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  1. Article ; Online: Prone Positioning in Awake, Nonintubated Patients With COVID-19: Necessity Is the Mother of Invention.

    Sarma, Aartik / Calfee, Carolyn S

    JAMA internal medicine

    2020  Volume 180, Issue 11, Page(s) 1539–1540

    MeSH term(s) COVID-19 ; Humans ; Inventions ; Patient Positioning ; Prone Position ; Respiratory Insufficiency ; SARS-CoV-2 ; Wakefulness
    Keywords covid19
    Language English
    Publishing date 2020-06-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2020.3027
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  2. Article ; Online: Research Bronchoscopy Standards and the Need for Noninvasive Sampling of the Failing Lungs.

    Bain, William / Bastarache, Julie A / Sarma, Aartik / McElvaney, Noel G / Baron, Rebecca M / McVerry, Bryan J / Kitsios, Georgios D

    Annals of the American Thoracic Society

    2023  Volume 21, Issue 1, Page(s) 183–184

    MeSH term(s) Humans ; Bronchoscopy ; Lung/diagnostic imaging
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Letter
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202306-589LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Prone Positioning in Awake, Nonintubated Patients With COVID-19 ; Necessity Is the Mother of Invention

    Sarma, Aartik / Calfee, Carolyn S.

    JAMA Internal Medicine

    2020  Volume 180, Issue 11, Page(s) 1539

    Keywords Internal Medicine ; covid19
    Language English
    Publisher American Medical Association (AMA)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2020.3027
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Molecular Phenotypes of Acute Respiratory Distress Syndrome in the ROSE Trial Have Differential Outcomes and Gene Expression Patterns That Differ at Baseline and Longitudinally over Time.

    Sinha, Pratik / Neyton, Lucile / Sarma, Aartik / Wu, Nelson / Jones, Chayse / Zhuo, Hanjing / Liu, Kathleen D / Sanchez Guerrero, Estella / Ghale, Rajani / Love, Christina / Mick, Eran / Delucchi, Kevin L / Langelier, Charles R / Thompson, B Taylor / Matthay, Michael A / Calfee, Carolyn S

    American journal of respiratory and critical care medicine

    2024  Volume 209, Issue 7, Page(s) 816–828

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Humans ; Phenotype ; Biomarkers ; Respiratory Distress Syndrome ; Blood Proteins/genetics ; Gene Expression
    Chemical Substances Biomarkers ; Blood Proteins
    Language English
    Publishing date 2024-01-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202308-1490OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Biological Effects of Corticosteroids on Pneumococcal Pneumonia in Mice and Humans.

    Taenaka, Hiroki / Wick, Katherine D / Sarma, Aartik / Matsumoto, Shotaro / Ghale, Rajani / Fang, Xiaohui / Maishan, Mazharul / Gotts, Jeffrey E / Langelier, Charles R / Calfee, Carolyn S / Matthay, Michael A

    Research square

    2024  

    Abstract: Background: Streptococcus pneumoniae: Methods: We studied gene expression with lower respiratory tract transcriptomes from a cohort of mechanically ventilated patients and in mice. We also carried out comprehensive physiologic, biochemical, and ... ...

    Abstract Background: Streptococcus pneumoniae
    Methods: We studied gene expression with lower respiratory tract transcriptomes from a cohort of mechanically ventilated patients and in mice. We also carried out comprehensive physiologic, biochemical, and histological analyses in mice to identify the mechanisms of lung injury in
    Results: Transcriptomic analysis identified pleiotropic effects of steroid therapy on the lower respiratory tract in critically ill patients with pneumococcal pneumonia, findings that were reproducible in mice. In mice with pneumonia, dexamethasone in combination with ceftriaxone reduced (1) pulmonary edema formation, (2) alveolar protein permeability, (3) proinflammatory cytokine release, (4) histopathologic lung injury score, and (5) hypoxemia but did not increase bacterial burden.
    Conclusions: The gene expression studies in patients and in the mice support the clinical relevance of the mouse studies, which replicate several features of pneumococcal pneumonia and steroid therapy in humans. In combination with appropriate antibiotic therapy in mice, treatment of pneumococcal pneumonia with steroid therapy reduced hypoxemia, pulmonary edema, lung permeability, and histologic criteria of lung injury, and also altered inflammatory responses at the protein and gene expression level. The results from these studies provide evidence for the mechanisms that may explain the beneficial effects of glucocorticoid therapy in patients with community acquired pneumonia from
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3962861/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Biomarkers and Precision Medicine: State of the Art.

