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  1. Article ; Online: Promoting platelets is a therapeutic option to combat severe viral infection of the lung.

    Qiu, Jiahuang / Ma, Juan / Zhang, Shuping / Han, Jinxiang / Liu, Sijin

    Blood advances

    2020  Volume 4, Issue 8, Page(s) 1640–1642

    MeSH term(s) Blood Platelets ; Humans ; Lung ; Virus Diseases
    Keywords covid19
    Language English
    Publishing date 2020-04-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2915908-8
    ISSN 2473-9537 ; 2473-9529
    ISSN (online) 2473-9537
    ISSN 2473-9529
    DOI 10.1182/bloodadvances.2020001669
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Endothelial Dysfunction and Platelet Hyperactivation in Diabetic Complications Induced by Glycemic Variability.

    Huang, Ye / Yue, Long / Qiu, Jiahuang / Gao, Ming / Liu, Sijin / Wang, Jingshang

    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme

    2022  Volume 54, Issue 7, Page(s) 419–428

    Abstract: The development and progression of the complications of chronic diabetes mellitus are attributed not only to increased blood glucose levels but also to glycemic variability. Therefore, a deeper understanding of the role of glycemic variability in the ... ...

    Abstract The development and progression of the complications of chronic diabetes mellitus are attributed not only to increased blood glucose levels but also to glycemic variability. Therefore, a deeper understanding of the role of glycemic variability in the development of diabetic complications may provide more insight into targeted clinical treatment strategies in the future. Previously, the mechanisms implicated in glycemic variability-induced diabetic complications have been comprehensively discussed. However, endothelial dysfunction and platelet hyperactivation, which are two newly recognized critical pathogenic factors, have not been fully elucidated yet. In this review, we first evaluate the assessment of glycemic variability and then summarise the roles of endothelial dysfunction and platelet hyperactivation in glycemic variability-induced complications of diabetes, highlighting the molecular mechanisms involved and their interconnections.
    MeSH term(s) Blood Glucose ; Diabetes Complications/etiology ; Diabetes Mellitus, Type 2 ; Glycated Hemoglobin A/analysis ; Humans ; Vascular Diseases
    Chemical Substances Blood Glucose ; Glycated Hemoglobin A
    Language English
    Publishing date 2022-07-14
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 80125-2
    ISSN 1439-4286 ; 0018-5043
    ISSN (online) 1439-4286
    ISSN 0018-5043
    DOI 10.1055/a-1880-0978
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 681: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: A Nomogram Model Involving Preoperative Fibrinogen and Prognostic Nutritional Index Score for Predicting Postoperative Outcome in Patients with Gastric Cancer.

    Wang, Panxing / Wang, Haijiang / Qiu, Guanglin / Liu, Jiahuang / Fan, Lin / Liao, Xinhua / Che, Xiangming

    Cancer management and research

    2021  Volume 13, Page(s) 4191–4201

    Abstract: Background: Inflammation and nutrition play vital roles in the development of gastric cancer (GC). We combined the preoperative fibrinogen with prognostic nutritional index (PNI) to create a novel scoring system named as the fibrinogen and prognostic ... ...

    Abstract Background: Inflammation and nutrition play vital roles in the development of gastric cancer (GC). We combined the preoperative fibrinogen with prognostic nutritional index (PNI) to create a novel scoring system named as the fibrinogen and prognostic nutritional index (FPNI) score and establish a more effective model.
    Patients and methods: A total of 689 patients with gastric adenocarcinoma who underwent gastrectomy from January 2012 to December 2016 were reviewed. We measured correlations between FPNI score and clinicopathological variables and overall survival (OS). A nomogram predicting OS was constructed. Its predictive performance was verified using the concordance index, calibration curves, receiver operating characteristic curves, decision curve analysis and time-dependent receiver operating characteristic analysis.
    Results: We observed that the FPNI score was an independent predictor of OS in patients with gastric cancer (
    Conclusion: The preoperative FPNI score is a novel, simple, and effective predictor of OS in patients with GC. Furthermore, the nomogram involving FPNI score will help clinicians to optimize individualized treatment plans.
    Language English
    Publishing date 2021-05-25
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2508013-1
    ISSN 1179-1322
    ISSN 1179-1322
    DOI 10.2147/CMAR.S311347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A Designed

