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Article ; Online: How Does Being Overweight Moderate Associations between Diet and Blood Pressure in Male Adolescents?

Yap, Jia / Ng, Hwei Min / Peddie, Meredith C / Fleming, Elizabeth A / Webster, Kirsten / Scott, Tessa / Haszard, Jillian J

Nutrients

2021 Volume 13, Issue 6

Abstract: Diet is one of the strongest modifiable risk factors for hypertension. In this study, we described the associations between dietary factors and blood pressure; and explored how weight status moderated these associations in a sample of New Zealand male ... ...

Abstract	Diet is one of the strongest modifiable risk factors for hypertension. In this study, we described the associations between dietary factors and blood pressure; and explored how weight status moderated these associations in a sample of New Zealand male adolescents. We collected demographics information, anthropometric, blood pressure, and dietary data from 108 male adolescents (15-17 years old). Mixed effects and logistic regression models were used to estimate relationships between dietary variables, blood pressure, and hypertension. Moderation effects of overweight status on the relationship between hypertension and diet were explored through forest plots. One-third (36%) of the sample was classified as hypertensive. Fruit intake was related to significantly lower systolic (-2.4 mmHg,
MeSH term(s)	Adolescent ; Animals ; Blood Pressure ; Body Mass Index ; Cross-Sectional Studies ; Diet ; Fruit ; Humans ; Hypertension/etiology ; Male ; Milk ; New Zealand ; Nutrition Surveys ; Obesity/complications ; Overweight/complications ; Risk Factors ; Surveys and Questionnaires ; Vegetables
Language	English
Publishing date	2021-06-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13062054
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Genetic differentiation between and within Northern Native American language groups: an argument for the expansion of the Native American CODIS database.

Weise, Jessica A / Ng, Jillian / Oldt, Robert F / Viray, Joy / McCulloh, Kelly L / Smith, David Glenn / Kanthaswamy, Sreetharan

Forensic sciences research

2021 Volume 7, Issue 4, Page(s) 662–672

Abstract: The National Research Council recommends that genetic differentiation among subgroups of ethnic samples be lower than 3% of the total genetic differentiation within the ethnic sample to be used for estimating reliable random match probabilities for ... ...

Abstract	The National Research Council recommends that genetic differentiation among subgroups of ethnic samples be lower than 3% of the total genetic differentiation within the ethnic sample to be used for estimating reliable random match probabilities for forensic use. Native American samples in the United States' Combined DNA Index System (CODIS) database represent four language families: Algonquian, Na-Dene, Eskimo-Aleut, and Salishan. However, a minimum of 27 Native American language families exists in the US, not including language isolates. Our goal was to ascertain whether genetic differences are correlated with language groupings and, if so, whether additional language families would provide a more accurate representation of current genetic diversity among tribal populations. The 21 short tandem repeat (STR) loci included in the Globalfiler® PCR Amplification Kit were used to characterize six indigenous language families, including three of the four represented in the CODIS database (i.e. Algonquian, Na-Dene, and Eskimo-Aleut), and two language isolates (Miwok and Seri) using major population genetic diversity metrics such as F statistics and Bayesian clustering analysis of genotype frequencies. Most of the genetic variation (97%) was found to be within language families instead of among them (3%). In contrast, when only the three of the four language families represented in both the CODIS database and the present study were considered, 4% of the genetic variation occurred among the language groups. Bayesian clustering resulted in a maximum posterior probability indicating three genetically distinct groups among the eight language families and isolates: (1) Eskimo, (2) Seri, and (3) all other language groups and isolates, thus confirming genetic subdivision among subgroups of the CODIS Native American database. This genetic structure indicates the need for an increased number of Native American populations based on language affiliation in the CODIS database as well as more robust sample sets for those language families. Supplemental data for this article is available online at https://doi.org/10.1080/20961790.2021.1963088 .
Language	English
Publishing date	2021-09-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2885963-7
ISSN	2471-1411 ; 2096-1790
ISSN (online)	2471-1411
ISSN	2096-1790
DOI	10.1080/20961790.2021.1963088
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Article: How Does Being Overweight Moderate Associations between Diet and Blood Pressure in Male Adolescents?

