post, Robert M.

    (CNS spectrums ; 9,1, Suppl. ; CME accredited roundtable monograph ; 2)

    2004  

    Author's details moderator Robert M. Post
    Series title CNS spectrums ; 9,1, Suppl.
    CME accredited roundtable monograph ; 2
    an expert panel review of clinical challenges in psychiatry and neurology
    Collection an expert panel review of clinical challenges in psychiatry and neurology
    Language English
    Size 12 S. : graph. Darst.
    Publisher MBL Communications
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT014060898
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 5171 -9,1,Suppl.- not available for loan Zeitschriften-Lesesaal

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