    Ma, Juan / He, Peng / Zhao, Chuanfang / Ren, Quanzhong / Dong, Zheng / Qiu, Jiahuang / Jing, Yang / Liu, Sijin / Du, Yuguo

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2020  Volume 7, Issue 14, Page(s) 2000609

    Abstract: Selective helper T cell 1 (Th1) priming agonists are a promising area of investigation for immunotherapeutic treatment of various diseases. ...

    Abstract Selective helper T cell 1 (Th1) priming agonists are a promising area of investigation for immunotherapeutic treatment of various diseases.
    Language English
    Publishing date 2020-06-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202000609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Computer‐Aided Discovery of Potent Broad‐Spectrum Vaccine Adjuvants

    Ma, Juan / Wang, Shenqing / Zhao, Chuanfang / Yan, Xiliang / Ren, Quanzhong / Dong, Zheng / Qiu, Jiahuang / Liu, Yin / Shan, Qing'e / Xu, Ming / Yan, Bing / Liu, Sijin

    Angewandte Chemie International Edition. 2023 Apr. 24, v. 62, no. 18, p. e202301059

    2023  

    Abstract: Adjuvants stimulate the immune system to vigorously respond to a vaccine. While current adjuvants such as aluminum salts and oil‐in‐water emulsions have been used for decades, they do not generate broad and long‐lasting responses in many vaccines. ... ...

    Abstract Adjuvants stimulate the immune system to vigorously respond to a vaccine. While current adjuvants such as aluminum salts and oil‐in‐water emulsions have been used for decades, they do not generate broad and long‐lasting responses in many vaccines. Consequently, more potent adjuvants are needed. Here, using computer‐aided molecule design and machine learning, we discovered 2 new, broad‐spectrum adjuvants that can boost vaccine responses. Our library containing 46 toll‐like receptor (TLR)‐targeting agonist ligands were assembled on Au nanoparticles. Comprehensive in vitro, ex vivo and in vivo studies showed both leads promoted dendritic cell activation via multiple TLRs and enhanced antigen presentation to T cells. When used together with tumor‐specific antigens to immunize mice against B16‐OVA melanoma and 4T1‐PD1 breast cancer, both adjuvants unleashed strong immune responses that suppressed tumor growth and lung metastases. Our results show computer‐aided design and screening can rapidly uncover potent adjuvants for tackling waning immunity in current vaccines.
    Keywords Toll-like receptors ; agonists ; aluminum ; antigen presentation ; breast neoplasms ; computer-aided design ; dendritic cells ; ligands ; lungs ; melanoma ; nanogold ; vaccines
    Language English
    Dates of publication 2023-0424
    Size p. e202301059
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202301059
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Airborne fine particles drive H1N1 viruses deep into the lower respiratory tract and distant organs.

    Dong, Zheng / Ma, Juan / Qiu, Jiahuang / Ren, Quanzhong / Shan, Qing'e / Duan, Xuefeng / Li, Guangle / Zuo, Yi Y / Qi, Yu / Liu, Yajun / Liu, Guoliang / Lynch, Iseult / Fang, Min / Liu, Sijin

    Science advances

    2023  Volume 9, Issue 23, Page(s) eadf2165

    Abstract: Mounting data suggest that environmental pollution due to airborne fine particles (AFPs) increases the occurrence and severity of respiratory virus infection in humans. However, it is unclear whether and how interactions with AFPs alter viral infection ... ...