    Sarma, Aartik / Calfee, Carolyn S / Ware, Lorraine B

    Critical care clinics

    2019  Volume 36, Issue 1, Page(s) 155–165

    Abstract: Critical illness syndromes, including sepsis and the acute respiratory distress syndrome (ARDS), are identified using consensus definitions that are based on broad, clinically available criteria and include patients with heterogeneous biology. This ... ...

    Abstract Critical illness syndromes, including sepsis and the acute respiratory distress syndrome (ARDS), are identified using consensus definitions that are based on broad, clinically available criteria and include patients with heterogeneous biology. This heterogeneity is a barrier to developing and testing effective therapies for these syndromes. Biomarkers identify clinically distinct molecular phenotypes of ARDS and sepsis. These molecular phenotypes are associated with differences in mortality and predict response to several treatments in retrospective analyses of clinical trials. Biomarkers can be used for prognostic and predictive enrichment of clinical trials in critical illness to incorporate precision medicine in critical care.
    MeSH term(s) Biomarkers/blood ; Critical Care/methods ; Humans ; Precision Medicine/methods ; Predictive Value of Tests ; Prognosis ; Respiratory Distress Syndrome, Adult/blood ; Respiratory Distress Syndrome, Adult/diagnosis ; Retrospective Studies ; Sepsis/blood ; Sepsis/diagnosis
    Chemical Substances Biomarkers
    Language English
    Publishing date 2019-10-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1006423-0
    ISSN 1557-8232 ; 0749-0704
    ISSN (online) 1557-8232
    ISSN 0749-0704
    DOI 10.1016/j.ccc.2019.08.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes.

    Neyton, Lucile P A / Sinha, Pratik / Sarma, Aartik / Mick, Eran / Kalantar, Katrina / Chen, Stephanie / Wu, Nelson / Delucchi, Kevin / Zhuo, Hanjing / Bos, Lieuwe D J / Jauregui, Alejandra / Gomez, Antonio / Hendrickson, Carolyn M / Kangelaris, Kirsten N / Leligdowicz, Aleksandra / Liu, Kathleen D / Matthay, Michael A / Langelier, Charles R / Calfee, Carolyn S

    American journal of respiratory and critical care medicine

    2023  Volume 209, Issue 7, Page(s) 805–815

    Abstract: Rationale: ...

    Abstract Rationale:
    MeSH term(s) Humans ; Prospective Studies ; Critical Illness ; Phenotype ; Sepsis/genetics ; Sepsis/complications ; Respiratory Distress Syndrome/complications
    Language English
    Publishing date 2023-12-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202308-1328OC
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19.

    Neyton, Lucile P A / Patel, Ravi K / Sarma, Aartik / Willmore, Andrew / Haller, Sidney C / Kangelaris, Kirsten N / Eckalbar, Walter L / Erle, David J / Krummel, Matthew F / Hendrickson, Carolyn M / Woodruff, Prescott G / Langelier, Charles R / Calfee, Carolyn S / Fragiadakis, Gabriela K

    Research square

    2023  

    Abstract: Dexamethasone is the standard of care for critically ill patients with COVID-19, but the mechanisms by which it decreases mortality and its immunological effects in this setting are not understood. We performed bulk and single-cell RNA sequencing of the ... ...