Yap, Jia / Ng, Hwei Min / Peddie, Meredith C. / Fleming, Elizabeth A. / Webster, Kirsten / Scott, Tessa / Haszard, Jillian J.

Nutrients. 2021 June 15, v. 13, no. 6

2021

Abstract	Diet is one of the strongest modifiable risk factors for hypertension. In this study, we described the associations between dietary factors and blood pressure; and explored how weight status moderated these associations in a sample of New Zealand male adolescents. We collected demographics information, anthropometric, blood pressure, and dietary data from 108 male adolescents (15–17 years old). Mixed effects and logistic regression models were used to estimate relationships between dietary variables, blood pressure, and hypertension. Moderation effects of overweight status on the relationship between hypertension and diet were explored through forest plots. One-third (36%) of the sample was classified as hypertensive. Fruit intake was related to significantly lower systolic (−2.4 mmHg, p = 0.005) and diastolic blood pressure (−3.9 mmHg, p = 0.001). Vegetable and milk intake was related to significantly lower diastolic blood pressure (−1.4 mmHg, p = 0.047) and (−2.2 mmHg, p = 0.003), respectively. In overweight participants, greater vegetable and milk, and lower meat intake appeared to reduce the odds of hypertension. Certain dietary factors may have more prominent effects on blood pressure depending on weight status.
Keywords	demographic statistics ; diastolic blood pressure ; forests ; fruit consumption ; hypertension ; males ; meat consumption ; milk ; milk consumption ; overweight ; regression analysis ; vegetables ; New Zealand
Language	English
Dates of publication	2021-0615
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu13062054
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Article ; Online: Systematic single amino acid affinity tuning of CD229 CAR T cells retains efficacy against multiple myeloma and eliminates on-target off-tumor toxicity.

Vander Mause, Erica R / Baker, Jillian M / Dietze, Kenneth A / Radhakrishnan, Sabarinath V / Iraguha, Thierry / Omili, Destiny / Davis, Patricia / Chidester, Sadie L / Modzelewska, Katarzyna / Panse, Jens / Marvin, James E / Olson, Michael L / Steinbach, Mary / Ng, David P / Lim, Carol S / Atanackovic, Djordje / Luetkens, Tim

Science translational medicine

2023 Volume 15, Issue 705, Page(s) eadd7900

Abstract: T cells expressing chimeric antigen receptors (CARs) have shown remarkable therapeutic activity against different types of cancer. However, the wider use of CAR T cells has been hindered by the potential for life-threatening toxicities due to on-target ... ...

Abstract	T cells expressing chimeric antigen receptors (CARs) have shown remarkable therapeutic activity against different types of cancer. However, the wider use of CAR T cells has been hindered by the potential for life-threatening toxicities due to on-target off-tumor killing of cells expressing low amounts of the target antigen. CD229, a signaling lymphocyte-activation molecule (SLAM) family member, has previously been identified as a target for CAR T cell-mediated treatment of multiple myeloma (MM) due to its high expression on the surfaces of MM cells. CD229 CAR T cells have shown effective clearance of MM cells in vitro and in vivo. However, healthy lymphocytes also express CD229, albeit at lower amounts than MM cells, causing their unintended targeting by CD229 CAR T cells. To increase the selectivity of CD229 CAR T cells for MM cells, we used a single amino acid substitution approach of the CAR binding domain to reduce CAR affinity. To identify CARs with increased selectivity, we screened variant binding domains using solid-phase binding assays and biolayer interferometry and determined the cytotoxic activity of variant CAR T cells against MM cells and healthy lymphocytes. We identified a CD229 CAR binding domain with micromolar affinity that, when combined with overexpression of c-Jun, confers antitumor activity comparable to parental CD229 CAR T cells but lacks the parental cells' cytotoxic activity toward healthy lymphocytes in vitro and in vivo. The results represent a promising strategy to improve the efficacy and safety of CAR T cell therapy that requires clinical validation.
MeSH term(s)	Humans ; Multiple Myeloma/pathology ; Amino Acids/metabolism ; T-Lymphocytes ; Receptors, Chimeric Antigen/metabolism ; Immunotherapy, Adoptive/methods ; Antineoplastic Agents/metabolism ; Xenograft Model Antitumor Assays ; Cell Line, Tumor
Chemical Substances	Amino Acids ; Receptors, Chimeric Antigen ; Antineoplastic Agents
Language	English
Publishing date	2023-07-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.add7900
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Article ; Online: Genetic differentiation between and within Northern Native American language groups