    Abstract Mounting data suggest that environmental pollution due to airborne fine particles (AFPs) increases the occurrence and severity of respiratory virus infection in humans. However, it is unclear whether and how interactions with AFPs alter viral infection and distribution. We report synergetic effects between various AFPs and the H1N1 virus, regulated by physicochemical properties of the AFPs. Unlike infection caused by virus alone, AFPs facilitated the internalization of virus through a receptor-independent pathway. Moreover, AFPs promoted the budding and dispersal of progeny virions, likely mediated by lipid rafts in the host plasma membrane. Infected animal models demonstrated that AFPs favored penetration of the H1N1 virus into the distal lung, and its translocation into extrapulmonary organs including the liver, spleen, and kidney, thus causing severe local and systemic disorders. Our findings revealed a key role of AFPs in driving viral infection throughout the respiratory tract and beyond. These insights entail stronger air quality management and air pollution reduction policies.
    MeSH term(s) Animals ; Humans ; Influenza A Virus, H1N1 Subtype ; Lung ; Air Pollution ; Carrier Proteins ; Models, Animal
    Chemical Substances Carrier Proteins
    Language English
    Publishing date 2023-06-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adf2165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Computer-Aided Discovery of Potent Broad-Spectrum Vaccine Adjuvants.

    Ma, Juan / Wang, Shenqing / Zhao, Chuanfang / Yan, Xiliang / Ren, Quanzhong / Dong, Zheng / Qiu, Jiahuang / Liu, Yin / Shan, Qing'e / Xu, Ming / Yan, Bing / Liu, Sijin

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 18, Page(s) e202301059

    Abstract: Adjuvants stimulate the immune system to vigorously respond to a vaccine. While current adjuvants such as aluminum salts and oil-in-water emulsions have been used for decades, they do not generate broad and long-lasting responses in many vaccines. ... ...

    Abstract Adjuvants stimulate the immune system to vigorously respond to a vaccine. While current adjuvants such as aluminum salts and oil-in-water emulsions have been used for decades, they do not generate broad and long-lasting responses in many vaccines. Consequently, more potent adjuvants are needed. Here, using computer-aided molecule design and machine learning, we discovered 2 new, broad-spectrum adjuvants that can boost vaccine responses. Our library containing 46 toll-like receptor (TLR)-targeting agonist ligands were assembled on Au nanoparticles. Comprehensive in vitro, ex vivo and in vivo studies showed both leads promoted dendritic cell activation via multiple TLRs and enhanced antigen presentation to T cells. When used together with tumor-specific antigens to immunize mice against B16-OVA melanoma and 4T1-PD1 breast cancer, both adjuvants unleashed strong immune responses that suppressed tumor growth and lung metastases. Our results show computer-aided design and screening can rapidly uncover potent adjuvants for tackling waning immunity in current vaccines.
    MeSH term(s) Animals ; Mice ; Adjuvants, Vaccine ; Gold ; Metal Nanoparticles ; Adjuvants, Immunologic/pharmacology ; Vaccines ; Neoplasms ; Antigens, Neoplasm
    Chemical Substances Adjuvants, Vaccine ; Gold (7440-57-5) ; Adjuvants, Immunologic ; Vaccines ; Antigens, Neoplasm
    Language English
    Publishing date 2023-03-23
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202301059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [No title information]

    Huang, Ye / Yue, Long / Qiu, Jiahuang / Gao, Ming / Liu, Sijin / Wang, Jingshang

    Hormone and Metabolic Research

    2022  Volume 54, Issue 07, Page(s) 419–428

    Abstract: The development and progression of the complications of chronic diabetes mellitus are attributed not only to increased blood glucose levels but also to glycemic variability. Therefore, a deeper understanding of the ...