    Abstract Dexamethasone is the standard of care for critically ill patients with COVID-19, but the mechanisms by which it decreases mortality and its immunological effects in this setting are not understood. We performed bulk and single-cell RNA sequencing of the lower respiratory tract and blood, and plasma cytokine profiling to study the effect of dexamethasone on systemic and pulmonary immune cells. We find decreased signatures of antigen presentation, T cell recruitment, and viral injury in patients treated with dexamethasone. We identify compartment- and cell- specific differences in the effect of dexamethasone in patients with severe COVID-19 that are reproducible in publicly available datasets. Our results highlight the importance of studying compartmentalized inflammation in critically ill patients.
    Language English
    Publishing date 2023-08-03
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3168149/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection.

    Maishan, Mazharul / Sarma, Aartik / Chun, Lauren F / Caldera, Saharai / Fang, Xiaohui / Abbott, Jason / Christenson, Stephanie A / Langelier, Charles R / Calfee, Carolyn S / Gotts, Jeffrey E / Matthay, Michael A

    Frontiers in immunology

    2023  Volume 14, Page(s) 1076772

    Abstract: E-cigarette use has rapidly increased as an alternative means of nicotine delivery by heated aerosolization. Recent studies demonstrate nicotine-containing e-cigarette aerosols can have immunosuppressive and pro-inflammatory effects, but it remains ... ...

    Abstract E-cigarette use has rapidly increased as an alternative means of nicotine delivery by heated aerosolization. Recent studies demonstrate nicotine-containing e-cigarette aerosols can have immunosuppressive and pro-inflammatory effects, but it remains unclear how e-cigarettes and the constituents of e-liquids may impact acute lung injury and the development of acute respiratory distress syndrome caused by viral pneumonia. Therefore, in these studies, mice were exposed one hour per day over nine consecutive days to aerosol generated by the clinically-relevant tank-style Aspire Nautilus aerosolizing e-liquid containing a mixture of vegetable glycerin and propylene glycol (VG/PG) with or without nicotine. Exposure to the nicotine-containing aerosol resulted in clinically-relevant levels of plasma cotinine, a nicotine-derived metabolite, and an increase in the pro-inflammatory cytokines IL-17A, CXCL1, and MCP-1 in the distal airspaces. Following the e-cigarette exposure, mice were intranasally inoculated with influenza A virus (H1N1 PR8 strain). Exposure to aerosols generated from VG/PG with and without nicotine caused greater influenza-induced production in the distal airspaces of the pro-inflammatory cytokines IFN-γ, TNFα, IL-1β, IL-6, IL-17A, and MCP-1 at 7 days post inoculation (dpi). Compared to the aerosolized carrier VG/PG, in mice exposed to aerosolized nicotine there was a significantly lower amount of Mucin 5 subtype AC (MUC5AC) in the distal airspaces and significantly higher lung permeability to protein and viral load in lungs at 7 dpi with influenza. Additionally, nicotine caused relative downregulation of genes associated with ciliary function and fluid clearance and an increased expression of pro-inflammatory pathways at 7 dpi. These results show that (1) the e-liquid carrier VG/PG increases the pro-inflammatory immune responses to viral pneumonia and that (2) nicotine in an e-cigarette aerosol alters the transcriptomic response to pathogens, blunts host defense mechanisms, increases lung barrier permeability, and reduces viral clearance during influenza infection. In conclusion, acute exposure to aerosolized nicotine can impair clearance of viral infection and exacerbate lung injury, findings that have implications for the regulation of e-cigarette products.
    MeSH term(s) Mice ; Animals ; Humans ; Nicotine/adverse effects ; Electronic Nicotine Delivery Systems ; Interleukin-17/pharmacology ; Influenza, Human ; Influenza A Virus, H1N1 Subtype ; Respiratory Aerosols and Droplets ; Lung ; Pneumonia, Viral ; Gene Expression
    Chemical Substances Nicotine (6M3C89ZY6R) ; Interleukin-17
    Language English
    Publishing date 2023-03-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1076772
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