Jessica A. Weise / Jillian Ng / Robert F. Oldt / Joy Viray / Kelly L. McCulloh / David Glenn Smith / Sreetharan Kanthaswamy

Forensic Sciences Research, Vol 0, Iss 0, Pp 1-

an argument for the expansion of the Native American CODIS database

2021 Volume 11

Abstract	The National Research Council recommends that genetic differentiation among subgroups of ethnic samples be lower than 3% of the total genetic differentiation within the ethnic sample to be used for estimating reliable random match probabilities for forensic use. Native American samples in the United States’ Combined DNA Index System (CODIS) database represent four language families: Algonquian, Na-Dene, Eskimo-Aleut, and Salishan. However, a minimum of 27 Native American language families exists in the US, not including language isolates. Our goal was to ascertain whether genetic differences are correlated with language groupings and, if so, whether additional language families would provide a more accurate representation of current genetic diversity among tribal populations. The 21 short tandem repeat (STR) loci included in the Globalfiler® PCR Amplification Kit were used to characterize six indigenous language families, including three of the four represented in the CODIS database (i.e. Algonquian, Na-Dene, and Eskimo-Aleut), and two language isolates (Miwok and Seri) using major population genetic diversity metrics such as F statistics and Bayesian clustering analysis of genotype frequencies. Most of the genetic variation (97%) was found to be within language families instead of among them (3%). In contrast, when only the three of the four language families represented in both the CODIS database and the present study were considered, 4% of the genetic variation occurred among the language groups. Bayesian clustering resulted in a maximum posterior probability indicating three genetically distinct groups among the eight language families and isolates: (1) Eskimo, (2) Seri, and (3) all other language groups and isolates, thus confirming genetic subdivision among subgroups of the CODIS Native American database. This genetic structure indicates the need for an increased number of Native American populations based on language affiliation in the CODIS database as well as more robust sample sets for those language ...
Keywords	forensic sciences ; population genetics ; native americans ; north america ; languages ; short tandem repeats (strs or microsatellites) ; Criminal law and procedure ; K5000-5582 ; Public aspects of medicine ; RA1-1270
Subject code	410
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Prone Positioning of Patients With Acute Respiratory Distress Syndrome Related to COVID-19: A Rehabilitation-Based Prone Team.

Ng, Jillian A / Miccile, Lauren A / Iracheta, Christine / Berndt, Carolyn / Detwiller, Meredith / Yuse, Carolyn / Tolland, Joseph

Physical therapy

2020 Volume 100, Issue 10, Page(s) 1737–1745

Abstract: Objective: Prone positioning is an effective intervention for acute respiratory distress syndrome (ARDS). An increasing number of patients with ARDS related to coronavirus disease 2019 require prone positioning, which poses a challenge to the intensive ... ...