    Abstract The development and progression of the complications of chronic diabetes mellitus are attributed not only to increased blood glucose levels but also to glycemic variability. Therefore, a deeper understanding of the role of glycemic variability in the development of diabetic complications may provide more insight into targeted clinical treatment strategies in the future. Previously, the mechanisms implicated in glycemic variability-induced diabetic complications have been comprehensively discussed. However, endothelial dysfunction and platelet hyperactivation, which are two newly recognized critical pathogenic factors, have not been fully elucidated yet. In this review, we first evaluate the assessment of glycemic variability and then summarise the roles of endothelial dysfunction and platelet hyperactivation in glycemic variability-induced complications of diabetes, highlighting the molecular mechanisms involved and their interconnections.
    Keywords diabetes mellitus ; glycaemic variability ; endothelial dysfunction ; platelet hyperactivation
    Language English
    Publishing date 2022-07-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80125-2
    ISSN 1439-4286 ; 0018-5043
    ISSN (online) 1439-4286
    ISSN 0018-5043
    DOI 10.1055/a-1880-0978
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 681: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Newly identified lncRNA-45 promotes breast cancer metastasis through activating the mTOR signaling pathway.

    Qiu, Jiahuang / Guo, Yifan / Wang, Shunhao / Ren, Quanzhong / Dong, Zheng / Gao, Ming / Ma, Juan / Chen, Shuguang / Liu, Sijin

    Biochemical and biophysical research communications

    2022  Volume 640, Page(s) 40–49

    Abstract: Background: Metastasis, a complex multi-stage process, is the primary cause of breast cancer-related death. Unfortunately, the molecular mechanisms underlying tumor metastasis have not been fully elucidated thus far. Long noncoding RNAs (lncRNAs) ... ...

    Abstract Background: Metastasis, a complex multi-stage process, is the primary cause of breast cancer-related death. Unfortunately, the molecular mechanisms underlying tumor metastasis have not been fully elucidated thus far. Long noncoding RNAs (lncRNAs) dictate the behaviours of tumor cells via multiple signaling pathways, resulting in tumor cell migration and invasion, as well as all stages of cancer progression. LncRNAs function as regulators in shaping cellular activities directly through influencing key genes involved in biological processes of the tumor, and representing promising novel targets in cancer diagnosis and therapy. We therefore sought to define the correlations between lncRNA expression and breast cancer metastasis, especially to investigate the functional pathway underlying lncRNA-mediated tumor invasion and metastasis process.
    Results: In this study, we compared the lncRNA transcriptome profiles between primary breast cancer 4T1 cells and high metastatic 4T1-LG12 cells. We found that many differently expressed lncRNAs greatly correlated to the metastatic propensity of 4T1-LG12 cells, particularly lncRNA-45, a new lncRNA without functional annotations, which was found to be the most upregulated lncRNA transcribed by an internal region within the regulatory associated with protein of mechanistic target of rapamycin kinase (mTOR) complex 1 (Rptor) gene. LncRNA-45 was uncovered to be involved in the epithelial-to-mesenchymal transition process of breast cancer cells, as evidenced by the observation that lncRNA-45 knockdown significantly suppressed the invasive capability of parental 4T1-LG12 cells. Molecular mechanistic investigation showed that reduced activity of mTORC1-associated pathway led to a decrease of total ribosomal protein S6 kinase, polypeptide 1 (S6K1) content and enhancement of autophagy, consequently compromising the metastatic propensity in lncRNA-45 knockdown cells.
    Conclusions: Overall, our experiments uncovered that the newly identified lncRNA-45 played a regulatory role in breast cancer cell metastasis.
    MeSH term(s) Female ; Humans ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; Mechanistic Target of Rapamycin Complex 1/metabolism ; Neoplasm Metastasis ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Signal Transduction/genetics ; TOR Serine-Threonine Kinases/metabolism ; Melanoma, Cutaneous Malignant
    Chemical Substances Mechanistic Target of Rapamycin Complex 1 (EC 2.7.11.1) ; MTOR protein, human (EC 2.7.1.1) ; RNA, Long Noncoding ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2022-12-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2022.11.099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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