Abstract	Objective: Prone positioning is an effective intervention for acute respiratory distress syndrome (ARDS). An increasing number of patients with ARDS related to coronavirus disease 2019 require prone positioning, which poses a challenge to the intensive care unit staff at Brigham and Women's Hospital. Methods: A prone team service of physical therapists and occupational therapists with critical care experience was established to assist with increasing demands for prone positioning of patients who were mechanically ventilated. The goals of the rehabilitation-based prone team were to provide support to nursing and respiratory therapy; create a consistent, efficient process; and ensure patient and staff safety. Results: The service evolved over 7 weeks, expanding to 24-hour coverage and adding responsibilities to support the staff as patient volume grew. The volume of requests to the rehabilitation-based prone team generally increased to week 4 and has, since then, declined. Key points for successful implementation included identification of rehabilitation therapists with intensive care unit experience and leadership qualities, multidisciplinary collaboration, availability of needed positioning devices and supplies to protect the integument, and well-defined roles of all disciplines participating in position change process. Conclusion: The description of the development, operations, evolution, and utilization of a rehabilitation therapist prone team acts as a guide for future development and implementation. Impact: This case report is one of the first reports of a rehabilitation-based prone team established to assist with positioning patients in prone as an intervention for ARDS related to coronavirus disease 2019 and will help guide other institutions.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/therapy ; Critical Care ; Humans ; Pandemics ; Patient Positioning ; Pneumonia, Viral/complications ; Pneumonia, Viral/therapy ; Prone Position ; Respiration, Artificial ; Respiratory Distress Syndrome/therapy ; Respiratory Distress Syndrome/virology ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-07-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	415886-6
ISSN	1538-6724 ; 0031-9023
ISSN (online)	1538-6724
ISSN	0031-9023
DOI	10.1093/ptj/pzaa124
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Article ; Online: ILROG Lymphoma Mini-Atlas Part II, Hodgkin Lymphoma.

Dabaja, Bouthaina Shbib / Ng, Andrea K / Terezakis, Stephanie A / Plastaras, John P / Yunes, Micheal / Wilson, Lynn D / Yang, Joanna / Gunther, Jillian R / Specht, Lena / Yahalom, Joachim

International journal of radiation oncology, biology, physics

2020 Volume 108, Issue 4, Page(s) 977–978

MeSH term(s)	Hodgkin Disease/pathology ; Hodgkin Disease/radiotherapy ; Humans ; Mediastinal Neoplasms/radiotherapy ; Organs at Risk ; Progression-Free Survival ; Radiation Injuries/prevention & control ; Radiotherapy, Conformal/methods
Language	English
Publishing date	2020-08-04
Publishing country	United States
Document type	Editorial
ZDB-ID	197614-x
ISSN	1879-355X ; 0360-3016
ISSN (online)	1879-355X
ISSN	0360-3016
DOI	10.1016/j.ijrobp.2020.05.063
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Article ; Online: "

Lawrence, Sarah / Moraa, Hellen / Wilson, Kate / Mutisya, Immaculate / Neary, Jillian / Kinuthia, John / Itindi, Janet / Nyaboe, Edward / Muhenje, Odylia / Chen, Tai-Ho / Singa, Benson / McGrath, Christine J / Ngugi, Evelyn / Kohler, Pamela / Roxby, Alison C / Katana, Abraham / Ng'ang'a, Lucy / John-Stewart, Grace C / Beima-Sofie, Kristin

Frontiers in reproductive health

2021 Volume 3, Page(s) 644832

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-04-26
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-3153
ISSN (online)	2673-3153
DOI	10.3389/frph.2021.644832
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Article ; Online: Determination of major histocompatibility class I and class II genetic composition of the Caribbean Primate Center specific pathogen-free rhesus macaque (Macaca mulatta) colony based on massively parallel sequencing.

Kanthaswamy, Sreetharan / Oldt, Robert F / Ng, Jillian / Smith, David Glenn / Martínez, Melween I / Sariol, Carlos A

Journal of medical primatology

2018 Volume 47, Issue 6, Page(s) 379–387

Abstract: Background: Knowledge of major histocompatibility complex (MHC) composition and distribution in rhesus macaque colonies is critical for management strategies that maximize the utility of this model for biomedical research.: Methods: Variation within ... ...

Abstract	Background: Knowledge of major histocompatibility complex (MHC) composition and distribution in rhesus macaque colonies is critical for management strategies that maximize the utility of this model for biomedical research. Methods: Variation within the Mamu-A and Mamu-B (class I) and DRB, DQA/B, and DPA/B (class II) regions of 379 animals from the Caribbean Primate Research Center's (CPRC) specific pathogen free (SPF) colony was examined using massively parallel sequencing. Results: Analyses of the 7 MHC loci revealed a background of Indian origin with high levels of variation despite past genetic bottlenecks. All loci exhibited mutual linkage disequilibria while conforming to Hardy-Weinberg expectations suggesting the achievement of mutation-selection balance. Conclusion: The CPRC's SPF colony is a significant resource for research on AIDS and other infectious agents. Characterizing colony-wide MHC variability facilitates the breeding and selection of animals bearing desired haplotypes and increases the investigator's ability to understand the immune responses mounted by these animals.
MeSH term(s)	Alleles ; Animals ; Animals, Laboratory/genetics ; Gene Frequency ; Genes, MHC Class I ; Genes, MHC Class II ; Haplotypes ; High-Throughput Nucleotide Sequencing ; Macaca mulatta/genetics ; Puerto Rico ; Specific Pathogen-Free Organisms
Language	English
Publishing date	2018-07-04
Publishing country	Denmark
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	121206-0
ISSN	1600-0684 ; 0047-2565
ISSN (online)	1600-0684
ISSN	0047-2565
DOI	10.1111/jmp.12353
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Article ; Online: Higher prevalence of stunting and poor growth outcomes in HIV-exposed uninfected than HIV-unexposed infants in Kenya.

Neary, Jillian / Langat, Agnes / Singa, Benson / Kinuthia, John / Itindi, Janet / Nyaboe, Edward / Ng'anga', Lucy W / Katana, Abraham / John-Stewart, Grace C / McGrath, Christine J

AIDS (London, England)

2021 Volume 36, Issue 4, Page(s) 605–610

Abstract: Background: With the growing population of HIV-exposed uninfected (HEU) children globally, it is important to determine population-level growth differences between HEU and HIV-unexposed uninfected (HUU) children.: Methods: We analyzed data from a ... ...

Abstract	Background: With the growing population of HIV-exposed uninfected (HEU) children globally, it is important to determine population-level growth differences between HEU and HIV-unexposed uninfected (HUU) children. Methods: We analyzed data from a population-level survey enrolling mother-infant pairs attending 6-week and 9-month immunizations in 140 clinics across Kenya. Weight-for-age (WAZ), length-for-age (LAZ), head circumference-for-age (HCAZ) z-scores and underweight (WAZ < -2), stunting (LAZ < -2), and microcephaly (HCAZ < -2), were compared between HEU and HUU. Correlates of growth faltering and poor growth were assessed using generalized Poisson and linear regression models. Results: Among 2457 infants, 456 (19%) were HEU. Among mothers living with HIV, 64% received antiretroviral therapy (ART) and 22% were on antiretroviral prophylaxis during pregnancy. At 9 months, 72% of HEU and 98% of HUU were breastfeeding. At 6 weeks, HEU had lower mean WAZ (-0.41 vs. -0.09; P < 0.001) and LAZ (-0.99 vs. -0.31; P = 0.001) than HUU. Stunting was higher in HEU than HUU at 6 weeks (34% vs. 18%, P < 0.001) and 9 months (20% vs. 10%, P < 0.001). In multivariable analyses, HEU had lower mean LAZ at 6 weeks (-0.67, 95% confidence interval [CI]: -1.07, -0.26) and 9 months (-0.57, 95% CI: -0.92, -0.21) and HEU had higher stunting prevalence (week-6 adjusted prevalence ratio [aPR]: 1.88, 95% CI: 1.35, 2.63; month-9 aPR: 2.10, 95% CI: 1.41, 3.13). HEU had lower mean head circumference (-0.49, 95% CI: -0.91, -0.07) and higher prevalence of microcephaly (aPR: 2.21, 95% CI: 1.11, 4.41) at 9 months. Conclusion: Despite high maternal ART coverage, HEU had poorer growth than HUU in this large population-level comparison. Optimizing breastfeeding practices in HEU may be useful to improve growth.
MeSH term(s)	Child ; Female ; Growth Disorders/epidemiology ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Infant ; Kenya/epidemiology ; Microcephaly ; Pregnancy ; Pregnancy Complications, Infectious/drug therapy ; Prevalence ; Prospective Studies
Language	English
Publishing date	2021-01-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/QAD.0000000000003124
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